Details for: GPANK1

Gene ID: 7918

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: GPANK1

Ensembl ID: ENSG00000204438

Description: G-patch domain and ankyrin repeats 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • hematopoietic stem cell CL0000037
    CSI 7.54
    rCSI 5.01%
    PRS 89.01
  • group 3 innate lymphoid cell CL0001071
    CSI 5.97
    rCSI 4.49%
    PRS 91.16
  • goblet cell CL0000160
    CSI 5.87
    rCSI 5.54%
    PRS 85.21
  • multi-ciliated epithelial cell CL0005012
    CSI 4.88
    rCSI 4.87%
    PRS 81.42
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 4.74
    rCSI 3.8%
    PRS 94.47
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 4.27
    rCSI 10.28%
    PRS 95.37
  • fibroblast of lung CL0002553
    CSI 3.89
    rCSI 3.62%
    PRS 88.15
  • rod bipolar cell CL0000751
    CSI 3.79
    rCSI 6.82%
    PRS 81.62
  • unswitched memory B cell CL0000970
    CSI 3.45
    rCSI 2.9%
    PRS 95.9
  • hematopoietic precursor cell CL0008001
    CSI 3.35
    rCSI 3.44%
    PRS 94.28
  • class switched memory B cell CL0000972
    CSI 3.28
    rCSI 2.45%
    PRS 95.12
  • myeloid leukocyte CL0000766
    CSI 3.26
    rCSI 3.01%
    PRS 88.2
  • bronchus fibroblast of lung CL2000093
    CSI 3.21
    rCSI 2.61%
    PRS 86.66
  • ionocyte CL0005006
    CSI 3.15
    rCSI 3.38%
    PRS 89.03
  • perivascular cell CL4033054
    CSI 3.1
    rCSI 4.23%
    PRS 90.76
  • pro-B cell CL0000826
    CSI 2.81
    rCSI 2.32%
    PRS 89.02
  • mature B cell CL0000785
    CSI 2.8
    rCSI 2.44%
    PRS 93.93
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.79
    rCSI 1.95%
    PRS 90.53
  • ON-bipolar cell CL0000749
    CSI 2.7
    rCSI 4.01%
    PRS 86.54
  • ciliated epithelial cell CL0000067
    CSI 2.67
    rCSI 2.35%
    PRS 77.86
  • tracheobronchial smooth muscle cell CL0019019
    CSI 2.67
    rCSI 4.7%
    PRS 90.5
  • early lymphoid progenitor CL0000936
    CSI 2.58
    rCSI 2.27%
    PRS 90.75
  • neural crest cell CL0011012
    CSI 2.58
    rCSI 2.04%
    PRS 78.54
  • mesodermal cell CL0000222
    CSI 2.57
    rCSI 3.08%
    PRS 85.61
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.52
    rCSI 1.94%
    PRS 90.3
  • fraction A pre-pro B cell CL0002045
    CSI 2.48
    rCSI 2.83%
    PRS 92.96
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.44
    rCSI 2.4%
    PRS 96.13
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.42
    rCSI 2.1%
    PRS 89.9
  • precursor B cell CL0000817
    CSI 2.39
    rCSI 2.1%
    PRS 92
  • intestine goblet cell CL0019031
    CSI 2.31
    rCSI 2.05%
    PRS 84.61
  • enteric smooth muscle cell CL0002504
    CSI 2.26
    rCSI 3.23%
    PRS 87.61
  • epithelial cell of lung CL0000082
    CSI 2.21
    rCSI 1.83%
    PRS 88.2
  • vascular associated smooth muscle cell CL0000359
    CSI 2.2
    rCSI 7.12%
    PRS 85.26
  • erythrocyte CL0000232
    CSI 2.13
    rCSI 4.83%
    PRS 86.3
  • transit amplifying cell of colon CL0009011
    CSI 2.1
    rCSI 2.47%
    PRS 87.89
  • intestinal tuft cell CL0019032
    CSI 2.08
    rCSI 3.18%
    PRS 89.64
  • colon epithelial cell CL0011108
    CSI 2.07
    rCSI 2.17%
    PRS 84.72
  • ependymal cell CL0000065
    CSI 1.95
    rCSI 3.95%
    PRS 68.01
  • promyelocyte CL0000836
    CSI 1.94
    rCSI 2.8%
    PRS 90.53
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.93
    rCSI 2.23%
    PRS 79.72
  • radial glial cell CL0000681
    CSI 1.91
    rCSI 2.66%
    PRS 85.47
  • common dendritic progenitor CL0001029
    CSI 1.9
    rCSI 2.39%
    PRS 93.01
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 1.84
    rCSI 2.36%
    PRS 83.55
  • common myeloid progenitor CL0000049
    CSI 1.77
    rCSI 1.43%
    PRS 88.83
  • IgG plasma cell CL0000985
    CSI 1.73
    rCSI 2.07%
    PRS 93.02
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.72
    rCSI 1.56%
    PRS 85.8
  • club cell CL0000158
    CSI 1.69
    rCSI 2.47%
    PRS 82.31
  • retinal cone cell CL0000573
    CSI 1.66
    rCSI 2.67%
    PRS 78.61
  • intestinal epithelial cell CL0002563
    CSI 1.62
    rCSI 1.69%
    PRS 84.69
  • peripheral nervous system neuron CL2000032
    CSI 1.51
    rCSI 2.06%
    PRS 80.12
  • lung ciliated cell CL1000271
    CSI 1.49
    rCSI 1.72%
    PRS 80.9
  • basal cell CL0000646
    CSI 1.47
    rCSI 1.96%
    PRS 84.69
  • glioblast CL0000030
    CSI 1.43
    rCSI 2.28%
    PRS 79.26
  • retina horizontal cell CL0000745
    CSI 1.39
    rCSI 2.11%
    PRS 84.27
  • large pre-B-II cell CL0000957
    CSI 1.25
    rCSI 3.58%
    PRS 89.15
  • platelet CL0000233
    CSI 1.09
    rCSI 4.52%
    PRS 84.06
  • promonocyte CL0000559
    CSI 1.01
    rCSI 1.73%
    PRS 90.47
  • mesenchymal cell CL0008019
    CSI 0.94
    rCSI 2.38%
    PRS 81.36
  • primitive red blood cell CL0002355
    CSI 0.91
    rCSI 4.92%
    PRS 90.22
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.69
    rCSI 2%
    PRS 86.39
  • erythroid progenitor cell CL0000038
    CSI 0.42
    rCSI 2.41%
    PRS 90.09

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [GPANK1](/details-gene/7918) (G-patch domain and ankyrin repeats 1) is a protein-coding gene located on human chromosome 6 within the major histocompatibility complex (MHC) class III region ([Link](https://doi.org/10.1038/nature02055), [Link](https://doi.org/10.1101/gr.1736803)). The encoded protein contains domains implicated in [nucleic acid binding](/details-go/GO:0003676) and [protein binding](/details-go/GO:0005515), suggesting a role as an adapter or regulatory molecule. Expression data indicates that [GPANK1](/details-gene/7918) is a significant gene in a broad range of cell types. **Overall**, it shows particularly high significance in [hematopoietic stem cell](/details-cell/CL0000037), as well as in diverse cell types including [group 3 innate lymphoid cell](/details-cell/CL0001071) and secretory [goblet cell](/details-cell/CL0000160), pointing towards fundamental roles in both hematopoietic development and specialized epithelial function. ## Cellular Roles and Expression Landscape The expression profile of [GPANK1](/details-gene/7918) suggests its importance across multiple, functionally distinct biological systems. The gene exhibits its highest significance in the context of hematopoiesis and immunity. It is a top marker in primitive cell types such as [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 7.54) and [hematopoietic multipotent progenitor cell](/details-cell/CL0000837), suggesting a potential role in the maintenance or early differentiation of the hematopoietic system. Its prominence extends to mature immune lineages, including lymphoid cells like [group 3 innate lymphoid cell](/details-cell/CL0001071), [CD4-positive, alpha-beta thymocyte](/details-cell/CL0000810), [unswitched memory B cell](/details-cell/CL0000970), and [class switched memory B cell](/details-cell/CL0000972), as well as [myeloid leukocyte](/details-cell/CL0000766). Beyond the immune system, [GPANK1](/details-gene/7918) is also highly significant in various epithelial and structural cells. This includes specialized secretory cells like [goblet cell](/details-cell/CL0000160), barrier cells such as [multi-ciliated epithelial cell](/details-cell/CL0005012) and [ionocyte](/details-cell/CL0005006), and stromal cells like [fibroblast of lung](/details-cell/CL0002553). This broad expression pattern indicates that [GPANK1](/details-gene/7918) may be involved in a fundamental cellular process that is in high demand across these diverse cell types, rather than being a specific marker for a single lineage. ## Pathways and Molecular Function The function of [GPANK1](/details-gene/7918) is inferred from its protein structure, which contains a G-patch domain and ankyrin repeats. G-patch domains are frequently associated with RNA processing and protein-protein interactions, while ankyrin repeats are well-characterized protein-protein interaction motifs. This is consistent with its Gene Ontology annotations for [nucleic acid binding](/details-go/GO:0003676) and [protein binding](/details-go/GO:0005515). These functions suggest that [GPANK1](/details-gene/7918) likely acts as a scaffolding protein or an adapter molecule, potentially mediating the assembly of larger macromolecular complexes involved in gene expression or signal transduction. Such a role would be consistent with its broad importance across the diverse cell types where it is highly expressed. The gene has been identified in large-scale proteomics studies investigating mitotic phosphorylation ([Link](https://doi.org/10.1073/pnas.0805139105)) and SUMOylation ([Link](https://doi.org/10.1038/nsmb.3366)), indicating it is subject to post-translational modifications that may regulate its activity and interactions. ## Research Directions The widespread yet significant expression of [GPANK1](/details-gene/7918) across hematopoietic, epithelial, and stromal lineages presents several avenues for future investigation. Its clinical association is noted in OMIM ([142610](https://omim.org/entry/142610)) and it has been found mutated in renal carcinoma ([Link](https://doi.org/10.1038/nature09639)). Based on the available data, several testable hypotheses can be proposed: 1. Given its high significance in hematopoietic progenitors, [GPANK1](/details-gene/7918) may be a critical regulator of hematopoietic stem cell self-renewal or lineage commitment. Its protein and nucleic acid binding functions could be central to orchestrating the transcriptional networks that maintain stemness or direct differentiation. 2. The high expression of [GPANK1](/details-gene/7918) in metabolically active, specialized cells like [goblet cell](/details-cell/CL0000160) and [group 3 innate lymphoid cell](/details-cell/CL0001071) suggests it may function as a general cofactor in essential cellular processes, such as RNA splicing or protein complex assembly, that are in high demand in these cell types. To test the first hypothesis regarding its role in hematopoiesis, a key experiment would be to generate a conditional knockout mouse model where [GPANK1](/details-gene/7918) is specifically deleted in hematopoietic stem and progenitor cells. The consequence of this deletion could be evaluated through serial bone marrow transplantation assays to assess self-renewal capacity, and the differentiation potential could be monitored by flow cytometry and single-cell RNA sequencing of hematopoietic compartments in the bone marrow and periphery. From a therapeutic perspective, the broad expression profile of [GPANK1](/details-gene/7918) in many essential cell types suggests that systemic targeting could lead to significant off-target toxicity. Therefore, its potential as a therapeutic target is likely limited, unless a specific dependency is discovered in a pathological context, such as in certain cancers where it might be aberrantly expressed or mutated. In such cases, developing highly targeted inhibitors might be a viable strategy.

Genular Protein ID: 2710534503

Symbol: GPAN1_HUMAN

Name: G patch domain and ankyrin repeat-containing protein 1

UniProtKB Accession Codes:

O95872 A6NG25 B0UXA2 Q5SQ49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 30 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 9 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 356
  • Mass: 39314
  • Checksum: AA57AA938A8C10E5
  • Sequence:
    • MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD ESSAPDSQRS 
QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL 
RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA 
AQLAEEAGFP EVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL 
SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS 
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF

Genular Protein ID: 1985605076

Symbol: B2RA66_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RA66

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 3 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 356
  • Mass: 39215
  • Checksum: 998E45ADE23B6DA6
  • Sequence:
    • MSRPLLITFT PATDPSDLWK DGQQQLQPEK PESTLDGAAA LAFYEALIGD ESSAPDSQRS 
QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL 
RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA 
AQLAEEAGFP GVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL 
SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS 
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF