Details for: GPANK1

Gene ID: 7918

Symbol: GPANK1

Ensembl ID: ENSG00000204438

Description: G-patch domain and ankyrin repeats 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.9855
    Cell Significance Index: -16.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.5859
    Cell Significance Index: -17.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.4016
    Cell Significance Index: -24.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.7868
    Cell Significance Index: -19.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.8108
    Cell Significance Index: -23.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.0004
    Cell Significance Index: -20.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.5919
    Cell Significance Index: -21.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6450
    Cell Significance Index: -20.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7627
    Cell Significance Index: -22.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3172
    Cell Significance Index: -13.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.3683
    Cell Significance Index: 38.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2145
    Cell Significance Index: 72.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1339
    Cell Significance Index: 123.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9379
    Cell Significance Index: 152.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8347
    Cell Significance Index: 22.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6384
    Cell Significance Index: 8.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6310
    Cell Significance Index: 5.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6275
    Cell Significance Index: 5.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6085
    Cell Significance Index: 42.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5396
    Cell Significance Index: 34.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5312
    Cell Significance Index: 15.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4856
    Cell Significance Index: 22.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4811
    Cell Significance Index: 47.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4435
    Cell Significance Index: 60.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4369
    Cell Significance Index: 22.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4166
    Cell Significance Index: 26.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4143
    Cell Significance Index: 53.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4104
    Cell Significance Index: 14.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3879
    Cell Significance Index: 69.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3582
    Cell Significance Index: 195.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3236
    Cell Significance Index: 15.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3074
    Cell Significance Index: 37.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2957
    Cell Significance Index: 58.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2739
    Cell Significance Index: 14.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2661
    Cell Significance Index: 5.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2651
    Cell Significance Index: 12.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2499
    Cell Significance Index: 47.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2358
    Cell Significance Index: 104.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2324
    Cell Significance Index: 12.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2258
    Cell Significance Index: 156.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2026
    Cell Significance Index: 4.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1636
    Cell Significance Index: 1.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1467
    Cell Significance Index: 17.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1444
    Cell Significance Index: 1.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1392
    Cell Significance Index: 2.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1320
    Cell Significance Index: 1.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1198
    Cell Significance Index: 1.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1037
    Cell Significance Index: 7.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0945
    Cell Significance Index: 7.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0723
    Cell Significance Index: 14.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0695
    Cell Significance Index: 8.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0617
    Cell Significance Index: 1.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0554
    Cell Significance Index: 2.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0468
    Cell Significance Index: 7.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0354
    Cell Significance Index: 0.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0184
    Cell Significance Index: 0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0106
    Cell Significance Index: 19.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0039
    Cell Significance Index: 0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0003
    Cell Significance Index: 0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0090
    Cell Significance Index: -12.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0230
    Cell Significance Index: -17.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0239
    Cell Significance Index: -2.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0252
    Cell Significance Index: -14.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0293
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0426
    Cell Significance Index: -4.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0478
    Cell Significance Index: -29.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0521
    Cell Significance Index: -1.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0577
    Cell Significance Index: -1.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0709
    Cell Significance Index: -3.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0805
    Cell Significance Index: -23.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0902
    Cell Significance Index: -1.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0936
    Cell Significance Index: -13.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0954
    Cell Significance Index: -11.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1024
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1174
    Cell Significance Index: -24.7200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1492
    Cell Significance Index: -6.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1506
    Cell Significance Index: -11.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2060
    Cell Significance Index: -21.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2068
    Cell Significance Index: -16.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2180
    Cell Significance Index: -6.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2514
    Cell Significance Index: -6.7300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2514
    Cell Significance Index: -2.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2640
    Cell Significance Index: -6.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2674
    Cell Significance Index: -5.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2918
    Cell Significance Index: -7.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3839
    Cell Significance Index: -23.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3896
    Cell Significance Index: -7.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4220
    Cell Significance Index: -6.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4330
    Cell Significance Index: -6.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4680
    Cell Significance Index: -20.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4757
    Cell Significance Index: -14.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5031
    Cell Significance Index: -18.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5036
    Cell Significance Index: -8.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPANK1 is a relatively small gene, comprising approximately 1.2 kilobases of coding sequence. Its protein product, GPAN1_HUMAN, exhibits a unique combination of G-patch and ankyrin repeat domains, which are thought to contribute to its ability to interact with nucleic acids and proteins. The gene's expression profile is characterized by a wide range of cell types, including those involved in immune responses, cellular migration, and tissue development. Notably, GPANK1 is also expressed in the nervous system, where it may play a role in regulating neural crest cell migration and differentiation. **Pathways and Functions:** The functional mechanisms underlying GPANK1's role remain poorly understood. However, several signaling pathways are thought to be involved in its activity. Nucleic acid binding and protein binding are key functional domains of GPAN1_HUMAN, which may enable the protein to interact with various cellular components, including RNA, DNA, and other proteins. The G-patch domain, in particular, is known to interact with specific RNA sequences, suggesting a potential role in regulating gene expression. Additionally, GPAN1_HUMAN may participate in protein-protein interactions, influencing cellular signaling pathways and migration. **Clinical Significance:** Despite its relatively low expression profile, GPANK1 has been implicated in various diseases, including cancer, neurological disorders, and autoimmune conditions. For instance, recent studies have suggested that GPANK1 may play a role in the regulation of immune cell migration and function, which could have implications for the treatment of autoimmune diseases. Additionally, the gene's involvement in cellular migration and differentiation may have relevance for the study of neurological disorders, such as Alzheimer's disease and Parkinson's disease. Further research is needed to fully elucidate the clinical significance of GPANK1 and its potential as a therapeutic target. In conclusion, GPANK1 is a complex gene with a multifaceted role in the human body. While its functional mechanisms remain poorly understood, emerging evidence suggests that GPANK1 plays a critical role in regulating immune cell migration, cellular differentiation, and gene expression. Further research is needed to fully elucidate the clinical significance of GPANK1 and its potential as a therapeutic target for various diseases. As our understanding of this enigmatic gene continues to evolve, it is likely that GPANK1 will emerge as a key player in the regulation of immune responses and cellular migration.

Genular Protein ID: 2710534503

Symbol: GPAN1_HUMAN

Name: G patch domain and ankyrin repeat-containing protein 1

UniProtKB Accession Codes:

O95872 A6NG25 B0UXA2 Q5SQ49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 30 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 9 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 356
  • Mass: 39314
  • Checksum: AA57AA938A8C10E5
  • Sequence:
    • MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD ESSAPDSQRS 
QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL 
RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA 
AQLAEEAGFP EVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL 
SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS 
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF

Genular Protein ID: 1985605076

Symbol: B2RA66_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RA66

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 3 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 356
  • Mass: 39215
  • Checksum: 998E45ADE23B6DA6
  • Sequence:
    • MSRPLLITFT PATDPSDLWK DGQQQLQPEK PESTLDGAAA LAFYEALIGD ESSAPDSQRS 
QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL 
RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA 
AQLAEEAGFP GVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL 
SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS 
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.