Details for: DDX39B

Gene ID: 7919

Symbol: DDX39B

Ensembl ID: ENSG00000198563

Description: DExD-box helicase 39B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 276.9934
    Cell Significance Index: -43.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 171.8949
    Cell Significance Index: -43.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.5797
    Cell Significance Index: -42.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.8548
    Cell Significance Index: -46.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.4727
    Cell Significance Index: -42.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.4814
    Cell Significance Index: -44.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.8546
    Cell Significance Index: -47.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5001
    Cell Significance Index: -45.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8125
    Cell Significance Index: -33.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.4450
    Cell Significance Index: 160.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.4086
    Cell Significance Index: 97.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.0802
    Cell Significance Index: 48.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6564
    Cell Significance Index: 203.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5982
    Cell Significance Index: 288.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.5267
    Cell Significance Index: 22.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4200
    Cell Significance Index: 182.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4106
    Cell Significance Index: 108.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3367
    Cell Significance Index: 132.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2830
    Cell Significance Index: 1158.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2232
    Cell Significance Index: 133.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2189
    Cell Significance Index: 35.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1769
    Cell Significance Index: 13.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9823
    Cell Significance Index: 197.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9520
    Cell Significance Index: 53.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8933
    Cell Significance Index: 22.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8718
    Cell Significance Index: 23.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8094
    Cell Significance Index: 111.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7653
    Cell Significance Index: 16.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6361
    Cell Significance Index: 41.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6259
    Cell Significance Index: 32.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5820
    Cell Significance Index: 40.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5670
    Cell Significance Index: 203.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5463
    Cell Significance Index: 298.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5354
    Cell Significance Index: 27.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5044
    Cell Significance Index: 348.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3461
    Cell Significance Index: 153.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3225
    Cell Significance Index: 52.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2857
    Cell Significance Index: 14.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2481
    Cell Significance Index: 2.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2334
    Cell Significance Index: 27.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2196
    Cell Significance Index: 7.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2179
    Cell Significance Index: 10.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0812
    Cell Significance Index: 5.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0398
    Cell Significance Index: 7.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0295
    Cell Significance Index: 0.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0121
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0246
    Cell Significance Index: -46.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0310
    Cell Significance Index: -57.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0320
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0338
    Cell Significance Index: -24.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0371
    Cell Significance Index: -57.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0422
    Cell Significance Index: -57.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0511
    Cell Significance Index: -37.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0535
    Cell Significance Index: -40.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0694
    Cell Significance Index: -44.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0704
    Cell Significance Index: -1.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0756
    Cell Significance Index: -42.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0814
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0907
    Cell Significance Index: -56.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1027
    Cell Significance Index: -46.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1479
    Cell Significance Index: -6.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1523
    Cell Significance Index: -26.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1567
    Cell Significance Index: -17.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1631
    Cell Significance Index: -46.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1918
    Cell Significance Index: -4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1963
    Cell Significance Index: -25.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2080
    Cell Significance Index: -15.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2104
    Cell Significance Index: -21.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2329
    Cell Significance Index: -49.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2377
    Cell Significance Index: -9.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2594
    Cell Significance Index: -30.2300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2803
    Cell Significance Index: -1.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3041
    Cell Significance Index: -14.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3092
    Cell Significance Index: -44.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3803
    Cell Significance Index: -10.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4819
    Cell Significance Index: -15.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5360
    Cell Significance Index: -8.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5574
    Cell Significance Index: -44.1500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5893
    Cell Significance Index: -8.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6251
    Cell Significance Index: -32.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6296
    Cell Significance Index: -38.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6323
    Cell Significance Index: -3.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6729
    Cell Significance Index: -14.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7070
    Cell Significance Index: -14.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7270
    Cell Significance Index: -43.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7353
    Cell Significance Index: -15.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7551
    Cell Significance Index: -26.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7560
    Cell Significance Index: -24.7500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.7747
    Cell Significance Index: -5.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7752
    Cell Significance Index: -15.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7886
    Cell Significance Index: -10.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.8769
    Cell Significance Index: -12.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8846
    Cell Significance Index: -16.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9032
    Cell Significance Index: -31.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9093
    Cell Significance Index: -28.9600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.9100
    Cell Significance Index: -5.4000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.9933
    Cell Significance Index: -10.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0032
    Cell Significance Index: -29.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0107
    Cell Significance Index: -25.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.0291
    Cell Significance Index: -20.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DDX39B is a 56-kDa protein that belongs to the DEAD-box helicase family, which is characterized by its ability to unwind double-stranded RNA (dsRNA) into single-stranded RNA (ssRNA). The protein contains a characteristic DEAD-box helicase motif, which is essential for its RNA-unwinding activity. DDX39B has been shown to interact with various RNA-binding proteins, including U2AF65, and has been implicated in the regulation of RNA processing and splicing. **Pathways and Functions** DDX39B is involved in various cellular processes, including: 1. **RNA metabolism**: DDX39B plays a crucial role in the regulation of RNA processing, splicing, and export. It has been shown to interact with RNA-binding proteins, such as U2AF65, to regulate the splicing of pre-mRNA and the export of mature mRNA. 2. **Transcription**: DDX39B has been implicated in the regulation of transcription, particularly in the context of RNA polymerase II-dependent transcription. It has been shown to interact with transcription factors and RNA polymerase II to regulate the initiation and elongation phases of transcription. 3. **Cell signaling**: DDX39B has been shown to modulate cell signaling pathways, including the Rho GTPase cycle. It has been implicated in the regulation of cell migration, proliferation, and differentiation. 4. **Nuclear speck formation**: DDX39B has been shown to be involved in the formation of nuclear specks, which are small, dynamic structures that play a crucial role in the regulation of RNA metabolism and cell signaling. **Clinical Significance** DDX39B has been implicated in various diseases, including: 1. **Cancer**: DDX39B has been shown to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. It has been implicated in the regulation of tumor progression and metastasis. 2. **Neurodegenerative diseases**: DDX39B has been shown to be involved in the regulation of RNA metabolism in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Immunological disorders**: DDX39B has been implicated in the regulation of immune cell function, particularly in the context of myeloid dendritic cells and T cells. In conclusion, DDX39B is a multifunctional protein that plays a crucial role in various cellular processes, including RNA metabolism, transcription, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of DDX39B.

Genular Protein ID: 2782887090

Symbol: DX39B_HUMAN

Name: 56 kDa U2AF65-associated protein

UniProtKB Accession Codes:

Q13838 B0S8C0 O43496 Q0EFA1 Q2L6F9 Q53GL9 Q5RJ64 Q5RJ66 Q5ST94 Q5STB4 Q5STB5 Q5STB7 Q5STB8 Q5STU4 Q5STU5 Q5STU6 Q5STU8 Q71V76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 6 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 1 EMBL 19 EMDB 3 Ensembl 19 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7601445

Title: The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family.

PubMed ID: 7601445

DOI: 10.1016/0888-7543(95)80203-x

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9242493

Title: U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction.

PubMed ID: 9242493

DOI: 10.1101/gad.11.14.1864

PubMed ID: 11675789

Title: Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly.

PubMed ID: 11675789

DOI: 10.1038/35098106

PubMed ID: 12944400

Title: An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.

PubMed ID: 12944400

DOI: 10.1074/jbc.m306856200

PubMed ID: 14667819

Title: Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.

PubMed ID: 14667819

DOI: 10.1016/s0888-7543(03)00235-0

PubMed ID: 15833825

Title: Linking transcriptional elongation and messenger RNA export to metastatic breast cancers.

PubMed ID: 15833825

DOI: 10.1158/0008-5472.can-04-3624

PubMed ID: 15998806

Title: Recruitment of the human TREX complex to mRNA during splicing.

PubMed ID: 15998806

DOI: 10.1101/gad.1302205

PubMed ID: 15870275

Title: Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.

PubMed ID: 15870275

DOI: 10.1128/mcb.25.10.4023-4033.2005

PubMed ID: 17190602

Title: Human mRNA export machinery recruited to the 5' end of mRNA.

PubMed ID: 17190602

DOI: 10.1016/j.cell.2006.10.044

PubMed ID: 16478985

Title: The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.

PubMed ID: 16478985

DOI: 10.1128/mcb.26.5.1631-1643.2006

PubMed ID: 17562711

Title: Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor.

PubMed ID: 17562711

DOI: 10.1074/jbc.m702304200

PubMed ID: 17984224

Title: ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.

PubMed ID: 17984224

DOI: 10.1128/mcb.01341-07

PubMed ID: 18974867

Title: Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.

PubMed ID: 18974867

DOI: 10.1371/journal.ppat.1000194

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19836239

Title: UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.

PubMed ID: 19836239

DOI: 10.1016/j.cub.2009.09.041

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20844015

Title: ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.

PubMed ID: 20844015

DOI: 10.1101/gad.1898610

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21859714

Title: Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.

PubMed ID: 21859714

DOI: 10.1074/jbc.m111.251843

PubMed ID: 22144908

Title: Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

PubMed ID: 22144908

DOI: 10.1371/journal.pgen.1002386

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22928037

Title: The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export.

PubMed ID: 22928037

DOI: 10.1371/journal.pone.0043804

PubMed ID: 23299939

Title: Chtop is a component of the dynamic TREX mRNA export complex.

PubMed ID: 23299939

DOI: 10.1038/emboj.2012.342

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23222130

Title: Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.

PubMed ID: 23222130

DOI: 10.1093/nar/gks1188

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25662211

Title: Luzp4 defines a new mRNA export pathway in cancer cells.

PubMed ID: 25662211

DOI: 10.1093/nar/gkv070

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15585580

Title: Crystal structure of the human ATP-dependent splicing and export factor UAP56.

PubMed ID: 15585580

DOI: 10.1073/pnas.0408172101

PubMed ID: 15296731

Title: Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export.

PubMed ID: 15296731

DOI: 10.1016/j.str.2004.06.006

PubMed ID: 33191911

Title: Structure of the human core transcription-export complex reveals a hub for multivalent interactions.

PubMed ID: 33191911

DOI: 10.7554/elife.61503

PubMed ID: 37578863

Title: Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly.

PubMed ID: 37578863

DOI: 10.1016/j.celrep.2023.112988

PubMed ID: 37020021

Title: mRNA recognition and packaging by the human transcription-export complex.

PubMed ID: 37020021

DOI: 10.1038/s41586-023-05904-0

Sequence Information:

  • Length: 428
  • Mass: 48991
  • Checksum: 7A55167BF576FB6F
  • Sequence:
    • MAENDVDNEL LDYEDDEVET AAGGDGAEAP AKKDVKGSYV SIHSSGFRDF LLKPELLRAI 
VDCGFEHPSE VQHECIPQAI LGMDVLCQAK SGMGKTAVFV LATLQQLEPV TGQVSVLVMC 
HTRELAFQIS KEYERFSKYM PNVKVAVFFG GLSIKKDEEV LKKNCPHIVV GTPGRILALA 
RNKSLNLKHI KHFILDECDK MLEQLDMRRD VQEIFRMTPH EKQVMMFSAT LSKEIRPVCR 
KFMQDPMEIF VDDETKLTLH GLQQYYVKLK DNEKNRKLFD LLDVLEFNQV VIFVKSVQRC 
IALAQLLVEQ NFPAIAIHRG MPQEERLSRY QQFKDFQRRI LVATNLFGRG MDIERVNIAF 
NYDMPEDSDT YLHRVARAGR FGTKGLAITF VSDENDAKIL NDVQDRFEVN ISELPDEIDI 
SSYIEQTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.