Details for: MTERF1

Gene ID: 7978

Symbol: MTERF1

Ensembl ID: ENSG00000127989

Description: mitochondrial transcription termination factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.0723
    Cell Significance Index: -30.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 64.0615
    Cell Significance Index: -26.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.4759
    Cell Significance Index: -23.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.4673
    Cell Significance Index: -23.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7616
    Cell Significance Index: -26.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2917
    Cell Significance Index: -13.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 5.6216
    Cell Significance Index: 177.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.9925
    Cell Significance Index: 2069.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7625
    Cell Significance Index: 66.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7059
    Cell Significance Index: 75.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6999
    Cell Significance Index: 48.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6482
    Cell Significance Index: 313.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0764
    Cell Significance Index: 386.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0068
    Cell Significance Index: 67.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9500
    Cell Significance Index: 154.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9264
    Cell Significance Index: 18.0800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.8486
    Cell Significance Index: 11.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7582
    Cell Significance Index: 58.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6068
    Cell Significance Index: 120.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6007
    Cell Significance Index: 33.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5093
    Cell Significance Index: 55.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4669
    Cell Significance Index: 23.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4043
    Cell Significance Index: 81.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3797
    Cell Significance Index: 10.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3777
    Cell Significance Index: 4.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3756
    Cell Significance Index: 22.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3494
    Cell Significance Index: 21.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2680
    Cell Significance Index: 6.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2509
    Cell Significance Index: 45.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2245
    Cell Significance Index: 26.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2095
    Cell Significance Index: 14.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1989
    Cell Significance Index: 4.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1937
    Cell Significance Index: 174.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1690
    Cell Significance Index: 16.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1193
    Cell Significance Index: 183.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1108
    Cell Significance Index: 70.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1055
    Cell Significance Index: 198.5800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0919
    Cell Significance Index: 1.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0806
    Cell Significance Index: 44.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0794
    Cell Significance Index: 107.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0768
    Cell Significance Index: 141.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0713
    Cell Significance Index: 3.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0705
    Cell Significance Index: 1.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0669
    Cell Significance Index: 30.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0581
    Cell Significance Index: 7.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0403
    Cell Significance Index: 17.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0303
    Cell Significance Index: 0.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0272
    Cell Significance Index: 3.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0250
    Cell Significance Index: 0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0179
    Cell Significance Index: 0.6300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0040
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0160
    Cell Significance Index: -2.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0270
    Cell Significance Index: -19.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0274
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0311
    Cell Significance Index: -23.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0352
    Cell Significance Index: -26.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0502
    Cell Significance Index: -1.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0504
    Cell Significance Index: -28.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0513
    Cell Significance Index: -32.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0528
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0675
    Cell Significance Index: -11.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0763
    Cell Significance Index: -8.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0806
    Cell Significance Index: -9.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0839
    Cell Significance Index: -24.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1261
    Cell Significance Index: -12.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1459
    Cell Significance Index: -18.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1493
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1513
    Cell Significance Index: -31.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1602
    Cell Significance Index: -5.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1656
    Cell Significance Index: -2.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1700
    Cell Significance Index: -2.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1824
    Cell Significance Index: -23.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1856
    Cell Significance Index: -9.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1935
    Cell Significance Index: -4.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2005
    Cell Significance Index: -20.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2011
    Cell Significance Index: -5.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2198
    Cell Significance Index: -10.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2317
    Cell Significance Index: -3.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2710
    Cell Significance Index: -16.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2756
    Cell Significance Index: -19.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2869
    Cell Significance Index: -18.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2943
    Cell Significance Index: -15.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3000
    Cell Significance Index: -22.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3378
    Cell Significance Index: -5.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3423
    Cell Significance Index: -17.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3720
    Cell Significance Index: -6.2300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3812
    Cell Significance Index: -5.3300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3871
    Cell Significance Index: -5.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4017
    Cell Significance Index: -5.4800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.4831
    Cell Significance Index: -5.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4881
    Cell Significance Index: -15.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5036
    Cell Significance Index: -16.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5159
    Cell Significance Index: -10.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5515
    Cell Significance Index: -19.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5597
    Cell Significance Index: -8.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5718
    Cell Significance Index: -8.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5743
    Cell Significance Index: -20.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6040
    Cell Significance Index: -10.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6552
    Cell Significance Index: -12.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MTERF1 is a mitochondrial protein that belongs to the termination factor 1 family. It is characterized by its ability to bind to mitochondrial DNA (mtDNA) and regulate the termination of mitochondrial transcription. MTERF1 is highly expressed in cells with high energy demands, such as cardiac muscle cells, dopaminergic neurons, and oligodendrocytes. The protein is also involved in the regulation of mitochondrial biogenesis, a process essential for maintaining cellular energy homeostasis. **Pathways and Functions:** MTERF1 is involved in several key pathways, including: 1. **Mitochondrial biogenesis:** MTERF1 regulates the expression of mitochondrial genes, ensuring the proper assembly and function of mitochondria. 2. **Transcriptional activation of mitochondrial biogenesis:** MTERF1 promotes the transcription of mitochondrial genes, thereby stimulating mitochondrial biogenesis. 3. **Termination of mitochondrial transcription:** MTERF1 terminates mitochondrial transcription, ensuring the accurate regulation of mtDNA expression. 4. **Regulation of DNA-templated transcription:** MTERF1 regulates the transcription of nuclear genes that are essential for mitochondrial function. **Clinical Significance:** Dysregulation of MTERF1 has been implicated in various diseases, including: 1. **Mitochondrial disorders:** Mutations in the MTERF1 gene have been associated with mitochondrial myopathies, neurodegenerative diseases, and other disorders. 2. **Cancer:** MTERF1 has been shown to play a role in cancer development and progression, particularly in cells with high energy demands. 3. **Neurodegenerative diseases:** MTERF1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where mitochondrial dysfunction plays a key role. In conclusion, MTERF1 is a critical protein that plays a pivotal role in regulating mitochondrial biogenesis, function, and transcription. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying MTERF1-mediated cellular processes.

Genular Protein ID: 583118512

Symbol: MTEF1_HUMAN

Name: Transcription termination factor 1, mitochondrial

UniProtKB Accession Codes:

Q99551 A4D1E3 Q32NF8 Q53H51 Q9BVR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9118945

Title: The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions.

PubMed ID: 9118945

DOI: 10.1093/emboj/16.5.1066

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15087485

Title: Phosphorylation of rat mitochondrial transcription termination factor (mTERF) is required for transcription termination but not for binding to DNA.

PubMed ID: 15087485

DOI: 10.1093/nar/gkh528

PubMed ID: 20550934

Title: Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription.

PubMed ID: 20550934

DOI: 10.1016/j.cell.2010.05.018

PubMed ID: 20543826

Title: Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.

PubMed ID: 20543826

DOI: 10.1038/nsmb.1859

Sequence Information:

  • Length: 399
  • Mass: 45778
  • Checksum: A0C6CE4A8498526E
  • Sequence:
    • MQSLSLGQTS ISKGLNYLTI MAPGNLWHMR NNFLFGSRCW MTRFSAENIF KSVSFRLFGV 
KCHNTDSEPL KNEDLLKNLL TMGVDIDMAR KRQPGVFHRM ITNEQDLKMF LLSKGASKEV 
IASIISRYPR AITRTPENLS KRWDLWRKIV TSDLEIVNIL ERSPESFFRS NNNLNLENNI 
KFLYSVGLTR KCLCRLLTNA PRTFSNSLDL NKQMVEFLQA AGLSLGHNDP ADFVRKIIFK 
NPFILIQSTK RVKANIEFLR STFNLNSEEL LVLICGPGAE ILDLSNDYAR RSYANIKEKL 
FSLGCTEEEV QKFVLSYPDV IFLAEKKFND KIDCLMEENI SISQIIENPR VLDSSISTLK 
SRIKELVNAG CNLSTLNITL LSWSKKRYEA KLKKLSRFA

Genular Protein ID: 61202576

Symbol: B4DPR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DPR9

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 SMART 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 379
  • Mass: 43642
  • Checksum: 749D0C90D1DD77E8
  • Sequence:
    • MAPGNLWHMR NNFLFGSRCW MTRFSAENIF KSVSFRLFGV KCHNTDSEPL KNEDLLKNLL 
TMGVDIDMAR KRQPGVFHRM ITNEQDLKMF LLSKGASKEV IASIISRYPR AITRTPENLS 
KRWDLWRKIV TSDLEIVNIL ERSPESFFRS NNNLNLENNI KFLYSVGLTR KCLCRLLTNA 
PRTFSNSLDL NKQMVEFLQA AGLSLGHNDP ADFVRKIIFK NPFILIQSTK RVKANIEFLR 
STFNLNSEEL LVLICGPGAE ILDLSNDYAR RSYANIKEKL FSLGCTEEEV QKFVLSYPDV 
IFLAEKKFND KIDCLMEENI SISQIIENPR VLDSSISTLK SRIKELVNAG CNLSTLNITL 
LSWSKKRYEA KLKKLSRFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.