Details for: KAT6A

Gene ID: 7994

Symbol: KAT6A

Ensembl ID: ENSG00000083168

Description: lysine acetyltransferase 6A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 433.5074
    Cell Significance Index: -67.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 258.5126
    Cell Significance Index: -65.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 148.3301
    Cell Significance Index: -70.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.9945
    Cell Significance Index: -57.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 128.1530
    Cell Significance Index: -65.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.3094
    Cell Significance Index: -57.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.3362
    Cell Significance Index: -69.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.9173
    Cell Significance Index: -66.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.2184
    Cell Significance Index: -62.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.7564
    Cell Significance Index: -41.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.7570
    Cell Significance Index: -70.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.0384
    Cell Significance Index: 170.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4685
    Cell Significance Index: 128.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4550
    Cell Significance Index: 487.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.4085
    Cell Significance Index: 34.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8709
    Cell Significance Index: 375.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4895
    Cell Significance Index: 114.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4293
    Cell Significance Index: 36.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4021
    Cell Significance Index: 502.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3784
    Cell Significance Index: 1244.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2012
    Cell Significance Index: 33.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0707
    Cell Significance Index: 740.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0678
    Cell Significance Index: 20.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9697
    Cell Significance Index: 59.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8939
    Cell Significance Index: 161.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8412
    Cell Significance Index: 103.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.7537
    Cell Significance Index: 470.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6633
    Cell Significance Index: 39.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6617
    Cell Significance Index: 16.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5927
    Cell Significance Index: 12.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5147
    Cell Significance Index: 14.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4488
    Cell Significance Index: 61.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4355
    Cell Significance Index: 192.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3565
    Cell Significance Index: 194.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3508
    Cell Significance Index: 23.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2903
    Cell Significance Index: 28.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2667
    Cell Significance Index: 43.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2664
    Cell Significance Index: 6.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2410
    Cell Significance Index: 45.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2217
    Cell Significance Index: 10.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2216
    Cell Significance Index: 100.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2023
    Cell Significance Index: 380.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1757
    Cell Significance Index: 111.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1337
    Cell Significance Index: 205.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1196
    Cell Significance Index: 220.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0788
    Cell Significance Index: 5.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0782
    Cell Significance Index: 1.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0635
    Cell Significance Index: 1.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0612
    Cell Significance Index: 83.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0404
    Cell Significance Index: 5.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0110
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0265
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0404
    Cell Significance Index: -29.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0495
    Cell Significance Index: -36.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0760
    Cell Significance Index: -2.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0794
    Cell Significance Index: -60.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0817
    Cell Significance Index: -46.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1032
    Cell Significance Index: -4.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1138
    Cell Significance Index: -7.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1222
    Cell Significance Index: -5.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1297
    Cell Significance Index: -2.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1743
    Cell Significance Index: -20.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1813
    Cell Significance Index: -38.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2023
    Cell Significance Index: -7.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2170
    Cell Significance Index: -31.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2184
    Cell Significance Index: -62.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2267
    Cell Significance Index: -15.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2470
    Cell Significance Index: -28.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2523
    Cell Significance Index: -29.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2574
    Cell Significance Index: -26.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2802
    Cell Significance Index: -13.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2944
    Cell Significance Index: -3.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3101
    Cell Significance Index: -40.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3867
    Cell Significance Index: -27.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3873
    Cell Significance Index: -20.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4268
    Cell Significance Index: -44.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4430
    Cell Significance Index: -50.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4887
    Cell Significance Index: -14.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5453
    Cell Significance Index: -40.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5760
    Cell Significance Index: -20.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6269
    Cell Significance Index: -17.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6417
    Cell Significance Index: -17.2000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6762
    Cell Significance Index: -9.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7159
    Cell Significance Index: -14.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7213
    Cell Significance Index: -37.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7473
    Cell Significance Index: -59.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7931
    Cell Significance Index: -16.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8584
    Cell Significance Index: -18.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8751
    Cell Significance Index: -12.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8811
    Cell Significance Index: -28.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8816
    Cell Significance Index: -54.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8875
    Cell Significance Index: -13.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0730
    Cell Significance Index: -30.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0968
    Cell Significance Index: -14.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1402
    Cell Significance Index: -10.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1462
    Cell Significance Index: -39.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1532
    Cell Significance Index: -19.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2628
    Cell Significance Index: -23.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3732
    Cell Significance Index: -44.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3752
    Cell Significance Index: -43.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KAT6A is a member of the lysine acetyltransferase family, which catalyzes the transfer of an acetyl group from acetyl-CoA to lysine residues on histone proteins. This process, known as histone acetylation, leads to the relaxation of chromatin structure, allowing for increased access of transcriptional machinery to DNA. KAT6A is unique in its ability to acetylate multiple histone residues, including histone H3, H4, and H14, which are involved in various aspects of chromatin organization and gene regulation. **Pathways and Functions:** KAT6A is involved in several key pathways, including: 1. **Chromatin Organization:** KAT6A regulates chromatin structure by acetylating histone residues, which in turn facilitates the assembly of nucleosomes and the organization of chromatin into higher-order structures. 2. **Transcriptional Regulation:** KAT6A acts as a transcriptional coactivator, promoting the recruitment of transcriptional machinery to specific genomic regions. 3. **Cell Differentiation:** KAT6A is required for the differentiation of various cell types, including neural cells and immune cells. 4. **Apoptosis:** KAT6A has been shown to regulate the activity of p53, a key pro-apoptotic protein, through acetylation. 5. **DNA Repair:** KAT6A is involved in the regulation of DNA repair pathways, including the repair of DNA double-strand breaks. **Clinical Significance:** Dysregulation of KAT6A has been implicated in various human diseases, including: 1. **Cancer:** KAT6A is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurological Disorders:** KAT6A mutations have been linked to neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Cardiovascular Diseases:** KAT6A has been implicated in the regulation of cardiovascular cell differentiation and survival, and its dysregulation has been linked to cardiovascular disease. 4. **Immune System Disorders:** KAT6A is involved in the regulation of immune cell differentiation and function, and its dysregulation has been linked to autoimmune diseases. In conclusion, KAT6A is a critical regulator of chromatin structure and gene expression, and its dysregulation has far-reaching implications for human health and disease. Further studies are needed to fully elucidate the mechanisms by which KAT6A regulates cellular processes and to understand the clinical significance of its dysregulation in human disease.

Genular Protein ID: 669607540

Symbol: KAT6A_HUMAN

Name: Histone acetyltransferase KAT6A

UniProtKB Accession Codes:

Q92794 Q76L81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8782817

Title: The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein.

PubMed ID: 8782817

DOI: 10.1038/ng0996-33

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 9558366

Title: A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.

PubMed ID: 9558366

PubMed ID: 10824998

Title: MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).

PubMed ID: 10824998

DOI: 10.1002/(sici)1098-2264(200006)28:2<138::aid-gcc2>3.0.co;2-2

PubMed ID: 11742995

Title: Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.

PubMed ID: 11742995

DOI: 10.1093/emboj/20.24.7184

PubMed ID: 11313971

Title: The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase.

PubMed ID: 11313971

DOI: 10.1038/sj.onc.1204114

PubMed ID: 11965546

Title: MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.

PubMed ID: 11965546

DOI: 10.1038/sj.onc.1205367

PubMed ID: 12676584

Title: MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.

PubMed ID: 12676584

DOI: 10.1016/s1535-6108(03)00051-5

PubMed ID: 12771199

Title: Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ.

PubMed ID: 12771199

DOI: 10.1093/nar/gkg401

PubMed ID: 15657427

Title: MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function.

PubMed ID: 15657427

DOI: 10.1128/mcb.25.3.988-1002.2005

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18794358

Title: Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

PubMed ID: 18794358

DOI: 10.1128/mcb.01297-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23431171

Title: MOZ increases p53 acetylation and premature senescence through its complex formation with PML.

PubMed ID: 23431171

DOI: 10.1073/pnas.1300490110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25728775

Title: De novo nonsense mutations in KAT6A, a lysine acetyl-transferase gene, cause a syndrome including microcephaly and global developmental delay.

PubMed ID: 25728775

DOI: 10.1016/j.ajhg.2015.01.017

PubMed ID: 25728777

Title: Dominant mutations in KAT6A cause intellectual disability with recognizable syndromic features.

PubMed ID: 25728777

DOI: 10.1016/j.ajhg.2015.01.016

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17925393

Title: The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting.

PubMed ID: 17925393

DOI: 10.1074/jbc.m705812200

Sequence Information:

  • Length: 2004
  • Mass: 225028
  • Checksum: 78357EFAC4698A5F
  • Sequence:
    • MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ LELSVKDGTI 
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQNVDWN KLIKRAVEGL AESGGSTLKS 
IERFLKGQKD VSALFGGSAA SGFHQQLRLA IKRAIGHGRL LKDGPLYRLN TKATNVDGKE 
SCESLSCLPP VSLLPHEKDK PVAEPIPICS FCLGTKEQNR EKKPEELISC ADCGNSGHPS 
CLKFSPELTV RVKALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM 
PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YTNPIGRPKN RLKKQNTVSK GPFSKVRTGP 
GRGRKRKITL SSQSASSSSE EGYLERIDGL DFCRDSNVSL KFNKKTKGLI DGLTKFFTPS 
PDGRKARGEV VDYSEQYRIR KRGNRKSSTS DWPTDNQDGW DGKQENEERL FGSQEIMTEK 
DMELFRDIQE QALQKVGVTG PPDPQVRCPS VIEFGKYEIH TWYSSPYPQE YSRLPKLYLC 
EFCLKYMKSR TILQQHMKKC GWFHPPANEI YRKNNISVFE VDGNVSTIYC QNLCLLAKLF 
LDHKTLYYDV EPFLFYVLTQ NDVKGCHLVG YFSKEKHCQQ KYNVSCIMIL PQYQRKGYGR 
FLIDFSYLLS KREGQAGSPE KPLSDLGRLS YMAYWKSVIL ECLYHQNDKQ ISIKKLSKLT 
GICPQDITST LHHLRMLDFR SDQFVIIRRE KLIQDHMAKL QLNLRPVDVD PECLRWTPVI 
VSNSVVSEEE EEEAEEGENE EPQCQERELE ISVGKSVSHE NKEQDSYSVE SEKKPEVMAP 
VSSTRLSKQV LPHDSLPANS QPSRRGRWGR KNRKTQERFG DKDSKLLLEE TSSAPQEQYG 
ECGEKSEATQ EQYTESEEQL VASEEQPSQD GKPDLPKRRL SEGVEPWRGQ LKKSPEALKC 
RLTEGSERLP RRYSEGDRAV LRGFSESSEE EEEPESPRSS SPPILTKPTL KRKKPFLHRR 
RRVRKRKHHN SSVVTETISE TTEVLDEPFE DSDSERPMPR LEPTFEIDEE EEEEDENELF 
PREYFRRLSS QDVLRCQSSS KRKSKDEEED EESDDADDTP ILKPVSLLRK RDVKNSPLEP 
DTSTPLKKKK GWPKGKSRKP IHWKKRPGRK PGFKLSREIM PVSTQACVIE PIVSIPKAGR 
KPKIQESEET VEPKEDMPLP EERKEEEEMQ AEAEEAEEGE EEDAASSEVP AASPADSSNS 
PETETKEPEV EEEEEKPRVS EEQRQSEEEQ QELEEPEPEE EEDAAAETAQ NDDHDADDED 
DGHLESTKKK ELEEQPTRED VKEEPGVQES FLDANMQKSR EKIKDKEETE LDSEEEQPSH 
DTSVVSEQMA GSEDDHEEDS HTKEELIELK EEEEIPHSEL DLETVQAVQS LTQEESSEHE 
GAYQDCEETL AACQTLQSYT QADEDPQMSM VEDCHASEHN SPISSVQSHP SQSVRSVSSP 
NVPALESGYT QISPEQGSLS APSMQNMETS PMMDVPSVSD HSQQVVDSGF SDLGSIESTT 
ENYENPSSYD STMGGSICGN SSSQSSCSYG GLSSSSSLTQ SSCVVTQQMA SMGSSCSMMQ 
QSSVQPAANC SIKSPQSCVV ERPPSNQQQQ PPPPPPQQPQ PPPPQPQPAP QPPPPQQQPQ 
QQPQPQPQQP PPPPPPQQQP PLSQCSMNNS FTPAPMIMEI PESGSTGNIS IYERIPGDFG 
AGSYSQPSAT FSLAKLQQLT NTIMDPHAMP YSHSPAVTSY ATSVSLSNTG LAQLAPSHPL 
AGTPQAQATM TPPPNLASTT MNLTSPLLQC NMSATNIGIP HTQRLQGQMP VKGHISIRSK 
SAPLPSAAAH QQQLYGRSPS AVAMQAGPRA LAVQRGMNMG VNLMPTPAYN VNSMNMNTLN 
AMNSYRMTQP MMNSSYHSNP AYMNQTAQYP MQMQMGMMGS QAYTQQPMQP NPHGNMMYTG 
PSHHSYMNAA GVPKQSLNGP YMRR

Genular Protein ID: 3300317225

Symbol: A5PLL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5PLL3

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 8 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 8 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SMART 2 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 815
  • Mass: 93237
  • Checksum: 113BD476538C3801
  • Sequence:
    • MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ LELSVKDGTI 
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQNVDWN KLIKRAVEGL AESGGSTLKS 
IERFLKGQKD VSALFGGSAA SGFHQQLRLA IKRAIGHGRL LKDGPLYRLN TKATNVDGKE 
SCESLSCLPP VSLLPHEKDK PVAEPIPICS FCLGTKEQNR EKKPEELISC ADCGNSGHPS 
CLKFSPELTV RVKALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM 
PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YTNPIGRPKN RLKKQNTVSK GPFSKVRTGP 
GRGRKRKITL SSQSASSSSE EGYLERIDGL DFCRDSNVSL KFNKKTKGLI DGLTKFFTPS 
PDGRKARGEV VDYSEQYRIR KRGNRKSSTS DWPTDNQDGW DGKQENEERL FGSQEIMTEK 
DMELFRDIQE QALQKVGVTG PPDPQVRCPS VIEFGKYEIH TWYSSPYPQE YSRLPKLYLC 
EFCLKYMKSR TILQQHMKKC GWFHPPANEI YRKNNISVFE VDGNVSTIYC QNLCLLAKLF 
LDHKTLYYDV EPFLFYVLTQ NDVKGCHLVG YFSKEKHCQQ KYNVSCIMIL PQYQRKGYGR 
FLIDFSYLLS KREGQAGSPE KPLSDLGRLS YMAYWKSVIL ECLYHQNDKQ ISIKKLSKLT 
GICPQDITST LHHLRMLDFR SDQFVIIRRE KLIQDHMAKL QLNLRPVDVD PECLRWTPVI 
VSNSVVSEEE EEEAEEGENE EPQCQERELE ISVRA

Genular Protein ID: 1814324569

Symbol: A5PKX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5PKX7

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 10 Gene3D 4 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 8 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SMART 2 SUPFAM 3 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1149
  • Mass: 131769
  • Checksum: FA0E7803578D36CE
  • Sequence:
    • MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ LELSVKDGTI 
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQNVDWN KLIKRAVEGL AESGGSTLKS 
IERFLKGQKD VSALFGGSAA SGFHQQLRLA IKRAIGHGRL LKDGPLYRLN TKATNVDGKE 
SCESLSCLPP VSLLPHEKDK PVAEPIPICS FCLGTKEQNR EKKPEELISC ADCGNSGHPS 
CLKFSPELTV RVKALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM 
PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YTNPIGRPKN RLKKQNTVSK GPFSKVRTGP 
GRGRKRKITL SSQSASSSSE EGYLERIDGL DFCRDSNVSL KFNKKTKGLI DGLTKFFTPS 
PDGRKARGEV VDYSEQYRIR KRGNRKSSTS DWPTDNQDGW DGKQENEERL FGSQEIMTEK 
DMELFRDIQE QALQKVGVTG PPDPQVRCPS VIEFGKYEIH TWYSSPYPQE YSRLPKLYLC 
EFCLKYMKSR TILQQHMKKC GWFHPPANEI YRKNNISVFE VDGNVSTIYC QNLCLLAKLF 
LDHKTLYYDV EPFLFYVLTQ NDVKGCHLVG YFSKEKHCQQ KYNVSCIMIL PQYQRKGYGR 
FLIDFSYLLS KREGQAGSPE KPLSDLGRLS YMAYWKSVIL ECLYHQNDKQ ISIKKLSKLT 
GICPQDITST LHHLRMLDFR SDQFVIIRRE KLIQDHMAKL QLNLRPVDVD PECLRWTPVI 
VSNSVVSEEE EEEAEEGENE EPQCQERELE ISVGKSVSHE NKEQDSYSVE SEKKPEVMAP 
VSSTRLSKQV LPHDSLPANS QPSRRGRWGR KNRKTQERFG DKDSKLLLEE TSSAPQEQYG 
ECGEKSEATQ EQYTESEEQL VASEEQPSQD GKPDLPKRRL SEGVEPWRGQ LKKSPEALKC 
RLTEGSERLP RRYSEGDRAV LRGFSESSEE EEEPESPRSS SPPILTKPTL KRKKPFLHRR 
RRVRKRKHHN SSVVTETISE TTEVLDEPFE DSDSERPMPR LEPTFEIDEE EEEEDENELF 
PREYFRRLSS QDVLRCQSSS KRKSKDEEED EESDDADDTP ILKPVSLLRK RDVKNSPLEP 
DTSTPLKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.