Details for: SLC25A16

Gene ID: 8034

Symbol: SLC25A16

Ensembl ID: ENSG00000122912

Description: solute carrier family 25 member 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.6192
    Cell Significance Index: -28.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.7674
    Cell Significance Index: -29.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9830
    Cell Significance Index: -29.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.8516
    Cell Significance Index: -29.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5569
    Cell Significance Index: -29.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0718
    Cell Significance Index: -11.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.3557
    Cell Significance Index: 677.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6955
    Cell Significance Index: 340.1200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4795
    Cell Significance Index: 24.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2496
    Cell Significance Index: 21.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2335
    Cell Significance Index: 244.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1688
    Cell Significance Index: 89.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0477
    Cell Significance Index: 26.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0118
    Cell Significance Index: 362.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9502
    Cell Significance Index: 857.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7782
    Cell Significance Index: 20.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6591
    Cell Significance Index: 39.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6420
    Cell Significance Index: 69.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5879
    Cell Significance Index: 68.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5633
    Cell Significance Index: 91.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5373
    Cell Significance Index: 11.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5106
    Cell Significance Index: 11.1800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.5043
    Cell Significance Index: 6.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4800
    Cell Significance Index: 30.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4730
    Cell Significance Index: 46.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4064
    Cell Significance Index: 281.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3994
    Cell Significance Index: 72.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3823
    Cell Significance Index: 11.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3640
    Cell Significance Index: 16.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3435
    Cell Significance Index: 9.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3396
    Cell Significance Index: 12.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3368
    Cell Significance Index: 41.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3139
    Cell Significance Index: 21.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3112
    Cell Significance Index: 14.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3064
    Cell Significance Index: 18.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2793
    Cell Significance Index: 15.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2716
    Cell Significance Index: 12.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2156
    Cell Significance Index: 5.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1987
    Cell Significance Index: 10.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1646
    Cell Significance Index: 11.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1475
    Cell Significance Index: 28.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1050
    Cell Significance Index: 2.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0867
    Cell Significance Index: 163.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0822
    Cell Significance Index: 36.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0816
    Cell Significance Index: 44.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0630
    Cell Significance Index: 28.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0589
    Cell Significance Index: 1.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0535
    Cell Significance Index: 34.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0526
    Cell Significance Index: 1.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0475
    Cell Significance Index: 8.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0336
    Cell Significance Index: 0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0326
    Cell Significance Index: 50.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0281
    Cell Significance Index: 38.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0268
    Cell Significance Index: 49.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0225
    Cell Significance Index: 0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0144
    Cell Significance Index: 1.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0194
    Cell Significance Index: -2.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0268
    Cell Significance Index: -20.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0321
    Cell Significance Index: -23.8100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0331
    Cell Significance Index: -0.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0410
    Cell Significance Index: -1.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0421
    Cell Significance Index: -1.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0465
    Cell Significance Index: -26.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0544
    Cell Significance Index: -33.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0877
    Cell Significance Index: -8.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0898
    Cell Significance Index: -13.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0901
    Cell Significance Index: -1.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1102
    Cell Significance Index: -14.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1147
    Cell Significance Index: -1.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1207
    Cell Significance Index: -7.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1329
    Cell Significance Index: -17.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1343
    Cell Significance Index: -2.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1516
    Cell Significance Index: -10.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1543
    Cell Significance Index: -32.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1699
    Cell Significance Index: -12.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1804
    Cell Significance Index: -20.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1943
    Cell Significance Index: -20.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2054
    Cell Significance Index: -4.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2168
    Cell Significance Index: -3.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2294
    Cell Significance Index: -10.7800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2389
    Cell Significance Index: -1.0400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2468
    Cell Significance Index: -3.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2545
    Cell Significance Index: -8.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2668
    Cell Significance Index: -16.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2847
    Cell Significance Index: -4.1000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2947
    Cell Significance Index: -3.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2975
    Cell Significance Index: -6.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3038
    Cell Significance Index: -24.0600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3160
    Cell Significance Index: -3.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3344
    Cell Significance Index: -8.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3694
    Cell Significance Index: -7.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4212
    Cell Significance Index: -11.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4227
    Cell Significance Index: -6.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4433
    Cell Significance Index: -4.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4525
    Cell Significance Index: -4.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4572
    Cell Significance Index: -14.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4619
    Cell Significance Index: -24.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4792
    Cell Significance Index: -15.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4852
    Cell Significance Index: -6.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC25A16 is a member of the solute carrier family 25 and is characterized by its ability to transport CoA across the mitochondrial inner membrane. This transporter is highly expressed in neurons, where it plays a critical role in maintaining the delicate balance of neurotransmitters and energy production. The gene is also expressed in other tissues, including the retina, where it is involved in the regulation of retinal ganglion cell function. **Pathways and Functions:** SLC25A16 is involved in several key pathways, including: 1. **Mitochondrial Coenzyme A Transmembrane Transport:** SLC25A16 facilitates the transport of CoA across the mitochondrial inner membrane, which is essential for the production of ATP, the primary energy currency of the cell. 2. **Metabolism of Vitamins and Cofactors:** SLC25A16 is involved in the metabolism of CoA, a critical cofactor in various cellular processes, including fatty acid synthesis and energy production. 3. **Pantothenate Metabolic Process:** SLC25A16 is also involved in the metabolism of pantothenate, a vitamin essential for the synthesis of CoA. 4. **Antiporter Activity:** SLC25A16 exhibits antiporter activity, which allows it to transport CoA across the mitochondrial inner membrane while also regulating the activity of other transporters. **Clinical Significance:** Dysregulation of SLC25A16 has been implicated in various neurological disorders, including: 1. **Neurodegenerative Diseases:** Mutations in SLC25A16 have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Neurodevelopmental Disorders:** SLC25A16 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Neuropathic Pain:** SLC25A16 has been shown to play a role in the regulation of pain perception, making it a potential target for the treatment of neuropathic pain. In conclusion, SLC25A16 is a critical gene that plays a pivotal role in mitochondrial function, neurotransmission, and metabolism. Its dysregulation has been implicated in various neurological disorders, highlighting the need for further research into the mechanisms underlying its function and the development of therapeutic strategies to target its dysregulation.

Genular Protein ID: 780057350

Symbol: GDC_HUMAN

Name: Solute carrier family 25 member 16

UniProtKB Accession Codes:

P16260 Q8N2U1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2575220

Title: Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins.

PubMed ID: 2575220

DOI: 10.1210/mend-3-9-1498

PubMed ID: 1457817

Title: Sequence and pattern of expression of a bovine homologue of a human mitochondrial transport protein associated with Grave's disease.

PubMed ID: 1457817

DOI: 10.3109/10425179209033999

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11158296

Title: The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix.

PubMed ID: 11158296

DOI: 10.1128/mcb.21.4.1089-1097.2001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 332
  • Mass: 36224
  • Checksum: 71C2C3D413F80246
  • Sequence:
    • MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA KTTVAPLDRV 
KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTL 
ITTKLGISGH VHRLMAGSMA GMTAVICTYP LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA 
KEGGFFGFYR GLMPTILGMA PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT 
HVNLLCGGVA GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL 
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN

Genular Protein ID: 725957343

Symbol: B4DPV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DPV4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 2 RuleBase 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 234
  • Mass: 26142
  • Checksum: 0452F7E02DF0E8A2
  • Sequence:
    • MMIRIFPYGA IQFMAFEHYK TLITTKLGIS GHVHRLMAGS MAGMTAVICT YPLDMVRVRL 
AFQVKGEHSY TGIIHAFKTI YAKEGGFFGF YRGLMPTILG MAPYAGVSFF TFGTLKSVGL 
SHAPTLLGRP SSDNPNVLVL KTHVNLLCGG VAGAIAQTIS YPFDVTRRRM QLGTVLPEFE 
KCLTMRDTMK YVYGHHGIRK GLYRGLSLNY IRCIPSQAVA FTTYELMKQF FHLN

Genular Protein ID: 2689899234

Symbol: B4DHV9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DHV9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 315
  • Mass: 34320
  • Checksum: 9B82E96266561976
  • Sequence:
    • MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA KTTVAPLDRV 
KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTL 
ITTKLGISGH VHRLMAGSMA GMTAVICTYP LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA 
KEGGFFGFYR GLMPTILGMA PYAGVSFFTF GTLKSVGLSH APTLLGRPTS DNPNVLVLKT 
HVNLLCGGVA GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LGHHLIIVFQ YHAGYYEVCL 
WTPWNSKRTL SWFIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.