Details for: SHOC2

Gene ID: 8036

Symbol: SHOC2

Ensembl ID: ENSG00000108061

Description: SHOC2 leucine rich repeat scaffold protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 337.3938
    Cell Significance Index: -52.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 206.7075
    Cell Significance Index: -52.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.3956
    Cell Significance Index: -58.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.4718
    Cell Significance Index: -48.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.2336
    Cell Significance Index: -54.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 87.4785
    Cell Significance Index: -58.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.6210
    Cell Significance Index: -48.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.5937
    Cell Significance Index: -56.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.5382
    Cell Significance Index: -52.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.6222
    Cell Significance Index: -57.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9934
    Cell Significance Index: -42.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.3331
    Cell Significance Index: -22.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7451
    Cell Significance Index: 350.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6976
    Cell Significance Index: 95.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9767
    Cell Significance Index: 350.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9211
    Cell Significance Index: 166.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9120
    Cell Significance Index: 107.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8254
    Cell Significance Index: 63.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8193
    Cell Significance Index: 162.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7983
    Cell Significance Index: 98.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6617
    Cell Significance Index: 19.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6590
    Cell Significance Index: 44.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6103
    Cell Significance Index: 83.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6000
    Cell Significance Index: 16.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5826
    Cell Significance Index: 402.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5001
    Cell Significance Index: 9.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4465
    Cell Significance Index: 28.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4250
    Cell Significance Index: 26.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4147
    Cell Significance Index: 183.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3975
    Cell Significance Index: 50.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3284
    Cell Significance Index: 179.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3254
    Cell Significance Index: 14.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3108
    Cell Significance Index: 7.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2825
    Cell Significance Index: 255.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2712
    Cell Significance Index: 12.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2478
    Cell Significance Index: 4.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1956
    Cell Significance Index: 8.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1899
    Cell Significance Index: 13.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1882
    Cell Significance Index: 5.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1613
    Cell Significance Index: 15.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1059
    Cell Significance Index: 199.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0771
    Cell Significance Index: 48.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0738
    Cell Significance Index: 2.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0734
    Cell Significance Index: 4.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0543
    Cell Significance Index: 2.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0414
    Cell Significance Index: 63.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0396
    Cell Significance Index: 6.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0386
    Cell Significance Index: 1.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0337
    Cell Significance Index: 15.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0337
    Cell Significance Index: 62.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0141
    Cell Significance Index: 19.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0235
    Cell Significance Index: -14.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0296
    Cell Significance Index: -21.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0383
    Cell Significance Index: -6.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0420
    Cell Significance Index: -2.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0516
    Cell Significance Index: -39.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0714
    Cell Significance Index: -13.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0747
    Cell Significance Index: -42.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0758
    Cell Significance Index: -5.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0802
    Cell Significance Index: -4.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1079
    Cell Significance Index: -3.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1122
    Cell Significance Index: -8.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1148
    Cell Significance Index: -14.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1587
    Cell Significance Index: -8.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1607
    Cell Significance Index: -16.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1608
    Cell Significance Index: -33.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1664
    Cell Significance Index: -47.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1702
    Cell Significance Index: -5.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1722
    Cell Significance Index: -20.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1761
    Cell Significance Index: -25.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2002
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2399
    Cell Significance Index: -27.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3263
    Cell Significance Index: -6.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3278
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3537
    Cell Significance Index: -40.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3715
    Cell Significance Index: -7.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4398
    Cell Significance Index: -45.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4421
    Cell Significance Index: -48.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4428
    Cell Significance Index: -10.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4471
    Cell Significance Index: -6.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4563
    Cell Significance Index: -13.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4618
    Cell Significance Index: -2.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4805
    Cell Significance Index: -10.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5441
    Cell Significance Index: -5.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5845
    Cell Significance Index: -46.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5964
    Cell Significance Index: -13.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7586
    Cell Significance Index: -12.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7773
    Cell Significance Index: -47.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8618
    Cell Significance Index: -22.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9546
    Cell Significance Index: -16.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9601
    Cell Significance Index: -30.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9750
    Cell Significance Index: -31.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9832
    Cell Significance Index: -26.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0187
    Cell Significance Index: -35.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0695
    Cell Significance Index: -31.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0745
    Cell Significance Index: -34.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0765
    Cell Significance Index: -26.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1400
    Cell Significance Index: -16.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SHOC2 is a leucine-rich repeat protein, which provides a framework for protein-protein interactions. Its ability to bind to various proteins, including Ras proteins, MAPKs, and protein phosphatases, makes it a critical regulator of signaling pathways. SHOC2 is also involved in the regulation of cellular differentiation and proliferation, particularly in the context of neural development and function. Its expression in multiple cell types suggests a pleiotropic role in various cellular processes. **Pathways and Functions** SHOC2 is integral to several key signaling pathways, including: 1. **Ras/MAPK signaling pathway**: SHOC2 modulates the activity of Ras proteins, which are essential for cell proliferation, differentiation, and survival. 2. **MAPK family signaling cascades**: SHOC2 interacts with MAPKs, influencing their activity and downstream effects on cellular processes. 3. **Protein phosphatase 1 binding**: SHOC2 interacts with protein phosphatase 1, regulating its activity and influencing cellular metabolism. 4. **Neuron differentiation and proliferation**: SHOC2 regulates the differentiation and proliferation of neurons, particularly in the context of neural development and function. **Clinical Significance** Dysregulation of SHOC2 has been implicated in various diseases, including: 1. **Neurodevelopmental disorders**: Mutations in SHOC2 have been associated with neurodevelopmental disorders, such as intellectual disability and autism spectrum disorder. 2. **Cancer**: SHOC2 is often overexpressed in cancer cells, where it contributes to tumor growth and metastasis. 3. **Neurodegenerative diseases**: SHOC2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, SHOC2 is a critical regulator of signaling pathways, cellular differentiation, and proliferation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying SHOC2 function and its role in human disease.

Genular Protein ID: 3969127645

Symbol: SHOC2_HUMAN

Name: Leucine-rich repeat protein SHOC-2

UniProtKB Accession Codes:

Q9UQ13 A8K9W8 B3KR23 O76063 Q5VZS8 Q5VZS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 2 Ensembl 8 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9674433

Title: SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.

PubMed ID: 9674433

DOI: 10.1016/s0092-8674(00)81227-1

PubMed ID: 9618511

Title: Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.

PubMed ID: 9618511

DOI: 10.1073/pnas.95.12.6903

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10783161

Title: The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.

PubMed ID: 10783161

PubMed ID: 16301319

Title: Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.

PubMed ID: 16301319

DOI: 10.1074/jbc.m507360200

PubMed ID: 16630891

Title: A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.

PubMed ID: 16630891

DOI: 10.1016/j.molcel.2006.03.027

PubMed ID: 19684605

Title: Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.

PubMed ID: 19684605

DOI: 10.1038/ng.425

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30368668

Title: Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.

PubMed ID: 30368668

DOI: 10.1007/s00439-018-1951-7

PubMed ID: 23918763

Title: Expanding the SHOC2 mutation associated phenotype of Noonan syndrome with loose anagen hair: structural brain anomalies and myelofibrosis.

PubMed ID: 23918763

DOI: 10.1002/ajmg.a.36098

PubMed ID: 25137548

Title: A Novel SHOC2 Variant in Rasopathy.

PubMed ID: 25137548

DOI: 10.1002/humu.22634

Sequence Information:

  • Length: 582
  • Mass: 64888
  • Checksum: F3F828646642A855
  • Sequence:
    • MSSSLGKEKD SKEKDPKVPS AKEREKEAKA SGGFGKESKE KEPKTKGKDA KDGKKDSSAA 
QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE NSMRLDLSKR SIHILPSSIK 
ELTQLTELYL YSNKLQSLPA EVGCLVNLMT LALSENSLTS LPDSLDNLKK LRMLDLRHNK 
LREIPSVVYR LDSLTTLYLR FNRITTVEKD IKNLSKLSML SIRENKIKQL PAEIGELCNL 
ITLDVAHNQL EHLPKEIGNC TQITNLDLQH NELLDLPDTI GNLSSLSRLG LRYNRLSAIP 
RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG PSQFSTIYSL 
NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT WTSMVELNLA TNQLTKIPED 
VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL RELDLEENKL ESLPNEIAYL KDLQKLVLTN 
NQLTTLPRGI GHLTNLTHLG LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC 
SKLSIMSIEN CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.