Details for: SSPN

Gene ID: 8082

Symbol: SSPN

Ensembl ID: ENSG00000123096

Description: sarcospan

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.6741
    Cell Significance Index: -22.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.7887
    Cell Significance Index: -22.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.7857
    Cell Significance Index: -19.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7349
    Cell Significance Index: -22.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9097
    Cell Significance Index: -15.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6286
    Cell Significance Index: -10.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.9914
    Cell Significance Index: 38.3100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.1838
    Cell Significance Index: 12.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9157
    Cell Significance Index: 245.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5967
    Cell Significance Index: 219.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2150
    Cell Significance Index: 34.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1518
    Cell Significance Index: 26.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1480
    Cell Significance Index: 24.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1380
    Cell Significance Index: 22.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8509
    Cell Significance Index: 11.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.7713
    Cell Significance Index: 18.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6801
    Cell Significance Index: 18.1600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.5910
    Cell Significance Index: 3.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5212
    Cell Significance Index: 64.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4773
    Cell Significance Index: 47.2200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4377
    Cell Significance Index: 4.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4265
    Cell Significance Index: 11.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4205
    Cell Significance Index: 379.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3456
    Cell Significance Index: 7.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3418
    Cell Significance Index: 151.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3405
    Cell Significance Index: 37.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3204
    Cell Significance Index: 57.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2647
    Cell Significance Index: 20.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2644
    Cell Significance Index: 43.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2283
    Cell Significance Index: 3.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1897
    Cell Significance Index: 2.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1552
    Cell Significance Index: 7.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1489
    Cell Significance Index: 81.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1332
    Cell Significance Index: 9.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1262
    Cell Significance Index: 237.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1056
    Cell Significance Index: 37.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0901
    Cell Significance Index: 18.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0714
    Cell Significance Index: 2.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0697
    Cell Significance Index: 1.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0690
    Cell Significance Index: 3.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0552
    Cell Significance Index: 10.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0506
    Cell Significance Index: 77.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0423
    Cell Significance Index: 2.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0275
    Cell Significance Index: 12.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0149
    Cell Significance Index: 9.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0112
    Cell Significance Index: 20.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0079
    Cell Significance Index: 1.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0005
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0029
    Cell Significance Index: -0.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0098
    Cell Significance Index: -1.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0135
    Cell Significance Index: -0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0196
    Cell Significance Index: -2.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0292
    Cell Significance Index: -0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0313
    Cell Significance Index: -23.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0330
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0336
    Cell Significance Index: -24.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0391
    Cell Significance Index: -22.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0403
    Cell Significance Index: -25.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0405
    Cell Significance Index: -0.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0580
    Cell Significance Index: -16.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0770
    Cell Significance Index: -3.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0810
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0838
    Cell Significance Index: -14.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0910
    Cell Significance Index: -2.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0924
    Cell Significance Index: -4.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1048
    Cell Significance Index: -5.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1091
    Cell Significance Index: -0.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1096
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1160
    Cell Significance Index: -24.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1210
    Cell Significance Index: -1.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1315
    Cell Significance Index: -15.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1324
    Cell Significance Index: -15.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1327
    Cell Significance Index: -8.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1370
    Cell Significance Index: -2.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1422
    Cell Significance Index: -3.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1468
    Cell Significance Index: -2.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1580
    Cell Significance Index: -2.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1611
    Cell Significance Index: -2.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1656
    Cell Significance Index: -17.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1739
    Cell Significance Index: -20.5100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1929
    Cell Significance Index: -2.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1948
    Cell Significance Index: -1.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1981
    Cell Significance Index: -4.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1993
    Cell Significance Index: -12.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2465
    Cell Significance Index: -3.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2542
    Cell Significance Index: -20.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2652
    Cell Significance Index: -11.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2738
    Cell Significance Index: -8.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2747
    Cell Significance Index: -3.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2830
    Cell Significance Index: -7.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3232
    Cell Significance Index: -12.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3268
    Cell Significance Index: -18.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3275
    Cell Significance Index: -3.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3540
    Cell Significance Index: -18.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3549
    Cell Significance Index: -22.3700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3619
    Cell Significance Index: -5.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3664
    Cell Significance Index: -23.6400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4381
    Cell Significance Index: -7.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSPN is a member of the sialoglycoprotein family, characterized by its high sialic acid content. This unique feature enables SSPN to interact with other proteins and lipids, facilitating its role in cell adhesion and signaling. SSPN has been identified as a component of the dystrophin-associated glycoprotein complex (DAGC), which plays a crucial role in maintaining muscle integrity and function. Additionally, SSPN has been implicated in the regulation of muscle contraction and the formation of transport vesicles. **Pathways and Functions:** SSPN's involvement in various cellular processes can be attributed to its interactions with other proteins and lipids. Some of the key pathways and functions associated with SSPN include: 1. **Cell Adhesion:** SSPN's high sialic acid content enables it to interact with selectins and other adhesion molecules, facilitating cell-cell interactions and tissue organization. 2. **Muscle Contraction:** SSPN's presence in the DAGC complex enables it to regulate muscle contraction by modulating the activity of dystrophin and other muscle proteins. 3. **Transport Vesicle Formation:** SSPN has been implicated in the formation of transport vesicles, which are essential for the regulation of cellular trafficking and protein transport. 4. **Signaling:** SSPN's interactions with other proteins and lipids enable it to regulate signaling pathways, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** The multifaceted role of SSPN in various cellular processes makes it an important protein in the context of human disease. Some of the clinical implications of SSPN dysregulation include: 1. **Muscle Disorders:** SSPN's role in maintaining muscle integrity and function makes it an important protein in the context of muscle disorders, such as muscular dystrophy. 2. **Neurological Disorders:** SSPN's involvement in signaling pathways and cell adhesion makes it an important protein in the context of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** SSPN's role in cell adhesion and signaling makes it an important protein in the context of cancer, where dysregulation of SSPN has been implicated in tumor progression and metastasis. In conclusion, SSPN is a multifaceted protein that plays a crucial role in various cellular processes, including cell adhesion, muscle contraction, and transport vesicle formation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and functions of SSPN.

Genular Protein ID: 333283294

Symbol: SSPN_HUMAN

Name: Sarcospan

UniProtKB Accession Codes:

Q14714 B3KS67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 5 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9395445

Title: Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex.

PubMed ID: 9395445

DOI: 10.1074/jbc.272.50.31221

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661122

Title: Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG.

PubMed ID: 8661122

DOI: 10.1006/geno.1996.0340

Sequence Information:

  • Length: 243
  • Mass: 26618
  • Checksum: 0D6B24B9848253F9
  • Sequence:
    • MGKNKQPRGQ QRQGGPPAAD AAGPDDMEPK KGTGAPKECG EEEPRTCCGC RFPLLLALLQ 
LALGIAVTVV GFLMASISSS LLVRDTPFWA GIIVCLVAYL GLFMLCVSYQ VDERTCIQFS 
MKLLYFLLSA LGLTVCVLAV AFAAHHYSQL TQFTCETTLD SCQCKLPSSE PLSRTFVYRD 
VTDCTSVTGT FKLFLLIQMI LNLVCGLVCL LACFVMWKHR YQVFYVGVRI CSLTASEGPQ 
QKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.