Details for: NPRL3
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: germ cell (CL0000586)
Fold Change: 2.7
Marker Score: 4721 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.34
Marker Score: 1873 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.75
Marker Score: 733 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.67
Marker Score: 17199 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.65
Marker Score: 35148 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.62
Marker Score: 6265 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.59
Marker Score: 60328 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.58
Marker Score: 14904 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.57
Marker Score: 96808 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.57
Marker Score: 14940 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.53
Marker Score: 11734 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.52
Marker Score: 13044 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.51
Marker Score: 881 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.5
Marker Score: 55208 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.49
Marker Score: 22323 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.46
Marker Score: 463 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.45
Marker Score: 1752.5 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.44
Marker Score: 5961 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.42
Marker Score: 28323 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.42
Marker Score: 387 - Cell Name: neuron (CL0000540)
Fold Change: 1.41
Marker Score: 5728 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.4
Marker Score: 2160 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.38
Marker Score: 1858 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.29
Marker Score: 5398 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.26
Marker Score: 1810 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.09
Marker Score: 1366 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.07
Marker Score: 727 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.06
Marker Score: 2162 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.04
Marker Score: 1197 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.02
Marker Score: 294 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71696 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1
Marker Score: 1074 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47921 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30393 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.98
Marker Score: 1878 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.96
Marker Score: 1090 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.95
Marker Score: 14823 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2397 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.94
Marker Score: 1169 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.94
Marker Score: 489 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.93
Marker Score: 4319 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 481 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.93
Marker Score: 1005 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 436 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2703 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.9
Marker Score: 989 - Cell Name: fat cell (CL0000136)
Fold Change: 0.89
Marker Score: 496 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.89
Marker Score: 2086 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.88
Marker Score: 19640 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.88
Marker Score: 256 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5294 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.87
Marker Score: 755 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.87
Marker Score: 505 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.87
Marker Score: 826 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.85
Marker Score: 1030 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.85
Marker Score: 413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4823 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.84
Marker Score: 3003 - Cell Name: Unknown (CL0002371)
Fold Change: 0.84
Marker Score: 893 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.82
Marker Score: 772 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.82
Marker Score: 5317 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.8
Marker Score: 253 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.8
Marker Score: 1295 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 318 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.79
Marker Score: 2153 - Cell Name: interneuron (CL0000099)
Fold Change: 0.79
Marker Score: 360 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.79
Marker Score: 1884 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.78
Marker Score: 3378 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.78
Marker Score: 1718.5 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.78
Marker Score: 877 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.78
Marker Score: 937 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 591 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.76
Marker Score: 1907 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.76
Marker Score: 4570 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.76
Marker Score: 500 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.76
Marker Score: 3166 - Cell Name: oocyte (CL0000023)
Fold Change: 0.76
Marker Score: 187 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.76
Marker Score: 800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.76
Marker Score: 239 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.75
Marker Score: 470 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.75
Marker Score: 370 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.75
Marker Score: 759 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.75
Marker Score: 393 - Cell Name: neural cell (CL0002319)
Fold Change: 0.75
Marker Score: 360 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.74
Marker Score: 408 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.74
Marker Score: 352 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.73
Marker Score: 670 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 375 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.72
Marker Score: 625 - Cell Name: podocyte (CL0000653)
Fold Change: 0.72
Marker Score: 265 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.71
Marker Score: 1008 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2985 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.71
Marker Score: 2786 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.71
Marker Score: 1478 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7
Marker Score: 7079 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.7
Marker Score: 620 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.69
Marker Score: 1172 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.69
Marker Score: 215 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.68
Marker Score: 160
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Other Information
Genular Protein ID: 2214431057
Symbol: NPRL3_HUMAN
Name: Protein CGTHBA
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8575760
Title: Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.
PubMed ID: 8575760
PubMed ID: 16728641
Title: A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.
PubMed ID: 16728641
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 19521502
Title: A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.
PubMed ID: 19521502
PubMed ID: 23723238
Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
PubMed ID: 23723238
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28199306
Title: KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
PubMed ID: 28199306
DOI: 10.1038/nature21423
PubMed ID: 36007018
Title: Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
PubMed ID: 36007018
PubMed ID: 29590090
Title: Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
PubMed ID: 29590090
DOI: 10.1038/nature26158
PubMed ID: 35338845
Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
PubMed ID: 35338845
PubMed ID: 26505888
Title: Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy.
PubMed ID: 26505888
DOI: 10.1002/ana.24547
PubMed ID: 26285051
Title: Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulator NPRL3.
PubMed ID: 26285051
DOI: 10.1002/ana.24502
PubMed ID: 27173016
Title: Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.
PubMed ID: 27173016
DOI: 10.1111/epi.13391
Sequence Information:
- Length: 569
- Mass: 63605
- Checksum: 44BEF42AA7F2841D
- Sequence:
MRDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTS KPRSRYAASN TGDHADEQDG DSRFSDVILA TILATKSEMC GQKFELKIDN VRFVGHPTLL QHALGQISKT DPSPKREAPT MILFNVVFAL RANADPSVIN CLHNLSRRIA TVLQHEERRC QYLTREAKLI LALQDEVSAM ADGNEGPQSP FHHILPKCKL ARDLKEAYDS LCTSGVVRLH INSWLEVSFC LPHKIHYAAS SLIPPEAIER SLKAIRPYHA LLLLSDEKSL LGELPIDCSP ALVRVIKTTS AVKNLQQLAQ DADLALLQVF QLAAHLVYWG KAIIIYPLCE NNVYMLSPNA SVCLYSPLAE QFSHQFPSHD LPSVLAKFSL PVSLSEFRNP LAPAVQETQL IQMVVWMLQR RLLIQLHTYV CLMASPSEEE PRPREDDVPF TARVGGRSLS TPNALSFGSP TSSDDMTLTS PSMDNSSAEL LPSGDSPLNQ RMTENLLASL SEHERAAILS VPAAQNPEDL RMFARLLHYF RGRHHLEEIM YNENTRRSQL LMLFDKFRSV LVVTTHEDPV IAVFQALLP
Genular Protein ID: 1914215432
Symbol: Q9BTE2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 390
- Mass: 43606
- Checksum: C0FF9F9EF59A63F2
- Sequence:
MADGNEGPQS PFHHILPKCK LARDLKEAYD SLCTSGVVRL HINSWLEVSF CLPHKIHYAA SSLIPPEAIE RSLKAIRPYH ALLLLSDEKS LLGELPIDCS PALVRVIKTT SAVKNLQQLA QDADLALLQV FQLAAHLVYW GKAIIIYPLC ENNVYMLSPN ASVCLYSPLA EQFSHQFPSH DLPSVLAKFS LPVSLSEFRN PLAPAVQETQ LIQMVVWMLQ RRLLIQLHTY VCLMASPSEE EPRPREDDVP FTARVGGRSL STPNALSFGS PTSSDDMTLT SPSMDNSSAE LLPSGDSPLN QRMTENLLAS LSEHERAAIL SVPAAQNPED LRMFARLLHY FRGRHHLEEI MYNENTRRSQ LLMLFDKFRS VLVVTTHEDP VIAVFQALLP
Genular Protein ID: 538858576
Symbol: B7Z6Q0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 544
- Mass: 60792
- Checksum: C6A12CEBC88DA304
- Sequence:
MRDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTS KPRSRYAASN TGDHADEQDG DSRFSDVILA TILATKSEMC GQKFELKIDN VRFVGHPTLL QHALGQANAD PSVINCLHNL SRRIATVLQH EERRCQYLTR EAKLILALQD EVSAMADGNE GPQSPFHHIL PKCKLARDLK EAYDSLCTSG VVRLHINSWL EVSFCLPHKI HYAASSLIPP EAIERSLKAI RPYHALLLLS DEKSLLGELP IDCSPALVRV IKTTSAVKNL QQLAQDADLA LLQVFQLAAH LVYWGKAIII YPLCENNVYM LSPNASVCLY SPLAEQFSHQ FPSHDLPSVL AKFSLPVSLS EFRNPLAPAV QETQLIQMVV WMLQRRLLIQ LHTYVCLMAS PSEEEPRPRE DDVPFTARVG GRSLSTPNAL SFGSPTSSDD MTLTSPSMDN SSAELLPSGD SPLNQRMTEN LLASLSEHER AAILSVPAAQ NPEDLRMFAR LLHYFRGRHH LEEIMYNENT RRSQLLMLFD KFRSVLVVTT HEDPVIAVFQ ALLP
Genular Protein ID: 3194030851
Symbol: B7Z220_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 491
- Mass: 55025
- Checksum: BC7CA4E9B4C0FAE7
- Sequence:
MCGQKFELEI DNVRFVGHPT LLQHALGQIS KTDPSPKREA PTMILFNVVF ALRANADPSV INCLHNLSRR IATVLQHEER RCQYLTREAK LILALQDEVS AMADGNEGPQ SPFHHILPKC KLARDLKEAY DSLCTSGVVR LHINSWLEVS FCLPHKIHYA ASSLIPPEAI ERSLKAIRPY HALLLLSDEK SLLGELPIDC SPALVRVIKT TSAVKNLQQL AQDADLALLQ VFQLAAHLVY WGKAIIIYPL CENNVYMLSP NASVCLYSPL AEQFSHQFPS HDLPSVLAKF SLPVSLSEFR NPLAPAVQET QLIQMVVWML QRRLLIQLHT YVCLMASPSE EEPRPREDDV PFTARVGGRS LSTPNALSFG SPTSSDDMTL TSPSMDNSSA ELLPSGDSPL NQRMTENLLA SLSEHERAAI LSVPAAQNPE DLRMFARLLH YFRGRHHLEE IMYNENTRRS QLLMLFDKFR SVLVVTTHED PVIAVFQALL P
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.