Details for: NCOA3

Gene ID: 8202

Symbol: NCOA3

Ensembl ID: ENSG00000124151

Description: nuclear receptor coactivator 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 353.2092
    Cell Significance Index: -54.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.7433
    Cell Significance Index: -53.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.1087
    Cell Significance Index: -47.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 102.9190
    Cell Significance Index: -52.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.4793
    Cell Significance Index: -47.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.8840
    Cell Significance Index: -55.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.3197
    Cell Significance Index: -46.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.0570
    Cell Significance Index: -53.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1052
    Cell Significance Index: -46.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.0774
    Cell Significance Index: -55.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 9.1748
    Cell Significance Index: 244.9800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.4239
    Cell Significance Index: 78.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.0347
    Cell Significance Index: 103.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3906
    Cell Significance Index: 672.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3004
    Cell Significance Index: 176.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0652
    Cell Significance Index: 57.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4905
    Cell Significance Index: 175.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1698
    Cell Significance Index: 25.0100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.1227
    Cell Significance Index: 18.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9839
    Cell Significance Index: 177.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9805
    Cell Significance Index: 120.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9089
    Cell Significance Index: 326.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8982
    Cell Significance Index: 17.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7990
    Cell Significance Index: 49.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7615
    Cell Significance Index: 82.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6916
    Cell Significance Index: 478.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6436
    Cell Significance Index: 104.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6063
    Cell Significance Index: 34.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4095
    Cell Significance Index: 223.6300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3855
    Cell Significance Index: 9.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3387
    Cell Significance Index: 67.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3329
    Cell Significance Index: 147.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3092
    Cell Significance Index: 21.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2813
    Cell Significance Index: 529.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2812
    Cell Significance Index: 14.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2476
    Cell Significance Index: 15.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1711
    Cell Significance Index: 8.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1650
    Cell Significance Index: 22.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1601
    Cell Significance Index: 144.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1503
    Cell Significance Index: 4.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1064
    Cell Significance Index: 2.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1059
    Cell Significance Index: 195.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0953
    Cell Significance Index: 9.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0922
    Cell Significance Index: 141.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0836
    Cell Significance Index: 3.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0715
    Cell Significance Index: 3.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0567
    Cell Significance Index: 25.7400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0390
    Cell Significance Index: 0.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0373
    Cell Significance Index: 7.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0348
    Cell Significance Index: 47.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0325
    Cell Significance Index: 20.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0149
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0148
    Cell Significance Index: 2.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0057
    Cell Significance Index: 0.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0018
    Cell Significance Index: 0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0128
    Cell Significance Index: -0.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0250
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0317
    Cell Significance Index: -19.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0417
    Cell Significance Index: -1.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0471
    Cell Significance Index: -34.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0621
    Cell Significance Index: -46.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0637
    Cell Significance Index: -35.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1028
    Cell Significance Index: -13.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1173
    Cell Significance Index: -5.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1278
    Cell Significance Index: -1.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1336
    Cell Significance Index: -2.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1413
    Cell Significance Index: -14.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1674
    Cell Significance Index: -48.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1750
    Cell Significance Index: -36.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1768
    Cell Significance Index: -2.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1832
    Cell Significance Index: -26.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1919
    Cell Significance Index: -22.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2006
    Cell Significance Index: -5.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2025
    Cell Significance Index: -14.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2278
    Cell Significance Index: -14.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2436
    Cell Significance Index: -31.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2953
    Cell Significance Index: -33.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3242
    Cell Significance Index: -37.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3749
    Cell Significance Index: -39.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4097
    Cell Significance Index: -5.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4453
    Cell Significance Index: -8.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5005
    Cell Significance Index: -22.1400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.5078
    Cell Significance Index: -5.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5168
    Cell Significance Index: -38.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6149
    Cell Significance Index: -7.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6181
    Cell Significance Index: -48.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6236
    Cell Significance Index: -18.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6272
    Cell Significance Index: -23.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7418
    Cell Significance Index: -45.4800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.7484
    Cell Significance Index: -4.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7531
    Cell Significance Index: -10.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8178
    Cell Significance Index: -41.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8349
    Cell Significance Index: -26.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8696
    Cell Significance Index: -18.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8733
    Cell Significance Index: -23.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8782
    Cell Significance Index: -19.2300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.8787
    Cell Significance Index: -7.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8864
    Cell Significance Index: -46.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9253
    Cell Significance Index: -26.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NCOA3 is a member of the nuclear receptor coactivator family, which is characterized by its ability to enhance the transcriptional activity of nuclear receptors. The protein contains multiple domains, including a histone acetyltransferase (HAT) domain, a transcriptional activation domain, and a protein-binding domain. These domains enable NCOA3 to interact with various transcription factors, including nuclear receptors, and to modulate gene expression in response to hormone stimulation. **Pathways and Functions:** NCOA3 is involved in multiple signaling pathways, including: 1. **Activation of Anterior Hox Genes in Hindbrain Development:** NCOA3 coactivates the nuclear receptor PPARα to regulate the expression of anterior hox genes, which are essential for hindbrain development during early embryogenesis. 2. **Activation of Hox Genes during Differentiation:** NCOA3 also regulates the expression of hox genes during cell differentiation, which is crucial for the development and maintenance of various cell types. 3. **Cell Dedifferentiation:** NCOA3 has been shown to regulate cell dedifferentiation, a process that involves the loss of cell-specific gene expression and the acquisition of a more pluripotent state. 4. **Cellular Response to Estradiol Stimulus:** NCOA3 coactivates the estrogen receptor (ER) to regulate the expression of genes involved in reproductive biology. 5. **Chromatin Remodeling:** NCOA3 interacts with histone-modifying enzymes to regulate chromatin structure and gene expression. **Clinical Significance:** Dysregulation of NCOA3 has been implicated in various diseases, including: 1. **Cancer:** NCOA3 overexpression has been observed in several types of cancer, including breast, prostate, and lung cancer. 2. **Metabolic Disorders:** NCOA3 regulates lipid metabolism, and its dysregulation has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 3. **Neurological Disorders:** NCOA3 has been implicated in the regulation of gene expression in the central nervous system, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive Disorders:** NCOA3 regulates reproductive biology, and its dysregulation has been implicated in reproductive disorders, such as infertility and menopause. In conclusion, NCOA3 is a key player in hormone-regulated gene expression and developmental biology. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in normal and pathological processes. Further research is needed to elucidate the mechanisms by which NCOA3 regulates gene expression and to identify potential therapeutic targets for the treatment of diseases associated with its dysregulation.

Genular Protein ID: 3113766594

Symbol: NCOA3_HUMAN

Name: Nuclear receptor coactivator 3

UniProtKB Accession Codes:

Q9Y6Q9 A4LAZ5 Q0VF45 Q5JYD9 Q5JYE0 Q9BR49 Q9UPC9 Q9UPG4 Q9UPG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 ELM 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 GO 25 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9346901

Title: TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.

PubMed ID: 9346901

DOI: 10.1074/jbc.272.44.27629

PubMed ID: 9267036

Title: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

PubMed ID: 9267036

DOI: 10.1016/s0092-8674(00)80516-4

PubMed ID: 9252329

Title: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.

PubMed ID: 9252329

DOI: 10.1126/science.277.5328.965

PubMed ID: 9238002

Title: RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.

PubMed ID: 9238002

DOI: 10.1073/pnas.94.16.8479

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9727751

Title: Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene).

PubMed ID: 9727751

DOI: 10.1111/j.1399-0004.1998.tb03704.x

PubMed ID: 10490106

Title: Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.

PubMed ID: 10490106

DOI: 10.1016/s0092-8674(00)80054-9

PubMed ID: 11094166

Title: RAC-3 is a NF-kappa B coactivator.

PubMed ID: 11094166

DOI: 10.1016/s0014-5793(00)02223-7

PubMed ID: 11250900

Title: A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.

PubMed ID: 11250900

DOI: 10.1093/emboj/20.6.1341

PubMed ID: 11971985

Title: Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.

PubMed ID: 11971985

DOI: 10.1128/mcb.22.10.3549-3561.2002

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 14645221

Title: Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.

PubMed ID: 14645221

DOI: 10.1074/jbc.m311973200

PubMed ID: 15698540

Title: FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors.

PubMed ID: 15698540

DOI: 10.1016/j.jsbmb.2004.09.003

PubMed ID: 16951154

Title: Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.

PubMed ID: 16951154

DOI: 10.1158/0008-5472.can-06-1636

PubMed ID: 16957778

Title: The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription.

PubMed ID: 16957778

DOI: 10.1038/sj.emboj.7601306

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17998543

Title: ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.

PubMed ID: 17998543

DOI: 10.1073/pnas.0705814104

PubMed ID: 18690216

Title: Cytosporone B is an agonist for nuclear orphan receptor Nur77.

PubMed ID: 18690216

DOI: 10.1038/nchembio.106

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19339517

Title: CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.

PubMed ID: 19339517

DOI: 10.1093/nar/gkp136

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 1424
  • Mass: 155293
  • Checksum: 732CDF0423161679
  • Sequence:
    • MSGLGENLDP LASDSRKRKL PCDTPGQGLT CSGEKRRREQ ESKYIEELAE LISANLSDID 
NFNVKPDKCA ILKETVRQIR QIKEQGKTIS NDDDVQKADV SSTGQGVIDK DSLGPLLLQA 
LDGFLFVVNR DGNIVFVSEN VTQYLQYKQE DLVNTSVYNI LHEEDRKDFL KNLPKSTVNG 
VSWTNETQRQ KSHTFNCRML MKTPHDILED INASPEMRQR YETMQCFALS QPRAMMEEGE 
DLQSCMICVA RRITTGERTF PSNPESFITR HDLSGKVVNI DTNSLRSSMR PGFEDIIRRC 
IQRFFSLNDG QSWSQKRHYQ EAYLNGHAET PVYRFSLADG TIVTAQTKSK LFRNPVTNDR 
HGFVSTHFLQ REQNGYRPNP NPVGQGIRPP MAGCNSSVGG MSMSPNQGLQ MPSSRAYGLA 
DPSTTGQMSG ARYGGSSNIA SLTPGPGMQS PSSYQNNNYG LNMSSPPHGS PGLAPNQQNI 
MISPRNRGSP KIASHQFSPV AGVHSPMASS GNTGNHSFSS SSLSALQAIS EGVGTSLLST 
LSSPGPKLDN SPNMNITQPS KVSNQDSKSP LGFYCDQNPV ESSMCQSNSR DHLSDKESKE 
SSVEGAENQR GPLESKGHKK LLQLLTCSSD DRGHSSLTNS PLDSSCKESS VSVTSPSGVS 
SSTSGGVSST SNMHGSLLQE KHRILHKLLQ NGNSPAEVAK ITAEATGKDT SSITSCGDGN 
VVKQEQLSPK KKENNALLRY LLDRDDPSDA LSKELQPQVE GVDNKMSQCT SSTIPSSSQE 
KDPKIKTETS EEGSGDLDNL DAILGDLTSS DFYNNSISSN GSHLGTKQQV FQGTNSLGLK 
SSQSVQSIRP PYNRAVSLDS PVSVGSSPPV KNISAFPMLP KQPMLGGNPR MMDSQENYGS 
SMGGPNRNVT VTQTPSSGDW GLPNSKAGRM EPMNSNSMGR PGGDYNTSLP RPALGGSIPT 
LPLRSNSIPG ARPVLQQQQQ MLQMRPGEIP MGMGANPYGQ AAASNQLGSW PDGMLSMEQV 
SHGTQNRPLL RNSLDDLVGP PSNLEGQSDE RALLDQLHTL LSNTDATGLE EIDRALGIPE 
LVNQGQALEP KQDAFQGQEA AVMMDQKAGL YGQTYPAQGP PMQGGFHLQG QSPSFNSMMN 
QMNQQGNFPL QGMHPRANIM RPRTNTPKQL RMQLQQRLQG QQFLNQSRQA LELKMENPTA 
GGAAVMRPMM QPQVSSQQGF LNAQMVAQRS RELLSHHFRQ QRVAMMMQQQ QQQQQQQQQQ 
QQQQQQQQQQ QQQQQQTQAF SPPPNVTASP SMDGLLAGPT MPQAPPQQFP YQPNYGMGQQ 
PDPAFGRVSS PPNAMMSSRM GPSQNPMMQH PQAASIYQSS EMKGWPSGNL ARNSSFSQQQ 
FAHQGNPAVY SMVHMNGSSG HMGQMNMNPM PMSGMPMGPD QKYC

Genular Protein ID: 2305522740

Symbol: Q59EE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EE8

Database IDs:

ARBA 6 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 3 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 4 PeptideAtlas 1 Pfam 7 PharmGKB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 1427
  • Mass: 155657
  • Checksum: A882D1D5ABE45ACB
  • Sequence:
    • CIFKMSGLGE NLDPLASDSR KRKLPCDTPG QGLTCSGEKR RREQESKYIE ELAELISANL 
SDIDNFNVKP DKCAILKETV RQIRQIKEQG KTISNDDDVQ KADVSSTGQG VIDKDSLGPL 
LLQALDGFLF VVNRDGNIVF VSENVTQYLQ YKQEDLVNTS VYNILHEEDR KDFLKNLPKS 
TVNGVSWTNE TQRQKSHTFN CRMLMKTPHD ILEDINASPE MRQRYETMQC FALSQPRAMM 
EEGEDLQSCM ICVARRITTG ERTFPSNPES FITRHDLSGK VVNIDTNSLR SSMRPGFEDI 
IRRCIQRFFS LNDGQSWSQK RHYQEAYLNG HAETPVYRFS LADGTIVTAQ TKSKLFRNPV 
TNDRHGFVST HFLQREQNGY RPNPNPVGQG IRPPMAGCNS SVGGMSMSPN QGLQMPSSRA 
YGLADPSTTG QMSGARYGGS SNIASLTPGP GMQSPSSYQN NNYGLNMSSP PHGSPGLAPN 
QQNIMISPRN RGSPKIASHQ FSPVAGVHSP MASSGNTGNH SFSSSSLSAL QAISEGVGTS 
LLSTLSSPGP KLDNSPNMNI TQPSKVSNQD SKSPLGFYCD QNPVESSMCQ SNSRDHLSDK 
ESKESSVEGA ENQRGPLESK GHKKLLQLLT CSSDDRGHSS LTNSPLDSSC KESSVSVTSP 
SGVSSSTSGG VSSTSNMHGS LLQEKHRILH KLLQNGNSPA EVAKITAEAT GKDTSSITSC 
GDGNVVKQEQ LSPKKKENNA LLRYLLDRDD PSDALSKELQ PQVEGVDNKM SQCTSSTIPS 
SSQEKDPKIK TETSEEGSGD LDNLDAILGD LTSSDFYNNS ISSNGSHLGT KQQVFQGTNS 
LGLKSSQSVQ SIRPPYNRAV SLDSPVSVGS SPPVKNISAF PMLPKQPMLG GNPRMMDSQE 
NYGSSMGGPN RNVTVTQTPS SGDWGLPNSK AGRMEPMNSN SMGRPGGDYN TSLPRPALGG 
SIPTLPLRSN SIPGARPVLQ QQQQMLQMRP GEIPMGMGAN PYGQAAASNQ LGSWPDGMLS 
MEQVSHGTQN RPLLRNSLDD LVGPPSNLEG QSDERALLDQ LHTLLSNTDA TGLEEIDRAL 
GIPELVNQGQ ALEPKQDAFQ GQEAAVMMDQ KAGLYGQTYP AQGPPMQGGF HLQGQSPSFN 
SMMNQMNQQG NFPLQGMHPR ANIMRPRTNT PKQLRMQLQQ RLQGQQFLNQ SRQALELKME 
NPTAGGAAVM RPMMQPQVSS QGFLNAQMVA QRSRELLSHH FRQQRVAMMM QQQQQQQQQQ 
QQQQQQQQQQ QQQQQQQQQT QAFSPPPNVT ASPSMDGLLA GPTMPQAPPQ QFPYQPNYGM 
GQQPDPAFGR VSSPPNAMMS SRMGPSQNPM MQHPQAASIY QSSEMKGWPS GNLARNSSFS 
QQQFAHQGNP AVYSMVHMNG SSGHMGQMNM NPMPMSGMPM GPDQKYC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.