Details for: ZRSR2

Gene ID: 8233

Symbol: ZRSR2

Ensembl ID: ENSG00000169249

Description: zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.3117
    Cell Significance Index: -19.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.6073
    Cell Significance Index: -18.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.2515
    Cell Significance Index: -20.4200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.5909
    Cell Significance Index: -20.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.2971
    Cell Significance Index: -20.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.5902
    Cell Significance Index: -20.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2446
    Cell Significance Index: -19.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6749
    Cell Significance Index: -12.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5621
    Cell Significance Index: -14.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3243
    Cell Significance Index: -21.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0875
    Cell Significance Index: 981.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7851
    Cell Significance Index: 157.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7717
    Cell Significance Index: 12.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7476
    Cell Significance Index: 81.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6539
    Cell Significance Index: 106.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6229
    Cell Significance Index: 39.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4776
    Cell Significance Index: 171.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3967
    Cell Significance Index: 27.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3495
    Cell Significance Index: 69.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3226
    Cell Significance Index: 20.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3049
    Cell Significance Index: 4.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2778
    Cell Significance Index: 12.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2729
    Cell Significance Index: 49.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2650
    Cell Significance Index: 33.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2335
    Cell Significance Index: 10.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2134
    Cell Significance Index: 29.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2118
    Cell Significance Index: 13.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2049
    Cell Significance Index: 24.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1933
    Cell Significance Index: 19.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1872
    Cell Significance Index: 7.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1848
    Cell Significance Index: 4.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1782
    Cell Significance Index: 3.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1744
    Cell Significance Index: 21.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1680
    Cell Significance Index: 91.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1510
    Cell Significance Index: 66.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1441
    Cell Significance Index: 6.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1196
    Cell Significance Index: 9.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1143
    Cell Significance Index: 5.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1123
    Cell Significance Index: 2.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1107
    Cell Significance Index: 3.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0844
    Cell Significance Index: 2.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0826
    Cell Significance Index: 3.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0512
    Cell Significance Index: 96.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0460
    Cell Significance Index: 8.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0310
    Cell Significance Index: 0.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0266
    Cell Significance Index: 1.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0259
    Cell Significance Index: 0.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0195
    Cell Significance Index: 12.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0095
    Cell Significance Index: 14.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0030
    Cell Significance Index: 5.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0097
    Cell Significance Index: -0.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0105
    Cell Significance Index: -0.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0117
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0155
    Cell Significance Index: -2.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0178
    Cell Significance Index: -13.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0186
    Cell Significance Index: -2.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0203
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0219
    Cell Significance Index: -16.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0297
    Cell Significance Index: -2.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0303
    Cell Significance Index: -17.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0363
    Cell Significance Index: -22.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0367
    Cell Significance Index: -0.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0373
    Cell Significance Index: -1.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0489
    Cell Significance Index: -6.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0568
    Cell Significance Index: -3.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0587
    Cell Significance Index: -16.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0724
    Cell Significance Index: -1.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0862
    Cell Significance Index: -10.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0898
    Cell Significance Index: -2.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0910
    Cell Significance Index: -1.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0924
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1029
    Cell Significance Index: -21.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1302
    Cell Significance Index: -2.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1308
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1330
    Cell Significance Index: -15.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1389
    Cell Significance Index: -2.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1688
    Cell Significance Index: -3.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1701
    Cell Significance Index: -17.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2164
    Cell Significance Index: -4.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2206
    Cell Significance Index: -5.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2258
    Cell Significance Index: -17.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2365
    Cell Significance Index: -8.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2402
    Cell Significance Index: -6.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2906
    Cell Significance Index: -8.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3256
    Cell Significance Index: -5.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3269
    Cell Significance Index: -20.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3556
    Cell Significance Index: -9.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3788
    Cell Significance Index: -8.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3830
    Cell Significance Index: -12.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3831
    Cell Significance Index: -8.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3846
    Cell Significance Index: -12.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3879
    Cell Significance Index: -9.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3920
    Cell Significance Index: -11.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3996
    Cell Significance Index: -20.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4164
    Cell Significance Index: -8.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4195
    Cell Significance Index: -8.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZRSR2 is a zinc finger protein that contains a CCCH-type RNA binding motif and a serine/arginine-rich domain. This unique combination of domains allows U2AFM to interact with both RNA and proteins, making it a crucial component of the spliceosome. The protein is highly conserved across species, indicating its essential role in RNA processing. **Pathways and Functions:** ZRSR2 is involved in various RNA processing pathways, including: 1. **Spliceosome assembly:** U2AFM plays a crucial role in the assembly of the U2AF complex, which is essential for the splicing of pre-mRNA. 2. **RNA splicing:** ZRSR2 is involved in the removal of introns and joining of exons to form mature mRNA. 3. **Metabolism of RNA:** U2AFM may also play a role in the regulation of RNA metabolism, including the processing of capped intron-containing pre-mRNAs. 4. **Metal ion binding:** The protein's metal ion-binding domain may interact with metal ions, which are essential for the proper functioning of the spliceosome. **Clinical Significance:** Dysregulation of ZRSR2 has been implicated in various neurological disorders, including: 1. **Spinal muscular atrophy (SMA):** Mutations in the FUS gene, which encodes a protein that interacts with U2AFM, have been associated with SMA. 2. **Frontotemporal dementia (FTD):** Alterations in ZRSR2 expression have been observed in FTD patients, suggesting its involvement in the disease. 3. **Neurodevelopmental disorders:** ZRSR2 may also play a role in neurodevelopmental disorders, such as autism spectrum disorder (ASD) and schizophrenia. In conclusion, ZRSR2 is a critical gene involved in RNA processing, and its dysregulation has been implicated in various neurological disorders. Further studies are needed to fully understand the role of ZRSR2 in human health and disease. **Implications for Research:** 1. **RNA processing:** Investigating the mechanisms of ZRSR2 in RNA processing may lead to the development of new therapies for RNA-related disorders. 2. **Neurological disorders:** Studying the role of ZRSR2 in neurodevelopmental disorders may provide insights into the underlying mechanisms of these diseases. 3. **Spliceosome assembly:** Understanding the role of ZRSR2 in spliceosome assembly may lead to the development of new therapeutic strategies for RNA-related disorders. **Future Directions:** 1. **Functional studies:** Conducting functional studies to understand the role of ZRSR2 in RNA processing and its implications in disease. 2. **Genetic analysis:** Performing genetic analysis to identify mutations in ZRSR2 associated with neurological disorders. 3. **Therapeutic development:** Developing new therapies targeting ZRSR2 or its downstream targets to treat RNA-related disorders.

Genular Protein ID: 1975329210

Symbol: U2AFM_HUMAN

Name: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8586425

Title: Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.

PubMed ID: 8586425

DOI: 10.1006/geno.1995.9879

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9237760

Title: A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.

PubMed ID: 9237760

DOI: 10.1038/41137

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21041408

Title: The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing.

PubMed ID: 21041408

DOI: 10.1101/gad.1974810

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 482
  • Mass: 58045
  • Checksum: 1DACC8A6CA4727A6
  • Sequence:
  • MAAPEKMTFP EKPSHKKYRA ALKKEKRKKR RQELARLRDS GLSQKEEEED TFIEEQQLEE 
    EKLLERERQR LHEEWLLREQ KAQEEFRIKK EKEEAAKKRQ EEQERKLKEQ WEEQQRKERE 
    EEEQKRQEKK EKEEALQKML DQAENELENG TTWQNPEPPV DFRVMEKDRA NCPFYSKTGA 
    CRFGDRCSRK HNFPTSSPTL LIKSMFTTFG MEQCRRDDYD PDASLEYSEE ETYQQFLDFY 
    EDVLPEFKNV GKVIQFKVSC NLEPHLRGNV YVQYQSEEEC QAALSLFNGR WYAGRQLQCE 
    FCPVTRWKMA ICGLFEIQQC PRGKHCNFLH VFRNPNNEFW EANRDIYLSP DRTGSSFGKN 
    SERRERMGHH DDYYSRLRGR RNPSPDHSYK RNGESERKSS RHRGKKSHKR TSKSRERHNS 
    RSRGRNRDRS RDRSRGRGSR SRSRSRSRRS RRSRSQSSSR SRSRGRRRSG NRDRTVQSPK 
    SK

Genular Protein ID: 317595032

Symbol: A0A8I5KSD0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 460
  • Mass: 55164
  • Checksum: 767508C34EFA4466
  • Sequence:
  • MTFLCFLRAL PASLVALCKE EEEDTFIEEQ QLEEEKLLER ERQRLHEEWL LREQKAQEEF 
    RIKKEKEEAA KKRQEEQERK LKEQWEEQQR KEREEEEQKR QEKKEKEEAL QKMLDQAENE 
    LENGTTWQNP EPPVDFRVME KDRANCPFYS KTGACRFGDR CSRKHNFPTS SPTLLIKSMF 
    TTFGMEQCRR DDYDPDASLE YSEEETYQQF LDFYEDVLPE FKNVGKVIQF KVSCNLEPHL 
    RGNVYVQYQS EEECQAALSL FNGRWYAGRQ LQCEFCPVTR WKMAICGLFE IQQCPRGKHC 
    NFLHVFRNPN NEFWEANRDI YLSPDRTGSS FGKNSERRER MGHHDDYYSR LRGRRNPSPD 
    HSYKRNGESE RKSSRHRGKK SHKRTSKSRE RHNSRSRGRN RDRSRDRSRG RGSRSRSRSR 
    SRRSRRSRSQ SSSRSRSRGR RRSETGSCYV AQTGGQWLFT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.