Details for: CDC45

Gene ID: 8318

Symbol: CDC45

Ensembl ID: ENSG00000093009

Description: cell division cycle 45

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.2827
    Cell Significance Index: -4.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.4737
    Cell Significance Index: -4.2600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 5.1822
    Cell Significance Index: 2.3600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 4.5003
    Cell Significance Index: -0.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.5849
    Cell Significance Index: -4.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9542
    Cell Significance Index: -5.2400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1496
    Cell Significance Index: 8.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9148
    Cell Significance Index: 22.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8688
    Cell Significance Index: 85.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7591
    Cell Significance Index: 45.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6264
    Cell Significance Index: 6.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5911
    Cell Significance Index: 64.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5341
    Cell Significance Index: 86.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5163
    Cell Significance Index: 13.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5087
    Cell Significance Index: 59.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3864
    Cell Significance Index: 11.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3537
    Cell Significance Index: 12.2900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.3454
    Cell Significance Index: 4.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3371
    Cell Significance Index: 304.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3296
    Cell Significance Index: 10.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2959
    Cell Significance Index: 58.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2848
    Cell Significance Index: 15.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2377
    Cell Significance Index: 4.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2287
    Cell Significance Index: 6.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2161
    Cell Significance Index: 5.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2088
    Cell Significance Index: 3.5000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.1575
    Cell Significance Index: 1.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1444
    Cell Significance Index: 4.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1424
    Cell Significance Index: 16.6000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1417
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1268
    Cell Significance Index: 1.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1242
    Cell Significance Index: 2.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0720
    Cell Significance Index: 1.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0714
    Cell Significance Index: 39.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0640
    Cell Significance Index: 4.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0637
    Cell Significance Index: 3.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0600
    Cell Significance Index: 3.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0553
    Cell Significance Index: 2.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0548
    Cell Significance Index: 24.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0387
    Cell Significance Index: 7.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0380
    Cell Significance Index: 0.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0305
    Cell Significance Index: 1.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0284
    Cell Significance Index: 0.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0210
    Cell Significance Index: 2.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0171
    Cell Significance Index: 0.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0167
    Cell Significance Index: 0.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0046
    Cell Significance Index: 0.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0101
    Cell Significance Index: -5.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0110
    Cell Significance Index: -1.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0115
    Cell Significance Index: -4.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0125
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.8200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0132
    Cell Significance Index: -0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0137
    Cell Significance Index: -2.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0178
    Cell Significance Index: -2.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0201
    Cell Significance Index: -0.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0205
    Cell Significance Index: -2.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0231
    Cell Significance Index: -2.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0257
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0280
    Cell Significance Index: -5.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0296
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0354
    Cell Significance Index: -6.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0398
    Cell Significance Index: -0.2500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0430
    Cell Significance Index: -0.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0444
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0465
    Cell Significance Index: -5.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0465
    Cell Significance Index: -4.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0584
    Cell Significance Index: -0.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0639
    Cell Significance Index: -3.9300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0681
    Cell Significance Index: -0.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0723
    Cell Significance Index: -5.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0736
    Cell Significance Index: -5.6500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0743
    Cell Significance Index: -1.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0773
    Cell Significance Index: -5.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0785
    Cell Significance Index: -3.6600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0812
    Cell Significance Index: -0.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0831
    Cell Significance Index: -3.9100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0849
    Cell Significance Index: -0.8400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.0897
    Cell Significance Index: -0.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0928
    Cell Significance Index: -5.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0982
    Cell Significance Index: -1.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1043
    Cell Significance Index: -2.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1079
    Cell Significance Index: -4.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1110
    Cell Significance Index: -5.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1112
    Cell Significance Index: -4.9200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1237
    Cell Significance Index: -1.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1272
    Cell Significance Index: -3.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDC45 is a human gene that encodes a protein essential for DNA replication. It belongs to the CDC45 family of cell division control proteins, which are characterized by their ability to bind to chromatin and regulate the assembly of the pre-replicative complex. The CDC45 protein is a hexameric complex that binds to single-stranded DNA, facilitating the unwinding of DNA and the recruitment of DNA polymerase and other replication proteins. **Pathways and Functions:** CDC45 is involved in several critical pathways that regulate DNA replication, including: 1. **Activation of the pre-replicative complex**: CDC45 binds to chromatin and recruits the pre-replicative complex, a multicomplex structure that assembles on the DNA before replication begins. 2. **DNA unwinding**: CDC45 facilitates the unwinding of DNA, allowing the replication machinery to access the template strands. 3. **Assembly of the replication machinery**: CDC45 recruits DNA polymerase and other replication proteins to the replication fork, ensuring accurate and efficient DNA synthesis. 4. **Cell cycle regulation**: CDC45 is involved in the regulation of the cell cycle, particularly in the G1/S transition, where it ensures the accurate unwinding of DNA and the assembly of the replication machinery. **Clinical Significance:** Dysregulation of CDC45 has been implicated in various diseases, including: 1. **Cancer**: Mutations in CDC45 have been associated with various cancers, including breast, lung, and colon cancer, suggesting its role in maintaining genomic stability. 2. **Genomic instability**: CDC45 deficiency has been linked to genomic instability, a hallmark of many cancers. 3. **Immunodeficiency**: CDC45 is highly expressed in immune cells, and its dysregulation may contribute to immunodeficiency disorders. 4. **Reproductive disorders**: CDC45 is essential for meiosis and DNA replication in germ cells, and its dysregulation may contribute to reproductive disorders, such as infertility. In conclusion, CDC45 is a critical gene that plays a central role in DNA replication, cell cycle regulation, and genomic stability. Its dysregulation has been implicated in various diseases, highlighting the importance of CDC45 in maintaining tissue homeostasis and immune function. Further research is needed to fully elucidate the mechanisms by which CDC45 regulates DNA replication and its role in human disease.

Genular Protein ID: 770444977

Symbol: CDC45_HUMAN

Name: Cell division control protein 45 homolog

UniProtKB Accession Codes:

O75419 B4DDB4 B4DDU3 E9PDH7 O60856 Q20WK8 Q6UW54 Q9UP68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 16 EMDB 4 Ensembl 3 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9755170

Title: Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk.

PubMed ID: 9755170

DOI: 10.1093/emboj/17.19.5699

PubMed ID: 9660782

Title: The human homolog of Saccharomyces cerevisiae CDC45.

PubMed ID: 9660782

DOI: 10.1074/jbc.273.29.18205

PubMed ID: 9724329

Title: Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene.

PubMed ID: 9724329

DOI: 10.1101/gr.8.8.834

PubMed ID: 10051334

Title: Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development.

PubMed ID: 10051334

DOI: 10.1007/s003359900996

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25933514

Title: Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.

PubMed ID: 25933514

DOI: 10.1016/j.yexcr.2015.04.014

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 32453425

Title: CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.

PubMed ID: 32453425

DOI: 10.1093/nar/gkaa429

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 27374770

Title: Mutations in CDC45, encoding an essential component of the pre-initiation complex, cause Meier-Gorlin syndrome and craniosynostosis.

PubMed ID: 27374770

DOI: 10.1016/j.ajhg.2016.05.019

Sequence Information:

  • Length: 566
  • Mass: 65569
  • Checksum: AE1BE2C8C8E5F867
  • Sequence:
    • MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET 
AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT HRPVNVVNVY NDTQIKLLIK 
QDDDLEVPAY EDIFRDEEED EEHSGNDSDG SEPSEKRTRL EEEIVEQTMR RRQRREWEAR 
RRDILFDYEQ YEYHGTSSAM VMFELAWMLS KDLNDMLWWA IVGLTDQWVQ DKITQMKYVT 
DVGVLQRHVS RHNHRNEDEE NTLSVDCTRI SFEYDLRLVL YQHWSLHDSL CNTSYTAARF 
KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ AMDISLKENL REMIEESANK FGMKDMRVQT 
FSIHFGFKHK FLASDVVFAT MSLMESPEKD GSGTDHFIQA LDSLSRSNLD KLYHGLELAK 
KQLRATQQTI ASCLCTNLVI SQGPFLYCSL MEGTPDVMLF SRPASLSLLS KHLLKSFVCS 
TKNRRCKLLP LVMAAPLSME HGTVTVVGIP PETDSSDRKN FFGRAFEKAA ESTSSRMLHN 
HFDLSVIELK AEDRSKFLDA LISLLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.