H2BC17 | ENSG00000274641 | NCBI 8348

Details for: H2BC17

Gene ID: 8348

Symbol: H2BC17

Ensembl ID: ENSG00000274641

Description: H2B clustered histone 17

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: proerythroblast (CL0000547)
Fold Change: 1.4494
Cell Significance Index: 20.7700
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.1334
Cell Significance Index: 16.4600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4567
Cell Significance Index: 6.5400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4491
Cell Significance Index: 12.9400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4037
Cell Significance Index: 18.3000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3241
Cell Significance Index: 10.3800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2803
Cell Significance Index: 53.3500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2638
Cell Significance Index: 26.1000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2319
Cell Significance Index: 4.8100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2312
Cell Significance Index: 14.9200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2236
Cell Significance Index: 24.3200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2084
Cell Significance Index: 5.5800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1876
Cell Significance Index: 30.5100
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.1780
Cell Significance Index: 2.2100
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1522
Cell Significance Index: 1.6500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1414
Cell Significance Index: 8.4900
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1377
Cell Significance Index: 1.9100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1311
Cell Significance Index: 118.3400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1159
Cell Significance Index: 2.5100
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.0961
Cell Significance Index: 0.8400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0928
Cell Significance Index: 1.3900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0908
Cell Significance Index: 3.1900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0884
Cell Significance Index: 6.1200
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.0704
Cell Significance Index: 0.4000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0685
Cell Significance Index: 3.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0376
Cell Significance Index: 4.4300
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.0172
Cell Significance Index: 0.1700
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0153
Cell Significance Index: 0.2200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0141
Cell Significance Index: 0.3000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0133
Cell Significance Index: 0.2000
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.0041
Cell Significance Index: 0.0300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0040
Cell Significance Index: 0.1000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0024
Cell Significance Index: 0.4800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0007
Cell Significance Index: 0.3300
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0011
Cell Significance Index: -0.1900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0011
Cell Significance Index: -0.7900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0012
Cell Significance Index: -0.0300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0013
Cell Significance Index: -0.7200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0014
Cell Significance Index: -0.2500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0026
Cell Significance Index: -0.1600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0028
Cell Significance Index: -2.1200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0029
Cell Significance Index: -0.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0037
Cell Significance Index: -2.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0060
Cell Significance Index: -0.6900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0067
Cell Significance Index: -0.1700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0097
Cell Significance Index: -1.9400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0115
Cell Significance Index: -1.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0122
Cell Significance Index: -1.5000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0152
Cell Significance Index: -0.7100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0186
Cell Significance Index: -1.9000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0195
Cell Significance Index: -0.5300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0222
Cell Significance Index: -0.4700
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0238
Cell Significance Index: -0.4100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0245
Cell Significance Index: -0.6800
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.0301
Cell Significance Index: -0.3200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0332
Cell Significance Index: -1.7500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0333
Cell Significance Index: -0.8900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0340
Cell Significance Index: -0.3700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0410
Cell Significance Index: -1.9300
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0412
Cell Significance Index: -0.3500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0443
Cell Significance Index: -1.4500
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0468
Cell Significance Index: -0.5300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0479
Cell Significance Index: -1.2600
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.0495
Cell Significance Index: -0.5500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0504
Cell Significance Index: -1.7500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0506
Cell Significance Index: -1.6100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0532
Cell Significance Index: -1.3600
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0535
Cell Significance Index: -0.7600
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0536
Cell Significance Index: -0.6800
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0545
Cell Significance Index: -0.6900
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0558
Cell Significance Index: -0.6100
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0566
Cell Significance Index: -0.7700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0573
Cell Significance Index: -1.1200
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0581
Cell Significance Index: -0.7500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0588
Cell Significance Index: -2.0600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0628
Cell Significance Index: -2.3100
Cell Name: paneth cell (CL0000510)
Fold Change: -0.0648
Cell Significance Index: -0.6700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0651
Cell Significance Index: -1.0900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0676
Cell Significance Index: -1.9900
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0682
Cell Significance Index: -1.3600
Cell Name: decidual cell (CL2000002)
Fold Change: -0.0707
Cell Significance Index: -1.1400
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0711
Cell Significance Index: -0.9200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0711
Cell Significance Index: -0.9700
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0733
Cell Significance Index: -1.8300
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: -0.0733
Cell Significance Index: -0.5700
Cell Name: myoblast (CL0000056)
Fold Change: -0.0738
Cell Significance Index: -0.7300
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.0768
Cell Significance Index: -0.7700
Cell Name: muscle cell (CL0000187)
Fold Change: -0.0805
Cell Significance Index: -0.7700
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0808
Cell Significance Index: -0.8800
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0808
Cell Significance Index: -1.7500
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0822
Cell Significance Index: -1.1700
Cell Name: thymocyte (CL0000893)
Fold Change: -0.0823
Cell Significance Index: -1.0400
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0823
Cell Significance Index: -1.1100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0824
Cell Significance Index: -1.6300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0826
Cell Significance Index: -2.0600
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.0830
Cell Significance Index: -1.1400
Cell Name: peg cell (CL4033014)
Fold Change: -0.0835
Cell Significance Index: -1.9300
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0854
Cell Significance Index: -1.2500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0869
Cell Significance Index: -2.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Clustered Histone**: H2BC17 is a member of the histone 2B family, characterized by its ability to form dimers and trimers with other histone proteins, such as H2A and H3. 2. **DNA Binding**: H2BC17 exhibits a high degree of affinity for DNA, allowing it to interact with specific DNA sequences and regulate gene expression. 3. **Histone Modification**: H2BC17 is a target for various histone modifications, including acetylation, methylation, and ubiquitination, which modulate its chromatin interactions and gene expression. 4. **DNA Repair**: H2BC17 is involved in the assembly of the pre-replicative complex and the repair of DNA double-strand breaks through homologous recombination and non-homologous end-joining. 5. **Cell Cycle Regulation**: H2BC17 plays a role in regulating the cell cycle, particularly during the G2/M phase, where it interacts with cyclin-dependent kinases and other regulatory proteins. **Pathways and Functions:** 1. **DNA Replication**: H2BC17 is essential for the assembly of the pre-replicative complex, which is necessary for DNA replication and the maintenance of genome stability. 2. **Apoptosis**: H2BC17 is involved in the regulation of apoptosis, particularly during the early stages of cell death, where it interacts with pro-apoptotic proteins and inhibits their activity. 3. **DNA Damage Response**: H2BC17 plays a role in the assembly of the pre-replicative complex and the repair of DNA double-strand breaks through homologous recombination and non-homologous end-joining. 4. **Gene Expression**: H2BC17 regulates gene expression by interacting with specific DNA sequences and modifying histone marks, which modulate chromatin accessibility and transcriptional activity. 5. **Cell Cycle Checkpoints**: H2BC17 is involved in regulating cell cycle checkpoints, particularly during the G2/M phase, where it interacts with cyclin-dependent kinases and other regulatory proteins. **Clinical Significance:** 1. **Cancer**: Aberrant expression of H2BC17 has been observed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 2. **Neurological Disorders**: H2BC17 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neurodegeneration and cognitive decline. 3. **Autoimmune Diseases**: H2BC17 has been involved in the regulation of immune responses, particularly in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to disease pathogenesis. 4. **Infectious Diseases**: H2BC17 has been implicated in the regulation of viral infections, particularly in HIV and influenza, where it may contribute to viral replication and disease progression. In conclusion, H2BC17 is a crucial protein involved in various cellular processes, including DNA replication, apoptosis, and gene expression. Its aberrant expression has been implicated in various diseases, including cancer, neurological disorders, autoimmune diseases, and infectious diseases. Further research is necessary to fully understand the role of H2BC17 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2B type 1-O

Genular Protein ID: 4128747431

Symbol: H2B1O_HUMAN

Name: Histone H2B type 1-O

UniProtKB Accession Codes:

P23527 Q3KPI7 Q8TCV6

Database IDs:

Citations:

PubMed ID: 1768865

Title: A novel divergently transcribed human histone H2A/H2B gene pair.

PubMed ID: 1768865

DOI: 10.3109/10425179109020799

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

Sequence Information:

Length: 126
Mass: 13906
Checksum: 041118811BBF6647
Sequence:

MPDPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document:

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Details for: H2BC17

Associated with

Cells (max top 100)

Other Information

A novel divergently transcribed human histone H2A/H2B gene pair. PubMed ID: 1768865

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Quantitative proteomic analysis of post-translational modifications of human histones. PubMed ID: 16627869

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. PubMed ID: 12757711

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. PubMed ID: 16307923

Inhibition of core histones acetylation by carcinogenic nickel(II). PubMed ID: 16283522

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. PubMed ID: 16713563

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. PubMed ID: 21726816

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. PubMed ID: 23824326

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. PubMed ID: 27105113

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. PubMed ID: 34874266