Details for: CASP2

Gene ID: 835

Symbol: CASP2

Ensembl ID: ENSG00000106144

Description: caspase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71723
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47948
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.91
    Marker Score: 619
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.9
    Marker Score: 911
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.89
    Marker Score: 564
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13503
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4891
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.84
    Marker Score: 3456
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.83
    Marker Score: 2250.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.78
    Marker Score: 532
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.74
    Marker Score: 497
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.74
    Marker Score: 7494
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1133
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.73
    Marker Score: 6920
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.72
    Marker Score: 1575.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.71
    Marker Score: 246
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7
    Marker Score: 43203
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.68
    Marker Score: 7021
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1598
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2813
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 211
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.65
    Marker Score: 171
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.64
    Marker Score: 310
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.63
    Marker Score: 457
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.62
    Marker Score: 665.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.62
    Marker Score: 1834
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.62
    Marker Score: 745
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.61
    Marker Score: 525
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.6
    Marker Score: 569
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.6
    Marker Score: 210
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.59
    Marker Score: 369
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.59
    Marker Score: 556
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 355
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 377
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 388
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.58
    Marker Score: 2285
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.58
    Marker Score: 986
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.58
    Marker Score: 203
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.58
    Marker Score: 285
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.57
    Marker Score: 1197.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.57
    Marker Score: 5356
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.57
    Marker Score: 732
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.57
    Marker Score: 814
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.57
    Marker Score: 519
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1136
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.56
    Marker Score: 273
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.56
    Marker Score: 592
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.56
    Marker Score: 293
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.56
    Marker Score: 2260
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.55
    Marker Score: 4685
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.54
    Marker Score: 136
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 222
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.53
    Marker Score: 560
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.53
    Marker Score: 153
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.53
    Marker Score: 815
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.53
    Marker Score: 374
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.52
    Marker Score: 384
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.52
    Marker Score: 560
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.51
    Marker Score: 1904
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.51
    Marker Score: 18817
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 487
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.5
    Marker Score: 543
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 3026
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5
    Marker Score: 534
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.49
    Marker Score: 358
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.49
    Marker Score: 158
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.49
    Marker Score: 509
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.49
    Marker Score: 491
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.49
    Marker Score: 199
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.49
    Marker Score: 223
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.48
    Marker Score: 182
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.48
    Marker Score: 9614
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.48
    Marker Score: 3088
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.48
    Marker Score: 311
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.48
    Marker Score: 16697
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.48
    Marker Score: 166
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.48
    Marker Score: 119
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.48
    Marker Score: 4191
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.48
    Marker Score: 214
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.48
    Marker Score: 358
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.48
    Marker Score: 503
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.47
    Marker Score: 537
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.47
    Marker Score: 119
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.47
    Marker Score: 451

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Other Information

**Key characteristics:** - CASP2 is a serine protease that is expressed in a variety of cell types, including immune cells, cancer cells, and neurons. - It is a key regulator of inflammation and cell death. - It is involved in the regulation of apoptosis, a form of programmed cell death. - It is also involved in the regulation of cell migration, proliferation, and differentiation. **Pathways and functions:** - CASP2 is involved in the regulation of inflammation through the activation of the innate immune system. - It is a key regulator of cell death signalling through the activation of the caspase cascade. - It is also involved in the regulation of cell migration, proliferation, and differentiation. **Clinical significance:** - Mutations in CASP2 have been linked to a number of human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - Caspase-2 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - CASP2 is a highly conserved protein that is found in all vertebrates. - It is a member of the caspase family of enzymes, which are a large family of proteases that are involved in a variety of cellular processes. - CASP2 is a relatively new protein, with the first sequence being identified in 1992.

Genular Protein ID: 2246371579

Symbol: CASP2_HUMAN

Name: Caspase-2

UniProtKB Accession Codes:

P42575 A8K5F9 D3DXD6 E9PDN0 P42576 Q59F21 Q7KZL6 Q86UJ3 Q9BUP7 Q9BZK9 Q9BZL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 17 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 15 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8087842

Title: Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.

PubMed ID: 8087842

DOI: 10.1016/s0092-8674(94)90422-7

PubMed ID: 11156409

Title: Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.

PubMed ID: 11156409

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8654923

Title: The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

PubMed ID: 8654923

DOI: 10.1101/gad.10.9.1073

PubMed ID: 9044836

Title: CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

PubMed ID: 9044836

PubMed ID: 8985253

Title: RAIDD is a new 'death' adaptor molecule.

PubMed ID: 8985253

DOI: 10.1038/385086a0

PubMed ID: 9560245

Title: ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.

PubMed ID: 9560245

DOI: 10.1073/pnas.95.9.5156

PubMed ID: 15073321

Title: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.

PubMed ID: 15073321

DOI: 10.1126/science.1095432

PubMed ID: 16652156

Title: Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.

PubMed ID: 16652156

DOI: 10.1038/sj.onc.1209569

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12920126

Title: Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.

PubMed ID: 12920126

DOI: 10.1074/jbc.m304895200

Sequence Information:

  • Length: 452
  • Mass: 50685
  • Checksum: 6EF0ED05EF808385
  • Sequence:
    • MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 
LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 
TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT 
PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV 
HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT 
RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY 
APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT

Genular Protein ID: 4011469976

Symbol: A0A087WYM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYM1

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 1 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 108
  • Mass: 12139
  • Checksum: 6D5CA26BAE8ED787
  • Sequence:
    • MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 
LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.