Details for: CASP2

Gene ID: 835

Symbol: CASP2

Ensembl ID: ENSG00000106144

Description: caspase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.3771
    Cell Significance Index: -13.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.2855
    Cell Significance Index: -11.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.4486
    Cell Significance Index: -15.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.5699
    Cell Significance Index: -15.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.0662
    Cell Significance Index: -16.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3534
    Cell Significance Index: -17.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2219
    Cell Significance Index: -16.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9753
    Cell Significance Index: -12.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0431
    Cell Significance Index: -6.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.5174
    Cell Significance Index: 40.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0637
    Cell Significance Index: 63.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0046
    Cell Significance Index: 109.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9565
    Cell Significance Index: 13.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8755
    Cell Significance Index: 142.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6301
    Cell Significance Index: 35.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5599
    Cell Significance Index: 36.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5592
    Cell Significance Index: 504.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5052
    Cell Significance Index: 14.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4762
    Cell Significance Index: 32.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4526
    Cell Significance Index: 90.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4344
    Cell Significance Index: 86.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3352
    Cell Significance Index: 41.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3285
    Cell Significance Index: 38.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3010
    Cell Significance Index: 15.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2978
    Cell Significance Index: 8.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2584
    Cell Significance Index: 114.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2576
    Cell Significance Index: 140.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2551
    Cell Significance Index: 18.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2510
    Cell Significance Index: 45.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2298
    Cell Significance Index: 31.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2257
    Cell Significance Index: 22.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1946
    Cell Significance Index: 8.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1669
    Cell Significance Index: 5.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1550
    Cell Significance Index: 9.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1171
    Cell Significance Index: 42.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1171
    Cell Significance Index: 3.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1159
    Cell Significance Index: 2.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1136
    Cell Significance Index: 5.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1096
    Cell Significance Index: 5.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0926
    Cell Significance Index: 2.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0666
    Cell Significance Index: 2.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0600
    Cell Significance Index: 4.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0523
    Cell Significance Index: 3.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0516
    Cell Significance Index: 35.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0304
    Cell Significance Index: 0.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0269
    Cell Significance Index: 3.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0263
    Cell Significance Index: 0.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0237
    Cell Significance Index: 0.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0229
    Cell Significance Index: 10.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0179
    Cell Significance Index: 0.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0057
    Cell Significance Index: 8.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0042
    Cell Significance Index: 7.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0124
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0146
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -10.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0159
    Cell Significance Index: -12.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0167
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0188
    Cell Significance Index: -13.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0229
    Cell Significance Index: -0.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0276
    Cell Significance Index: -15.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0399
    Cell Significance Index: -7.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0413
    Cell Significance Index: -11.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0456
    Cell Significance Index: -6.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0478
    Cell Significance Index: -3.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0540
    Cell Significance Index: -6.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0540
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0651
    Cell Significance Index: -11.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0795
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0857
    Cell Significance Index: -9.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0901
    Cell Significance Index: -18.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0922
    Cell Significance Index: -10.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1174
    Cell Significance Index: -1.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1175
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1263
    Cell Significance Index: -8.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1379
    Cell Significance Index: -14.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1664
    Cell Significance Index: -5.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1744
    Cell Significance Index: -1.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1845
    Cell Significance Index: -11.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1920
    Cell Significance Index: -4.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1956
    Cell Significance Index: -15.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1969
    Cell Significance Index: -10.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2308
    Cell Significance Index: -5.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2334
    Cell Significance Index: -5.1100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2945
    Cell Significance Index: -1.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3107
    Cell Significance Index: -9.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3129
    Cell Significance Index: -7.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3140
    Cell Significance Index: -9.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3306
    Cell Significance Index: -10.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3514
    Cell Significance Index: -3.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3555
    Cell Significance Index: -11.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3674
    Cell Significance Index: -6.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3713
    Cell Significance Index: -6.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3715
    Cell Significance Index: -7.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Caspase 2 is a caspase enzyme that belongs to the initiator caspase family, which includes caspases-1, -2, -8, and -9. These enzymes are characterized by their ability to activate downstream caspases, leading to the execution phase of apoptosis. Caspase 2 is distinct from other caspases in its substrate specificity and regulatory mechanisms. Unlike other initiator caspases, caspase 2 is not cleaved by the apoptotic protease activating factor-1 (APAF-1), but rather by the initiator caspase-8. This unique regulatory mechanism allows caspase 2 to be activated in response to different stimuli, including DNA damage, endoplasmic reticulum stress, and death receptor signaling. **Pathways and Functions:** Caspase 2 is involved in various cellular processes, including apoptosis, cell death signaling, and immune responses. Its pathways and functions can be broadly categorized into the following: 1. **Apoptotic signaling pathway:** Caspase 2 is activated in response to DNA damage, leading to the activation of downstream caspases, which ultimately result in cell death. 2. **Death receptor signaling:** Caspase 2 is also activated by death receptor signaling, which involves the interaction of death receptors with their ligands, leading to the activation of caspase-8 and subsequent caspase 2 activation. 3. **Immune responses:** Caspase 2 plays a crucial role in the regulation of immune responses, particularly in the context of innate immunity. It is involved in the signaling pathways of NLRP3, NLRP4, and NLRC4, which are responsible for the detection of microbial pathogens and the activation of immune cells. 4. **Neuronal apoptosis:** Caspase 2 is also implicated in the regulation of neuronal apoptosis, particularly in the context of neurodegenerative diseases such as Alzheimer's and Parkinson's. **Clinical Significance:** Caspase 2 plays a critical role in maintaining tissue homeostasis and responding to cellular stress. Its dysregulation has been implicated in various diseases, including: 1. **Cancer:** Caspase 2 is involved in the regulation of apoptosis in cancer cells, and its dysregulation has been linked to cancer development and progression. 2. **Neurodegenerative diseases:** Caspase 2 is involved in the regulation of neuronal apoptosis in neurodegenerative diseases, and its dysregulation has been linked to disease progression. 3. **Inflammatory disorders:** Caspase 2 is involved in the regulation of immune responses, particularly in the context of innate immunity, and its dysregulation has been linked to inflammatory disorders such as atherosclerosis and rheumatoid arthritis. In conclusion, caspase 2 is a complex enzyme that plays a critical role in regulating apoptosis, immune responses, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research is needed to fully elucidate the complexities of caspase 2 and its role in maintaining tissue health and responding to cellular stress.

Genular Protein ID: 2246371579

Symbol: CASP2_HUMAN

Name: Caspase-2

UniProtKB Accession Codes:

P42575 A8K5F9 D3DXD6 E9PDN0 P42576 Q59F21 Q7KZL6 Q86UJ3 Q9BUP7 Q9BZK9 Q9BZL0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 17 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8087842

Title: Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.

PubMed ID: 8087842

DOI: 10.1016/s0092-8674(94)90422-7

PubMed ID: 11156409

Title: Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.

PubMed ID: 11156409

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8654923

Title: The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

PubMed ID: 8654923

DOI: 10.1101/gad.10.9.1073

PubMed ID: 9044836

Title: CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

PubMed ID: 9044836

PubMed ID: 8985253

Title: RAIDD is a new 'death' adaptor molecule.

PubMed ID: 8985253

DOI: 10.1038/385086a0

PubMed ID: 9560245

Title: ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.

PubMed ID: 9560245

DOI: 10.1073/pnas.95.9.5156

PubMed ID: 15073321

Title: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.

PubMed ID: 15073321

DOI: 10.1126/science.1095432

PubMed ID: 16652156

Title: Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.

PubMed ID: 16652156

DOI: 10.1038/sj.onc.1209569

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12920126

Title: Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.

PubMed ID: 12920126

DOI: 10.1074/jbc.m304895200

PubMed ID: 37880421

Title: Bi-allelic truncating variants in CASP2 underlie a neurodevelopmental disorder with lissencephaly.

PubMed ID: 37880421

DOI: 10.1038/s41431-023-01461-2

Sequence Information:

  • Length: 452
  • Mass: 50685
  • Checksum: 6EF0ED05EF808385
  • Sequence:
    • MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 
LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 
TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT 
PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV 
HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT 
RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY 
APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT

Genular Protein ID: 4011469976

Symbol: A0A087WYM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYM1

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 108
  • Mass: 12139
  • Checksum: 6D5CA26BAE8ED787
  • Sequence:
    • MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 
LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.