H4C1 | ENSG00000278637 | NCBI 8359

Details for: H4C1

Gene ID: 8359

Symbol: H4C1

Ensembl ID: ENSG00000278637

Description: H4 clustered histone 1

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.5926
Cell Significance Index: 8.8800
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.5846
Cell Significance Index: 4.2500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5696
Cell Significance Index: 16.4100
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.5375
Cell Significance Index: 1.4400
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.4009
Cell Significance Index: 4.0200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3735
Cell Significance Index: 9.9900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3552
Cell Significance Index: 7.5700
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.3065
Cell Significance Index: 2.6800
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.3045
Cell Significance Index: 3.3000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2895
Cell Significance Index: 18.6800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2573
Cell Significance Index: 48.9700
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.2502
Cell Significance Index: 2.5900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2409
Cell Significance Index: 23.8300
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.2064
Cell Significance Index: 2.1400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2063
Cell Significance Index: 4.4700
Cell Name: thymocyte (CL0000893)
Fold Change: 0.1994
Cell Significance Index: 2.5200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1986
Cell Significance Index: 4.1200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1873
Cell Significance Index: 6.5800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1693
Cell Significance Index: 27.5300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1659
Cell Significance Index: 18.0400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1491
Cell Significance Index: 3.9200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1394
Cell Significance Index: 7.2400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.1326
Cell Significance Index: 1.6800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1286
Cell Significance Index: 4.1200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1187
Cell Significance Index: 107.2000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1163
Cell Significance Index: 6.9900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1039
Cell Significance Index: 2.5900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0771
Cell Significance Index: 3.5000
Cell Name: myometrial cell (CL0002366)
Fold Change: 0.0521
Cell Significance Index: 0.6000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0513
Cell Significance Index: 0.7200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0438
Cell Significance Index: 2.7600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0320
Cell Significance Index: 5.7600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0310
Cell Significance Index: 3.6600
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0243
Cell Significance Index: 0.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0240
Cell Significance Index: 0.6000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0209
Cell Significance Index: 0.3200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0191
Cell Significance Index: 1.3200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0063
Cell Significance Index: 0.0900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0043
Cell Significance Index: 0.5900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0041
Cell Significance Index: 1.8200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0033
Cell Significance Index: 0.4200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0003
Cell Significance Index: -0.1500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0015
Cell Significance Index: -0.8600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0016
Cell Significance Index: -3.0000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0016
Cell Significance Index: -1.2100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0017
Cell Significance Index: -1.0500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0039
Cell Significance Index: -2.9700
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0039
Cell Significance Index: -0.0300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0045
Cell Significance Index: -3.2800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0045
Cell Significance Index: -0.5200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0046
Cell Significance Index: -2.9500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0068
Cell Significance Index: -1.4400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0069
Cell Significance Index: -3.1200
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0076
Cell Significance Index: -1.5100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0081
Cell Significance Index: -2.9000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0099
Cell Significance Index: -0.2800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0101
Cell Significance Index: -1.7300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0102
Cell Significance Index: -2.0400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0115
Cell Significance Index: -0.5000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0121
Cell Significance Index: -0.3100
Cell Name: surface ectodermal cell (CL0000114)
Fold Change: -0.0139
Cell Significance Index: -0.1100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0151
Cell Significance Index: -1.8600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0157
Cell Significance Index: -0.9600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0173
Cell Significance Index: -1.2200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0196
Cell Significance Index: -0.9200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0201
Cell Significance Index: -2.9200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0243
Cell Significance Index: -2.4800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0286
Cell Significance Index: -0.3200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0306
Cell Significance Index: -3.9500
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0307
Cell Significance Index: -0.4300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0316
Cell Significance Index: -0.8600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0375
Cell Significance Index: -1.7500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0409
Cell Significance Index: -2.1500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0418
Cell Significance Index: -3.3100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0435
Cell Significance Index: -3.3400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0473
Cell Significance Index: -0.9900
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0483
Cell Significance Index: -0.3300
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0486
Cell Significance Index: -0.5300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0505
Cell Significance Index: -2.8400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0538
Cell Significance Index: -4.0100
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0552
Cell Significance Index: -0.3600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0585
Cell Significance Index: -2.0500
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.0625
Cell Significance Index: -0.6900
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.0631
Cell Significance Index: -0.7300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0640
Cell Significance Index: -0.8200
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.0682
Cell Significance Index: -0.4900
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.0773
Cell Significance Index: -0.7300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0788
Cell Significance Index: -2.7400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0810
Cell Significance Index: -1.1100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0835
Cell Significance Index: -2.4000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0840
Cell Significance Index: -3.1800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0855
Cell Significance Index: -2.8000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0863
Cell Significance Index: -2.0900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0863
Cell Significance Index: -2.7500
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0865
Cell Significance Index: -1.2400
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0868
Cell Significance Index: -1.2600
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0875
Cell Significance Index: -0.9900
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0880
Cell Significance Index: -1.2500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0890
Cell Significance Index: -1.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H4C1 is a type I histone gene that encodes a protein with a high degree of sequence similarity to other histone 4 genes. The protein is composed of 114 amino acids, with a histone fold domain and a C-terminal tail. H4C1 is highly methylated and acetylated, which regulates its interaction with chromatin-modifying enzymes. The gene is expressed in a tissue-specific manner, with high expression levels in kidney proximal convoluted tubule epithelial cells, colon goblet cells, and intestinal epithelial cells. **Pathways and Functions** H4C1 is involved in several cellular pathways, including: 1. **DNA Damage Response**: H4C1 is involved in the response to DNA damage, including double-strand breaks and single-strand breaks. It interacts with DNA damage response proteins, such as ATM and ATR, to regulate DNA repair. 2. **Apoptosis**: H4C1 is involved in the regulation of apoptosis, including the activation of pro-apoptotic genes and the repression of anti-apoptotic genes. 3. **Cellular Senescence**: H4C1 is involved in the regulation of cellular senescence, including the activation of senescence-associated secretory phenotype (SASP) genes. 4. **Chromatin Structure**: H4C1 is involved in the assembly of nucleosomes, which regulates chromatin structure and gene expression. 5. **Transcriptional Regulation**: H4C1 regulates transcriptional activity by interacting with transcription factors and chromatin-modifying enzymes. **Clinical Significance** Dysregulation of H4C1 has been implicated in various diseases, including: 1. **Cancer**: H4C1 is involved in the regulation of cancer cell proliferation and survival. Abnormal expression of H4C1 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: H4C1 is involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Autoimmune Diseases**: H4C1 is involved in the regulation of autoimmune diseases, including rheumatoid arthritis and lupus. 4. **Aging and Senescence**: H4C1 is involved in the regulation of aging and senescence, including the activation of SASP genes. In conclusion, H4C1 is a critical gene involved in various cellular processes, including DNA damage response, apoptosis, cellular senescence, chromatin structure, and transcriptional regulation. Dysregulation of H4C1 has been implicated in various diseases, including cancer, neurodegenerative diseases, autoimmune diseases, and aging and senescence. Further research is needed to fully understand the role of H4C1 in human disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.