Gene CASP3 - ENSG00000164305 | NCBI Gene ID: 836

Details for: CASP3

Gene ID: 836

Symbol: CASP3

Ensembl ID: ENSG00000164305

Description: caspase 3

Associated with

Activation of caspases through apoptosome-mediated cleavage
(R-HSA-111459)
Apoptosis
(R-HSA-109581)
Apoptosis induced dna fragmentation
(R-HSA-140342)
Apoptotic cleavage of cell adhesion proteins
(R-HSA-351906)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Apoptotic factor-mediated response
(R-HSA-111471)
Caspase-mediated cleavage of cytoskeletal proteins
(R-HSA-264870)
Caspase activation via dependence receptors in the absence of ligand
(R-HSA-418889)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Cytochrome c-mediated apoptotic response
(R-HSA-111461)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Degradation of the extracellular matrix
(R-HSA-1474228)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Nade modulates death signalling
(R-HSA-205025)
Other interleukin signaling
(R-HSA-449836)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Programmed cell death
(R-HSA-5357801)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Signaling by hippo
(R-HSA-2028269)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Smac(diablo)-mediated dissociation of iap:caspase complexes
(R-HSA-111464)
Smac (diablo) binds to iaps
(R-HSA-111463)
Smac, xiap-regulated apoptotic response
(R-HSA-111469)
Stimulation of the cell death response by pak-2p34
(R-HSA-211736)
Apoptotic process
(GO:0006915)
Aspartic-type endopeptidase activity
(GO:0004190)
Axonal fasciculation
(GO:0007413)
B cell homeostasis
(GO:0001782)
Cell fate commitment
(GO:0045165)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:0097199)
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
(GO:0097200)
Death receptor binding
(GO:0005123)
Dna damage response
(GO:0006974)
Enzyme activator activity
(GO:0008047)
Erythrocyte differentiation
(GO:0030218)
Fibroblast apoptotic process
(GO:0044346)
Glial cell apoptotic process
(GO:0034349)
Heart development
(GO:0007507)
Hippocampus development
(GO:0021766)
Intrinsic apoptotic signaling pathway in response to osmotic stress
(GO:0008627)
Keratinocyte differentiation
(GO:0030216)
Learning or memory
(GO:0007611)
Luteolysis
(GO:0001554)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of b cell proliferation
(GO:0030889)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cytokine production
(GO:0001818)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Peptidase activity
(GO:0008233)
Phospholipase a2 activator activity
(GO:0016005)
Platelet formation
(GO:0030220)
Positive regulation of neuron apoptotic process
(GO:0043525)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein maturation
(GO:0051604)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of macroautophagy
(GO:0016241)
Regulation of protein stability
(GO:0031647)
Response to amino acid
(GO:0043200)
Response to cobalt ion
(GO:0032025)
Response to estradiol
(GO:0032355)
Response to glucocorticoid
(GO:0051384)
Response to glucose
(GO:0009749)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to nicotine
(GO:0035094)
Response to tumor necrosis factor
(GO:0034612)
Response to uv
(GO:0009411)
Response to wounding
(GO:0009611)
Response to x-ray
(GO:0010165)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of sound
(GO:0007605)
Striated muscle cell differentiation
(GO:0051146)
T cell homeostasis
(GO:0043029)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.4
Marker Score: 1924
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.52
Marker Score: 1596
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.48
Marker Score: 1006
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167854
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.39
Marker Score: 5678
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.36
Marker Score: 342
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.35
Marker Score: 5228
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.27
Marker Score: 408
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.25
Marker Score: 3462.5
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.2
Marker Score: 1692.5
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1
Marker Score: 4317
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.09
Marker Score: 1001
Cell Name: plasmablast (CL0000980)
Fold Change: 1.08
Marker Score: 1437
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.07
Marker Score: 728
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.06
Marker Score: 710
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.06
Marker Score: 240
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.05
Marker Score: 6728
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.04
Marker Score: 288
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 1.01
Marker Score: 281
Cell Name: enterocyte (CL0000584)
Fold Change: 1
Marker Score: 4793
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71668.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47893
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30385
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.96
Marker Score: 1060
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.95
Marker Score: 2012.5
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.94
Marker Score: 936
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.94
Marker Score: 2557
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2389
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.94
Marker Score: 1383
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.93
Marker Score: 5947
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.93
Marker Score: 14570
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.92
Marker Score: 1421
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.92
Marker Score: 924
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.91
Marker Score: 7879
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.91
Marker Score: 468
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.9
Marker Score: 426
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5141
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2687
Cell Name: basal cell (CL0000646)
Fold Change: 0.89
Marker Score: 1151
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.87
Marker Score: 229
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 305
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.84
Marker Score: 294
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.84
Marker Score: 2061
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.83
Marker Score: 479
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.83
Marker Score: 249
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.79
Marker Score: 276
Cell Name: mature T cell (CL0002419)
Fold Change: 0.78
Marker Score: 7767
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.78
Marker Score: 2311.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 312
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.78
Marker Score: 822
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.78
Marker Score: 1116
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1260
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.77
Marker Score: 188
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.77
Marker Score: 223
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.77
Marker Score: 319
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 0.77
Marker Score: 246
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.77
Marker Score: 313
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 586.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.77
Marker Score: 28321
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.76
Marker Score: 952
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.75
Marker Score: 200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.75
Marker Score: 6479.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.75
Marker Score: 513
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.74
Marker Score: 1048
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.74
Marker Score: 238
Cell Name: Unknown (CL0000548)
Fold Change: 0.74
Marker Score: 536
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.72
Marker Score: 5380
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.72
Marker Score: 301
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.72
Marker Score: 225
Cell Name: male germ cell (CL0000015)
Fold Change: 0.72
Marker Score: 206.5
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.72
Marker Score: 24805
Cell Name: mature B cell (CL0000785)
Fold Change: 0.72
Marker Score: 525
Cell Name: neuron (CL0000540)
Fold Change: 0.72
Marker Score: 2915
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 458
Cell Name: blood cell (CL0000081)
Fold Change: 0.71
Marker Score: 8290.5
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.71
Marker Score: 159
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.71
Marker Score: 351
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.71
Marker Score: 367
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.71
Marker Score: 169
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.71
Marker Score: 274
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.7
Marker Score: 369
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.7
Marker Score: 322
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.7
Marker Score: 2199
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2931
Cell Name: astrocyte (CL0000127)
Fold Change: 0.7
Marker Score: 605
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.7
Marker Score: 522
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.7
Marker Score: 1213
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.7
Marker Score: 250
Cell Name: neural cell (CL0002319)
Fold Change: 0.69
Marker Score: 335
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.69
Marker Score: 661
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.69
Marker Score: 579
Cell Name: erythroblast (CL0000765)
Fold Change: 0.69
Marker Score: 429
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.69
Marker Score: 646.5
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.68
Marker Score: 537
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.68
Marker Score: 333
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.68
Marker Score: 603
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.67
Marker Score: 676.5
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.67
Marker Score: 167

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**Key characteristics:** - CASP3 is a large protein with a molecular weight of approximately 120 kDa. - It is produced by multiple mRNA transcripts, each encoding a different isoform of the protein. - CASP3 is found in various cell types, including immune cells, cancer cells, and neurons. **Pathways and functions:** - CASP3 is involved in both the intrinsic and extrinsic apoptotic pathways. - In the intrinsic pathway, CASP3 is activated by the binding of cytochrome c to its death domain. - In the extrinsic pathway, CASP3 is activated by a variety of stimuli, including death receptors, cytokines, and reactive oxygen species. - Once activated, CASP3 proteolytically cleaves various cellular proteins, leading to cell death. **Clinical significance:** - Dysregulation of CASP3 has been linked to various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - Targeting CASP3 with small molecule inhibitors is a promising therapeutic strategy for treating these diseases. **Additional notes:** - CASP3 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a key regulator of cell growth, differentiation, and apoptosis. - Mutations in CASP3 have been linked to the development of several human cancers.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

SREBP cleavage activity 1

Genular Protein ID: 2558045105

Symbol: CASP3_HUMAN

Name: SREBP cleavage activity 1

UniProtKB Accession Codes:

P42574 A8K5M2 D3DP53 Q96AN1 Q96KP2

Database IDs:

Citations:

PubMed ID: 7983002

Title: CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

PubMed ID: 7983002

DOI: 10.1016/s0021-9258(18)47344-9

PubMed ID: 7774019

Title: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.

PubMed ID: 7774019

DOI: 10.1016/0092-8674(95)90541-3

PubMed ID: 15003516

Title: Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit.

PubMed ID: 15003516

DOI: 10.1016/j.bbrc.2004.02.021

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7596430

Title: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.

PubMed ID: 7596430

DOI: 10.1038/376037a0

PubMed ID: 8755496

Title: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

PubMed ID: 8755496

DOI: 10.1073/pnas.93.15.7464

PubMed ID: 8696339

Title: Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

PubMed ID: 8696339

DOI: 10.1038/ng0896-442

PubMed ID: 10497198

Title: Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

PubMed ID: 10497198

DOI: 10.1074/jbc.274.40.28379

PubMed ID: 10213689

Title: Fas-induced caspase denitrosylation.

PubMed ID: 10213689

DOI: 10.1126/science.284.5414.651

PubMed ID: 15200957

Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

PubMed ID: 15200957

DOI: 10.1016/j.molcel.2004.05.018

PubMed ID: 16374543

Title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.

PubMed ID: 16374543

DOI: 10.1007/s10495-005-3276-y

PubMed ID: 18723680

Title: Executioner caspase-3 and caspase-7 are functionally distinct proteases.

PubMed ID: 18723680

DOI: 10.1073/pnas.0707715105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20566630

Title: Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.

PubMed ID: 20566630

DOI: 10.1074/jbc.m110.126573

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21357690

Title: RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons.

PubMed ID: 21357690

DOI: 10.1074/jbc.m110.195461

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23152800

Title: OGDHL is a modifier of AKT-dependent signaling and NF-kappaB function.

PubMed ID: 23152800

DOI: 10.1371/journal.pone.0048770

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23845944

Title: Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.

PubMed ID: 23845944

DOI: 10.1126/science.1236758

PubMed ID: 28459430

Title: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

PubMed ID: 28459430

DOI: 10.1038/nature22393

PubMed ID: 28045099

Title: Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.

PubMed ID: 28045099

DOI: 10.1038/ncomms14128

PubMed ID: 30878284

Title: Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3.

PubMed ID: 30878284

DOI: 10.1016/j.molcel.2019.02.013

PubMed ID: 33725486

Title: Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.

PubMed ID: 33725486

DOI: 10.1016/j.molcel.2021.02.025

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 8673606

Title: The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.

PubMed ID: 8673606

DOI: 10.1038/nsb0796-619

PubMed ID: 9045680

Title: Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.

PubMed ID: 9045680

DOI: 10.1074/jbc.272.10.6539

PubMed ID: 10821855

Title: Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

PubMed ID: 10821855

DOI: 10.1074/jbc.275.21.16007

PubMed ID: 23650375

Title: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.

PubMed ID: 23650375

DOI: 10.1073/pnas.1306759110

PubMed ID: 36423631

Title: Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin.

PubMed ID: 36423631

DOI: 10.1016/j.molcel.2022.10.032

Sequence Information:

Length: 277
Mass: 31608
Checksum: 2F35CD3BCF7FF64A
Sequence:

MENTENSVDS KSIKNLEPKI IHGSESMDSG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG 
MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS 
HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETDSGVDD 
DMACHKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN 
RKVATEFESF SFDATFHAKK QIPCIVSMLT KELYFYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CASP3

Associated with

Cells (max top 100)

Other Information

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. PubMed ID: 7983002

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. PubMed ID: 7774019

Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit. PubMed ID: 15003516

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. PubMed ID: 7596430

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. PubMed ID: 8755496

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. PubMed ID: 8696339

Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. PubMed ID: 10497198

Fas-induced caspase denitrosylation. PubMed ID: 10213689

Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. PubMed ID: 15200957

Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis. PubMed ID: 16374543

Executioner caspase-3 and caspase-7 are functionally distinct proteases. PubMed ID: 18723680

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells. PubMed ID: 20566630

Initial characterization of the human central proteome. PubMed ID: 21269460

RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. PubMed ID: 21357690

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

OGDHL is a modifier of AKT-dependent signaling and NF-kappaB function. PubMed ID: 23152800

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. PubMed ID: 23845944

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. PubMed ID: 28459430

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. PubMed ID: 28045099

Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3. PubMed ID: 30878284

Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. PubMed ID: 33725486

Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases. PubMed ID: 35446120

Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases. PubMed ID: 35338844

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. PubMed ID: 8673606

Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. PubMed ID: 9045680

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. PubMed ID: 10821855

Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. PubMed ID: 23650375

Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. PubMed ID: 36423631