Details for: HYAL3

Gene ID: 8372

Symbol: HYAL3

Ensembl ID: ENSG00000186792

Description: hyaluronidase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.4658
    Cell Significance Index: -3.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.5660
    Cell Significance Index: -2.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.6398
    Cell Significance Index: -3.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.6913
    Cell Significance Index: -4.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.2523
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6217
    Cell Significance Index: 10.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6174
    Cell Significance Index: 117.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6109
    Cell Significance Index: 8.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5152
    Cell Significance Index: 13.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3954
    Cell Significance Index: 23.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2853
    Cell Significance Index: 31.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2456
    Cell Significance Index: 3.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2436
    Cell Significance Index: 12.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2390
    Cell Significance Index: 215.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1975
    Cell Significance Index: 5.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1908
    Cell Significance Index: 31.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1844
    Cell Significance Index: 4.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1472
    Cell Significance Index: 4.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1382
    Cell Significance Index: 9.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1011
    Cell Significance Index: 1.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0903
    Cell Significance Index: 8.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0849
    Cell Significance Index: 1.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0841
    Cell Significance Index: 2.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0783
    Cell Significance Index: 54.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0758
    Cell Significance Index: 3.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0501
    Cell Significance Index: 10.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0450
    Cell Significance Index: 1.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0432
    Cell Significance Index: 0.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0356
    Cell Significance Index: 1.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0323
    Cell Significance Index: 1.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0319
    Cell Significance Index: 6.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0281
    Cell Significance Index: 3.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0232
    Cell Significance Index: 4.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0202
    Cell Significance Index: 11.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0162
    Cell Significance Index: 1.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0147
    Cell Significance Index: 0.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0138
    Cell Significance Index: 0.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0116
    Cell Significance Index: 5.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0106
    Cell Significance Index: 0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0079
    Cell Significance Index: 2.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0067
    Cell Significance Index: 0.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0065
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0058
    Cell Significance Index: 0.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0046
    Cell Significance Index: 0.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0012
    Cell Significance Index: 0.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0004
    Cell Significance Index: -0.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0012
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0032
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0116
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0146
    Cell Significance Index: -4.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0147
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0163
    Cell Significance Index: -2.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0170
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0178
    Cell Significance Index: -2.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0183
    Cell Significance Index: -2.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0187
    Cell Significance Index: -0.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0220
    Cell Significance Index: -0.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0232
    Cell Significance Index: -2.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0252
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0254
    Cell Significance Index: -5.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0285
    Cell Significance Index: -0.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0345
    Cell Significance Index: -1.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0380
    Cell Significance Index: -3.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0419
    Cell Significance Index: -1.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0466
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0472
    Cell Significance Index: -3.7400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0482
    Cell Significance Index: -0.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0483
    Cell Significance Index: -0.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0486
    Cell Significance Index: -3.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0512
    Cell Significance Index: -3.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0535
    Cell Significance Index: -3.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0604
    Cell Significance Index: -0.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0622
    Cell Significance Index: -3.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0634
    Cell Significance Index: -1.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0637
    Cell Significance Index: -0.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0654
    Cell Significance Index: -1.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0656
    Cell Significance Index: -0.9200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0708
    Cell Significance Index: -0.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0764
    Cell Significance Index: -2.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0769
    Cell Significance Index: -3.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0857
    Cell Significance Index: -1.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0858
    Cell Significance Index: -1.4700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0859
    Cell Significance Index: -0.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0884
    Cell Significance Index: -0.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0892
    Cell Significance Index: -1.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0902
    Cell Significance Index: -3.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0915
    Cell Significance Index: -2.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HYAL3 is a member of the hyaluronidase family, characterized by its ability to degrade HA, a key component of the extracellular matrix. The enzyme is specifically expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, cardiac endothelial cells, and immune cells such as immature innate lymphoid cells. HYAL3 has been shown to exhibit both endogenous and exogenous hyaluronidase activities, suggesting a complex role in both HA metabolism and immune responses. **Pathways and Functions:** HYAL3 is involved in various cellular processes, including: 1. **Inflammation**: HYAL3 has been shown to regulate the inflammatory response by modulating the levels of HA, a pro-inflammatory mediator. 2. **Cell migration**: HYAL3 is involved in the degradation of HA, facilitating cell migration and tissue remodeling. 3. **Immune regulation**: HYAL3 has been implicated in the regulation of immune responses, including the activation of immune cells and the suppression of autoimmune reactions. 4. **Development**: HYAL3 is essential for the development of various tissues, including the kidney, heart, and brain, where it regulates HA metabolism and cell migration. **Clinical Significance:** Aberrant HYAL3 expression has been linked to various diseases, including: 1. **Inflammatory disorders**: HYAL3 has been implicated in the pathogenesis of inflammatory diseases, such as arthritis and asthma. 2. **Cancer**: HYAL3 has been shown to play a role in cancer progression, where it regulates HA metabolism and cell migration. 3. **Neurological disorders**: HYAL3 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and multiple sclerosis. 4. **Kidney disease**: HYAL3 has been shown to play a critical role in kidney development and function, where its dysregulation can lead to kidney disease. In conclusion, HYAL3 is a multifunctional enzyme with a complex role in immune regulation, development, and disease. Further research is necessary to fully elucidate the mechanisms by which HYAL3 regulates these processes, as well as to explore its therapeutic potential in various diseases. **Recommendations:** 1. **Further research**: Investigate the mechanisms by which HYAL3 regulates HA metabolism and immune responses. 2. **Therapeutic targeting**: Explore the therapeutic potential of HYAL3 inhibitors in inflammatory and cancer diseases. 3. **Disease modeling**: Use HYAL3-deficient mice to study the role of HYAL3 in disease models of kidney disease, cancer, and neurological disorders. By further elucidating the role of HYAL3 in immune regulation and development, we can gain a deeper understanding of its complex functions and potential therapeutic applications.

Genular Protein ID: 470520671

Symbol: HYAL3_HUMAN

Name: Hyaluronidase-3

UniProtKB Accession Codes:

O43820 O60540 Q8NFK2 Q8NFK3 Q8NFK4 Q96E56 Q9BRW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 9 Ensembl 6 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10493834

Title: Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31.

PubMed ID: 10493834

DOI: 10.1006/geno.1999.5876

PubMed ID: 12084718

Title: Regulation of hyaluronidase activity by alternative mRNA splicing.

PubMed ID: 12084718

DOI: 10.1074/jbc.m203821200

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20586096

Title: Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm.

PubMed ID: 20586096

DOI: 10.1002/mrd.21217

PubMed ID: 21699545

Title: Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes.

PubMed ID: 21699545

DOI: 10.1111/j.1751-1097.2011.00959.x

Sequence Information:

  • Length: 417
  • Mass: 46501
  • Checksum: A6E7DE5369EF2BB8
  • Sequence:
    • MTTQLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCEARFGVHL PLNALGIIAN 
RGQHFHGQNM TIFYKNQLGL YPYFGPRGTA HNGGIPQALP LDRHLALAAY QIHHSLRPGF 
AGPAVLDWEE WCPLWAGNWG RRRAYQAASW AWAQQVFPDL DPQEQLYKAY TGFEQAARAL 
MEDTLRVAQA LRPHGLWGFY HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA 
LFPSIYLPPR LPPAHHQAFV RHRLEEAFRV ALVGHRHPLP VLAYVRLTHR RSGRFLSQDD 
LVQSIGVSAA LGAAGVVLWG DLSLSSSEEE CWHLHDYLVD TLGPYVINVT RAAMACSHQR 
CHGHGRCARR DPGQMEAFLH LWPDGSLGDW KSFSCHCYWG WAGPTCQEPR PGPKEAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.