Details for: CASP7

Gene ID: 840

Symbol: CASP7

Ensembl ID: ENSG00000165806

Description: caspase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 116.0434
    Cell Significance Index: -18.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.3423
    Cell Significance Index: -16.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.7945
    Cell Significance Index: -19.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.8270
    Cell Significance Index: -16.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.6131
    Cell Significance Index: -19.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.0622
    Cell Significance Index: -16.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.7937
    Cell Significance Index: -18.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6517
    Cell Significance Index: -15.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6198
    Cell Significance Index: -18.2300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7453
    Cell Significance Index: 28.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5387
    Cell Significance Index: 250.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1795
    Cell Significance Index: 61.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0126
    Cell Significance Index: 29.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9952
    Cell Significance Index: 51.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7120
    Cell Significance Index: 19.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6927
    Cell Significance Index: 9.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6806
    Cell Significance Index: 129.5200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6333
    Cell Significance Index: 9.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6078
    Cell Significance Index: 74.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5893
    Cell Significance Index: 26.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5488
    Cell Significance Index: 98.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4168
    Cell Significance Index: 10.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4130
    Cell Significance Index: 30.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4069
    Cell Significance Index: 44.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3662
    Cell Significance Index: 330.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3646
    Cell Significance Index: 17.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3593
    Cell Significance Index: 196.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3306
    Cell Significance Index: 7.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3001
    Cell Significance Index: 132.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2965
    Cell Significance Index: 14.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2729
    Cell Significance Index: 12.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2561
    Cell Significance Index: 35.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2482
    Cell Significance Index: 7.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2344
    Cell Significance Index: 23.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2318
    Cell Significance Index: 3.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2156
    Cell Significance Index: 42.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2141
    Cell Significance Index: 13.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2074
    Cell Significance Index: 30.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1370
    Cell Significance Index: 15.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1368
    Cell Significance Index: 2.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1321
    Cell Significance Index: 22.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1319
    Cell Significance Index: 16.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0984
    Cell Significance Index: 6.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0960
    Cell Significance Index: 60.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0877
    Cell Significance Index: 0.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0825
    Cell Significance Index: 0.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0800
    Cell Significance Index: 10.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0328
    Cell Significance Index: 11.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0192
    Cell Significance Index: 2.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0165
    Cell Significance Index: 1.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0141
    Cell Significance Index: 0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0110
    Cell Significance Index: 2.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0045
    Cell Significance Index: 8.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0083
    Cell Significance Index: -5.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0154
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0176
    Cell Significance Index: -0.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0203
    Cell Significance Index: -11.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0261
    Cell Significance Index: -11.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0298
    Cell Significance Index: -8.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0319
    Cell Significance Index: -3.2600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0506
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0519
    Cell Significance Index: -10.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0558
    Cell Significance Index: -6.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0623
    Cell Significance Index: -0.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0691
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0814
    Cell Significance Index: -4.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0874
    Cell Significance Index: -2.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0885
    Cell Significance Index: -10.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1078
    Cell Significance Index: -3.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1288
    Cell Significance Index: -3.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1361
    Cell Significance Index: -1.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1723
    Cell Significance Index: -17.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1836
    Cell Significance Index: -11.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1842
    Cell Significance Index: -5.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1973
    Cell Significance Index: -15.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2054
    Cell Significance Index: -4.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2373
    Cell Significance Index: -6.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2720
    Cell Significance Index: -16.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2731
    Cell Significance Index: -18.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2765
    Cell Significance Index: -5.9100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2805
    Cell Significance Index: -4.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2825
    Cell Significance Index: -6.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2940
    Cell Significance Index: -8.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2999
    Cell Significance Index: -7.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3003
    Cell Significance Index: -18.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3045
    Cell Significance Index: -8.1600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3104
    Cell Significance Index: -1.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3106
    Cell Significance Index: -5.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3112
    Cell Significance Index: -16.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3149
    Cell Significance Index: -13.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3184
    Cell Significance Index: -4.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3186
    Cell Significance Index: -7.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Caspase Family Member**: CASP7 is a member of the caspase family, a group of cysteine proteases that play essential roles in the regulation of apoptosis, inflammation, and cellular differentiation. 2. **Apoptosis Execution**: CASP7 is involved in the execution phase of apoptosis, where it cleaves and activates downstream targets to initiate the apoptotic cascade. 3. **Significant Expression**: CASP7 is significantly expressed in various cell types, including germ cells, epithelial cells, astrocytes, and neurons, highlighting its widespread involvement in cellular differentiation, development, and response to stress. 4. **Regulation of Cell Death**: CASP7 regulates cell death in response to various stimuli, including DNA damage, oxidative stress, and inflammatory signals. **Pathways and Functions:** 1. **Activation of Caspases**: CASP7 activates caspases through apoptosome-mediated cleavage, a process that involves the formation of the apoptosome complex, which recruits and activates downstream caspases. 2. **Apoptotic Cleavage of Cellular Proteins**: CASP7 cleaves and activates downstream targets, including cytoskeletal proteins, which leads to the reorganization of the cytoskeleton and the induction of apoptosis. 3. **Cytoskeletal Remodeling**: CASP7 cleaves cytoskeletal proteins, leading to the reorganization of the cytoskeleton and the induction of apoptosis. 4. **Regulation of Inflammation**: CASP7 regulates inflammation by cleaving and activating pro-inflammatory cytokines, which leads to the elimination of damaged or unwanted cells. **Clinical Significance:** 1. **Cancer Therapy**: CASP7 is overexpressed in various types of cancer, including breast, lung, and colon cancer, making it a potential target for cancer therapy. 2. **Neurodegenerative Diseases**: CASP7 is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it contributes to the elimination of damaged or unwanted neurons. 3. **Infectious Diseases**: CASP7 is involved in the regulation of the innate immune response to bacterial and viral infections, where it contributes to the elimination of infected cells. 4. **Regenerative Medicine**: CASP7 is involved in the regulation of cellular differentiation and development, making it a potential target for regenerative medicine applications. In conclusion, CASP7 is a critical gene involved in the regulation of apoptosis, cellular response to stress, and inflammation. Its significant expression in various cell types highlights its widespread involvement in cellular differentiation, development, and response to stress. Understanding the functions and regulation of CASP7 can provide valuable insights into the pathogenesis of various diseases and the development of novel therapeutic strategies.

Genular Protein ID: 2327044668

Symbol: CASP7_HUMAN

Name: Caspase-7 subunit p20

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8521391

Title: Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

PubMed ID: 8521391

PubMed ID: 8576161

Title: ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.

PubMed ID: 8576161

DOI: 10.1074/jbc.271.3.1621

PubMed ID: 8567622

Title: Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32.

PubMed ID: 8567622

DOI: 10.1074/jbc.271.4.1825

PubMed ID: 9070923

Title: Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3.

PubMed ID: 9070923

DOI: 10.1006/geno.1996.4548

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8643593

Title: Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.

PubMed ID: 8643593

DOI: 10.1073/pnas.93.11.5437

PubMed ID: 8755496

Title: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

PubMed ID: 8755496

DOI: 10.1073/pnas.93.15.7464

PubMed ID: 9852092

Title: Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

PubMed ID: 9852092

DOI: 10.1074/jbc.273.51.34278

PubMed ID: 10497198

Title: Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

PubMed ID: 10497198

DOI: 10.1074/jbc.274.40.28379

PubMed ID: 10821855

Title: Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

PubMed ID: 10821855

DOI: 10.1074/jbc.275.21.16007

PubMed ID: 12824163

Title: Human caspase-7 activity and regulation by its N-terminal peptide.

PubMed ID: 12824163

DOI: 10.1074/jbc.m305110200

PubMed ID: 15200957

Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

PubMed ID: 15200957

DOI: 10.1016/j.molcel.2004.05.018

PubMed ID: 16123041

Title: Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.

PubMed ID: 16123041

DOI: 10.1074/jbc.m506460200

PubMed ID: 16374543

Title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.

PubMed ID: 16374543

DOI: 10.1007/s10495-005-3276-y

PubMed ID: 16352606

Title: Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.

PubMed ID: 16352606

DOI: 10.1074/jbc.m507393200

PubMed ID: 16916640

Title: Engineered hybrid dimers: tracking the activation pathway of caspase-7.

PubMed ID: 16916640

DOI: 10.1016/j.molcel.2006.06.020

PubMed ID: 17646170

Title: Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.

PubMed ID: 17646170

DOI: 10.1074/jbc.m705265200

PubMed ID: 18723680

Title: Executioner caspase-3 and caspase-7 are functionally distinct proteases.

PubMed ID: 18723680

DOI: 10.1073/pnas.0707715105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19617626

Title: Calpain-1 cleaves and activates caspase-7.

PubMed ID: 19617626

DOI: 10.1074/jbc.m109.038174

PubMed ID: 19581639

Title: Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.

PubMed ID: 19581639

DOI: 10.1074/jbc.m109.001826

PubMed ID: 20159985

Title: Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.

PubMed ID: 20159985

DOI: 10.1074/jbc.m109.068221

PubMed ID: 20566630

Title: Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.

PubMed ID: 20566630

DOI: 10.1074/jbc.m110.126573

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21157428

Title: Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.

PubMed ID: 21157428

DOI: 10.1038/emboj.2010.326

PubMed ID: 21555521

Title: Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.

PubMed ID: 21555521

DOI: 10.1074/jbc.m111.236596

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 22184066

Title: Phosphorylation of the transcription factor YY1 by CK2alpha prevents cleavage by caspase 7 during apoptosis.

PubMed ID: 22184066

DOI: 10.1128/mcb.06466-11

PubMed ID: 22451931

Title: Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.

PubMed ID: 22451931

DOI: 10.1073/pnas.1200934109

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26045166

Title: KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.

PubMed ID: 26045166

DOI: 10.1158/0008-5472.can-14-3751

PubMed ID: 28863261

Title: Characterization of Hsp90 co-chaperone p23 cleavage by caspase-7 uncovers a peptidase-substrate interaction involving intrinsically disordered regions.

PubMed ID: 28863261

DOI: 10.1021/acs.biochem.7b00298

PubMed ID: 30455355

Title: Physiological and pathophysiological characteristics of ataxin-3 isoforms.

PubMed ID: 30455355

DOI: 10.1074/jbc.ra118.005801

PubMed ID: 31586028

Title: Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins.

PubMed ID: 31586028

DOI: 10.1073/pnas.1909283116

PubMed ID: 34156061

Title: Characterization of caspase-7 interaction with RNA.

PubMed ID: 34156061

DOI: 10.1042/bcj20210366

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 36758104

Title: Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.

PubMed ID: 36758104

DOI: 10.1126/science.ade5750

PubMed ID: 36758106

Title: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.

PubMed ID: 36758106

DOI: 10.1126/science.ade8840

PubMed ID: 11257230

Title: Structural basis of caspase-7 inhibition by XIAP.

PubMed ID: 11257230

DOI: 10.1016/s0092-8674(01)00272-0

PubMed ID: 11257231

Title: Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.

PubMed ID: 11257231

DOI: 10.1016/s0092-8674(02)02075-5

PubMed ID: 11701129

Title: Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.

PubMed ID: 11701129

DOI: 10.1016/s0092-8674(01)00544-x

PubMed ID: 11752425

Title: Structural basis for the activation of human procaspase-7.

PubMed ID: 11752425

DOI: 10.1073/pnas.221580098

PubMed ID: 15314233

Title: Discovery of an allosteric site in the caspases.

PubMed ID: 15314233

DOI: 10.1073/pnas.0404781101

PubMed ID: 17697120

Title: Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.

PubMed ID: 17697120

DOI: 10.1111/j.1742-4658.2007.05994.x

PubMed ID: 23897474

Title: Structural asymmetry of procaspase-7 bound to a specific inhibitor.

PubMed ID: 23897474

DOI: 10.1107/s0907444913010196

PubMed ID: 23650375

Title: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.

PubMed ID: 23650375

DOI: 10.1073/pnas.1306759110

PubMed ID: 24779913

Title: Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise.

PubMed ID: 24779913

DOI: 10.1042/bj20131456

PubMed ID: 27032039

Title: Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition.

PubMed ID: 27032039

DOI: 10.1021/acschembio.5b00971

PubMed ID: 27889207

Title: Dual site phosphorylation of caspase-7 by PAK2 blocks apoptotic activity by two distinct mechanisms.

PubMed ID: 27889207

DOI: 10.1016/j.str.2016.11.001

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

Sequence Information:

  • Length: 303
  • Mass: 34277
  • Checksum: CD373EE54A232CA4
  • Sequence:
  • MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT TRDRVPTYQY 
    NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC FRSLGFDVIV YNDCSCAKMQ 
    DLLKKASEED HTNAACFACI LLSHGEENVI YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL 
    FFIQACRGTE LDDGIQADSG PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW 
    FVQALCSILE EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY 
    FSQ

Genular Protein ID: 1109387154

Symbol: A0A0A0MRL7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 388
  • Mass: 43728
  • Checksum: 9F53F2E039587105
  • Sequence:
  • MRAGTRVALG SSTPAERTTP SQGRCKPRPA LPRAAPPSAA PRLLVSLSLK GPQTLAAERR 
    RETVPVPAAL PPWERWQMIR AVLKSRGLRI QQMKIQWMLS QTGPRLYRPS SAPDSGTLYF 
    TSKKKKNVTM RSIKTTRDRV PTYQYNMNFE KLGKCIIINN KNFDKVTGMG VRNGTDKDAE 
    ALFKCFRSLG FDVIVYNDCS CAKMQDLLKK ASEEDHTNAA CFACILLSHG EENVIYGKDG 
    VTPIKDLTAH FRGDRCKTLL EKPKLFFIQA CRGTELDDGI QADSGPINDT DANPRYKIPV 
    EADFLFAYST VPGYYSWRSP GRGSWFVQAL CSILEEHGKD LEIMQILTRV NDRVARHFES 
    QSDDPHFHEK KQIPCVVSML TKELYFSQ

Genular Protein ID: 529458691

Symbol: B4DWA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 311
  • Mass: 35416
  • Checksum: BD453E06BC8D5A46
  • Sequence:
  • MSRAVLKSRG LRIQQMKIQW MLSQTGPRLY RPSSAPDSGT LYFTSKKKKN VTMRSIKTTR 
    DRVPTYQYNM NFEKLGKCII INNKNFDKVT GMGVRNGTVK DAEALFKCFR SLGFDVIVYN 
    DCSCAKMQDL LKKASEEDHT NAACFACILL SHGEENVIYG KDGVTPIKDL TAHFRGDRCK 
    TLLEKPKLFF IQACRGTELD DGVQADSGPI NDTDANPRYK IPVEADFLFA YSTVPGYYSW 
    RSPGRGSWFV QALCSILEEH GKDLEIMQIL TRVNDRVARH FESQSDDPHF HEKKQIPCVV 
    SMLTKELYFS Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.