Details for: CASP7

Gene ID: 840

Symbol: CASP7

Ensembl ID: ENSG00000165806

Description: caspase 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.9
    Marker Score: 3328
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.72
    Marker Score: 5396
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.51
    Marker Score: 7238
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.32
    Marker Score: 902
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.19
    Marker Score: 7622
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.14
    Marker Score: 1093
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.12
    Marker Score: 23869
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.05
    Marker Score: 1547
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71725
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47949
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.99
    Marker Score: 289
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.97
    Marker Score: 649
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.96
    Marker Score: 1002
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.96
    Marker Score: 2187
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 979
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.93
    Marker Score: 8139
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.91
    Marker Score: 3142
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.91
    Marker Score: 7921
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5186
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.91
    Marker Score: 1003
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.89
    Marker Score: 226
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5240
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.86
    Marker Score: 423
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.85
    Marker Score: 245
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13279
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.85
    Marker Score: 210
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.84
    Marker Score: 839
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.82
    Marker Score: 20951
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.79
    Marker Score: 229
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.78
    Marker Score: 1123
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.77
    Marker Score: 1413
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.77
    Marker Score: 536
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.77
    Marker Score: 1180
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.75
    Marker Score: 357
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.74
    Marker Score: 2871
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.73
    Marker Score: 971
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.73
    Marker Score: 911
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.73
    Marker Score: 1711
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1471
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.72
    Marker Score: 1046
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.72
    Marker Score: 871
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.71
    Marker Score: 268
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7
    Marker Score: 200
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 897
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.68
    Marker Score: 626
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.68
    Marker Score: 1295
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.67
    Marker Score: 1595.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.67
    Marker Score: 1521
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2779
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.66
    Marker Score: 22721
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.65
    Marker Score: 7343
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.65
    Marker Score: 303.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.65
    Marker Score: 1151
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.62
    Marker Score: 258
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.61
    Marker Score: 573
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.61
    Marker Score: 749
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6
    Marker Score: 1201
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.6
    Marker Score: 4443
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.6
    Marker Score: 642
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 394
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.6
    Marker Score: 347
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.59
    Marker Score: 1508
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 184
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.58
    Marker Score: 347
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.58
    Marker Score: 140
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.57
    Marker Score: 447
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.57
    Marker Score: 505
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.57
    Marker Score: 357
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.56
    Marker Score: 509
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.56
    Marker Score: 126
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.56
    Marker Score: 537
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.55
    Marker Score: 497
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.55
    Marker Score: 1168
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.55
    Marker Score: 874
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.55
    Marker Score: 641
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.55
    Marker Score: 400
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.54
    Marker Score: 148
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.54
    Marker Score: 134
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3238
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.54
    Marker Score: 312
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.53
    Marker Score: 521
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.53
    Marker Score: 189
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.53
    Marker Score: 305
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.52
    Marker Score: 1420
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.52
    Marker Score: 3172

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Other Information

**Key characteristics:** - CASP7 is a member of the caspase family of cysteine proteases, which are involved in a wide range of cellular processes, including apoptosis, cell differentiation, and tissue remodeling. - It is a pro-apoptotic protein, meaning it is inactive in the cell. - Upon activation, CASP7 undergoes a conformational change that exposes its active site, allowing it to cleave various substrates and initiate apoptosis. **Pathways and functions:** - Activation of caspases through apoptosome-mediated cleavage: CASP7 is a key enzyme in the activation of caspases by the apoptosome, a protein complex that is responsible for initiating apoptosis. - Apoptosis: CASP7 is a key enzyme in the apoptotic process, where cells undergo programmed cell death. - Apoptotic cleavage of cellular proteins: CASP7 is responsible for the apoptotic cleavage of various cellular proteins, including those involved in cell cycle regulation, DNA repair, and protein degradation. - Apoptotic factor-mediated response: CASP7 is involved in the apoptotic response triggered by various apoptotic factors, including those released from damaged or stressed cells. - Aspartic-type endopeptidase activity: CASP7 has aspartic-type endopeptidase activity, which is involved in the processing of various substrates, including those involved in cell cycle regulation and apoptosis. **Clinical significance:** - Dysregulation of CASP7 has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. - Inhibition of CASP7 has shown therapeutic potential in preclinical models of cancer and neurodegenerative diseases. - Therefore, targeting CASP7 is a promising therapeutic strategy for treating diseases characterized by uncontrolled cell death.

Genular Protein ID: 2327044668

Symbol: CASP7_HUMAN

Name: Caspase-7 subunit p20

UniProtKB Accession Codes:

P55210 B4DQU7 B5BU45 D3DRB8 Q13364 Q53YD5 Q5SVL0 Q5SVL3 Q96BA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 ELM 1 EMBL 19 EMDB 1 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 74 PDBsum 43 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 8 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8521391

Title: Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

PubMed ID: 8521391

PubMed ID: 8576161

Title: ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.

PubMed ID: 8576161

DOI: 10.1074/jbc.271.3.1621

PubMed ID: 8567622

Title: Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32.

PubMed ID: 8567622

DOI: 10.1074/jbc.271.4.1825

PubMed ID: 9070923

Title: Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3.

PubMed ID: 9070923

DOI: 10.1006/geno.1996.4548

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8643593

Title: Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.

PubMed ID: 8643593

DOI: 10.1073/pnas.93.11.5437

PubMed ID: 8755496

Title: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

PubMed ID: 8755496

DOI: 10.1073/pnas.93.15.7464

PubMed ID: 9852092

Title: Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

PubMed ID: 9852092

DOI: 10.1074/jbc.273.51.34278

PubMed ID: 10497198

Title: Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

PubMed ID: 10497198

DOI: 10.1074/jbc.274.40.28379

PubMed ID: 10821855

Title: Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

PubMed ID: 10821855

DOI: 10.1074/jbc.275.21.16007

PubMed ID: 12824163

Title: Human caspase-7 activity and regulation by its N-terminal peptide.

PubMed ID: 12824163

DOI: 10.1074/jbc.m305110200

PubMed ID: 15200957

Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

PubMed ID: 15200957

DOI: 10.1016/j.molcel.2004.05.018

PubMed ID: 16123041

Title: Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.

PubMed ID: 16123041

DOI: 10.1074/jbc.m506460200

PubMed ID: 16374543

Title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.

PubMed ID: 16374543

DOI: 10.1007/s10495-005-3276-y

PubMed ID: 16352606

Title: Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.

PubMed ID: 16352606

DOI: 10.1074/jbc.m507393200

PubMed ID: 16916640

Title: Engineered hybrid dimers: tracking the activation pathway of caspase-7.

PubMed ID: 16916640

DOI: 10.1016/j.molcel.2006.06.020

PubMed ID: 17646170

Title: Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.

PubMed ID: 17646170

DOI: 10.1074/jbc.m705265200

PubMed ID: 18723680

Title: Executioner caspase-3 and caspase-7 are functionally distinct proteases.

PubMed ID: 18723680

DOI: 10.1073/pnas.0707715105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19617626

Title: Calpain-1 cleaves and activates caspase-7.

PubMed ID: 19617626

DOI: 10.1074/jbc.m109.038174

PubMed ID: 19581639

Title: Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.

PubMed ID: 19581639

DOI: 10.1074/jbc.m109.001826

PubMed ID: 20159985

Title: Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.

PubMed ID: 20159985

DOI: 10.1074/jbc.m109.068221

PubMed ID: 20566630

Title: Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.

PubMed ID: 20566630

DOI: 10.1074/jbc.m110.126573

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21157428

Title: Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.

PubMed ID: 21157428

DOI: 10.1038/emboj.2010.326

PubMed ID: 21555521

Title: Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.

PubMed ID: 21555521

DOI: 10.1074/jbc.m111.236596

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 22184066

Title: Phosphorylation of the transcription factor YY1 by CK2alpha prevents cleavage by caspase 7 during apoptosis.

PubMed ID: 22184066

DOI: 10.1128/mcb.06466-11

PubMed ID: 22451931

Title: Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.

PubMed ID: 22451931

DOI: 10.1073/pnas.1200934109

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26045166

Title: KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.

PubMed ID: 26045166

DOI: 10.1158/0008-5472.can-14-3751

PubMed ID: 28863261

Title: Characterization of Hsp90 co-chaperone p23 cleavage by caspase-7 uncovers a peptidase-substrate interaction involving intrinsically disordered regions.

PubMed ID: 28863261

DOI: 10.1021/acs.biochem.7b00298

PubMed ID: 30455355

Title: Physiological and pathophysiological characteristics of ataxin-3 isoforms.

PubMed ID: 30455355

DOI: 10.1074/jbc.ra118.005801

PubMed ID: 31586028

Title: Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins.

PubMed ID: 31586028

DOI: 10.1073/pnas.1909283116

PubMed ID: 34156061

Title: Characterization of caspase-7 interaction with RNA.

PubMed ID: 34156061

DOI: 10.1042/bcj20210366

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 11257230

Title: Structural basis of caspase-7 inhibition by XIAP.

PubMed ID: 11257230

DOI: 10.1016/s0092-8674(01)00272-0

PubMed ID: 11257231

Title: Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.

PubMed ID: 11257231

DOI: 10.1016/s0092-8674(02)02075-5

PubMed ID: 11701129

Title: Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.

PubMed ID: 11701129

DOI: 10.1016/s0092-8674(01)00544-x

PubMed ID: 11752425

Title: Structural basis for the activation of human procaspase-7.

PubMed ID: 11752425

DOI: 10.1073/pnas.221580098

PubMed ID: 15314233

Title: Discovery of an allosteric site in the caspases.

PubMed ID: 15314233

DOI: 10.1073/pnas.0404781101

PubMed ID: 17697120

Title: Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.

PubMed ID: 17697120

DOI: 10.1111/j.1742-4658.2007.05994.x

PubMed ID: 23897474

Title: Structural asymmetry of procaspase-7 bound to a specific inhibitor.

PubMed ID: 23897474

DOI: 10.1107/s0907444913010196

PubMed ID: 23650375

Title: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.

PubMed ID: 23650375

DOI: 10.1073/pnas.1306759110

PubMed ID: 24779913

Title: Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise.

PubMed ID: 24779913

DOI: 10.1042/bj20131456

PubMed ID: 27032039

Title: Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition.

PubMed ID: 27032039

DOI: 10.1021/acschembio.5b00971

PubMed ID: 27889207

Title: Dual site phosphorylation of caspase-7 by PAK2 blocks apoptotic activity by two distinct mechanisms.

PubMed ID: 27889207

DOI: 10.1016/j.str.2016.11.001

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

Sequence Information:

  • Length: 303
  • Mass: 34277
  • Checksum: CD373EE54A232CA4
  • Sequence:
    • MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT TRDRVPTYQY 
NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC FRSLGFDVIV YNDCSCAKMQ 
DLLKKASEED HTNAACFACI LLSHGEENVI YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL 
FFIQACRGTE LDDGIQADSG PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW 
FVQALCSILE EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY 
FSQ

Genular Protein ID: 1109387154

Symbol: A0A0A0MRL7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRL7

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 MEROPS 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 388
  • Mass: 43728
  • Checksum: 9F53F2E039587105
  • Sequence:
    • MRAGTRVALG SSTPAERTTP SQGRCKPRPA LPRAAPPSAA PRLLVSLSLK GPQTLAAERR 
RETVPVPAAL PPWERWQMIR AVLKSRGLRI QQMKIQWMLS QTGPRLYRPS SAPDSGTLYF 
TSKKKKNVTM RSIKTTRDRV PTYQYNMNFE KLGKCIIINN KNFDKVTGMG VRNGTDKDAE 
ALFKCFRSLG FDVIVYNDCS CAKMQDLLKK ASEEDHTNAA CFACILLSHG EENVIYGKDG 
VTPIKDLTAH FRGDRCKTLL EKPKLFFIQA CRGTELDDGI QADSGPINDT DANPRYKIPV 
EADFLFAYST VPGYYSWRSP GRGSWFVQAL CSILEEHGKD LEIMQILTRV NDRVARHFES 
QSDDPHFHEK KQIPCVVSML TKELYFSQ

Genular Protein ID: 529458691

Symbol: B4DWA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWA2

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 8 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 6 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 311
  • Mass: 35416
  • Checksum: BD453E06BC8D5A46
  • Sequence:
    • MSRAVLKSRG LRIQQMKIQW MLSQTGPRLY RPSSAPDSGT LYFTSKKKKN VTMRSIKTTR 
DRVPTYQYNM NFEKLGKCII INNKNFDKVT GMGVRNGTVK DAEALFKCFR SLGFDVIVYN 
DCSCAKMQDL LKKASEEDHT NAACFACILL SHGEENVIYG KDGVTPIKDL TAHFRGDRCK 
TLLEKPKLFF IQACRGTELD DGVQADSGPI NDTDANPRYK IPVEADFLFA YSTVPGYYSW 
RSPGRGSWFV QALCSILEEH GKDLEIMQIL TRVNDRVARH FESQSDDPHF HEKKQIPCVV 
SMLTKELYFS Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.