Details for: CUL2

Gene ID: 8453

Symbol: CUL2

Ensembl ID: ENSG00000108094

Description: cullin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.3486
    Cell Significance Index: -30.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.8944
    Cell Significance Index: -31.4300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.2522
    Cell Significance Index: -34.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.8034
    Cell Significance Index: -33.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.8726
    Cell Significance Index: -27.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.2491
    Cell Significance Index: -32.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.4320
    Cell Significance Index: -28.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.5216
    Cell Significance Index: -32.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5198
    Cell Significance Index: -30.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4059
    Cell Significance Index: -33.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8627
    Cell Significance Index: -24.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3374
    Cell Significance Index: -13.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4601
    Cell Significance Index: 292.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4527
    Cell Significance Index: 38.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1964
    Cell Significance Index: 130.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1022
    Cell Significance Index: 66.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8267
    Cell Significance Index: 164.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6081
    Cell Significance Index: 218.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5476
    Cell Significance Index: 24.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5099
    Cell Significance Index: 19.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4993
    Cell Significance Index: 345.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4963
    Cell Significance Index: 25.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4686
    Cell Significance Index: 84.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4090
    Cell Significance Index: 5.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3926
    Cell Significance Index: 22.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3460
    Cell Significance Index: 9.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3270
    Cell Significance Index: 21.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3226
    Cell Significance Index: 19.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3166
    Cell Significance Index: 43.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3142
    Cell Significance Index: 24.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2834
    Cell Significance Index: 125.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2820
    Cell Significance Index: 34.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2605
    Cell Significance Index: 142.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2537
    Cell Significance Index: 7.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2305
    Cell Significance Index: 11.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2056
    Cell Significance Index: 12.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1530
    Cell Significance Index: 138.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1343
    Cell Significance Index: 25.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1137
    Cell Significance Index: 5.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1050
    Cell Significance Index: 2.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0966
    Cell Significance Index: 15.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0665
    Cell Significance Index: 4.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0478
    Cell Significance Index: 0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0453
    Cell Significance Index: 85.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0411
    Cell Significance Index: 4.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0408
    Cell Significance Index: 1.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0336
    Cell Significance Index: 2.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0281
    Cell Significance Index: 43.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0265
    Cell Significance Index: 16.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0243
    Cell Significance Index: 44.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0237
    Cell Significance Index: 2.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0198
    Cell Significance Index: 0.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0188
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0081
    Cell Significance Index: 11.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0267
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0269
    Cell Significance Index: -4.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0305
    Cell Significance Index: -22.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0347
    Cell Significance Index: -26.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0361
    Cell Significance Index: -5.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0407
    Cell Significance Index: -1.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0504
    Cell Significance Index: -28.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0586
    Cell Significance Index: -36.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0686
    Cell Significance Index: -1.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0950
    Cell Significance Index: -2.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0953
    Cell Significance Index: -27.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1089
    Cell Significance Index: -11.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1101
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1201
    Cell Significance Index: -14.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1288
    Cell Significance Index: -16.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1357
    Cell Significance Index: -15.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1418
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1682
    Cell Significance Index: -35.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1950
    Cell Significance Index: -4.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2157
    Cell Significance Index: -4.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2222
    Cell Significance Index: -4.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2524
    Cell Significance Index: -18.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2814
    Cell Significance Index: -4.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2817
    Cell Significance Index: -29.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3041
    Cell Significance Index: -2.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3470
    Cell Significance Index: -3.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3476
    Cell Significance Index: -27.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3636
    Cell Significance Index: -12.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3686
    Cell Significance Index: -9.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3731
    Cell Significance Index: -11.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3931
    Cell Significance Index: -20.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4093
    Cell Significance Index: -11.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4159
    Cell Significance Index: -25.5000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4693
    Cell Significance Index: -6.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4873
    Cell Significance Index: -10.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4886
    Cell Significance Index: -14.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4947
    Cell Significance Index: -10.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5009
    Cell Significance Index: -13.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5075
    Cell Significance Index: -6.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5168
    Cell Significance Index: -6.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5309
    Cell Significance Index: -16.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5400
    Cell Significance Index: -17.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ubiquitin ligase activity**: CUL2 is a member of the RING E3 ubiquitin ligase family, which mediates the transfer of ubiquitin molecules to target proteins, marking them for degradation by the proteasome. 2. **Adaptive immune system**: CUL2 is involved in the adaptive immune response, particularly in the processing and presentation of antigens to T-cells via class I MHC molecules. 3. **Antigen processing**: CUL2 regulates the ubiquitination and proteasomal degradation of antigens, ensuring their presentation to the immune system. 4. **Cellular responses to stress**: CUL2 is involved in the regulation of cellular responses to stress, including hypoxia, oxidative stress, and DNA damage. 5. **Neuronal function**: CUL2 is expressed in neurons and plays a role in axon guidance, neuronal development, and the regulation of protein degradation in these cells. **Pathways and Functions** 1. **Adaptive immune system**: CUL2 regulates the processing and presentation of antigens to T-cells via class I MHC molecules, ensuring proper immune function. 2. **Antigen processing**: CUL2 is involved in the ubiquitination and proteasomal degradation of antigens, ensuring their presentation to the immune system. 3. **Cellular responses to stress**: CUL2 regulates cellular responses to stress, including hypoxia, oxidative stress, and DNA damage. 4. **Protein degradation**: CUL2 is involved in the regulation of protein degradation, including the ubiquitination and proteasomal degradation of target proteins. 5. **Cell cycle regulation**: CUL2 regulates the G1/S transition of the cell cycle, ensuring proper cell proliferation and differentiation. **Clinical Significance** 1. **Immunodeficiency disorders**: Mutations in the CUL2 gene have been associated with immunodeficiency disorders, highlighting its importance in immune function. 2. **Cancer**: CUL2 has been implicated in the regulation of protein degradation in cancer cells, and its dysregulation may contribute to tumorigenesis. 3. **Neurological disorders**: CUL2 is expressed in neurons and plays a role in neuronal development and function, suggesting its potential involvement in neurological disorders, such as neurodegenerative diseases. 4. **Developmental biology**: CUL2 is involved in the regulation of protein degradation during development, highlighting its importance in embryonic development and tissue patterning. In conclusion, CUL2 is a crucial gene involved in various cellular processes, including the adaptive immune system, antigen processing, and protein degradation. Its dysregulation has been implicated in immunodeficiency disorders, cancer, and neurological disorders, highlighting its importance in human health and disease.

Genular Protein ID: 3846004637

Symbol: CUL2_HUMAN

Name: Cullin-2

UniProtKB Accession Codes:

Q13617 B3KT95 B7Z6K8 D3DRY6 G3V1S2 O00200 Q5T2B6 Q9UNF9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 12 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 13 EMDB 29 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 30 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9122164

Title: The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.

PubMed ID: 9122164

DOI: 10.1073/pnas.94.6.2156

PubMed ID: 10092517

Title: Identification of NEDD8-conjugation site in human cullin-2.

PubMed ID: 10092517

DOI: 10.1006/bbrc.1999.0339

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8681378

Title: cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.

PubMed ID: 8681378

DOI: 10.1016/s0092-8674(00)81267-2

PubMed ID: 10230407

Title: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.

PubMed ID: 10230407

DOI: 10.1016/s1097-2765(00)80482-7

PubMed ID: 10973499

Title: Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.

PubMed ID: 10973499

DOI: 10.1073/pnas.190332597

PubMed ID: 11384984

Title: Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.

PubMed ID: 11384984

DOI: 10.1074/jbc.m103093200

PubMed ID: 12149480

Title: Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.

PubMed ID: 12149480

DOI: 10.1073/pnas.162424199

PubMed ID: 12609982

Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.

PubMed ID: 12609982

DOI: 10.1074/jbc.m213070200

PubMed ID: 10597293

Title: Covalent modification of all members of human cullin family proteins by NEDD8.

PubMed ID: 10597293

DOI: 10.1038/sj.onc.1203093

PubMed ID: 15601820

Title: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

PubMed ID: 15601820

DOI: 10.1101/gad.1252404

PubMed ID: 17304241

Title: The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.

PubMed ID: 17304241

DOI: 10.1038/sj.embor.7400895

PubMed ID: 17251292

Title: Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase.

PubMed ID: 17251292

DOI: 10.1128/jvi.02303-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23102700

Title: The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

PubMed ID: 23102700

DOI: 10.1016/j.molcel.2012.09.018

PubMed ID: 22286099

Title: The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

PubMed ID: 22286099

DOI: 10.1038/ncb2424

PubMed ID: 24076655

Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

PubMed ID: 24076655

DOI: 10.1038/emboj.2013.209

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23401859

Title: DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.

PubMed ID: 23401859

DOI: 10.1128/mcb.01342-12

PubMed ID: 23201271

Title: Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.

PubMed ID: 23201271

DOI: 10.1016/j.str.2012.10.013

PubMed ID: 24192928

Title: Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.

PubMed ID: 24192928

DOI: 10.1158/1078-0432.ccr-13-1252

PubMed ID: 27565346

Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.

PubMed ID: 27565346

DOI: 10.1016/j.cell.2016.07.027

PubMed ID: 26906416

Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

PubMed ID: 26906416

DOI: 10.1242/jcs.181784

PubMed ID: 26138980

Title: SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

PubMed ID: 26138980

DOI: 10.1126/science.aab0515

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 29775578

Title: C-terminal end-directed protein elimination by CRL2 ubiquitin ligases.

PubMed ID: 29775578

DOI: 10.1016/j.molcel.2018.04.006

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

Sequence Information:

  • Length: 745
  • Mass: 86983
  • Checksum: 30647248F671AB0E
  • Sequence:
    • MSLKPRVVDF DETWNKLLTT IKAVVMLEYV ERATWNDRFS DIYALCVAYP EPLGERLYTE 
TKIFLENHVR HLHKRVLESE EQVLVMYHRY WEEYSKGADY MDCLYRYLNT QFIKKNKLTE 
ADLQYGYGGV DMNEPLMEIG ELALDMWRKL MVEPLQAILI RMLLREIKND RGGEDPNQKV 
IHGVINSFVH VEQYKKKFPL KFYQEIFESP FLTETGEYYK QEASNLLQES NCSQYMEKVL 
GRLKDEEIRC RKYLHPSSYT KVIHECQQRM VADHLQFLHA ECHNIIRQEK KNDMANMYVL 
LRAVSTGLPH MIQELQNHIH DEGLRATSNL TQENMPTLFV ESVLEVHGKF VQLINTVLNG 
DQHFMSALDK ALTSVVNYRE PKSVCKAPEL LAKYCDNLLK KSAKGMTENE VEDRLTSFIT 
VFKYIDDKDV FQKFYARMLA KRLIHGLSMS MDSEEAMINK LKQACGYEFT SKLHRMYTDM 
SVSADLNNKF NNFIKNQDTV IDLGISFQIY VLQAGAWPLT QAPSSTFAIP QELEKSVQMF 
ELFYSQHFSG RKLTWLHYLC TGEVKMNYLG KPYVAMVTTY QMAVLLAFNN SETVSYKELQ 
DSTQMNEKEL TKTIKSLLDV KMINHDSEKE DIDAESSFSL NMNFSSKRTK FKITTSMQKD 
TPQEMEQTRS AVDEDRKMYL QAAIVRIMKA RKVLRHNALI QEVISQSRAR FNPSISMIKK 
CIEVLIDKQY IERSQASADE YSYVA

Genular Protein ID: 1649295460

Symbol: A0A8I5KVR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8I5KVR3

Database IDs:

ARBA 5 CTD 1 DisGeNET 1 EMBL 2 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 3 UniPathway 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 682
  • Mass: 79518
  • Checksum: CB4CD9BFECFDA251
  • Sequence:
    • MSLKPRVVDF DETWNKLLTT IKAVVMLEYV ERATWNDRFS DIYALCVAYP EPLGERLYTE 
TKIFLENHVR HLHKRVLESE EQVLVMYHRY WEEYSKGADY MDCLYSDRGG EDPNQKVIHG 
VINSFVHVEQ YKKKFPLKFY QEIFESPFLT ETGEYYKQEA SNLLQESNCS QYMEKVLGRL 
KDEEIRCRKY LHPSSYTKVI HECQQRMVAD HLQFLHAECH NIIRQEKKND MANMYVLLRA 
VSTGLPHMIQ ELQNHIHDEG LRATSNLTQE NMPTLFVESV LEVHGKFVQL INTVLNGDQH 
FMSALDKALT SVVNYREPKS VCKAPELLAK YCDNLLKKSA KGMTENEVED RLTSFITVFK 
YIDDKDVFQK FYARMLAKRL IHGLSMSMDS EEAMINKLKQ ACGYEFTSKL HRMYTDMSVS 
ADLNNKFNNF IKNQDTVIDL GISFQIYVLQ AGAWPLTQAP SSTFAIPQEL EKSVQMFELF 
YSQHFSGRKL TWLHYLCTGE VKMNYLGKPY VAMVTTYQMA VLLAFNNSET VSYKELQDST 
QMNEKELTKT IKSLLDVKMI NHDSEKEDID AESSFSLNMN FSSKRTKFKI TTSMQKDTPQ 
EMEQTRSAVD EDRKMYLQAA IVRIMKARKV LRHNALIQEV ISQSRARFNP SISMIKKCIE 
VLIDKQYIER SQASADEYSY VA

Genular Protein ID: 609978033

Symbol: B7Z1Y1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1Y1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 582
  • Mass: 67866
  • Checksum: 585E4C2EC4F5EE4D
  • Sequence:
    • MSLKPRVVDF DETWNKLLTT IKAVVMLEYV ERATWNDRFS DIYALCVAYP EPLGERLYTE 
TKIFLENHVR HLHKRVLESE EQVLVMYHRY WEEYSKGADY MDCLYSDRGG EDPNQKVIHG 
VINSFVHVEQ YKKKFPLKFY QEIFESPFLT ETGEYYKQEA SNLLQESNCS QYMEKVLGRL 
KDEEIRCRKY LHPSSYTKVI HECQQRMVAD HLQFLHAECH NIIRQEKKND MANMYVLLRA 
VSTGLPHMIQ ELQNHIHDEG LRATSNLTQE NMPTLFVESV LEVHGKFVQL INTVLNGDQH 
FMSALDKALT SVVNYREPKS VCKAPELLAK YCDNLLKKSA KGMTENEVED RLTSFITVFK 
YIDDKDVFQK FYARMLAKRL IHGLSMSMDS EEAMINKLKQ ACGYEFTSKL HRMYTDMSVS 
ADLNNKFNNF IKNQDTVIDL GISFQIYVLQ AGAWPLTQAP SSTFAIPQEL EKSVQMFELF 
YSQHFSGRKL TWLHYLCTGE VKMNYLGKPY VAMVTTYQMA VLLAFNNSET VSYKELQDST 
QMNEKELTKT IKSLLDVKMI NHDSEKEDID AESSFSLNMN FS

Genular Protein ID: 4190002926

Symbol: A0A0A0MTN0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MTN0

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 3 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 758
  • Mass: 88506
  • Checksum: 126BC92627C9420A
  • Sequence:
    • MVPGKEFQHY TCTMSLKPRV VDFDETWNKL LTTIKAVVML EYVERATWND RFSDIYALCV 
AYPEPLGERL YTETKIFLEN HVRHLHKRVL ESEEQVLVMY HRYWEEYSKG ADYMDCLYRY 
LNTQFIKKNK LTEADLQYGY GGVDMNEPLM EIGELALDMW RKLMVEPLQA ILIRMLLREI 
KNDRGGEDPN QKVIHGVINS FVHVEQYKKK FPLKFYQEIF ESPFLTETGE YYKQEASNLL 
QESNCSQYME KVLGRLKDEE IRCRKYLHPS SYTKVIHECQ QRMVADHLQF LHAECHNIIR 
QEKKNDMANM YVLLRAVSTG LPHMIQELQN HIHDEGLRAT SNLTQENMPT LFVESVLEVH 
GKFVQLINTV LNGDQHFMSA LDKALTSVVN YREPKSVCKA PELLAKYCDN LLKKSAKGMT 
ENEVEDRLTS FITVFKYIDD KDVFQKFYAR MLAKRLIHGL SMSMDSEEAM INKLKQACGY 
EFTSKLHRMY TDMSVSADLN NKFNNFIKNQ DTVIDLGISF QIYVLQAGAW PLTQAPSSTF 
AIPQELEKSV QMFELFYSQH FSGRKLTWLH YLCTGEVKMN YLGKPYVAMV TTYQMAVLLA 
FNNSETVSYK ELQDSTQMNE KELTKTIKSL LDVKMINHDS EKEDIDAESS FSLNMNFSSK 
RTKFKITTSM QKDTPQEMEQ TRSAVDEDRK MYLQAAIVRI MKARKVLRHN ALIQEVISQS 
RARFNPSISM IKKCIEVLID KQYIERSQAS ADEYSYVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.