Details for: TTF2

Gene ID: 8458

Symbol: TTF2

Ensembl ID: ENSG00000116830

Description: transcription termination factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.4484
    Cell Significance Index: -12.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.8695
    Cell Significance Index: -13.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.4025
    Cell Significance Index: -13.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2656
    Cell Significance Index: -13.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.1229
    Cell Significance Index: -16.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.8084
    Cell Significance Index: -15.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3221
    Cell Significance Index: -13.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1928
    Cell Significance Index: -16.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3903
    Cell Significance Index: -7.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9843
    Cell Significance Index: 196.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0392
    Cell Significance Index: 58.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7812
    Cell Significance Index: 84.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7723
    Cell Significance Index: 20.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7564
    Cell Significance Index: 21.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7393
    Cell Significance Index: 120.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7021
    Cell Significance Index: 42.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6266
    Cell Significance Index: 565.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5128
    Cell Significance Index: 14.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5102
    Cell Significance Index: 101.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4288
    Cell Significance Index: 27.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4116
    Cell Significance Index: 21.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4104
    Cell Significance Index: 10.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3753
    Cell Significance Index: 8.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3242
    Cell Significance Index: 58.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3195
    Cell Significance Index: 37.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3169
    Cell Significance Index: 36.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3086
    Cell Significance Index: 21.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3026
    Cell Significance Index: 37.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2779
    Cell Significance Index: 12.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2264
    Cell Significance Index: 123.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2044
    Cell Significance Index: 4.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1956
    Cell Significance Index: 70.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1748
    Cell Significance Index: 1.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1650
    Cell Significance Index: 72.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1542
    Cell Significance Index: 3.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1394
    Cell Significance Index: 3.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1278
    Cell Significance Index: 2.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1182
    Cell Significance Index: 22.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1082
    Cell Significance Index: 2.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1057
    Cell Significance Index: 14.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0732
    Cell Significance Index: 14.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0707
    Cell Significance Index: 5.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0681
    Cell Significance Index: 2.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0557
    Cell Significance Index: 2.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0331
    Cell Significance Index: 5.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0194
    Cell Significance Index: 36.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0192
    Cell Significance Index: 12.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0045
    Cell Significance Index: 8.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0033
    Cell Significance Index: 5.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0022
    Cell Significance Index: 1.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0012
    Cell Significance Index: 1.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0010
    Cell Significance Index: -0.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0025
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0117
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0171
    Cell Significance Index: -12.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0197
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0236
    Cell Significance Index: -1.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0237
    Cell Significance Index: -0.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0251
    Cell Significance Index: -0.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0261
    Cell Significance Index: -14.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0288
    Cell Significance Index: -18.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0343
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0358
    Cell Significance Index: -4.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0378
    Cell Significance Index: -10.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0434
    Cell Significance Index: -4.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0496
    Cell Significance Index: -0.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0605
    Cell Significance Index: -7.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0707
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0839
    Cell Significance Index: -17.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0858
    Cell Significance Index: -1.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1233
    Cell Significance Index: -7.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1314
    Cell Significance Index: -8.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1389
    Cell Significance Index: -8.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1402
    Cell Significance Index: -3.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1433
    Cell Significance Index: -14.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1729
    Cell Significance Index: -13.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1917
    Cell Significance Index: -6.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1975
    Cell Significance Index: -5.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2037
    Cell Significance Index: -5.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2089
    Cell Significance Index: -10.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2095
    Cell Significance Index: -3.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2107
    Cell Significance Index: -13.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2207
    Cell Significance Index: -1.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2488
    Cell Significance Index: -3.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2541
    Cell Significance Index: -7.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2599
    Cell Significance Index: -2.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2610
    Cell Significance Index: -6.0300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2834
    Cell Significance Index: -1.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2865
    Cell Significance Index: -4.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2950
    Cell Significance Index: -8.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2989
    Cell Significance Index: -6.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3013
    Cell Significance Index: -15.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3176
    Cell Significance Index: -5.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3183
    Cell Significance Index: -8.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3368
    Cell Significance Index: -7.3800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3510
    Cell Significance Index: -4.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TTF2 is a highly conserved protein that belongs to the termination factor family, which includes other factors such as TTF1 and TTF3. It is characterized by its ability to interact with RNA polymerase II and other transcriptional regulators, thereby regulating the termination of transcription. TTF2 is also involved in the regulation of alternative splicing and mRNA processing. Its expression is restricted to specific cell types, including neurons, epithelial cells, and stem cells. **Pathways and Functions** The primary function of TTF2 is to regulate the termination of RNA polymerase II-dependent transcription. It achieves this by interacting with the transcriptional machinery, including RNA polymerase II, and recruiting factors that facilitate the termination of transcription. TTF2 is also involved in the regulation of alternative splicing and mRNA processing, which are critical processes for the generation of diverse protein isoforms. Additionally, TTF2 has been implicated in the regulation of chromatin remodeling and DNA repair, suggesting a broader role in the regulation of gene expression. **Clinical Significance** Dysregulation of TTF2 has been implicated in various diseases, including neurological disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). TTF2 has also been shown to play a role in the development of cancer, including colorectal cancer and breast cancer. Furthermore, TTF2 has been implicated in the regulation of stem cell maintenance and differentiation, suggesting a potential role in regenerative medicine. The dysregulation of TTF2 has also been associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. **Mechanisms of Disease** The mechanisms by which TTF2 dysregulation contributes to disease are complex and multifaceted. TTF2 has been shown to interact with various transcriptional regulators, including transcription factors and chromatin remodelers, thereby regulating the expression of genes involved in disease pathogenesis. Additionally, TTF2 has been implicated in the regulation of cellular stress responses, including apoptosis and autophagy, which are critical processes for maintaining cellular homeostasis. **Therapeutic Strategies** Therapeutic strategies targeting TTF2 have been proposed for the treatment of various diseases, including neurological disorders and cancer. These strategies include the development of small molecule inhibitors that target TTF2's interaction with the transcriptional machinery, as well as the use of RNA-based therapies that modulate TTF2 expression. Additionally, TTF2 has been identified as a potential therapeutic target for regenerative medicine, with potential applications in the treatment of neurodegenerative diseases and tissue repair. In conclusion, TTF2 is a multifunctional protein that plays a critical role in the regulation of gene expression. Its dysregulation has been implicated in various diseases, including neurological disorders and cancer. Further research is needed to fully understand the mechanisms by which TTF2 dysregulation contributes to disease, as well as the development of therapeutic strategies that target this protein.

Genular Protein ID: 774030859

Symbol: TTF2_HUMAN

Name: Transcription termination factor 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9748214

Title: A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member.

PubMed ID: 9748214

DOI: 10.1074/jbc.273.40.25541

PubMed ID: 12927788

Title: hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.

PubMed ID: 12927788

DOI: 10.1016/s0006-291x(03)01486-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10455150

Title: Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer.

PubMed ID: 10455150

DOI: 10.1074/jbc.274.35.24779

PubMed ID: 15125840

Title: Involvement of transcription termination factor 2 in mitotic repression of transcription elongation.

PubMed ID: 15125840

DOI: 10.1016/s1097-2765(04)00234-5

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1162
  • Mass: 129588
  • Checksum: 858BAA22B2D2D5C9
  • Sequence:
  • MEEVRCPEHG TFCFLKTGVR DGPNKGKSFY VCRADTCSFV RATDIPVSHC LLHEDFVVEL 
    QGLLLPQDKK EYRLFFRCIR SKAEGKRWCG SIPWQDPDSK EHSVSNKSQH ASETFHHSSN 
    WLRNPFKVLD KNQEPALWKQ LIKGEGEEKK ADKKQREKGD QLFDQKKEQK PEMMEKDLSS 
    GLVPKKKQSV VQEKKQEEGA EIQCEAETGG THKRDFSEIK SQQCQGNELT RPSASSQEKS 
    SGKSQDVQRE SEPLREKVTQ LLPQNVHSHN SISKPQKGGP LNKEYTNWEA KETKAKDGPS 
    IQATQKSLPQ GHFQERPETH SVPAPGGPAA QAAPAAPGLS LGEGREAATS SDDEEEDDVV 
    FVSSKPGSPL LFDSTLDLET KENLQFPDRS VQRKVSPASG VSKKVEPSDP VARRVYLTTQ 
    LKQKKSTLAS VNIQALPDKG QKLIKQIQEL EEVLSGLTLS PEQGTNEKSN SQVPQQSHFT 
    KTTTGPPHLV PPQPLPRRGT QPVGSLELKS ACQVTAGGSS QCYRGHTNQD HVHAVWKITS 
    EAIGQLHRSL ESCPGETVVA EDPAGLKVPL LLHQKQALAW LLWRESQKPQ GGILADDMGL 
    GKTLTMIALI LTQKNQEKKE EKEKSTALTW LSKDDSCDFT SHGTLIICPA SLIHHWKNEV 
    EKRVNSNKLR VYLYHGPNRD SRARVLSTYD IVITTYSLVA KEIPTNKQEA EIPGANLNVE 
    GTSTPLLRIA WARIILDEAH NVKNPRVQTS IAVCKLQACA RWAVTGTPIQ NNLLDMYSLL 
    KFLRCSPFDE FNLWRSQVDN GSKKGGERLS ILTKSLLLRR TKDQLDSTGR PLVILPQRKF 
    QLHHLKLSED EETVYNVFFA RSRSALQSYL KRHESRGNQS GRSPNNPFSR VALEFGSEEP 
    RHSEAADSPR SSTVHILSQL LRLRQCCCHL SLLKSALDPM ELKGEGLVLS LEEQLSALTL 
    SELRDSEPSS TVSLNGTFFK MELFEGMRES TKISSLLAEL EAIQRNSASQ KSVIVSQWTN 
    MLKVVALHLK KHGLTYATID GSVNPKQRMD LVEAFNHSRG PQVMLISLLA GGVGLNLTGG 
    NHLFLLDMHW NPSLEDQACD RIYRVGQQKD VVIHRFVCEG TVEEKILQLQ EKKKDLAKQV 
    LSGSGESVTK LTLADLRVLF GI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.