Gene CDC42BPA - ENSG00000143776 | NCBI Gene ID: 8476

Details for: CDC42BPA

Gene ID: 8476

Symbol: CDC42BPA

Ensembl ID: ENSG00000143776

Description: CDC42 binding protein kinase alpha

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Rac1 gtpase cycle
(R-HSA-9013149)
Rho gtpase cycle
(R-HSA-9012999)
Rhoj gtpase cycle
(R-HSA-9013409)
Rhoq gtpase cycle
(R-HSA-9013406)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton organization
(GO:0030036)
Actomyosin
(GO:0042641)
Actomyosin structure organization
(GO:0031032)
Atp binding
(GO:0005524)
Cell-cell junction
(GO:0005911)
Cell leading edge
(GO:0031252)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Lamellipodium
(GO:0030027)
Magnesium ion binding
(GO:0000287)
Peptidyl-threonine phosphorylation
(GO:0018107)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.6
Marker Score: 188993
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 5.44
Marker Score: 18235
Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.2
Marker Score: 5646.5
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.09
Marker Score: 21461
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.93
Marker Score: 4753
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.76
Marker Score: 17410
Cell Name: granule cell (CL0000120)
Fold Change: 3.57
Marker Score: 26945
Cell Name: stellate neuron (CL0000122)
Fold Change: 3.56
Marker Score: 19120
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.56
Marker Score: 6847
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.4
Marker Score: 7463.5
Cell Name: macroglial cell (CL0000126)
Fold Change: 3.37
Marker Score: 7751
Cell Name: contractile cell (CL0000183)
Fold Change: 3.37
Marker Score: 1827
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.29
Marker Score: 3135
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.26
Marker Score: 3751
Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.22
Marker Score: 4016
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.2
Marker Score: 7651
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.16
Marker Score: 13208
Cell Name: CNS interneuron (CL0000402)
Fold Change: 3.1
Marker Score: 1488
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.09
Marker Score: 68955
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.07
Marker Score: 12814
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.99
Marker Score: 9807.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.99
Marker Score: 63712.5
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.9
Marker Score: 1689.5
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.83
Marker Score: 56217
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.81
Marker Score: 2167
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.78
Marker Score: 1659
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.78
Marker Score: 41502
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 2.76
Marker Score: 2079
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.76
Marker Score: 1612.5
Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.73
Marker Score: 788
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.72
Marker Score: 20841
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.68
Marker Score: 101724
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.66
Marker Score: 1491
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.63
Marker Score: 1463
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.61
Marker Score: 1517
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.61
Marker Score: 827
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.6
Marker Score: 7418
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.58
Marker Score: 814
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.57
Marker Score: 1783
Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.55
Marker Score: 1680
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.55
Marker Score: 3707
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.55
Marker Score: 10569
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.54
Marker Score: 1340
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.52
Marker Score: 4233
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.49
Marker Score: 1044
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.47
Marker Score: 1278.5
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.47
Marker Score: 1650
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.4
Marker Score: 88640
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.35
Marker Score: 5881
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.31
Marker Score: 676
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.3
Marker Score: 40801
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.28
Marker Score: 8123
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.28
Marker Score: 3208
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.28
Marker Score: 8808
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.17
Marker Score: 20375
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.14
Marker Score: 1058
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.14
Marker Score: 1895
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.13
Marker Score: 2635
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.12
Marker Score: 814
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.11
Marker Score: 2274
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 2.1
Marker Score: 762
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.07
Marker Score: 127170
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.05
Marker Score: 523
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.04
Marker Score: 2184
Cell Name: podocyte (CL0000653)
Fold Change: 2.01
Marker Score: 743
Cell Name: lactocyte (CL0002325)
Fold Change: 2
Marker Score: 32095
Cell Name: neuron (CL0000540)
Fold Change: 2
Marker Score: 8126
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.99
Marker Score: 517
Cell Name: fat cell (CL0000136)
Fold Change: 1.97
Marker Score: 1101
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.97
Marker Score: 20300
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.93
Marker Score: 6863
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.93
Marker Score: 1666
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.91
Marker Score: 18160
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.91
Marker Score: 522
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.88
Marker Score: 2275
Cell Name: astrocyte (CL0000127)
Fold Change: 1.86
Marker Score: 1614
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.86
Marker Score: 15967
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.79
Marker Score: 1179
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.69
Marker Score: 1715
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.65
Marker Score: 863
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.63
Marker Score: 405
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.63
Marker Score: 2029
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.62
Marker Score: 2506
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.59
Marker Score: 596
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.58
Marker Score: 10189
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.56
Marker Score: 1185
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.56
Marker Score: 1762
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.52
Marker Score: 2156
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.51
Marker Score: 8117
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.47
Marker Score: 465
Cell Name: secretory cell (CL0000151)
Fold Change: 1.46
Marker Score: 2656
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.45
Marker Score: 531
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.45
Marker Score: 1192
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.45
Marker Score: 6237.5
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.44
Marker Score: 1596
Cell Name: acinar cell (CL0000622)
Fold Change: 1.43
Marker Score: 1011
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.43
Marker Score: 394
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.43
Marker Score: 3370
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.41
Marker Score: 479.5
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.4
Marker Score: 520

Hover over a box to see details here...

**Key Characteristics:** 1. **Cellular localization:** CDC42BPA is predominantly expressed in Purkinje cells, neuronal brush cells, anterior lens cells, and various immune cells, including inhibitory interneurons, granule cells, and kidney interstitial fibroblasts. 2. **Protein kinase activity:** CDC42BPA is a serine/threonine kinase that phosphorylates specific amino acid residues, thereby modulating protein function and signaling. 3. **GTPase cycle regulation:** CDC42BPA interacts with Rho GTPases, modulating their activity and influencing cytoskeleton organization, cell migration, and signaling. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** CDC42BPA regulates the organization of the actin cytoskeleton, which is essential for cell migration, adhesion, and shape changes. 2. **Rho GTPase cycle:** CDC42BPA modulates the activity of Rho GTPases, influencing their downstream signaling pathways, including cytoskeleton organization, cell migration, and cell proliferation. 3. **Cell migration:** CDC42BPA plays a critical role in regulating immune cell migration, particularly in the context of tissue inflammation and immune responses. 4. **Signaling by Rho GTPases:** CDC42BPA interacts with Rho GTPases, modulating their signaling pathways, which are essential for immune cell function, including migration, proliferation, and differentiation. **Clinical Significance:** 1. **Immune cell migration disorders:** Alterations in CDC42BPA expression or function may contribute to immune cell migration disorders, such as leukocyte adhesion deficiency or immune-related inflammatory diseases. 2. **Cancer progression:** CDC42BPA may be involved in the regulation of cancer cell migration and invasion, highlighting its potential as a therapeutic target in cancer therapy. 3. **Neurological disorders:** CDC42BPA expression and function may be altered in neurological disorders, such as Parkinson's disease or multiple sclerosis, suggesting its potential as a biomarker or therapeutic target. 4. **Regulation of immune responses:** CDC42BPA may play a role in regulating immune responses, including the activation and regulation of immune cells, such as T cells and B cells. In conclusion, CDC42BPA is a critical regulator of immune cell migration, cytoskeleton organization, and signaling pathways. Further research is necessary to fully elucidate its role in immune cell function and its potential applications in immunotherapy and disease treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein kinase MRCK alpha

Genular Protein ID: 1685480209

Symbol: MRCKA_HUMAN

Name: Serine/threonine-protein kinase MRCK alpha

UniProtKB Accession Codes:

Q5VT25 O75039 Q59GZ1 Q5H9N9 Q5T797 Q5VT26 Q5VT27 Q86XX2 Q86XX3 Q99646

Database IDs:

Citations:

PubMed ID: 15723050

Title: Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion.

PubMed ID: 15723050

DOI: 10.1038/ncb1230

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 9092543

Title: Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.

PubMed ID: 9092543

DOI: 10.1074/jbc.272.15.10013

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 9418861

Title: Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.

PubMed ID: 9418861

DOI: 10.1128/mcb.18.1.130

PubMed ID: 11399775

Title: Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.

PubMed ID: 11399775

DOI: 10.1074/jbc.m102615200

PubMed ID: 11340065

Title: Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.

PubMed ID: 11340065

DOI: 10.1074/jbc.c100196200

PubMed ID: 11283256

Title: Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha.

PubMed ID: 11283256

DOI: 10.1128/mcb.21.8.2767-2778.2001

PubMed ID: 12568720

Title: Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity.

PubMed ID: 12568720

DOI: 10.1016/s0378-1119(02)01185-x

PubMed ID: 18854160

Title: A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.

PubMed ID: 18854160

DOI: 10.1016/j.cell.2008.09.018

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20188707

Title: Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake.

PubMed ID: 20188707

DOI: 10.1016/j.bbrc.2010.02.148

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21457715

Title: Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.

PubMed ID: 21457715

DOI: 10.1016/j.febslet.2011.03.054

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29162624

Title: MRCKalpha is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.

PubMed ID: 29162624

DOI: 10.1083/jcb.201703044

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1732
Mass: 197307
Checksum: 48B10F81B5405A0A
Sequence:

MSGEVRLRQL EQFILDGPAQ TNGQCFSVET LLDILICLYD ECNNSPLRRE KNILEYLEWA 
KPFTSKVKQM RLHREDFEIL KVIGRGAFGE VAVVKLKNAD KVFAMKILNK WEMLKRAETA 
CFREERDVLV NGDNKWITTL HYAFQDDNNL YLVMDYYVGG DLLTLLSKFE DRLPEDMARF 
YLAEMVIAID SVHQLHYVHR DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT 
PDYISPEILQ AMEDGKGRYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER 
FQFPAQVTDV SENAKDLIRR LICSREHRLG QNGIEDFKKH PFFSGIDWDN IRNCEAPYIP 
EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV GFTYTSSCVL SDRSCLRVTA 
GPTSLDLDVN VQRTLDNNLA TEAYERRIKR LEQEKLELSR KLQESTQTVQ ALQYSTVDGP 
LTASKDLEIK NLKEEIEKLR KQVTESSHLE QQLEEANAVR QELDDAFRQI KAYEKQIKTL 
QQEREDLNKE LVQASERLKN QSKELKDAHC QRKLAMQEFM EINERLTELH TQKQKLARHV 
RDKEEEVDLV MQKVESLRQE LRRTERAKKE LEVHTEALAA EASKDRKLRE QSEHYSKQLE 
NELEGLKQKQ ISYSPGVCSI EHQQEITKLK TDLEKKSIFY EEELSKREGI HANEIKNLKK 
ELHDSEGQQL ALNKEIMILK DKLEKTRRES QSEREEFESE FKQQYEREKV LLTEENKKLT 
SELDKLTTLY ENLSIHNQQL EEEVKDLADK KESVAHWEAQ ITEIIQWVSD EKDARGYLQA 
LASKMTEELE ALRNSSLGTR ATDMPWKMRR FAKLDMSARL ELQSALDAEI RAKQAIQEEL 
NKVKASNIIT ECKLKDSEKK NLELLSEIEQ LIKDTEELRS EKGIEHQDSQ HSFLAFLNTP 
TDALDQFERS PSCTPASKGR RTVDSTPLSV HTPTLRKKGC PGSTGFPPKR KTHQFFVKSF 
TTPTKCHQCT SLMVGLIRQG CSCEVCGFSC HITCVNKAPT TCPVPPEQTK GPLGIDPQKG 
IGTAYEGHVR IPKPAGVKKG WQRALAIVCD FKLFLYDIAE GKASQPSVVI SQVIDMRDEE 
FSVSSVLASD VIHASRKDIP CIFRVTASQL SASNNKCSIL MLADTENEKN KWVGVLSELH 
KILKKNKFRD RSVYVPKEAY DSTLPLIKTT QAAAIIDHER IALGNEEGLF VVHVTKDEII 
RVGDNKKIHQ IELIPNDQLV AVISGRNRHV RLFPMSALDG RETDFYKLSE TKGCQTVTSG 
KVRHGALTCL CVAMKRQVLC YELFQSKTRH RKFKEIQVPY NVQWMAIFSE QLCVGFQSGF 
LRYPLNGEGN PYSMLHSNDH TLSFIAHQPM DAICAVEISS KEYLLCFNSI GIYTDCQGRR 
SRQQELMWPA NPSSCCYNAP YLSVYSENAV DIFDVNSMEW IQTLPLKKVR PLNNEGSLNL 
LGLETIRLIY FKNKMAEGDE LVVPETSDNS RKQMVRNINN KRRYSFRVPE EERMQQRREM 
LRDPEMRNKL ISNPTNFNHI AHMGPGDGIQ ILKDLPMNPR PQESRTVFSG SVSIPSITKS 
RPEPGRSMSA SSGLSARSSA QNGSALKREF SGGSYSAKRQ PMPSPSEGSL SSGGMDQGSD 
APARDFDGED SDSPRHSTAS NSSNLSSPPS PASPRKTKSL SLESTDRGSW DP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CDC42BPA

Associated with

Cells (max top 100)

Other Information

Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. PubMed ID: 15723050

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. PubMed ID: 9092543

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. PubMed ID: 9455484

Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. PubMed ID: 9418861

Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. PubMed ID: 11399775

Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. PubMed ID: 11340065

Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. PubMed ID: 11283256

Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity. PubMed ID: 12568720

A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. PubMed ID: 18854160

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake. PubMed ID: 20188707

Initial characterization of the human central proteome. PubMed ID: 21269460

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. PubMed ID: 21457715

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

MRCKalpha is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion. PubMed ID: 29162624

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846