Details for: GEMIN2

Gene ID: 8487

Symbol: GEMIN2

Ensembl ID: ENSG00000092208

Description: gem nuclear organelle associated protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.7050
    Cell Significance Index: -11.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.7980
    Cell Significance Index: -11.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.8818
    Cell Significance Index: -14.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9128
    Cell Significance Index: -13.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5616
    Cell Significance Index: -12.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5529
    Cell Significance Index: -14.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9009
    Cell Significance Index: -8.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1830
    Cell Significance Index: 192.4100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0652
    Cell Significance Index: 17.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9181
    Cell Significance Index: 55.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8219
    Cell Significance Index: 742.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4781
    Cell Significance Index: 55.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4093
    Cell Significance Index: 28.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3721
    Cell Significance Index: 10.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3596
    Cell Significance Index: 72.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3426
    Cell Significance Index: 21.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2898
    Cell Significance Index: 3.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2647
    Cell Significance Index: 144.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2289
    Cell Significance Index: 6.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2239
    Cell Significance Index: 4.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2167
    Cell Significance Index: 95.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2164
    Cell Significance Index: 4.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2068
    Cell Significance Index: 28.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1992
    Cell Significance Index: 5.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1917
    Cell Significance Index: 6.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1891
    Cell Significance Index: 18.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1791
    Cell Significance Index: 21.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1679
    Cell Significance Index: 116.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1564
    Cell Significance Index: 56.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1450
    Cell Significance Index: 28.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1040
    Cell Significance Index: 18.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0980
    Cell Significance Index: 3.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0923
    Cell Significance Index: 6.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0749
    Cell Significance Index: 9.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0714
    Cell Significance Index: 8.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0709
    Cell Significance Index: 10.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0685
    Cell Significance Index: 3.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0659
    Cell Significance Index: 12.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0633
    Cell Significance Index: 3.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0590
    Cell Significance Index: 1.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0421
    Cell Significance Index: 1.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0404
    Cell Significance Index: 1.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0325
    Cell Significance Index: 0.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0185
    Cell Significance Index: 0.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0154
    Cell Significance Index: 0.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0090
    Cell Significance Index: 0.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0085
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0074
    Cell Significance Index: 14.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0013
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -3.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0098
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0130
    Cell Significance Index: -5.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0188
    Cell Significance Index: -0.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0241
    Cell Significance Index: -13.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0243
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0249
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0256
    Cell Significance Index: -16.0100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0356
    Cell Significance Index: -0.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0356
    Cell Significance Index: -3.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0361
    Cell Significance Index: -0.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0387
    Cell Significance Index: -2.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0396
    Cell Significance Index: -11.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0417
    Cell Significance Index: -5.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0517
    Cell Significance Index: -5.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0518
    Cell Significance Index: -1.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0565
    Cell Significance Index: -2.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0650
    Cell Significance Index: -4.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0876
    Cell Significance Index: -2.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0877
    Cell Significance Index: -1.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0884
    Cell Significance Index: -6.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0931
    Cell Significance Index: -1.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1052
    Cell Significance Index: -3.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1240
    Cell Significance Index: -7.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1266
    Cell Significance Index: -13.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1470
    Cell Significance Index: -11.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1594
    Cell Significance Index: -4.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1643
    Cell Significance Index: -4.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1645
    Cell Significance Index: -3.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1646
    Cell Significance Index: -4.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1703
    Cell Significance Index: -3.7300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1708
    Cell Significance Index: -1.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2227
    Cell Significance Index: -2.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2364
    Cell Significance Index: -5.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2729
    Cell Significance Index: -8.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2777
    Cell Significance Index: -4.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2790
    Cell Significance Index: -9.1400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2802
    Cell Significance Index: -4.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2905
    Cell Significance Index: -8.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3018
    Cell Significance Index: -2.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3094
    Cell Significance Index: -10.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3116
    Cell Significance Index: -3.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GEMIN2 is a nuclear protein that interacts with other components of the spliceosomal complex, influencing RNA splicing and processing. It is also involved in the assembly of gemini of coiled bodies (GCBs), which are unique nuclear structures that play a role in regulating RNA metabolism and transcription. GEMIN2 has been shown to interact with other proteins, including Smn protein complex components, to regulate RNA binding and translation. **Pathways and Functions** GEMIN2 is involved in various cellular pathways, including: 1. **RNA Splicing**: GEMIN2 interacts with the spliceosomal complex to regulate RNA splicing and processing. 2. **Translation Regulation**: GEMIN2 modulates host translation machinery in response to viral infections, including SARS-CoV-2. 3. **Viral Infection Pathways**: GEMIN2 is involved in the regulation of viral infection pathways, including SARS-CoV-2-host interactions. 4. **Gemini of Coiled Bodies (GCBs) Assembly**: GEMIN2 plays a role in the assembly of GCBs, which are unique nuclear structures involved in regulating RNA metabolism and transcription. **Clinical Significance** The study of GEMIN2 has implications for our understanding of various diseases, including: 1. **SARS-CoV-2 Infection**: GEMIN2's role in modulating host translation machinery in response to SARS-CoV-2 infection highlights its potential as a therapeutic target for treating COVID-19. 2. **RNA-Related Diseases**: GEMIN2's involvement in RNA splicing and processing suggests its potential as a therapeutic target for diseases related to RNA metabolism, such as muscular dystrophy and myotonic dystrophy. 3. **Cancer**: GEMIN2's expression in various cell types, including extravillous trophoblasts and immune cells, suggests its potential as a biomarker for cancer diagnosis and prognosis. 4. **Neurological Disorders**: GEMIN2's expression in cerebral cortex GABAergic interneurons highlights its potential as a therapeutic target for neurological disorders, such as epilepsy and Alzheimer's disease. In conclusion, GEMIN2 is a nuclear protein involved in various cellular processes, including RNA splicing, translation regulation, and viral infection pathways. Its clinical significance is underscored by its potential as a therapeutic target for treating SARS-CoV-2 infection, RNA-related diseases, cancer, and neurological disorders. Further research is needed to fully elucidate the functions and clinical significance of GEMIN2.

Genular Protein ID: 3133218870

Symbol: GEMI2_HUMAN

Name: Gem-associated protein 2

UniProtKB Accession Codes:

O14893 B2R9W8 Q2M3B3 Q9H4F5 Q9NS77 Q9NS78 Q9NS79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9323129

Title: The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.

PubMed ID: 9323129

DOI: 10.1016/s0092-8674(00)80367-0

PubMed ID: 11943600

Title: Increased expression level of the splicing variant of SIP1 in motor neuron diseases.

PubMed ID: 11943600

DOI: 10.1016/s1357-2725(01)00150-9

PubMed ID: 10909848

Title: An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA).

PubMed ID: 10909848

DOI: 10.1038/sj.ejhg.5200479

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11714716

Title: Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.

PubMed ID: 11714716

DOI: 10.1074/jbc.m109448200

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 17178713

Title: A comprehensive interaction map of the human survival of motor neuron (SMN) complex.

PubMed ID: 17178713

DOI: 10.1074/jbc.m608528200

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23022347

Title: The survival motor neuron protein forms soluble glycine zipper oligomers.

PubMed ID: 23022347

DOI: 10.1016/j.str.2012.08.024

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26092730

Title: Oligomeric Properties of Survival Motor Neuron.Gemin2 Complexes.

PubMed ID: 26092730

DOI: 10.1074/jbc.m115.667279

PubMed ID: 21816274

Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.

PubMed ID: 21816274

DOI: 10.1016/j.cell.2011.06.043

PubMed ID: 22607171

Title: Solution structure of the core SMN-Gemin2 complex.

PubMed ID: 22607171

DOI: 10.1042/bj20120241

PubMed ID: 31799625

Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.

PubMed ID: 31799625

DOI: 10.1093/nar/gkz1135

Sequence Information:

  • Length: 280
  • Mass: 31585
  • Checksum: 3232F410EA98EB81
  • Sequence:
    • MRRAELAGLK TMAWVPAESA VEELMPRLLP VEPCDLTEGF DPSVPPRTPQ EYLRRVQIEA 
AQCPDVVVAQ IDPKKLKRKQ SVNISLSGCQ PAPEGYSPTL QWQQQQVAQF STVRQNVNKH 
RSHWKSQQLD SNVTMPKSED EEGWKKFCLG EKLCADGAVG PATNESPGID YVQIGFPPLL 
SIVSRMNQAT VTSVLEYLSN WFGERDFTPE LGRWLYALLA CLEKPLLPEA HSLIRQLARR 
CSEVRLLVDS KDDERVPALN LLICLVSRYF DQRDLADEPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.