Details for: API5

Gene ID: 8539

Symbol: API5

Ensembl ID: ENSG00000166181

Description: apoptosis inhibitor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.1417
    Cell Significance Index: -30.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 130.6165
    Cell Significance Index: -33.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 85.8483
    Cell Significance Index: -35.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.9895
    Cell Significance Index: -30.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.6310
    Cell Significance Index: -35.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.0995
    Cell Significance Index: -34.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.1134
    Cell Significance Index: -30.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.4033
    Cell Significance Index: -35.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7513
    Cell Significance Index: -31.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3615
    Cell Significance Index: -31.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1357
    Cell Significance Index: -36.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0159
    Cell Significance Index: -15.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.4796
    Cell Significance Index: 443.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8924
    Cell Significance Index: 1708.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7007
    Cell Significance Index: 102.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6894
    Cell Significance Index: 23.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3931
    Cell Significance Index: 279.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3275
    Cell Significance Index: 215.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0389
    Cell Significance Index: 27.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9292
    Cell Significance Index: 184.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8078
    Cell Significance Index: 45.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7141
    Cell Significance Index: 128.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6852
    Cell Significance Index: 84.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5714
    Cell Significance Index: 204.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5125
    Cell Significance Index: 35.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4916
    Cell Significance Index: 57.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4752
    Cell Significance Index: 13.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4429
    Cell Significance Index: 241.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4317
    Cell Significance Index: 20.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4247
    Cell Significance Index: 187.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3833
    Cell Significance Index: 25.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3462
    Cell Significance Index: 7.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3363
    Cell Significance Index: 46.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3178
    Cell Significance Index: 20.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2949
    Cell Significance Index: 13.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2734
    Cell Significance Index: 14.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2400
    Cell Significance Index: 18.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2216
    Cell Significance Index: 9.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2085
    Cell Significance Index: 12.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1947
    Cell Significance Index: 10.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1936
    Cell Significance Index: 36.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1827
    Cell Significance Index: 6.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1821
    Cell Significance Index: 31.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1649
    Cell Significance Index: 11.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0867
    Cell Significance Index: 3.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0753
    Cell Significance Index: 141.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0734
    Cell Significance Index: 2.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0554
    Cell Significance Index: 0.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0520
    Cell Significance Index: 6.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0506
    Cell Significance Index: 1.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0428
    Cell Significance Index: 27.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0337
    Cell Significance Index: 0.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0334
    Cell Significance Index: 2.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0256
    Cell Significance Index: 0.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0240
    Cell Significance Index: 3.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0176
    Cell Significance Index: 27.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0156
    Cell Significance Index: 28.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0137
    Cell Significance Index: 0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0128
    Cell Significance Index: 5.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0048
    Cell Significance Index: 0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0153
    Cell Significance Index: -0.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0189
    Cell Significance Index: -14.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0277
    Cell Significance Index: -1.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0378
    Cell Significance Index: -21.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0406
    Cell Significance Index: -1.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0432
    Cell Significance Index: -4.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0495
    Cell Significance Index: -5.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0534
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1020
    Cell Significance Index: -11.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1024
    Cell Significance Index: -2.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1082
    Cell Significance Index: -15.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1082
    Cell Significance Index: -31.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1905
    Cell Significance Index: -21.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1973
    Cell Significance Index: -3.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2198
    Cell Significance Index: -2.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2440
    Cell Significance Index: -7.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2836
    Cell Significance Index: -29.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2844
    Cell Significance Index: -6.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2893
    Cell Significance Index: -6.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3147
    Cell Significance Index: -6.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3212
    Cell Significance Index: -25.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3616
    Cell Significance Index: -3.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4144
    Cell Significance Index: -6.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4738
    Cell Significance Index: -29.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5048
    Cell Significance Index: -12.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6251
    Cell Significance Index: -19.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6341
    Cell Significance Index: -20.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6695
    Cell Significance Index: -21.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6700
    Cell Significance Index: -14.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6722
    Cell Significance Index: -14.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6850
    Cell Significance Index: -10.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6945
    Cell Significance Index: -14.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7261
    Cell Significance Index: -10.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7337
    Cell Significance Index: -18.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** API5 is a member of the antiapoptosis protein family, which is characterized by its ability to inhibit apoptosis and promote cell survival. The gene is primarily expressed in the brain, where it is involved in the regulation of neuronal growth and development. API5 has been shown to interact with other proteins, including spliceosomal complex components, which suggests its involvement in RNA processing and cellular regulation. **Pathways and Functions** API5 is involved in several cellular pathways, including: 1. **Negative regulation of apoptotic process**: API5 inhibits apoptosis by interacting with pro-apoptotic proteins and promoting the expression of anti-apoptotic genes. 2. **Negative regulation of fibroblast apoptotic process**: API5 regulates apoptosis in fibroblasts, suggesting its role in maintaining tissue homeostasis. 3. **Fibroblast growth factor binding**: API5 interacts with fibroblast growth factor (FGF) receptors, which suggests its involvement in regulating cellular growth and differentiation. 4. **Protein binding**: API5 interacts with various proteins, including spliceosomal complex components, which suggests its role in RNA processing and cellular regulation. **Clinical Significance** The clinical significance of API5 is still unclear, but its expression in various neuronal and non-neuronal cells suggests its potential role in neurodegenerative diseases and other conditions characterized by altered apoptosis and cellular growth. Some potential clinical applications of API5 include: 1. **Neuroprotection**: API5 may serve as a target for neuroprotective therapies aimed at preventing or treating neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer therapy**: API5 may be involved in cancer cell survival and apoptosis, suggesting its potential role as a target for cancer therapy. 3. **Regenerative medicine**: API5 may play a role in tissue repair and regeneration, suggesting its potential application in regenerative medicine. In conclusion, API5 is a gene that encodes a protein involved in the regulation of apoptosis and cellular growth. Its expression in various neuronal and non-neuronal cells suggests its potential role in neurodegenerative diseases and other conditions characterized by altered apoptosis and cellular growth. Further research is needed to fully understand the clinical significance of API5 and its potential applications in medicine.

Genular Protein ID: 2078202284

Symbol: API5_HUMAN

Name: Antiapoptosis clone 11 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9307294

Title: AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal.

PubMed ID: 9307294

PubMed ID: 10393420

Title: Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene.

PubMed ID: 10393420

DOI: 10.1159/000015247

PubMed ID: 11075807

Title: FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2.

PubMed ID: 11075807

DOI: 10.1210/mend.14.11.0556

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8889549

Title: Generation and analysis of 280,000 human expressed sequence tags.

PubMed ID: 8889549

DOI: 10.1101/gr.6.9.807

PubMed ID: 10780674

Title: AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis.

PubMed ID: 10780674

DOI: 10.1038/labinvest.3780063

PubMed ID: 11557113

Title: Expression of the antiapoptosis gene, AAC-11, as a prognosis marker in non-small cell lung cancer.

PubMed ID: 11557113

DOI: 10.1016/s0169-5002(01)00213-6

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17112319

Title: Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.

PubMed ID: 17112319

DOI: 10.1371/journal.pgen.0020196

PubMed ID: 17827341

Title: The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up-regulated in B cell chronic lymphoid leukemia.

PubMed ID: 17827341

DOI: 10.1189/jlb.0607425

PubMed ID: 19387494

Title: The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation.

PubMed ID: 19387494

DOI: 10.1038/emboj.2009.106

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 22334682

Title: Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.

PubMed ID: 22334682

DOI: 10.1074/jbc.m111.317594

Sequence Information:

  • Length: 524
  • Mass: 59005
  • Checksum: A2EA6BE4D8318BB9
  • Sequence:
  • MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA 
    DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA 
    LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK 
    KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ 
    CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM 
    EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF 
    LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN 
    INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRASEDT TSGSPPKKSS AGPKRDARQI 
    YNPPSGKYSS NLGNFNYEQR GAFRGSRGGR GWGTRGNRSR GRLY

Genular Protein ID: 2661738722

Symbol: B4DDR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 331
  • Mass: 37508
  • Checksum: D6E3EC7C3DDAFCB9
  • Sequence:
  • MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA 
    DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA 
    LLSIFKMEKL ETNLRKLFDK LLEYMPLPPE EAENGENAGN EEPKLQFSYV ECLLYSFHQL 
    GRKLPDFLTA KLNAEKLKDF KIRLQYFARG LQVYIRQLRL ALQGKTGEAL KTEENKIKVV 
    ALKITNNINV LIKDLFHIPP SYKSTVTLSW KPVQKVEIGQ KRASEDTTSG SPPKKSSAGP 
    KRDARQIYNP PSGKYSSNLG NFNYERSLQG K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.