Details for: AP3B1

Gene ID: 8546

Symbol: AP3B1

Ensembl ID: ENSG00000132842

Description: adaptor related protein complex 3 subunit beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 385.3220
    Cell Significance Index: -59.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 230.3234
    Cell Significance Index: -58.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 131.7392
    Cell Significance Index: -53.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.8579
    Cell Significance Index: -60.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 94.2592
    Cell Significance Index: -63.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.1198
    Cell Significance Index: -53.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.2492
    Cell Significance Index: -61.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.9664
    Cell Significance Index: -58.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.1152
    Cell Significance Index: -55.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.2211
    Cell Significance Index: -37.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.7981
    Cell Significance Index: -62.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7178
    Cell Significance Index: 152.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5332
    Cell Significance Index: 49.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1711
    Cell Significance Index: 430.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6511
    Cell Significance Index: 331.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4490
    Cell Significance Index: 19.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.3635
    Cell Significance Index: 29.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2576
    Cell Significance Index: 96.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1353
    Cell Significance Index: 30.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0584
    Cell Significance Index: 29.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8346
    Cell Significance Index: 577.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8225
    Cell Significance Index: 148.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7177
    Cell Significance Index: 257.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7167
    Cell Significance Index: 88.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6569
    Cell Significance Index: 45.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5697
    Cell Significance Index: 16.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5322
    Cell Significance Index: 11.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5003
    Cell Significance Index: 4.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4336
    Cell Significance Index: 391.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4283
    Cell Significance Index: 6.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4116
    Cell Significance Index: 19.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3566
    Cell Significance Index: 23.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3553
    Cell Significance Index: 194.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2854
    Cell Significance Index: 12.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2557
    Cell Significance Index: 35.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2383
    Cell Significance Index: 105.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2126
    Cell Significance Index: 400.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1952
    Cell Significance Index: 31.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1833
    Cell Significance Index: 6.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1680
    Cell Significance Index: 6.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1576
    Cell Significance Index: 242.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1560
    Cell Significance Index: 287.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1258
    Cell Significance Index: 57.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1232
    Cell Significance Index: 78.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1088
    Cell Significance Index: 6.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0840
    Cell Significance Index: 114.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0716
    Cell Significance Index: 8.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0698
    Cell Significance Index: 13.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0570
    Cell Significance Index: 9.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0523
    Cell Significance Index: 2.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0242
    Cell Significance Index: 2.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0111
    Cell Significance Index: -0.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0320
    Cell Significance Index: -1.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0397
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0406
    Cell Significance Index: -30.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0490
    Cell Significance Index: -30.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0499
    Cell Significance Index: -7.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0661
    Cell Significance Index: -50.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0735
    Cell Significance Index: -41.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0932
    Cell Significance Index: -6.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0938
    Cell Significance Index: -4.8800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0940
    Cell Significance Index: -1.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1166
    Cell Significance Index: -5.4800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1290
    Cell Significance Index: -2.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1364
    Cell Significance Index: -13.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1709
    Cell Significance Index: -36.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1806
    Cell Significance Index: -23.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1879
    Cell Significance Index: -54.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2192
    Cell Significance Index: -11.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2727
    Cell Significance Index: -7.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3032
    Cell Significance Index: -39.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3759
    Cell Significance Index: -43.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3777
    Cell Significance Index: -26.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3782
    Cell Significance Index: -43.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3977
    Cell Significance Index: -41.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4686
    Cell Significance Index: -9.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5054
    Cell Significance Index: -54.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5368
    Cell Significance Index: -40.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5608
    Cell Significance Index: -64.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5663
    Cell Significance Index: -5.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5757
    Cell Significance Index: -14.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6216
    Cell Significance Index: -49.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6505
    Cell Significance Index: -3.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7766
    Cell Significance Index: -47.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8203
    Cell Significance Index: -51.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8646
    Cell Significance Index: -12.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9077
    Cell Significance Index: -47.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9220
    Cell Significance Index: -32.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9949
    Cell Significance Index: -28.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0023
    Cell Significance Index: -16.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0150
    Cell Significance Index: -27.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0416
    Cell Significance Index: -30.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0832
    Cell Significance Index: -30.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0889
    Cell Significance Index: -29.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1062
    Cell Significance Index: -26.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.1241
    Cell Significance Index: -18.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1430
    Cell Significance Index: -16.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1783
    Cell Significance Index: -25.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2864
    Cell Significance Index: -40.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AP3B1 is a member of the AP-3 adaptor protein complex, which is composed of three subunits: beta 1, mu 2, and gamma 2. The AP-3 complex plays a central role in the regulation of protein trafficking, including the transport of proteins between the cell surface and the endoplasmic reticulum (ER), Golgi apparatus, and lysosomes. AP3B1 is specifically involved in the regulation of protein localization to the cell surface, endosomes, and lysosomes, and is also implicated in the regulation of protein degradation and antigen processing. **Pathways and Functions** AP3B1 is involved in a wide range of cellular processes, including: 1. **Protein trafficking**: AP3B1 is involved in the transport of proteins between the cell surface and the ER, Golgi apparatus, and lysosomes. 2. **Antigen processing and presentation**: AP3B1 is involved in the regulation of antigen processing and presentation by major histocompatibility complex (MHC) class I and II molecules. 3. **Cell signaling**: AP3B1 is involved in the regulation of cell signaling pathways, including those involving growth factor receptors and second messengers. 4. **Inflammatory response**: AP3B1 is involved in the regulation of the inflammatory response, including the transport of pro-inflammatory and anti-inflammatory cytokines. 5. **Cell differentiation and development**: AP3B1 is involved in the regulation of cell differentiation and development, including the differentiation of hematopoietic progenitor cells and the development of the nervous system. **Clinical Significance** Dysregulation of AP3B1 has been implicated in various diseases, including: 1. **Neurodegenerative diseases**: AP3B1 has been implicated in the regulation of protein trafficking and aggregation in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Immunological disorders**: AP3B1 is involved in the regulation of antigen processing and presentation, and dysregulation of AP3B1 has been implicated in immunological disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: AP3B1 is involved in the regulation of cell signaling and protein trafficking, and dysregulation of AP3B1 has been implicated in the development and progression of cancer. 4. **Neurodevelopmental disorders**: AP3B1 is involved in the regulation of cell differentiation and development, and dysregulation of AP3B1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, AP3B1 is a multifaceted adaptor protein involved in various cellular processes, including protein trafficking, antigen processing and presentation, and cell signaling. Dysregulation of AP3B1 has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis and normal physiological processes. Further research is needed to fully elucidate the role of AP3B1 in human disease and to develop therapeutic strategies for the treatment of AP3B1-related disorders.

Genular Protein ID: 572145882

Symbol: AP3B1_HUMAN

Name: AP-3 complex subunit beta-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9151686

Title: Characterization of the adaptor-related protein complex, AP-3.

PubMed ID: 9151686

DOI: 10.1083/jcb.137.4.835

PubMed ID: 9182526

Title: Beta3A-adaptin, a subunit of the adaptor-like complex AP-3.

PubMed ID: 9182526

DOI: 10.1074/jbc.272.24.15078

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19934039

Title: Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release.

PubMed ID: 19934039

DOI: 10.1073/pnas.0909176106

PubMed ID: 10024875

Title: Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor.

PubMed ID: 10024875

DOI: 10.1016/s1097-2765(00)80170-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 1094
  • Mass: 121320
  • Checksum: AC683CE18EF90555
  • Sequence:
  • MSSNSFPYNE QSGGGEATEL GQEATSTISP SGAFGLFSSD LKKNEDLKQM LESNKDSAKL 
    DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV YLVRYAEEQQ DLALLSISTF 
    QRALKDPNQL IRASALRVLS SIRVPIIVPI MMLAIKEASA DLSPYVRKNA AHAIQKLYSL 
    DPEQKEMLIE VIEKLLKDKS TLVAGSVVMA FEEVCPDRID LIHKNYRKLC NLLVDVEEWG 
    QVVIIHMLTR YARTQFVSPW KEGDELEDNG KNFYESDDDQ KEKTDKKKKP YTMDPDHRLL 
    IRNTKPLLQS RNAAVVMAVA QLYWHISPKS EAGIISKSLV RLLRSNREVQ YIVLQNIATM 
    SIQRKGMFEP YLKSFYVRST DPTMIKTLKL EILTNLANEA NISTLLREFQ TYVKSQDKQF 
    AAATIQTIGR CATNILEVTD TCLNGLVCLL SNRDEIVVAE SVVVIKKLLQ MQPAQHGEII 
    KHMAKLLDSI TVPVARASIL WLIGENCERV PKIAPDVLRK MAKSFTSEDD LVKLQILNLG 
    AKLYLTNSKQ TKLLTQYILN LGKYDQNYDI RDRTRFIRQL IVPNVKSGAL SKYAKKIFLA 
    QKPAPLLESP FKDRDHFQLG TLSHTLNIKA TGYLELSNWP EVAPDPSVRN VEVIELAKEW 
    TPAGKAKQEN SAKKFYSESE EEEDSSDSSS DSESESGSES GEQGESGEEG DSNEDSSEDS 
    SSEQDSESGR ESGLENKRTA KRNSKAKGKS DSEDGEKENE KSKTSDSSND ESSSIEDSSS 
    DSESESEPES ESESRRVTKE KEKKTKQDRT PLTKDVSLLD LDDFNPVSTP VALPTPALSP 
    SLMADLEGLH LSTSSSVISV STPAFVPTKT HVLLHRMSGK GLAAHYFFPR QPCIFGDKMV 
    SIQITLNNTT DRKIENIHIG EKKLPIGMKM HVFNPIDSLE PEGSITVSMG IDFCDSTQTA 
    SFQLCTKDDC FNVNIQPPVG ELLLPVAMSE KDFKKEQGVL TGMNETSAVI IAAPQNFTPS 
    VIFQKVVNVA NVGAVPSGQD NIHRFAAKTV HSGSLMLVTV ELKEGSTAQL IINTEKTVIG 
    SVLLRELKPV LSQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.