AP3B1 | ENSG00000132842 | NCBI 8546

Details for: AP3B1

Gene ID: 8546

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: AP3B1

Ensembl ID: ENSG00000132842

Description: adaptor related protein complex 3 subunit beta 1

Cell Significance Landscape

Display Count:

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Golgi associated vesicle biogenesis
(R-HSA-432722)
Membrane trafficking
(R-HSA-199991)
Oncogenic mapk signaling
(R-HSA-6802957)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Trans-golgi network vesicle budding
(R-HSA-199992)
Anterograde axonal transport
(GO:0008089)
Anterograde synaptic vesicle transport
(GO:0048490)
Antigen processing and presentation, exogenous lipid antigen via mhc class ib
(GO:0048007)
Ap-3 adaptor complex
(GO:0030123)
Axon cytoplasm
(GO:1904115)
Blood coagulation
(GO:0007596)
Cell morphogenesis
(GO:0000902)
Clathrin-coated vesicle cargo loading, ap-3-mediated
(GO:0035654)
Clathrin-coated vesicle membrane
(GO:0030665)
Clathrin adaptor complex
(GO:0030131)
Early endosome
(GO:0005769)
Establishment of protein localization to mitochondrial membrane involved in mitochondrial fission
(GO:0090152)
Golgi apparatus
(GO:0005794)
Granulocyte differentiation
(GO:0030851)
Gtp-dependent protein binding
(GO:0030742)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Homeostasis of number of cells
(GO:0048872)
Inflammatory response
(GO:0006954)
Intracellular protein transport
(GO:0006886)
Intracellular transport
(GO:0046907)
Intracellular zinc ion homeostasis
(GO:0006882)
Lung morphogenesis
(GO:0060425)
Lysosomal membrane
(GO:0005765)
Lysosome organization
(GO:0007040)
Melanosome assembly
(GO:1903232)
Melanosome organization
(GO:0032438)
Membrane
(GO:0016020)
Microvesicle
(GO:1990742)
Mitochondrion
(GO:0005739)
Mrna transcription by rna polymerase ii
(GO:0042789)
Platelet dense granule organization
(GO:0060155)
Positive regulation of nk t cell differentiation
(GO:0051138)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Protein modification process
(GO:0036211)
Protein phosphatase binding
(GO:0019903)
Protein targeting to lysosome
(GO:0006622)
Respiratory system process
(GO:0003016)
Single fertilization
(GO:0007338)
Skin epidermis development
(GO:0098773)
Spermatogenesis
(GO:0007283)
Toll-like receptor signaling pathway
(GO:0002224)
Vesicle-mediated transport
(GO:0016192)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

lung secretory cell CL1000272

CSI 23.87

rCSI 59.08%

PRS 32.71
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 20.96

rCSI 35.86%

PRS 55.47
Hofbauer cell CL3000001

CSI 17.12

rCSI 32.33%

PRS 43.19
perivascular cell CL4033054

CSI 17.12

rCSI 23.4%

PRS 38.46
glioblast CL0000030

CSI 15.21

rCSI 24.26%

PRS 29.56
blood vessel endothelial cell CL0000071

CSI 12.72

rCSI 26.4%

PRS 33.44
renal alpha-intercalated cell CL0005011

CSI 12.68

rCSI 16.96%

PRS 41.96
Kupffer cell CL0000091

CSI 10.09

rCSI 23.07%

PRS 33.96
kidney connecting tubule epithelial cell CL1000768

CSI 9.8

rCSI 24.85%

PRS 26.97
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 9.7

rCSI 25.07%

PRS 31.64
double negative thymocyte CL0002489

CSI 9.27

rCSI 6.45%

PRS 41.4
renal beta-intercalated cell CL0002201

CSI 9.07

rCSI 21.62%

PRS 37.51
sst GABAergic cortical interneuron CL4023017

CSI 8.87

rCSI 11.43%

PRS 22.71
chondrocyte CL0000138

CSI 8.69

rCSI 13.81%

PRS 29.18
pro-B cell CL0000826

CSI 8.22

rCSI 6.81%

PRS 35.11
early lymphoid progenitor CL0000936

CSI 8.11

rCSI 7.12%

PRS 39.04
multi-ciliated epithelial cell CL0005012

CSI 7.56

rCSI 7.55%

PRS 29.63
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 7.25

rCSI 26.11%

PRS 20.93
fallopian tube secretory epithelial cell CL4030006

CSI 6.63

rCSI 6.38%

PRS 35.24
paneth cell CL0000510

CSI 6.56

rCSI 9.68%

PRS 50.66
mononuclear phagocyte CL0000113

CSI 6.56

rCSI 14.43%

PRS 38.27
retinal ganglion cell CL0000740

CSI 6.53

rCSI 14.43%

PRS 25.24
blood vessel smooth muscle cell CL0019018

CSI 6.37

rCSI 51.84%

PRS 31.07
intestine goblet cell CL0019031

CSI 6.36

rCSI 5.64%

PRS 34.03
helper T cell CL0000912

CSI 5.99

rCSI 8.47%

PRS 44.19
small intestine goblet cell CL1000495

CSI 5.71

rCSI 12.5%

PRS 44
group 3 innate lymphoid cell CL0001071

CSI 5.69

rCSI 4.28%

PRS 37.09
intermediate monocyte CL0002393

CSI 5.66

rCSI 8.54%

PRS 35.69
CD4-positive, alpha-beta memory T cell CL0000897

CSI 5.65

rCSI 4.06%

PRS 45.85
adipocyte CL0000136

CSI 5.46

rCSI 7.01%

PRS 32.24
lung pericyte CL0009089

CSI 5.04

rCSI 13.31%

PRS 40.68
radial glial cell CL0000681

CSI 4.7

rCSI 6.53%

PRS 34.54
extravillous trophoblast CL0008036

CSI 4.57

rCSI 5.65%

PRS 30.84
alveolar macrophage CL0000583

CSI 4.55

rCSI 7.49%

PRS 39.36
enteric smooth muscle cell CL0002504

CSI 4.52

rCSI 6.45%

PRS 36.98
transit amplifying cell of colon CL0009011

CSI 4.4

rCSI 5.16%

PRS 38.06
ciliated cell CL0000064

CSI 4.37

rCSI 7.08%

PRS 33.73
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 4.29

rCSI 10.43%

PRS 21.33
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 4.26

rCSI 25.1%

PRS 23.08
naive B cell CL0000788

CSI 4.2

rCSI 3.61%

PRS 44.99
inhibitory interneuron CL0000498

CSI 4.01

rCSI 9.26%

PRS 28.52
retinal rod cell CL0000604

CSI 3.96

rCSI 6.97%

PRS 33.56
brush cell of tracheobronchial tree CL0002075

CSI 3.8

rCSI 11.28%

PRS 45.04
myeloid leukocyte CL0000766

CSI 3.66

rCSI 3.37%

PRS 35.58
neuroendocrine cell CL0000165

CSI 3.63

rCSI 14.04%

PRS 54.67
goblet cell CL0000160

CSI 3.52

rCSI 3.32%

PRS 35.58
retinal pigment epithelial cell CL0002586

CSI 3.51

rCSI 6.96%

PRS 34.56
lung macrophage CL1001603

CSI 3.48

rCSI 7.77%

PRS 40.03
Mueller cell CL0000636

CSI 3.4

rCSI 7.77%

PRS 29.67
lymphoid lineage restricted progenitor cell CL0000838

CSI 3.38

rCSI 13.15%

PRS 53.53
neuroblast (sensu Vertebrata) CL0000031

CSI 3.34

rCSI 4.28%

PRS 32.93
pvalb GABAergic cortical interneuron CL4023018

CSI 3.33

rCSI 4.14%

PRS 20.68
enteroendocrine cell CL0000164

CSI 3.28

rCSI 4.48%

PRS 37.15
interstitial cell of Cajal CL0002088

CSI 3.28

rCSI 4.18%

PRS 39.05
small pre-B-II cell CL0000954

CSI 3.24

rCSI 3.11%

PRS 58.83
endothelial cell of vascular tree CL0002139

CSI 3.22

rCSI 17.62%

PRS 41.31
mucosal invariant T cell CL0000940

CSI 3.13

rCSI 2.53%

PRS 46.09
placental villous trophoblast CL2000060

CSI 3.12

rCSI 4.82%

PRS 32.66
parietal epithelial cell CL1000452

CSI 2.99

rCSI 7.98%

PRS 29.24
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.93

rCSI 2.23%

PRS 44.17
vascular leptomeningeal cell CL4023051

CSI 2.92

rCSI 5.12%

PRS 27.94
direct pathway medium spiny neuron CL4023026

CSI 2.91

rCSI 69.71%

PRS 21.42
indirect pathway medium spiny neuron CL4023029

CSI 2.9

rCSI 69.96%

PRS 22.23
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.84

rCSI 4.03%

PRS 32.15
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.82

rCSI 2.77%

PRS 48.86
mesodermal cell CL0000222

CSI 2.71

rCSI 3.26%

PRS 33.05
unswitched memory B cell CL0000970

CSI 2.6

rCSI 2.19%

PRS 50.63
ON midget ganglion cell CL4033046

CSI 2.59

rCSI 52.77%

PRS 29.27
plasmacytoid dendritic cell, human CL0001058

CSI 2.59

rCSI 1.81%

PRS 36.16
hepatic stellate cell CL0000632

CSI 2.57

rCSI 9.63%

PRS 29.32
regular ventricular cardiac myocyte CL0002131

CSI 2.55

rCSI 15.9%

PRS 28.45
ependymal cell CL0000065

CSI 2.54

rCSI 5.15%

PRS 20.58
rod bipolar cell CL0000751

CSI 2.53

rCSI 4.55%

PRS 29.16
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.51

rCSI 2.9%

PRS 30.16
retinal bipolar neuron CL0000748

CSI 2.5

rCSI 4.68%

PRS 26.23
ciliated epithelial cell CL0000067

CSI 2.5

rCSI 2.2%

PRS 25.63
granulocyte monocyte progenitor cell CL0000557

CSI 2.44

rCSI 2.12%

PRS 37.99
monocyte CL0000576

CSI 2.43

rCSI 4.39%

PRS 60.63
neural crest cell CL0011012

CSI 2.42

rCSI 1.92%

PRS 24.39
hematopoietic stem cell CL0000037

CSI 2.39

rCSI 1.59%

PRS 38.79
cerebellar granule cell CL0001031

CSI 2.39

rCSI 3.51%

PRS 31.97
renal principal cell CL0005009

CSI 2.37

rCSI 6.16%

PRS 40.5
retinal blood vessel endothelial cell CL0002585

CSI 2.37

rCSI 3.78%

PRS 37.38
alpha-beta T cell CL0000789

CSI 2.33

rCSI 2.73%

PRS 47.63
naive T cell CL0000898

CSI 2.31

rCSI 1.61%

PRS 46.16
glutamatergic neuron CL0000679

CSI 2.31

rCSI 4.75%

PRS 31.67
respiratory suprabasal cell CL4033048

CSI 2.3

rCSI 2.95%

PRS 38.8
Langerhans cell CL0000453

CSI 2.3

rCSI 3.51%

PRS 52.03
epithelial cell of proximal tubule CL0002306

CSI 2.29

rCSI 5.6%

PRS 32.1
skeletal muscle satellite cell CL0000594

CSI 2.28

rCSI 6.68%

PRS 68.41
myeloid dendritic cell CL0000782

CSI 2.27

rCSI 3.29%

PRS 49.51
mature T cell CL0002419

CSI 2.22

rCSI 1.73%

PRS 49.3
kidney distal convoluted tubule epithelial cell CL1000849

CSI 2.22

rCSI 23.53%

PRS 38.12
amacrine cell CL0000561

CSI 2.21

rCSI 6.41%

PRS 27.76
hematopoietic precursor cell CL0008001

CSI 2.21

rCSI 2.27%

PRS 51.03
stromal cell CL0000499

CSI 2.21

rCSI 6.22%

PRS 37.51
stem cell CL0000034

CSI 2.2

rCSI 2.12%

PRS 26.59
S cone cell CL0003050

CSI 2.19

rCSI 9.61%

PRS 32.47
astrocyte of the cerebral cortex CL0002605

CSI 2.18

rCSI 4.9%

PRS 22.5
IgA plasma cell CL0000987

CSI 2.17

rCSI 2.22%

PRS 53.23

medium spiny neuron CL1001474

CSI 0.1

rCSI 1.0%

PRS 23.5%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.0%

PRS 46.7%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.2

rCSI 1.0%

PRS 58.0%
erythroid progenitor cell CL0000038

CSI 0.2

rCSI 1.3%

PRS 45.6%
mesangial cell CL0000650

CSI 0.2

rCSI 1.0%

PRS 46.1%
ON parasol ganglion cell CL4033052

CSI 0.3

rCSI 4.3%

PRS 28.9%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.3

rCSI 3.6%

PRS 70.9%
pancreatic stellate cell CL0002410

CSI 0.4

rCSI 2.2%

PRS 45.9%
colon macrophage CL0009038

CSI 0.4

rCSI 1.7%

PRS 57.8%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.4

rCSI 1.0%

PRS 26.1%
cardiac blood vessel endothelial cell CL0010006

CSI 0.5

rCSI 3.5%

PRS 31.4%
intestinal crypt stem cell of colon CL0009043

CSI 0.5

rCSI 3.7%

PRS 54.9%
diffuse bipolar 1 cell CL4033027

CSI 0.5

rCSI 3.7%

PRS 32.9%
tracheal goblet cell CL1000329

CSI 0.5

rCSI 1.1%

PRS 55.1%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.5

rCSI 1.2%

PRS 33.9%
pancreatic PP cell CL0002275

CSI 0.5

rCSI 2.1%

PRS 50.3%
invaginating midget bipolar cell CL4033034

CSI 0.6

rCSI 3.3%

PRS 33.9%
mesenchymal cell CL0008019

CSI 0.6

rCSI 1.5%

PRS 32.3%
IgG plasma cell CL0000985

CSI 0.6

rCSI 0.7%

PRS 53.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.6

rCSI 1.8%

PRS 24.8%
follicular B cell CL0000843

CSI 0.6

rCSI 2.1%

PRS 72.1%
retina horizontal cell CL0000745

CSI 0.6

rCSI 0.9%

PRS 32.0%
regular atrial cardiac myocyte CL0002129

CSI 0.6

rCSI 1.9%

PRS 34.8%
squamous epithelial cell CL0000076

CSI 0.6

rCSI 1.4%

PRS 40.1%
podocyte CL0000653

CSI 0.6

rCSI 2.7%

PRS 33.2%
large pre-B-II cell CL0000957

CSI 0.6

rCSI 1.7%

PRS 49.8%
diffuse bipolar 3b cell CL4033030

CSI 0.6

rCSI 4.1%

PRS 34.5%
enteroglial cell CL4040002

CSI 0.6

rCSI 3.3%

PRS 45.2%
pancreatic ductal cell CL0002079

CSI 0.6

rCSI 1.2%

PRS 35.8%
luminal epithelial cell of mammary gland CL0002326

CSI 0.7

rCSI 1.2%

PRS 49.7%
foveolar cell of stomach CL0002179

CSI 0.7

rCSI 1.5%

PRS 49.4%
GABAergic amacrine cell CL4030027

CSI 0.7

rCSI 2.4%

PRS 29.0%
transit amplifying cell of small intestine CL0009012

CSI 0.7

rCSI 3.2%

PRS 54.6%
lung ciliated cell CL1000271

CSI 0.7

rCSI 0.8%

PRS 26.2%
alveolar adventitial fibroblast CL4028006

CSI 0.8

rCSI 1.2%

PRS 35.1%
GABAergic neuron CL0000617

CSI 0.8

rCSI 2.6%

PRS 25.8%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 0.8

rCSI 6.7%

PRS 39.3%
type B pancreatic cell CL0000169

CSI 0.8

rCSI 1.7%

PRS 31.9%
retinal cone cell CL0000573

CSI 0.8

rCSI 1.3%

PRS 27.0%
kidney collecting duct intercalated cell CL1001432

CSI 0.8

rCSI 5.9%

PRS 44.0%
microcirculation associated smooth muscle cell CL0008035

CSI 0.9

rCSI 2.5%

PRS 37.3%
mucus secreting cell CL0000319

CSI 0.9

rCSI 1.4%

PRS 43.5%
respiratory basal cell CL0002633

CSI 0.9

rCSI 0.9%

PRS 39.8%
tracheobronchial smooth muscle cell CL0019019

CSI 0.9

rCSI 1.6%

PRS 42.7%
basophil CL0000767

CSI 0.9

rCSI 1.9%

PRS 56.5%
cardiac endothelial cell CL0010008

CSI 0.9

rCSI 3.7%

PRS 33.3%
colon goblet cell CL0009039

CSI 0.9

rCSI 2.2%

PRS 46.9%
glandular epithelial cell CL0000150

CSI 0.9

rCSI 2.5%

PRS 57.6%
macroglial cell CL0000126

CSI 1.0

rCSI 2.5%

PRS 39.0%
BEST4+ enteroycte CL4030026

CSI 1.0

rCSI 1.2%

PRS 36.8%
granulocyte CL0000094

CSI 1.0

rCSI 1.5%

PRS 42.7%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 1.0

rCSI 5.9%

PRS 60.9%
tissue-resident macrophage CL0000864

CSI 1.0

rCSI 4.6%

PRS 55.2%
dendritic cell, human CL0001056

CSI 1.0

rCSI 1.5%

PRS 40.5%
keratocyte CL0002363

CSI 1.0

rCSI 2.4%

PRS 45.3%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.0

rCSI 1.7%

PRS 21.9%
innate lymphoid cell CL0001065

CSI 1.0

rCSI 2.1%

PRS 43.2%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.0

rCSI 2.7%

PRS 67.1%
tuft cell of colon CL0009041

CSI 1.1

rCSI 2.4%

PRS 54.7%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.1

rCSI 4.0%

PRS 22.8%
neural progenitor cell CL0011020

CSI 1.1

rCSI 4.7%

PRS 29.8%
mature B cell CL0000785

CSI 1.1

rCSI 1.0%

PRS 42.5%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.1

rCSI 2.9%

PRS 43.1%
pulmonary alveolar type 2 cell CL0002063

CSI 1.1

rCSI 1.7%

PRS 45.0%
common lymphoid progenitor CL0000051

CSI 1.1

rCSI 1.5%

PRS 56.7%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.1

rCSI 1.0%

PRS 31.7%
elicited macrophage CL0000861

CSI 1.1

rCSI 1.0%

PRS 40.6%
diffuse bipolar 6 cell CL4033032

CSI 1.1

rCSI 5.9%

PRS 35.0%
common myeloid progenitor CL0000049

CSI 1.1

rCSI 0.9%

PRS 34.8%
paneth cell of epithelium of small intestine CL1000343

CSI 1.1

rCSI 3.2%

PRS 49.2%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.1

rCSI 0.7%

PRS 47.3%
enteroendocrine cell of small intestine CL0009006

CSI 1.2

rCSI 2.5%

PRS 48.6%
intestinal tuft cell CL0019032

CSI 1.2

rCSI 1.8%

PRS 38.7%
Schwann cell CL0002573

CSI 1.2

rCSI 3.4%

PRS 35.7%
tendon cell CL0000388

CSI 1.2

rCSI 3.1%

PRS 61.4%
alternatively activated macrophage CL0000890

CSI 1.2

rCSI 1.5%

PRS 47.7%
lung neuroendocrine cell CL1000223

CSI 1.2

rCSI 1.8%

PRS 38.7%
choroid plexus epithelial cell CL0000706

CSI 1.2

rCSI 2.0%

PRS 27.1%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.2

rCSI 2.2%

PRS 29.9%
central nervous system neuron CL2000029

CSI 1.2

rCSI 9.0%

PRS 24.5%
cardiac muscle cell CL0000746

CSI 1.2

rCSI 1.8%

PRS 27.5%
sncg GABAergic cortical interneuron CL4023015

CSI 1.2

rCSI 2.0%

PRS 23.8%
intrahepatic cholangiocyte CL0002538

CSI 1.3

rCSI 3.1%

PRS 52.0%
pulmonary artery endothelial cell CL1001568

CSI 1.3

rCSI 1.7%

PRS 46.9%
common dendritic progenitor CL0001029

CSI 1.3

rCSI 1.6%

PRS 43.2%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.3

rCSI 1.2%

PRS 48.8%
adventitial cell CL0002503

CSI 1.3

rCSI 3.2%

PRS 46.0%
epithelial cell of lower respiratory tract CL0002632

CSI 1.4

rCSI 1.1%

PRS 34.1%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.4

rCSI 1.6%

PRS 41.0%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.4

rCSI 3.9%

PRS 50.0%
fibroblast of cardiac tissue CL0002548

CSI 1.4

rCSI 6.6%

PRS 32.5%
acinar cell CL0000622

CSI 1.4

rCSI 2.0%

PRS 44.2%
contractile cell CL0000183

CSI 1.4

rCSI 4.2%

PRS 33.2%
endothelial cell of placenta CL0009092

CSI 1.4

rCSI 7.1%

PRS 44.7%
endocardial cell CL0002350

CSI 1.5

rCSI 6.9%

PRS 37.8%
immature B cell CL0000816

CSI 1.5

rCSI 1.1%

PRS 46.9%
promonocyte CL0000559

CSI 1.5

rCSI 2.5%

PRS 43.5%
basal cell CL0000646

CSI 1.5

rCSI 2.0%

PRS 36.3%
glycinergic amacrine cell CL4030028

CSI 1.5

rCSI 3.9%

PRS 34.7%
inflammatory macrophage CL0000863

CSI 1.5

rCSI 2.6%

PRS 60.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [AP3B1](/details-gene/8546) (adaptor related protein complex 3 subunit beta 1) is a protein-coding gene located on chromosome 5q14.1. It encodes the beta-1 subunit of the heterotetrameric Adaptor Protein complex 3 (AP-3). This complex is a critical component of the intracellular machinery responsible for vesicle-mediated transport, specifically in sorting cargo proteins from the trans-Golgi network and early endosomes to lysosomes and lysosome-related organelles like melanosomes and platelet dense granules [Link](https://doi.org/10.1083/jcb.137.4.835). Reflecting this fundamental role, [AP3B1](/details-gene/8546) shows significant expression in a wide range of cell types with high trafficking demands, including [lung secretory cell](/details-cell/CL1000272) and various immune cells such as [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049). Clinically, mutations in [AP3B1](/details-gene/8546) are associated with Hermansky-Pudlak syndrome type 2, a disorder characterized by oculocutaneous albinism, bleeding diathesis, and immunodeficiency, underscoring the gene's essential function in multiple physiological systems [Link](https://doi.org/10.1016/s1097-2765(00)80170-7). ## Cellular Roles and Expression Landscape The expression profile of [AP3B1](/details-gene/8546) highlights its integral function in cells with high secretory or specialized vesicular transport activities. **Overall**, the gene exhibits its highest significance in [lung secretory cell](/details-cell/CL1000272) (CSI: 23.87), consistent with its role in managing the trafficking of secreted proteins. Its importance extends broadly across the immune system, with high CSI values in both the adaptive and innate compartments, including [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049) (CSI: 20.96), placental macrophages known as [Hofbauer cell](/details-cell/CL3000001) (CSI: 17.12), and liver-resident macrophages, [Kupffer cell](/details-cell/CL0000091) (CSI: 10.09). This pattern suggests a crucial role in processes like cytotoxic granule release, antigen presentation, and phagocytosis. Furthermore, [AP3B1](/details-gene/8546) is significantly expressed in various specialized epithelial and endothelial cells, such as [blood vessel endothelial cell](/details-cell/CL0000071) and distinct populations of kidney tubule cells like [renal alpha-intercalated cell](/details-cell/CL0005011) and [kidney connecting tubule epithelial cell](/details-cell/CL1000768). This indicates its involvement in a wide array of physiological transport processes beyond immunity. Notably, the high significance in [glioblast](/details-cell/CL0000030), a type of brain tumor cell, suggests that its trafficking functions may also be co-opted in pathological states. ## Pathways and Molecular Function The functions of [AP3B1](/details-gene/8546) are centered on intracellular protein transport and vesicle trafficking, as detailed by its functional annotations. As a core component of the [AP-3 adaptor complex](/details-cell/GO:0030123), it participates directly in [Vesicle-mediated transport](/details-cell/R-HSA-5653656) and [Golgi associated vesicle biogenesis](/details-cell/R-HSA-432722). This machinery is essential for [Protein targeting to lysosome](/details-cell/GO:0006622) and the organization of lysosome-related organelles, including [Melanosome organization](/details-cell/GO:0032438) and [Platelet dense granule organization](/details-cell/GO:0060155). Its role in the immune system is further clarified by its involvement in [Antigen processing and presentation, exogenous lipid antigen via mhc class ib](/details-cell/GO:0048007) and the [Toll-like receptor signaling pathway](/details-cell/GO:0002224). These pathways are consistent with its high expression in professional antigen-presenting cells and lymphocytes. The Reactome pathway annotations also link [AP3B1](/details-gene/8546) to disease processes, including [Oncogenic mapk signaling](/details-cell/R-HSA-6802957), which may explain its significance in [glioblast](/details-cell/CL0000030) and suggests a potential role in cancer biology. ## Research Directions The data suggest that [AP3B1](/details-gene/8546) is a fundamental trafficking protein whose function is critical in both physiological and pathological contexts. Its high CSI in [glioblast](/details-cell/CL0000030) and connection to oncogenic signaling pathways point towards a potential role in tumorigenesis, which warrants further investigation. Based on the available data, several testable hypotheses can be proposed: 1. **Hypothesis 1:** Given its high significance in [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049), [AP3B1](/details-gene/8546) is essential for the proper trafficking and exocytosis of cytotoxic granules (containing perforin and granzymes), thereby directly regulating the anti-tumor and anti-viral efficacy of cytotoxic T lymphocytes. 2. **Hypothesis 2:** In [glioblast](/details-cell/CL0000030), the upregulation or altered function of [AP3B1](/details-gene/8546)-mediated trafficking contributes to tumor progression by enhancing the secretion of pro-angiogenic factors or by controlling the surface localization of critical growth factor receptors involved in oncogenic signaling. **Experimental Approach for Hypothesis 1:** To test the role of [AP3B1](/details-gene/8546) in T cell cytotoxicity, one could utilize a CRISPR-Cas9 system to knock out the gene in primary human CD8+ T cells. Following activation, these [AP3B1](/details-gene/8546)-deficient T cells could be co-cultured with target tumor cells in a cytotoxicity assay (e.g., chromium-release or flow cytometry-based killing assay). A significant reduction in killing capacity compared to control cells would support the hypothesis. Furthermore, confocal microscopy could be used to visualize the localization of lytic granules in response to target cell engagement, predicting a failure of these granules to polarize to the immunological synapse in knockout cells. **Therapeutic Potential:** As an intracellular protein essential for a fundamental cellular process, [AP3B1](/details-gene/8546) presents a challenging therapeutic target. Systemic inhibition would likely cause significant toxicity, mirroring the pleiotropic defects seen in Hermansky-Pudlak syndrome. However, if its role in glioblastoma is substantiated and found to be a key dependency, developing highly specific small molecule inhibitors capable of crossing the blood-brain barrier could represent a long-term therapeutic strategy. The goal would be **inhibition** to disrupt the pathological trafficking pathways that support tumor maintenance and growth.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AP-3 complex subunit beta-1

Genular Protein ID: 572145882

Symbol: AP3B1_HUMAN

Name: AP-3 complex subunit beta-1

UniProtKB Accession Codes:

O00203 E5RJ68 O00580 Q7Z393 Q9HD66

Database IDs:

Citations:

PubMed ID: 9151686

Title: Characterization of the adaptor-related protein complex, AP-3.

PubMed ID: 9151686

DOI: 10.1083/jcb.137.4.835

PubMed ID: 9182526

Title: Beta3A-adaptin, a subunit of the adaptor-like complex AP-3.

PubMed ID: 9182526

DOI: 10.1074/jbc.272.24.15078

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19934039

Title: Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release.

PubMed ID: 19934039

DOI: 10.1073/pnas.0909176106

PubMed ID: 10024875

Title: Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor.

PubMed ID: 10024875

DOI: 10.1016/s1097-2765(00)80170-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 1094
Mass: 121320
Checksum: AC683CE18EF90555
Sequence:

MSSNSFPYNE QSGGGEATEL GQEATSTISP SGAFGLFSSD LKKNEDLKQM LESNKDSAKL 
DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV YLVRYAEEQQ DLALLSISTF 
QRALKDPNQL IRASALRVLS SIRVPIIVPI MMLAIKEASA DLSPYVRKNA AHAIQKLYSL 
DPEQKEMLIE VIEKLLKDKS TLVAGSVVMA FEEVCPDRID LIHKNYRKLC NLLVDVEEWG 
QVVIIHMLTR YARTQFVSPW KEGDELEDNG KNFYESDDDQ KEKTDKKKKP YTMDPDHRLL 
IRNTKPLLQS RNAAVVMAVA QLYWHISPKS EAGIISKSLV RLLRSNREVQ YIVLQNIATM 
SIQRKGMFEP YLKSFYVRST DPTMIKTLKL EILTNLANEA NISTLLREFQ TYVKSQDKQF 
AAATIQTIGR CATNILEVTD TCLNGLVCLL SNRDEIVVAE SVVVIKKLLQ MQPAQHGEII 
KHMAKLLDSI TVPVARASIL WLIGENCERV PKIAPDVLRK MAKSFTSEDD LVKLQILNLG 
AKLYLTNSKQ TKLLTQYILN LGKYDQNYDI RDRTRFIRQL IVPNVKSGAL SKYAKKIFLA 
QKPAPLLESP FKDRDHFQLG TLSHTLNIKA TGYLELSNWP EVAPDPSVRN VEVIELAKEW 
TPAGKAKQEN SAKKFYSESE EEEDSSDSSS DSESESGSES GEQGESGEEG DSNEDSSEDS 
SSEQDSESGR ESGLENKRTA KRNSKAKGKS DSEDGEKENE KSKTSDSSND ESSSIEDSSS 
DSESESEPES ESESRRVTKE KEKKTKQDRT PLTKDVSLLD LDDFNPVSTP VALPTPALSP 
SLMADLEGLH LSTSSSVISV STPAFVPTKT HVLLHRMSGK GLAAHYFFPR QPCIFGDKMV 
SIQITLNNTT DRKIENIHIG EKKLPIGMKM HVFNPIDSLE PEGSITVSMG IDFCDSTQTA 
SFQLCTKDDC FNVNIQPPVG ELLLPVAMSE KDFKKEQGVL TGMNETSAVI IAAPQNFTPS 
VIFQKVVNVA NVGAVPSGQD NIHRFAAKTV HSGSLMLVTV ELKEGSTAQL IINTEKTVIG 
SVLLRELKPV LSQG

Details for: AP3B1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Characterization of the adaptor-related protein complex, AP-3. PubMed ID: 9151686

Beta3A-adaptin, a subunit of the adaptor-like complex AP-3. PubMed ID: 9182526

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release. PubMed ID: 19934039

Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. PubMed ID: 10024875

Initial characterization of the human central proteome. PubMed ID: 21269460