Details for: MAPKAPK5
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 30.94rCSI 54.83%PRS 38
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CSI 27.66rCSI 39.12%PRS 68.87
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CSI 26.89rCSI 32.58%PRS 50.57
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CSI 25rCSI 34.07%PRS 34.36
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CSI 20.2rCSI 32.97%PRS 33.9
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CSI 18.53rCSI 29.47%PRS 57.2
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CSI 11.51rCSI 17.02%PRS 70.04
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CSI 10.48rCSI 14.32%PRS 70.86
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CSI 9.69rCSI 11.2%PRS 55.15
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CSI 8.12rCSI 23.53%PRS 54.33
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CSI 7.3rCSI 10.42%PRS 66.76
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CSI 7.19rCSI 8.44%PRS 66.92
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CSI 6.36rCSI 7.6%PRS 46.01
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CSI 6.12rCSI 35.06%PRS 73.44
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CSI 5.48rCSI 4.87%PRS 62.65
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CSI 5.05rCSI 14.98%PRS 74.4
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CSI 4.95rCSI 2.92%PRS 81.96
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CSI 4.73rCSI 5.67%PRS 62.91
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CSI 4.62rCSI 28.84%PRS 56.56
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CSI 4.35rCSI 7.66%PRS 61.34
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CSI 4.18rCSI 4.03%PRS 55.64
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CSI 4.13rCSI 5.67%PRS 83.36
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CSI 4.02rCSI 9.59%PRS 65.4
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CSI 3.92rCSI 2.72%PRS 76
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CSI 3.78rCSI 15.24%PRS 63.73
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CSI 3.75rCSI 3.55%PRS 64.11
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CSI 3.7rCSI 8.98%PRS 44.66
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CSI 3.27rCSI 7.33%PRS 46.92
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CSI 3.24rCSI 4.76%PRS 58.05
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CSI 3.23rCSI 2.39%PRS 57.38
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CSI 3.22rCSI 3.21%PRS 58.15
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CSI 3.01rCSI 3.22%PRS 64.58
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CSI 2.98rCSI 4.08%PRS 57.86
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CSI 2.98rCSI 2.26%PRS 77.84
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CSI 2.97rCSI 5.34%PRS 58
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CSI 2.89rCSI 9.67%PRS 49.63
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CSI 2.84rCSI 3.54%PRS 44.37
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CSI 2.81rCSI 4.6%PRS 53.87
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CSI 2.78rCSI 2.3%PRS 67.2
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CSI 2.7rCSI 5.43%PRS 53.79
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CSI 2.66rCSI 7.85%PRS 67.51
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CSI 2.64rCSI 2.22%PRS 81.3
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CSI 2.6rCSI 5.76%PRS 62.93
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CSI 2.54rCSI 5.79%PRS 56.4
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CSI 2.52rCSI 20.46%PRS 58.06
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CSI 2.49rCSI 3.2%PRS 61.71
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CSI 2.48rCSI 2.6%PRS 68.32
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CSI 2.47rCSI 2.43%PRS 67.56
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CSI 2.46rCSI 6.42%PRS 64.53
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CSI 2.39rCSI 4.22%PRS 45.3
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CSI 2.36rCSI 56.5%PRS 45.26
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CSI 2.31rCSI 1.83%PRS 51.63
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CSI 2.3rCSI 2.26%PRS 80.43
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CSI 2.29rCSI 1.9%PRS 64.23
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CSI 2.27rCSI 4.71%PRS 61.9
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CSI 2.22rCSI 1.65%PRS 78.06
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CSI 2.22rCSI 2.6%PRS 80.77
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CSI 2.22rCSI 2.57%PRS 73.67
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CSI 2.21rCSI 1.93%PRS 73.85
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CSI 2.18rCSI 2.65%PRS 72.24
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CSI 2.17rCSI 52.48%PRS 46.06
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CSI 2.17rCSI 2.51%PRS 57.64
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CSI 2.13rCSI 2.95%PRS 63.19
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CSI 2.1rCSI 3.63%PRS 54.89
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CSI 2.08rCSI 7.8%PRS 56.65
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CSI 2.07rCSI 2.93%PRS 61.19
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CSI 2.06rCSI 9.07%PRS 54.86
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CSI 2.04rCSI 2.73%PRS 73.69
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CSI 2rCSI 1.39%PRS 67.5
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CSI 1.98rCSI 4.38%PRS 50.75
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CSI 1.96rCSI 4.85%PRS 63.33
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CSI 1.95rCSI 3.42%PRS 56.79
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CSI 1.95rCSI 3.49%PRS 63.99
-
CSI 1.93rCSI 3.07%PRS 57.09
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CSI 1.91rCSI 1.54%PRS 66.29
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CSI 1.91rCSI 2.15%PRS 80.89
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CSI 1.9rCSI 7.23%PRS 55.31
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CSI 1.89rCSI 4.88%PRS 59.83
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CSI 1.88rCSI 6.78%PRS 44.51
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CSI 1.83rCSI 1.41%PRS 65.53
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CSI 1.79rCSI 6.97%PRS 84.11
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CSI 1.77rCSI 1.33%PRS 70.41
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CSI 1.74rCSI 2.08%PRS 83.59
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CSI 1.71rCSI 1.15%PRS 78.01
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CSI 1.71rCSI 1.78%PRS 62.7
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CSI 1.68rCSI 1.3%PRS 67.27
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CSI 1.68rCSI 3.83%PRS 64.79
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CSI 1.67rCSI 1.5%PRS 61.71
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CSI 1.66rCSI 1.7%PRS 77.05
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CSI 1.64rCSI 2.5%PRS 61.23
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CSI 1.62rCSI 2.09%PRS 47.47
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CSI 1.61rCSI 2.31%PRS 67.74
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CSI 1.61rCSI 5.02%PRS 47.87
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CSI 1.58rCSI 2.31%PRS 69.82
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CSI 1.55rCSI 1.36%PRS 52.69
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CSI 1.53rCSI 1.6%PRS 61.16
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CSI 1.51rCSI 8.89%PRS 47.34
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CSI 1.5rCSI 1.86%PRS 61.45
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CSI 1.5rCSI 2.04%PRS 56.38
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CSI 1.5rCSI 1.88%PRS 75.2
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CSI 0.3rCSI 1.4%PRS 77.3%
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CSI 0.6rCSI 2.7%PRS 64.7%
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CSI 0.6rCSI 1.7%PRS 55.8%
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CSI 0.8rCSI 1.2%PRS 69.0%
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CSI 0.8rCSI 2.4%PRS 50.3%
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CSI 0.8rCSI 2.0%PRS 73.2%
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CSI 1.0rCSI 0.9%PRS 75.5%
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CSI 1.0rCSI 2.2%PRS 72.5%
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CSI 1.0rCSI 2.6%PRS 54.2%
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CSI 1.2rCSI 8.5%PRS 51.3%
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CSI 1.2rCSI 4.4%PRS 46.9%
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CSI 1.2rCSI 1.9%PRS 48.2%
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CSI 1.2rCSI 2.3%PRS 52.9%
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CSI 1.3rCSI 2.0%PRS 54.3%
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CSI 1.3rCSI 2.1%PRS 46.2%
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CSI 1.5rCSI 3.0%PRS 65.2%
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CSI 1.5rCSI 2.4%PRS 68.9%
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CSI 1.5rCSI 1.9%PRS 75.2%
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CSI 1.5rCSI 2.0%PRS 56.4%
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CSI 1.5rCSI 1.9%PRS 61.5%
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CSI 1.5rCSI 8.9%PRS 47.3%
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CSI 1.5rCSI 1.6%PRS 61.2%
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CSI 1.6rCSI 1.4%PRS 52.7%
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CSI 1.6rCSI 2.3%PRS 69.8%
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CSI 1.6rCSI 5.0%PRS 47.9%
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CSI 1.6rCSI 2.3%PRS 67.7%
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CSI 1.6rCSI 2.1%PRS 47.5%
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CSI 1.6rCSI 2.5%PRS 61.2%
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CSI 1.7rCSI 1.7%PRS 77.1%
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CSI 1.7rCSI 1.5%PRS 61.7%
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CSI 1.7rCSI 3.8%PRS 64.8%
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CSI 1.7rCSI 1.3%PRS 67.3%
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CSI 1.7rCSI 1.8%PRS 62.7%
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CSI 1.7rCSI 1.2%PRS 78.0%
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CSI 1.7rCSI 2.1%PRS 83.6%
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CSI 1.8rCSI 1.3%PRS 70.4%
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CSI 1.8rCSI 7.0%PRS 84.1%
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CSI 1.8rCSI 1.4%PRS 65.5%
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CSI 1.9rCSI 6.8%PRS 44.5%
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CSI 1.9rCSI 4.9%PRS 59.8%
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CSI 1.9rCSI 7.2%PRS 55.3%
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CSI 1.9rCSI 2.2%PRS 80.9%
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CSI 1.9rCSI 1.5%PRS 66.3%
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CSI 1.9rCSI 3.1%PRS 57.1%
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CSI 2.0rCSI 3.5%PRS 64.0%
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CSI 2.0rCSI 3.4%PRS 56.8%
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CSI 2.0rCSI 4.9%PRS 63.3%
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CSI 2.0rCSI 4.4%PRS 50.8%
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CSI 2.0rCSI 1.4%PRS 67.5%
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CSI 2.0rCSI 2.7%PRS 73.7%
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CSI 2.1rCSI 9.1%PRS 54.9%
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CSI 2.1rCSI 2.9%PRS 61.2%
-
CSI 2.1rCSI 7.8%PRS 56.7%
-
CSI 2.1rCSI 3.6%PRS 54.9%
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CSI 2.1rCSI 3.0%PRS 63.2%
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CSI 2.2rCSI 2.5%PRS 57.6%
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CSI 2.2rCSI 52.5%PRS 46.1%
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CSI 2.2rCSI 2.7%PRS 72.2%
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CSI 2.2rCSI 1.9%PRS 73.9%
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CSI 2.2rCSI 2.6%PRS 73.7%
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CSI 2.2rCSI 2.6%PRS 80.8%
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CSI 2.2rCSI 1.7%PRS 78.1%
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CSI 2.3rCSI 4.7%PRS 61.9%
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CSI 2.3rCSI 1.9%PRS 64.2%
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CSI 2.3rCSI 2.3%PRS 80.4%
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CSI 2.3rCSI 1.8%PRS 51.6%
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CSI 2.4rCSI 56.5%PRS 45.3%
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CSI 2.4rCSI 4.2%PRS 45.3%
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CSI 2.5rCSI 6.4%PRS 64.5%
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CSI 2.5rCSI 2.4%PRS 67.6%
-
CSI 2.5rCSI 2.6%PRS 68.3%
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CSI 2.5rCSI 3.2%PRS 61.7%
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CSI 2.5rCSI 20.5%PRS 58.1%
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CSI 2.5rCSI 5.8%PRS 56.4%
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CSI 2.6rCSI 5.8%PRS 62.9%
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CSI 2.6rCSI 2.2%PRS 81.3%
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CSI 2.7rCSI 7.9%PRS 67.5%
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CSI 2.7rCSI 5.4%PRS 53.8%
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CSI 2.8rCSI 2.3%PRS 67.2%
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CSI 2.8rCSI 4.6%PRS 53.9%
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CSI 2.8rCSI 3.5%PRS 44.4%
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CSI 2.9rCSI 9.7%PRS 49.6%
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CSI 3.0rCSI 5.3%PRS 58.0%
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CSI 3.0rCSI 2.3%PRS 77.8%
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CSI 3.0rCSI 4.1%PRS 57.9%
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CSI 3.0rCSI 3.2%PRS 64.6%
-
CSI 3.2rCSI 3.2%PRS 58.2%
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CSI 3.2rCSI 2.4%PRS 57.4%
-
CSI 3.2rCSI 4.8%PRS 58.1%
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CSI 3.3rCSI 7.3%PRS 46.9%
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CSI 3.7rCSI 9.0%PRS 44.7%
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CSI 3.8rCSI 3.6%PRS 64.1%
-
CSI 3.8rCSI 15.2%PRS 63.7%
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CSI 3.9rCSI 2.7%PRS 76.0%
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CSI 4.0rCSI 9.6%PRS 65.4%
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CSI 4.1rCSI 5.7%PRS 83.4%
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CSI 4.2rCSI 4.0%PRS 55.6%
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CSI 4.4rCSI 7.7%PRS 61.3%
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CSI 4.6rCSI 28.8%PRS 56.6%
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CSI 4.7rCSI 5.7%PRS 62.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 649870493
Symbol: MAPK5_HUMAN
Name: MAP kinase-activated protein kinase 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9628874
Title: PRAK, a novel protein kinase regulated by the p38 MAP kinase.
PubMed ID: 9628874
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 10708586
PubMed ID: 12808055
Title: Regulation of PRAK subcellular location by p38 MAP kinases.
PubMed ID: 12808055
PubMed ID: 17728103
Title: 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization.
PubMed ID: 17728103
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19166925
Title: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.
PubMed ID: 19166925
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 17254968
Title: PRAK is essential for ras-induced senescence and tumor suppression.
PubMed ID: 17254968
PubMed ID: 21329882
Title: The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.
PubMed ID: 21329882
PubMed ID: 20227494
Title: Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: menage a trois or menage a quatre?
PubMed ID: 20227494
PubMed ID: 33442026
Title: Biallelic truncating variants in MAPKAPK5 cause a new developmental disorder involving neurological, cardiac, and facial anomalies combined with synpolydactyly.
PubMed ID: 33442026
Sequence Information:
- Length: 473
- Mass: 54220
- Checksum: F3D9DDC83CC0C49D
- Sequence:
MSEESDMDKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF TEKQASQVTK QIALALRHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKIDQGDL MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP FYSKHHSRTI PKDMRRKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL RKRKLLGTKP KDSVYIHDHE NGAEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ EAWKYNRECK LLRDTLQSFS WNGRGFTDKV DRLKLAEIVK QVIEEQTTSH ESQ