Details for: MAPKAPK5

Gene ID: 8550

Symbol: MAPKAPK5

Ensembl ID: ENSG00000089022

Description: MAPK activated protein kinase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.0085
    Cell Significance Index: -36.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.9242
    Cell Significance Index: -37.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.0822
    Cell Significance Index: -39.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.7186
    Cell Significance Index: -31.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.0860
    Cell Significance Index: -37.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.5378
    Cell Significance Index: -32.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.0855
    Cell Significance Index: -39.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0895
    Cell Significance Index: -35.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1747
    Cell Significance Index: -40.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4374
    Cell Significance Index: -25.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8382
    Cell Significance Index: 1659.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4242
    Cell Significance Index: 154.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2720
    Cell Significance Index: 255.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1399
    Cell Significance Index: 226.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7621
    Cell Significance Index: 16.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7530
    Cell Significance Index: 21.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7400
    Cell Significance Index: 51.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6780
    Cell Significance Index: 9.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6528
    Cell Significance Index: 29.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6100
    Cell Significance Index: 60.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5876
    Cell Significance Index: 210.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3681
    Cell Significance Index: 59.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3478
    Cell Significance Index: 62.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2880
    Cell Significance Index: 18.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2706
    Cell Significance Index: 119.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2650
    Cell Significance Index: 11.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2578
    Cell Significance Index: 140.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2444
    Cell Significance Index: 30.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2426
    Cell Significance Index: 15.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2397
    Cell Significance Index: 6.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2361
    Cell Significance Index: 8.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2320
    Cell Significance Index: 13.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2193
    Cell Significance Index: 30.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1632
    Cell Significance Index: 12.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1602
    Cell Significance Index: 110.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1317
    Cell Significance Index: 3.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1214
    Cell Significance Index: 5.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1074
    Cell Significance Index: 20.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1033
    Cell Significance Index: 13.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0970
    Cell Significance Index: 3.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0930
    Cell Significance Index: 5.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0840
    Cell Significance Index: 2.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0831
    Cell Significance Index: 5.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0778
    Cell Significance Index: 5.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0646
    Cell Significance Index: 7.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0590
    Cell Significance Index: 111.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0407
    Cell Significance Index: 5.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0377
    Cell Significance Index: 2.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0279
    Cell Significance Index: 1.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0243
    Cell Significance Index: 37.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0237
    Cell Significance Index: 43.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0108
    Cell Significance Index: 0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0082
    Cell Significance Index: 11.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0080
    Cell Significance Index: 5.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0281
    Cell Significance Index: -20.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0360
    Cell Significance Index: -27.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0429
    Cell Significance Index: -31.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0536
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0616
    Cell Significance Index: -10.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0678
    Cell Significance Index: -38.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0694
    Cell Significance Index: -43.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0749
    Cell Significance Index: -7.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0844
    Cell Significance Index: -24.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0934
    Cell Significance Index: -4.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1306
    Cell Significance Index: -15.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1459
    Cell Significance Index: -2.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1494
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1632
    Cell Significance Index: -18.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1998
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2078
    Cell Significance Index: -43.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2300
    Cell Significance Index: -5.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2808
    Cell Significance Index: -3.9900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3108
    Cell Significance Index: -3.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3376
    Cell Significance Index: -35.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3537
    Cell Significance Index: -5.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3862
    Cell Significance Index: -11.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4090
    Cell Significance Index: -8.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4094
    Cell Significance Index: -10.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4168
    Cell Significance Index: -33.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4350
    Cell Significance Index: -7.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4377
    Cell Significance Index: -22.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4548
    Cell Significance Index: -9.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4627
    Cell Significance Index: -11.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4888
    Cell Significance Index: -9.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4997
    Cell Significance Index: -13.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5015
    Cell Significance Index: -25.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5216
    Cell Significance Index: -5.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5233
    Cell Significance Index: -15.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5657
    Cell Significance Index: -34.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6780
    Cell Significance Index: -16.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7794
    Cell Significance Index: -22.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8167
    Cell Significance Index: -26.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8198
    Cell Significance Index: -26.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8354
    Cell Significance Index: -17.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8612
    Cell Significance Index: -30.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8639
    Cell Significance Index: -10.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8641
    Cell Significance Index: -18.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8692
    Cell Significance Index: -23.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAPKAPK5 is a serine/threonine kinase that exhibits a unique substrate specificity, with a preference for phosphorylating serine and threonine residues on target proteins. The enzyme is activated by the phosphorylation of two specific sites, Thr-172 and Ser-176, which are required for its kinase activity. MKP5 is also known to interact with other proteins, including calmodulin, which regulates its activity in response to calcium-dependent signaling pathways. The enzyme is highly expressed in neural cells, including neurons and glial cells, where it plays a critical role in regulating synaptic plasticity, neuronal survival, and stress response. **Pathways and Functions** MAPKAPK5 is involved in several key signaling pathways, including: 1. **MAPK signaling pathway**: MKP5 is activated by the phosphorylation of MAPKs, such as MAPK6 and MAPK4, which are involved in cellular responses to external stimuli, such as growth factors, heat shock, and oxidative stress. 2. **p53 signaling pathway**: MKP5 phosphorylates and regulates the activity of p53, a transcription factor that plays a critical role in cell cycle regulation, apoptosis, and senescence. 3. **Stress response pathway**: MKP5 is involved in regulating the cellular response to stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. 4. **Neurotransmission pathway**: MKP5 is involved in regulating synaptic plasticity and neuronal survival in neural cells, including neurons and glial cells. **Clinical Significance** Dysregulation of MAPKAPK5 has been implicated in various diseases, including: 1. **Neurodegenerative diseases**: MKP5 has been shown to play a critical role in regulating synaptic plasticity and neuronal survival in models of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: MKP5 has been implicated in regulating cell cycle regulation, apoptosis, and senescence in cancer cells, and its dysregulation has been associated with cancer progression. 3. **Neurodevelopmental disorders**: MKP5 has been shown to play a critical role in regulating neuronal development and synaptic plasticity in models of neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In summary, MAPKAPK5 is a critical regulator of cellular processes, including stress response, cell survival, and transcriptional regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis and promoting tissue health.

Genular Protein ID: 649870493

Symbol: MAPK5_HUMAN

Name: MAP kinase-activated protein kinase 5

UniProtKB Accession Codes:

Q8IW41 B3KVA5 O60491 Q86X46 Q9BVX9 Q9UG86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9628874

Title: PRAK, a novel protein kinase regulated by the p38 MAP kinase.

PubMed ID: 9628874

DOI: 10.1093/emboj/17.12.3372

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10708586

Title: p62 functions as a p38 MAP kinase regulator.

PubMed ID: 10708586

DOI: 10.1006/bbrc.2000.2333

PubMed ID: 12808055

Title: Regulation of PRAK subcellular location by p38 MAP kinases.

PubMed ID: 12808055

DOI: 10.1091/mbc.e02-08-0538

PubMed ID: 17728103

Title: 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization.

PubMed ID: 17728103

DOI: 10.1016/j.cellsig.2007.07.016

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19166925

Title: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

PubMed ID: 19166925

DOI: 10.1016/j.cellsig.2009.01.009

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 17254968

Title: PRAK is essential for ras-induced senescence and tumor suppression.

PubMed ID: 17254968

DOI: 10.1016/j.cell.2006.11.050

PubMed ID: 21329882

Title: The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.

PubMed ID: 21329882

DOI: 10.1016/j.molcel.2011.01.023

PubMed ID: 20227494

Title: Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: menage a trois or menage a quatre?

PubMed ID: 20227494

DOI: 10.1016/j.cellsig.2010.03.002

PubMed ID: 33442026

Title: Biallelic truncating variants in MAPKAPK5 cause a new developmental disorder involving neurological, cardiac, and facial anomalies combined with synpolydactyly.

PubMed ID: 33442026

DOI: 10.1038/s41436-020-01052-2

Sequence Information:

  • Length: 473
  • Mass: 54220
  • Checksum: F3D9DDC83CC0C49D
  • Sequence:
    • MSEESDMDKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR 
NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF 
TEKQASQVTK QIALALRHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKIDQGDL 
MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP 
FYSKHHSRTI PKDMRRKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD 
HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL 
RKRKLLGTKP KDSVYIHDHE NGAEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ 
EAWKYNRECK LLRDTLQSFS WNGRGFTDKV DRLKLAEIVK QVIEEQTTSH ESQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.