Details for: STK16

Gene ID: 8576

Symbol: STK16

Ensembl ID: ENSG00000115661

Description: serine/threonine kinase 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.4642
    Cell Significance Index: -16.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.4659
    Cell Significance Index: -16.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.9039
    Cell Significance Index: -17.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.1924
    Cell Significance Index: -19.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.8899
    Cell Significance Index: -19.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.6861
    Cell Significance Index: -19.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8886
    Cell Significance Index: -19.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9727
    Cell Significance Index: -16.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2977
    Cell Significance Index: -20.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1283
    Cell Significance Index: -12.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0129
    Cell Significance Index: 208.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5812
    Cell Significance Index: 171.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2406
    Cell Significance Index: 201.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0173
    Cell Significance Index: 13.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9215
    Cell Significance Index: 47.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8468
    Cell Significance Index: 39.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7910
    Cell Significance Index: 714.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6573
    Cell Significance Index: 42.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6361
    Cell Significance Index: 347.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6152
    Cell Significance Index: 5.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5771
    Cell Significance Index: 16.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5166
    Cell Significance Index: 63.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4946
    Cell Significance Index: 89.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4448
    Cell Significance Index: 52.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3602
    Cell Significance Index: 49.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3505
    Cell Significance Index: 26.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3023
    Cell Significance Index: 6.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2980
    Cell Significance Index: 4.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2798
    Cell Significance Index: 2.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2671
    Cell Significance Index: 7.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2566
    Cell Significance Index: 11.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2514
    Cell Significance Index: 111.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2511
    Cell Significance Index: 11.8000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2421
    Cell Significance Index: 3.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2308
    Cell Significance Index: 43.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2133
    Cell Significance Index: 21.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2067
    Cell Significance Index: 26.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1917
    Cell Significance Index: 13.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1840
    Cell Significance Index: 4.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1759
    Cell Significance Index: 22.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1610
    Cell Significance Index: 3.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1325
    Cell Significance Index: 26.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1250
    Cell Significance Index: 1.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1150
    Cell Significance Index: 1.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1068
    Cell Significance Index: 6.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0893
    Cell Significance Index: 2.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0578
    Cell Significance Index: 2.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0439
    Cell Significance Index: 1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0266
    Cell Significance Index: 5.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0214
    Cell Significance Index: 3.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0184
    Cell Significance Index: 12.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0141
    Cell Significance Index: 0.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0099
    Cell Significance Index: 0.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0086
    Cell Significance Index: 0.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0064
    Cell Significance Index: 0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0032
    Cell Significance Index: 2.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0023
    Cell Significance Index: 1.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0161
    Cell Significance Index: -24.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0166
    Cell Significance Index: -1.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0195
    Cell Significance Index: -26.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0228
    Cell Significance Index: -14.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0241
    Cell Significance Index: -13.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0270
    Cell Significance Index: -9.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0350
    Cell Significance Index: -21.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0442
    Cell Significance Index: -20.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0516
    Cell Significance Index: -14.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0854
    Cell Significance Index: -9.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0877
    Cell Significance Index: -2.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0992
    Cell Significance Index: -11.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1062
    Cell Significance Index: -22.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1079
    Cell Significance Index: -15.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1215
    Cell Significance Index: -4.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1449
    Cell Significance Index: -4.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1532
    Cell Significance Index: -4.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1693
    Cell Significance Index: -13.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1981
    Cell Significance Index: -20.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2026
    Cell Significance Index: -12.4500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2229
    Cell Significance Index: -1.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2381
    Cell Significance Index: -18.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2415
    Cell Significance Index: -2.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2502
    Cell Significance Index: -2.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2627
    Cell Significance Index: -7.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2768
    Cell Significance Index: -18.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2797
    Cell Significance Index: -5.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2802
    Cell Significance Index: -3.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3012
    Cell Significance Index: -15.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3118
    Cell Significance Index: -4.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3305
    Cell Significance Index: -20.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3471
    Cell Significance Index: -19.4800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3664
    Cell Significance Index: -2.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3712
    Cell Significance Index: -9.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3857
    Cell Significance Index: -11.3600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4258
    Cell Significance Index: -0.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4314
    Cell Significance Index: -15.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4357
    Cell Significance Index: -11.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STK16 is a non-membrane spanning protein tyrosine kinase, which implies that it lacks a transmembrane domain and is not directly involved in cell-cell interactions. However, its ability to bind to various proteins and regulate their activity makes it a key player in numerous cellular processes. STK16 is also known to be involved in the regulation of transcription by RNA polymerase II, which suggests its potential role in gene expression and cellular differentiation. **Pathways and Functions:** STK16 is involved in several signaling pathways, including: 1. **ATP binding**: STK16 is a member of the ATP-binding protein kinase family, which plays a crucial role in energy metabolism and signal transduction. 2. **Cellular response to transforming growth factor beta (TGF-β) stimulus**: STK16 is activated by TGF-β, a cytokine that regulates cell growth, differentiation, and apoptosis. 3. **Cytoplasmic and cytosolic regulation**: STK16 is localized to the cytoplasm and cytosol, where it regulates protein kinase activity and transcriptional regulation. 4. **Golgi-associated vesicle and Golgi apparatus regulation**: STK16 is also involved in the regulation of Golgi-associated vesicle and Golgi apparatus function, which is essential for protein processing and secretion. 5. **Protein autophosphorylation**: STK16 exhibits protein autophosphorylation activity, which is a critical mechanism for its activation and regulation. **Clinical Significance:** STK16 has been implicated in various disease states, including: 1. **Cancer**: Overexpression of STK16 has been observed in several types of cancer, including lung, breast, and colon cancer. This suggests that STK16 may play a role in tumorigenesis and cancer progression. 2. **Neurological disorders**: STK16 has been implicated in the regulation of neuronal function and survival. Alterations in STK16 expression have been observed in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Autoimmune diseases**: STK16 has been implicated in the regulation of immune responses and has been observed to be overexpressed in autoimmune diseases, such as rheumatoid arthritis and lupus. **Conclusion:** STK16 is a multifunctional protein kinase that plays a critical role in various cellular processes, including proliferation, differentiation, and survival. Its involvement in signaling pathways and regulation of transcriptional activity makes it a key player in disease states, including cancer, neurological disorders, and autoimmune diseases. Further research is necessary to fully elucidate the role of STK16 in human disease and to explore its potential as a therapeutic target. **References:** * [Insert references to relevant studies on STK16] **Note:** As an expert immunologist, this review aims to provide a comprehensive analysis of STK16's immunological significance, including its involvement in disease states and potential as a therapeutic target. However, further research is necessary to fully elucidate the role of STK16 in human disease.

Genular Protein ID: 285813423

Symbol: STK16_HUMAN

Name: Serine/threonine-protein kinase 16

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9712705

Title: Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases.

PubMed ID: 9712705

DOI: 10.1006/bbrc.1998.9163

PubMed ID: 10364453

Title: Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase.

PubMed ID: 10364453

DOI: 10.1006/bbrc.1999.0811

PubMed ID: 10947953

Title: A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway.

PubMed ID: 10947953

DOI: 10.1042/bj3500395

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18184589

Title: Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture.

PubMed ID: 18184589

DOI: 10.1016/j.str.2007.10.026

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 305
  • Mass: 34656
  • Checksum: 593B2AEB8505009C
  • Sequence:
  • MGHALCVCSR GTVIIDNKRY LFIQKLGEGG FSYVDLVEGL HDGHFYALKR ILCHEQQDRE 
    EAQREADMHR LFNHPNILRL VAYCLRERGA KHEAWLLLPF FKRGTLWNEI ERLKDKGNFL 
    TEDQILWLLL GICRGLEAIH AKGYAHRDLK PTNILLGDEG QPVLMDLGSM NQACIHVEGS 
    RQALTLQDWA AQRCTISYRA PELFSVQSHC VIDERTDVWS LGCVLYAMMF GEGPYDMVFQ 
    KGDSVALAVQ NQLSIPQSPR HSSALRQLLN SMMTVDPHQR PHIPLLLSQL EALQPPAPGQ 
    HTTQI

Genular Protein ID: 901922490

Symbol: B4DPS1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 187
  • Mass: 20694
  • Checksum: F3B54AD77C850DF0
  • Sequence:
  • MGHALCVCSR GTVIIDNKRY LFIQKLGEGD LKPTNILLGD EGQPVLMDLG SMNQACIHVE 
    GSRQALTLQD WAAQRCTISY RAPELFSVQS HCVIDERTDV WSLGCVLYAM MFGEGPYDMV 
    FQKGDSVALA VQNQLSIPQS PRHSSALRQL LNSMMTVDPH QRPHIPLLLS QLEALQPPAP 
    GQHTTQI

Genular Protein ID: 3593414264

Symbol: B8ZZI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 273
  • Mass: 30891
  • Checksum: E6467785A3545338
  • Sequence:
  • MGHALCVCSR GTVIIDNKRY LFIQKLGEGG FSYVDLVEGL HDGHFYALKR ILCHEQQDRE 
    EAQREADMHR LFNHPNILRL VAYCLRERGA KHEAWLLLPF FKRGTLWNEI ERLKDKGNFL 
    TEDQILWLLL GICRGLEAIH AKGYAHRDLK PTNILLGDEG QPVLMDLGSM NQACIHVEGS 
    RQALTLQSLG CVLYAMMFGE GPYDMVFQKG DSVALAVQNQ LSIPQSPRHS SALRQLLNSM 
    MTVDPHQRPH IPLLLSQLEA LQPPAPGQHT TQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.