Details for: PLPP3

Gene ID: 8613

Symbol: PLPP3

Ensembl ID: ENSG00000162407

Description: phospholipid phosphatase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.7766
    Cell Significance Index: -42.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.3317
    Cell Significance Index: -45.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.6565
    Cell Significance Index: -46.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2318
    Cell Significance Index: -42.2300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 14.5668
    Cell Significance Index: 54.2900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 8.4732
    Cell Significance Index: 57.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.8538
    Cell Significance Index: 196.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.9490
    Cell Significance Index: 83.3700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.7602
    Cell Significance Index: 29.4500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 4.3944
    Cell Significance Index: 31.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.2008
    Cell Significance Index: 62.4700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.1691
    Cell Significance Index: 45.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.0940
    Cell Significance Index: 396.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5445
    Cell Significance Index: 349.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.4475
    Cell Significance Index: 137.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1068
    Cell Significance Index: 161.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8101
    Cell Significance Index: 359.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1991
    Cell Significance Index: 25.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.1597
    Cell Significance Index: 58.6100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.0591
    Cell Significance Index: 14.8100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.0418
    Cell Significance Index: 8.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0147
    Cell Significance Index: 916.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9630
    Cell Significance Index: 112.2300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.9152
    Cell Significance Index: 8.7000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8932
    Cell Significance Index: 14.1700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.8622
    Cell Significance Index: 8.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5457
    Cell Significance Index: 88.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5117
    Cell Significance Index: 55.6600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4615
    Cell Significance Index: 8.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4236
    Cell Significance Index: 269.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3390
    Cell Significance Index: 638.2700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.3191
    Cell Significance Index: 1.1100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.2664
    Cell Significance Index: 1.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2604
    Cell Significance Index: 46.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2535
    Cell Significance Index: 31.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2382
    Cell Significance Index: 130.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2116
    Cell Significance Index: 96.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1818
    Cell Significance Index: 12.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1776
    Cell Significance Index: 63.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1678
    Cell Significance Index: 16.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1436
    Cell Significance Index: 2.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1193
    Cell Significance Index: 52.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1070
    Cell Significance Index: 5.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1035
    Cell Significance Index: 19.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0195
    Cell Significance Index: 0.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0188
    Cell Significance Index: 0.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0056
    Cell Significance Index: 0.1600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0138
    Cell Significance Index: -0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0181
    Cell Significance Index: -33.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0187
    Cell Significance Index: -25.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0206
    Cell Significance Index: -15.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0216
    Cell Significance Index: -33.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0468
    Cell Significance Index: -35.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0553
    Cell Significance Index: -40.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0623
    Cell Significance Index: -0.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0648
    Cell Significance Index: -1.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0726
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0917
    Cell Significance Index: -51.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0990
    Cell Significance Index: -7.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1121
    Cell Significance Index: -16.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1187
    Cell Significance Index: -12.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1275
    Cell Significance Index: -25.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1283
    Cell Significance Index: -2.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1338
    Cell Significance Index: -38.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1346
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1390
    Cell Significance Index: -23.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1646
    Cell Significance Index: -4.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1727
    Cell Significance Index: -7.8300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1887
    Cell Significance Index: -2.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2154
    Cell Significance Index: -27.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2215
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2264
    Cell Significance Index: -25.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2459
    Cell Significance Index: -51.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2995
    Cell Significance Index: -22.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3558
    Cell Significance Index: -41.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3875
    Cell Significance Index: -23.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3911
    Cell Significance Index: -20.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3994
    Cell Significance Index: -41.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4610
    Cell Significance Index: -16.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4621
    Cell Significance Index: -21.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5337
    Cell Significance Index: -42.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6015
    Cell Significance Index: -12.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6236
    Cell Significance Index: -41.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6536
    Cell Significance Index: -40.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6803
    Cell Significance Index: -4.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7245
    Cell Significance Index: -46.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7408
    Cell Significance Index: -38.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7556
    Cell Significance Index: -39.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8336
    Cell Significance Index: -52.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8492
    Cell Significance Index: -22.3300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.8716
    Cell Significance Index: -10.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9065
    Cell Significance Index: -29.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.0484
    Cell Significance Index: -16.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0612
    Cell Significance Index: -46.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0643
    Cell Significance Index: -39.0700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.1667
    Cell Significance Index: -14.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.2124
    Cell Significance Index: -11.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2363
    Cell Significance Index: -30.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2501
    Cell Significance Index: -36.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2586
    Cell Significance Index: -47.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional enzyme**: PLPP3 exhibits a wide range of enzymatic activities, including ceramide-1-phosphate phosphatase activity, sphingosine-1-phosphate phosphatase activity, and phospholipid dephosphorylation. 2. **Cellular localization**: PLPP3 is primarily localized to the plasma membrane, Golgi apparatus, and endoplasmic reticulum membranes, where it interacts with various signaling molecules and lipids. 3. **Regulation of cell-cell adhesion**: PLPP3 modulates cell-cell adhesion by dephosphorylating phospholipids, which are essential for maintaining the integrity of adherens junctions and integrin-mediated signaling pathways. 4. **Lipid metabolism**: PLPP3 plays a critical role in regulating lipid metabolism, including sphingolipid catabolism, sphingosine-1-phosphate phosphatase activity, and ceramide metabolic process. **Pathways and Functions:** 1. **Adherens junction and cell-cell adhesion**: PLPP3 regulates the activity of adherens junction proteins, such as cadherins and catenins, by dephosphorylating phospholipids that interact with these proteins. 2. **Integrin-mediated signaling pathway**: PLPP3 modulates the activity of integrins, which are essential for cell adhesion, migration, and signaling. 3. **Sphingolipid-mediated signaling pathway**: PLPP3 regulates the activity of sphingolipids, which are involved in various cellular processes, including cell growth, differentiation, and survival. 4. **Wnt signaling pathway**: PLPP3 modulates the activity of Wnt proteins, which are essential for cell proliferation, differentiation, and survival. 5. **Endoplasmic reticulum-Golgi intermediate compartment membrane**: PLPP3 regulates the activity of proteins and lipids that interact with the ER-Golgi intermediate compartment membrane, thereby modulating protein synthesis and secretion. **Clinical Significance:** 1. **Cardiac disease**: PLPP3 has been implicated in the pathogenesis of cardiac disease, including heart failure and arrhythmias, due to its role in regulating cell-cell adhesion and sphingolipid metabolism. 2. **Cancer**: PLPP3 has been shown to be overexpressed in various types of cancer, including breast, prostate, and lung cancer, and is associated with tumor progression and metastasis. 3. **Neurological disorders**: PLPP3 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, due to its role in regulating sphingolipid metabolism and Wnt signaling pathway. 4. **Wound healing**: PLPP3 has been shown to play a critical role in wound healing, as it regulates the activity of proteins and lipids involved in cell adhesion, migration, and signaling. In conclusion, PLPP3 is a multifunctional enzyme that plays a crucial role in regulating various cellular processes, including cell-cell adhesion, signal transduction, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of PLPP3 in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of PLPP3 in human disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 439537174

Symbol: PLPP3_HUMAN

Name: Lipid phosphate phosphohydrolase 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9305923

Title: Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase.

PubMed ID: 9305923

DOI: 10.1074/jbc.272.39.24572

PubMed ID: 9705349

Title: Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.

PubMed ID: 9705349

DOI: 10.1074/jbc.273.34.22059

PubMed ID: 12660161

Title: Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP.

PubMed ID: 12660161

DOI: 10.1093/emboj/cdg165

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9607309

Title: Identification of a novel human phosphatidic acid phosphatase type 2 isoform.

PubMed ID: 9607309

DOI: 10.1016/s0014-5793(98)00421-9

PubMed ID: 14527693

Title: Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.

PubMed ID: 14527693

DOI: 10.1016/s0014-5793(03)00931-1

PubMed ID: 14725715

Title: Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity.

PubMed ID: 14725715

DOI: 10.1186/1471-2091-5-2

PubMed ID: 16099422

Title: Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.

PubMed ID: 16099422

DOI: 10.1016/j.bbrc.2005.07.157

PubMed ID: 17005594

Title: Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.

PubMed ID: 17005594

DOI: 10.1093/jb/mvj195

PubMed ID: 18215144

Title: Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.

PubMed ID: 18215144

DOI: 10.1042/bj20071607

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20123964

Title: Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.

PubMed ID: 20123964

DOI: 10.1128/mcb.00038-09

PubMed ID: 21569306

Title: Lipid phosphate phosphatase-3 regulates tumor growth via beta-catenin and CYCLIN-D1 signaling.

PubMed ID: 21569306

DOI: 10.1186/1476-4598-10-51

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23591818

Title: Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway.

PubMed ID: 23591818

DOI: 10.1242/jcs.117705

PubMed ID: 27694435

Title: Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

PubMed ID: 27694435

DOI: 10.1093/cvr/cvw217

Sequence Information:

  • Length: 311
  • Mass: 35116
  • Checksum: CB3F60189044DA31
  • Sequence:
  • MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK 
    PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN 
    PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR 
    CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY 
    TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD 
    IIDRNNHHNM M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.