Details for: PLPP3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 103.7766
Cell Significance Index: -42.1600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 97.3317
Cell Significance Index: -45.9500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 68.6565
Cell Significance Index: -46.0700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 44.2318
Cell Significance Index: -42.2300 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 14.5668
Cell Significance Index: 54.2900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 8.4732
Cell Significance Index: 57.4100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 6.8538
Cell Significance Index: 196.4700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.9490
Cell Significance Index: 83.3700 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 4.7602
Cell Significance Index: 29.4500 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 4.3944
Cell Significance Index: 31.5600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.2008
Cell Significance Index: 62.4700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.1691
Cell Significance Index: 45.5800 - Cell Name: odontoblast (CL0000060)
Fold Change: 3.0940
Cell Significance Index: 396.6300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.5445
Cell Significance Index: 349.4300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.4475
Cell Significance Index: 137.3400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.1068
Cell Significance Index: 161.6700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8101
Cell Significance Index: 359.2300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1991
Cell Significance Index: 25.1000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 1.1597
Cell Significance Index: 58.6100 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 1.0591
Cell Significance Index: 14.8100 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.0418
Cell Significance Index: 8.2200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0147
Cell Significance Index: 916.1900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.9630
Cell Significance Index: 112.2300 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.9152
Cell Significance Index: 8.7000 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.8932
Cell Significance Index: 14.1700 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.8622
Cell Significance Index: 8.9300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5457
Cell Significance Index: 88.7500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5117
Cell Significance Index: 55.6600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4615
Cell Significance Index: 8.1600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.4236
Cell Significance Index: 269.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3390
Cell Significance Index: 638.2700 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.3191
Cell Significance Index: 1.1100 - Cell Name: perivascular cell (CL4033054)
Fold Change: 0.2664
Cell Significance Index: 1.2300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2604
Cell Significance Index: 46.9500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2535
Cell Significance Index: 31.1800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2382
Cell Significance Index: 130.0800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2116
Cell Significance Index: 96.0200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1818
Cell Significance Index: 12.5800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1776
Cell Significance Index: 63.7100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1678
Cell Significance Index: 16.6000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1436
Cell Significance Index: 2.1200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1193
Cell Significance Index: 52.7300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1070
Cell Significance Index: 5.0300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1035
Cell Significance Index: 19.6900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0195
Cell Significance Index: 0.5200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0188
Cell Significance Index: 0.3200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0056
Cell Significance Index: 0.1600 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.0138
Cell Significance Index: -0.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0181
Cell Significance Index: -33.3400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0187
Cell Significance Index: -25.4300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0206
Cell Significance Index: -15.0900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0216
Cell Significance Index: -33.2000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0468
Cell Significance Index: -35.4000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0553
Cell Significance Index: -40.9800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0623
Cell Significance Index: -0.9200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0648
Cell Significance Index: -1.6200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0726
Cell Significance Index: -0.9300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0917
Cell Significance Index: -51.7200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0990
Cell Significance Index: -7.0000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1121
Cell Significance Index: -16.3000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1187
Cell Significance Index: -12.1300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1275
Cell Significance Index: -25.5700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1283
Cell Significance Index: -2.7800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1338
Cell Significance Index: -38.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1346
Cell Significance Index: -4.7300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1390
Cell Significance Index: -23.7400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1646
Cell Significance Index: -4.6000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1727
Cell Significance Index: -7.8300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1887
Cell Significance Index: -2.7100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2154
Cell Significance Index: -27.8200 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2215
Cell Significance Index: -3.8300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2264
Cell Significance Index: -25.9400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2459
Cell Significance Index: -51.7900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2995
Cell Significance Index: -22.3200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3558
Cell Significance Index: -41.9600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3875
Cell Significance Index: -23.8200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3911
Cell Significance Index: -20.3700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3994
Cell Significance Index: -41.5900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4610
Cell Significance Index: -16.0200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4621
Cell Significance Index: -21.5500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5337
Cell Significance Index: -42.2700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6015
Cell Significance Index: -12.8100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6236
Cell Significance Index: -41.9300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6536
Cell Significance Index: -40.0700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6803
Cell Significance Index: -4.1100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7245
Cell Significance Index: -46.7400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7408
Cell Significance Index: -38.4800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7556
Cell Significance Index: -39.6700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8336
Cell Significance Index: -52.5400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8492
Cell Significance Index: -22.3300 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.8716
Cell Significance Index: -10.9800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9065
Cell Significance Index: -29.0400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.0484
Cell Significance Index: -16.2200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0612
Cell Significance Index: -46.9400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0643
Cell Significance Index: -39.0700 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -1.1667
Cell Significance Index: -14.9600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.2124
Cell Significance Index: -11.1700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -1.2363
Cell Significance Index: -30.8400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.2501
Cell Significance Index: -36.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.2586
Cell Significance Index: -47.6600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 439537174
Symbol: PLPP3_HUMAN
Name: Lipid phosphate phosphohydrolase 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9305923
Title: Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase.
PubMed ID: 9305923
PubMed ID: 9705349
Title: Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.
PubMed ID: 9705349
PubMed ID: 12660161
Title: Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP.
PubMed ID: 12660161
DOI: 10.1093/emboj/cdg165
PubMed ID: 9110174
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9607309
Title: Identification of a novel human phosphatidic acid phosphatase type 2 isoform.
PubMed ID: 9607309
PubMed ID: 14527693
Title: Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.
PubMed ID: 14527693
PubMed ID: 14725715
Title: Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity.
PubMed ID: 14725715
PubMed ID: 16099422
Title: Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
PubMed ID: 16099422
PubMed ID: 17005594
Title: Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.
PubMed ID: 17005594
DOI: 10.1093/jb/mvj195
PubMed ID: 18215144
Title: Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.
PubMed ID: 18215144
DOI: 10.1042/bj20071607
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20123964
Title: Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.
PubMed ID: 20123964
DOI: 10.1128/mcb.00038-09
PubMed ID: 21569306
Title: Lipid phosphate phosphatase-3 regulates tumor growth via beta-catenin and CYCLIN-D1 signaling.
PubMed ID: 21569306
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23591818
Title: Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway.
PubMed ID: 23591818
DOI: 10.1242/jcs.117705
PubMed ID: 27694435
Title: Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.
PubMed ID: 27694435
DOI: 10.1093/cvr/cvw217
Sequence Information:
- Length: 311
- Mass: 35116
- Checksum: CB3F60189044DA31
- Sequence:
MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD IIDRNNHHNM M
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.