Details for: PLPP3

Gene ID: 8613

Symbol: PLPP3

Ensembl ID: ENSG00000162407

Description: phospholipid phosphatase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.02
    Marker Score: 66711.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.09
    Marker Score: 2693
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.67
    Marker Score: 3133
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.48
    Marker Score: 118329
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.13
    Marker Score: 2454
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.98
    Marker Score: 1958
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.95
    Marker Score: 62907
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.95
    Marker Score: 764
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.94
    Marker Score: 1226
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.67
    Marker Score: 1525
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.42
    Marker Score: 1408
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.37
    Marker Score: 6197
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.33
    Marker Score: 536
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.31
    Marker Score: 536
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.24
    Marker Score: 9671
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.16
    Marker Score: 549
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.15
    Marker Score: 535
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.13
    Marker Score: 535
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.12
    Marker Score: 23905
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.03
    Marker Score: 789
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.03
    Marker Score: 2174
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.03
    Marker Score: 2167
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.95
    Marker Score: 1104
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.94
    Marker Score: 608
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.93
    Marker Score: 938
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.93
    Marker Score: 564
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.88
    Marker Score: 42040
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.83
    Marker Score: 444
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.82
    Marker Score: 399
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.81
    Marker Score: 3974
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.79
    Marker Score: 969
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.77
    Marker Score: 487
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.76
    Marker Score: 6914
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.7
    Marker Score: 2783.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.69
    Marker Score: 418
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.67
    Marker Score: 2179
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.67
    Marker Score: 6173
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.67
    Marker Score: 6972
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.66
    Marker Score: 712.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.65
    Marker Score: 2283.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.58
    Marker Score: 1039
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.57
    Marker Score: 875
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.56
    Marker Score: 6750
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.55
    Marker Score: 8360
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.54
    Marker Score: 1331
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.53
    Marker Score: 3107
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.52
    Marker Score: 3589
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.51
    Marker Score: 9693
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.5
    Marker Score: 383
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.5
    Marker Score: 3002
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167533
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.43
    Marker Score: 523
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.38
    Marker Score: 436
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.36
    Marker Score: 1468
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20837
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.3
    Marker Score: 1895
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.3
    Marker Score: 2509
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.3
    Marker Score: 1258
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3
    Marker Score: 8462
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.29
    Marker Score: 378
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.29
    Marker Score: 1152
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.27
    Marker Score: 336
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.24
    Marker Score: 2964
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.23
    Marker Score: 1061
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.21
    Marker Score: 3059
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.19
    Marker Score: 1097
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.18
    Marker Score: 1066
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.17
    Marker Score: 282
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.16
    Marker Score: 8636
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.16
    Marker Score: 1335
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.16
    Marker Score: 328
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.15
    Marker Score: 1219
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.13
    Marker Score: 2220
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.13
    Marker Score: 4014
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.13
    Marker Score: 10590
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.12
    Marker Score: 457
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.11
    Marker Score: 858
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.11
    Marker Score: 743
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.11
    Marker Score: 701.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.1
    Marker Score: 617
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.1
    Marker Score: 581
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.1
    Marker Score: 2066
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.1
    Marker Score: 1182
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.1
    Marker Score: 733
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.09
    Marker Score: 2783
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.08
    Marker Score: 1829
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.08
    Marker Score: 1013
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.07
    Marker Score: 250
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.07
    Marker Score: 399.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.05
    Marker Score: 1441
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.05
    Marker Score: 751
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.05
    Marker Score: 558
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.04
    Marker Score: 1447
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.02
    Marker Score: 681
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.99
    Marker Score: 2659
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.98
    Marker Score: 672
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.97
    Marker Score: 5848
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.97
    Marker Score: 247

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Other Information

**Key Characteristics:** 1. **Multifunctional enzyme**: PLPP3 exhibits a wide range of enzymatic activities, including ceramide-1-phosphate phosphatase activity, sphingosine-1-phosphate phosphatase activity, and phospholipid dephosphorylation. 2. **Cellular localization**: PLPP3 is primarily localized to the plasma membrane, Golgi apparatus, and endoplasmic reticulum membranes, where it interacts with various signaling molecules and lipids. 3. **Regulation of cell-cell adhesion**: PLPP3 modulates cell-cell adhesion by dephosphorylating phospholipids, which are essential for maintaining the integrity of adherens junctions and integrin-mediated signaling pathways. 4. **Lipid metabolism**: PLPP3 plays a critical role in regulating lipid metabolism, including sphingolipid catabolism, sphingosine-1-phosphate phosphatase activity, and ceramide metabolic process. **Pathways and Functions:** 1. **Adherens junction and cell-cell adhesion**: PLPP3 regulates the activity of adherens junction proteins, such as cadherins and catenins, by dephosphorylating phospholipids that interact with these proteins. 2. **Integrin-mediated signaling pathway**: PLPP3 modulates the activity of integrins, which are essential for cell adhesion, migration, and signaling. 3. **Sphingolipid-mediated signaling pathway**: PLPP3 regulates the activity of sphingolipids, which are involved in various cellular processes, including cell growth, differentiation, and survival. 4. **Wnt signaling pathway**: PLPP3 modulates the activity of Wnt proteins, which are essential for cell proliferation, differentiation, and survival. 5. **Endoplasmic reticulum-Golgi intermediate compartment membrane**: PLPP3 regulates the activity of proteins and lipids that interact with the ER-Golgi intermediate compartment membrane, thereby modulating protein synthesis and secretion. **Clinical Significance:** 1. **Cardiac disease**: PLPP3 has been implicated in the pathogenesis of cardiac disease, including heart failure and arrhythmias, due to its role in regulating cell-cell adhesion and sphingolipid metabolism. 2. **Cancer**: PLPP3 has been shown to be overexpressed in various types of cancer, including breast, prostate, and lung cancer, and is associated with tumor progression and metastasis. 3. **Neurological disorders**: PLPP3 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, due to its role in regulating sphingolipid metabolism and Wnt signaling pathway. 4. **Wound healing**: PLPP3 has been shown to play a critical role in wound healing, as it regulates the activity of proteins and lipids involved in cell adhesion, migration, and signaling. In conclusion, PLPP3 is a multifunctional enzyme that plays a crucial role in regulating various cellular processes, including cell-cell adhesion, signal transduction, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of PLPP3 in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of PLPP3 in human disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 439537174

Symbol: PLPP3_HUMAN

Name: Lipid phosphate phosphohydrolase 3

UniProtKB Accession Codes:

O14495 B2R651 D3DQ52 Q5U0F7 Q96GW0 Q99782

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 36 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EPD 1 Ensembl 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 18 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9305923

Title: Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase.

PubMed ID: 9305923

DOI: 10.1074/jbc.272.39.24572

PubMed ID: 9705349

Title: Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.

PubMed ID: 9705349

DOI: 10.1074/jbc.273.34.22059

PubMed ID: 12660161

Title: Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP.

PubMed ID: 12660161

DOI: 10.1093/emboj/cdg165

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9607309

Title: Identification of a novel human phosphatidic acid phosphatase type 2 isoform.

PubMed ID: 9607309

DOI: 10.1016/s0014-5793(98)00421-9

PubMed ID: 14527693

Title: Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.

PubMed ID: 14527693

DOI: 10.1016/s0014-5793(03)00931-1

PubMed ID: 14725715

Title: Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity.

PubMed ID: 14725715

DOI: 10.1186/1471-2091-5-2

PubMed ID: 16099422

Title: Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.

PubMed ID: 16099422

DOI: 10.1016/j.bbrc.2005.07.157

PubMed ID: 17005594

Title: Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.

PubMed ID: 17005594

DOI: 10.1093/jb/mvj195

PubMed ID: 18215144

Title: Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.

PubMed ID: 18215144

DOI: 10.1042/bj20071607

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20123964

Title: Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.

PubMed ID: 20123964

DOI: 10.1128/mcb.00038-09

PubMed ID: 21569306

Title: Lipid phosphate phosphatase-3 regulates tumor growth via beta-catenin and CYCLIN-D1 signaling.

PubMed ID: 21569306

DOI: 10.1186/1476-4598-10-51

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23591818

Title: Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway.

PubMed ID: 23591818

DOI: 10.1242/jcs.117705

PubMed ID: 27694435

Title: Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

PubMed ID: 27694435

DOI: 10.1093/cvr/cvw217

Sequence Information:

  • Length: 311
  • Mass: 35116
  • Checksum: CB3F60189044DA31
  • Sequence:
    • MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK 
PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN 
PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR 
CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY 
TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD 
IIDRNNHHNM M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.