Details for: HSD17B6

Gene ID: 8630

Symbol: HSD17B6

Ensembl ID: ENSG00000025423

Description: hydroxysteroid 17-beta dehydrogenase 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.9183
    Cell Significance Index: -9.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.7839
    Cell Significance Index: -9.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.2580
    Cell Significance Index: -8.6200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.8296
    Cell Significance Index: 25.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.6726
    Cell Significance Index: -9.4600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.4189
    Cell Significance Index: 25.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0136
    Cell Significance Index: 123.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5925
    Cell Significance Index: 26.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8814
    Cell Significance Index: 39.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7069
    Cell Significance Index: 134.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6411
    Cell Significance Index: 63.4200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6030
    Cell Significance Index: 9.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4763
    Cell Significance Index: 7.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4759
    Cell Significance Index: 10.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4287
    Cell Significance Index: 6.1400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4098
    Cell Significance Index: 2.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3755
    Cell Significance Index: 339.0300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3664
    Cell Significance Index: 4.2200
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.3137
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3101
    Cell Significance Index: 50.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2716
    Cell Significance Index: 29.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2227
    Cell Significance Index: 4.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1597
    Cell Significance Index: 9.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1478
    Cell Significance Index: 29.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1310
    Cell Significance Index: 3.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1218
    Cell Significance Index: 3.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1153
    Cell Significance Index: 87.2800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1048
    Cell Significance Index: 1.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1003
    Cell Significance Index: 2.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0772
    Cell Significance Index: 5.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0767
    Cell Significance Index: 53.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0590
    Cell Significance Index: 26.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0538
    Cell Significance Index: 10.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0527
    Cell Significance Index: 2.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0494
    Cell Significance Index: 1.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0419
    Cell Significance Index: 1.1700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0387
    Cell Significance Index: 0.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0327
    Cell Significance Index: 4.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0111
    Cell Significance Index: 3.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0100
    Cell Significance Index: 1.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0032
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0022
    Cell Significance Index: -0.9800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0026
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0084
    Cell Significance Index: -4.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0203
    Cell Significance Index: -11.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0226
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0278
    Cell Significance Index: -0.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0294
    Cell Significance Index: -8.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0301
    Cell Significance Index: -3.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0434
    Cell Significance Index: -1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0523
    Cell Significance Index: -7.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0525
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0553
    Cell Significance Index: -11.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0606
    Cell Significance Index: -10.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0610
    Cell Significance Index: -7.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0650
    Cell Significance Index: -3.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0752
    Cell Significance Index: -9.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0821
    Cell Significance Index: -8.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0862
    Cell Significance Index: -10.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0866
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0961
    Cell Significance Index: -11.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0985
    Cell Significance Index: -3.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1219
    Cell Significance Index: -7.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1230
    Cell Significance Index: -9.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1241
    Cell Significance Index: -3.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1291
    Cell Significance Index: -8.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1292
    Cell Significance Index: -9.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1304
    Cell Significance Index: -10.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1390
    Cell Significance Index: -7.0200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1423
    Cell Significance Index: -2.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1438
    Cell Significance Index: -9.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1451
    Cell Significance Index: -7.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1467
    Cell Significance Index: -8.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1481
    Cell Significance Index: -6.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1591
    Cell Significance Index: -10.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1696
    Cell Significance Index: -7.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1772
    Cell Significance Index: -3.8800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1799
    Cell Significance Index: -1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1843
    Cell Significance Index: -8.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1943
    Cell Significance Index: -3.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2002
    Cell Significance Index: -7.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2052
    Cell Significance Index: -7.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2059
    Cell Significance Index: -4.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2111
    Cell Significance Index: -1.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2179
    Cell Significance Index: -9.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2183
    Cell Significance Index: -6.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2266
    Cell Significance Index: -7.4200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2286
    Cell Significance Index: -3.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2342
    Cell Significance Index: -3.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2367
    Cell Significance Index: -7.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2383
    Cell Significance Index: -4.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2508
    Cell Significance Index: -6.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSD17B6 is a type VI 17-beta-hydroxysteroid dehydrogenase, characterized by its ability to catalyze the interconversion of androgens and their metabolites. The enzyme exhibits specificity towards androstenedione and testosterone, with a preference for NAD(P)H as a reducing agent. HSD17B6 is primarily expressed in liver cells, particularly in the periportal, centrilobular, and midzonal regions, where it plays a crucial role in androgen metabolism. The enzyme is also expressed in various epithelial tissues, including those of the lung, colon, and alveoli, suggesting its involvement in androgen-mediated functions in these tissues. **Pathways and Functions:** HSD17B6 is involved in several key pathways, including: 1. **Androgen biosynthetic process:** HSD17B6 catalyzes the interconversion of androstenedione and testosterone, regulating the levels of these hormones and influencing androgen-mediated functions. 2. **Androgen catabolic process:** The enzyme participates in the degradation of androgens, contributing to the termination of their biological activities. 3. **Retinoid metabolic process:** HSD17B6 has been implicated in the regulation of retinoid metabolism, influencing visual phototransduction and sensory perception. 4. **Electron transport chain:** The enzyme plays a role in the electron transport chain, contributing to the generation of ATP in mitochondria. **Clinical Significance:** Dysregulation of HSD17B6 has been implicated in various diseases, including: 1. **Hypertension:** Elevated androgen levels, resulting from HSD17B6 activity, have been associated with hypertension. 2. **Atherosclerosis:** Androgen-mediated effects, influenced by HSD17B6 activity, contribute to the development of atherosclerosis. 3. **Visual disorders:** Impairments in retinoid metabolism, resulting from HSD17B6 dysfunction, can lead to visual disorders, including night blindness and color vision deficiency. 4. **Cancer:** Altered androgen metabolism, influenced by HSD17B6 activity, has been implicated in the development and progression of various cancers, including prostate cancer. In conclusion, HSD17B6 is a critical enzyme involved in the metabolism of androgens and retinoids, playing a pivotal role in maintaining the delicate balance of these hormones. Dysregulation of HSD17B6 has been implicated in various diseases, highlighting the importance of this enzyme in human health and disease. Further research is necessary to elucidate the mechanisms underlying HSD17B6 function and to explore its potential as a therapeutic target for the treatment of diseases associated with androgen and retinoid metabolism.

Genular Protein ID: 1322899149

Symbol: H17B6_HUMAN

Name: 17-beta-hydroxysteroid dehydrogenase type 6

UniProtKB Accession Codes:

O14756 O43275

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 52 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 7 EMBL 4 Ensembl 5 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 8 Rhea 19 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9188497

Title: Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate.

PubMed ID: 9188497

DOI: 10.1074/jbc.272.25.15959

PubMed ID: 10896656

Title: Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase.

PubMed ID: 10896656

DOI: 10.1074/jbc.m000562200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11360992

Title: Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase.

PubMed ID: 11360992

DOI: 10.1006/abbi.2000.2203

PubMed ID: 11513953

Title: Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha-->beta)-hydroxysteroid epimerase.

PubMed ID: 11513953

DOI: 10.1016/s0167-4781(01)00247-0

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 317
  • Mass: 35966
  • Checksum: 46F1E940605CBEE9
  • Sequence:
    • MWLYLAAFVG LYYLLHWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD ARGLRVLAAC 
LTEKGAEQLR GQTSDRLETV TLDVTKMESI AAATQWVKEH VGDRGLWGLV NNAGILTPIT 
LCEWLNTEDS MNMLKVNLIG VIQVTLSMLP LVRRARGRIV NVSSILGRVA FFVGGYCVSK 
YGVEAFSDIL RREIQHFGVK ISIVEPGYFR TGMTNMTQSL ERMKQSWKEA PKHIKETYGQ 
QYFDALYNIM KEGLLNCSTN LNLVTDCMEH ALTSVHPRTR YSAGWDAKFF FIPLSYLPTS 
LADYILTRSW PKPAQAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.