Details for: OASL

Gene ID: 8638

Symbol: OASL

Ensembl ID: ENSG00000135114

Description: 2'-5'-oligoadenylate synthetase like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.8534
    Cell Significance Index: -7.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.9884
    Cell Significance Index: -7.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.2212
    Cell Significance Index: -8.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.4398
    Cell Significance Index: -7.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8293
    Cell Significance Index: -8.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7752
    Cell Significance Index: 144.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.6108
    Cell Significance Index: 39.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.2700
    Cell Significance Index: 35.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9817
    Cell Significance Index: -7.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7101
    Cell Significance Index: 49.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6287
    Cell Significance Index: 35.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.5342
    Cell Significance Index: -4.1100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6691
    Cell Significance Index: 5.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6455
    Cell Significance Index: 11.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5688
    Cell Significance Index: 108.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4778
    Cell Significance Index: 16.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4529
    Cell Significance Index: 13.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4134
    Cell Significance Index: 18.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3489
    Cell Significance Index: 6.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2973
    Cell Significance Index: 29.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2658
    Cell Significance Index: 240.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2512
    Cell Significance Index: 5.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2351
    Cell Significance Index: 27.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1867
    Cell Significance Index: 11.2100
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.1866
    Cell Significance Index: 1.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1778
    Cell Significance Index: 19.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1650
    Cell Significance Index: 26.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1557
    Cell Significance Index: 3.2300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1153
    Cell Significance Index: 1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0981
    Cell Significance Index: 17.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0923
    Cell Significance Index: 6.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0569
    Cell Significance Index: 7.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0264
    Cell Significance Index: 3.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0172
    Cell Significance Index: 0.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0028
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0056
    Cell Significance Index: -8.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0066
    Cell Significance Index: -8.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0090
    Cell Significance Index: -1.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0093
    Cell Significance Index: -4.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0122
    Cell Significance Index: -6.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0126
    Cell Significance Index: -7.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0150
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0153
    Cell Significance Index: -8.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0183
    Cell Significance Index: -6.5800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0184
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0186
    Cell Significance Index: -8.4400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0208
    Cell Significance Index: -0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0223
    Cell Significance Index: -4.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0255
    Cell Significance Index: -7.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0278
    Cell Significance Index: -2.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0398
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0430
    Cell Significance Index: -9.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0433
    Cell Significance Index: -7.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0451
    Cell Significance Index: -2.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0509
    Cell Significance Index: -7.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0522
    Cell Significance Index: -7.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0673
    Cell Significance Index: -7.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0726
    Cell Significance Index: -8.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0750
    Cell Significance Index: -7.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0890
    Cell Significance Index: -0.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0930
    Cell Significance Index: -2.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1004
    Cell Significance Index: -7.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1005
    Cell Significance Index: -4.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1008
    Cell Significance Index: -7.1300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1070
    Cell Significance Index: -0.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1172
    Cell Significance Index: -7.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1173
    Cell Significance Index: -9.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1190
    Cell Significance Index: -8.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1342
    Cell Significance Index: -6.7800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1348
    Cell Significance Index: -1.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1368
    Cell Significance Index: -8.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1488
    Cell Significance Index: -2.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1520
    Cell Significance Index: -7.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1550
    Cell Significance Index: -6.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1634
    Cell Significance Index: -7.6200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1748
    Cell Significance Index: -1.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1759
    Cell Significance Index: -9.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1812
    Cell Significance Index: -2.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1838
    Cell Significance Index: -8.1300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1889
    Cell Significance Index: -1.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2012
    Cell Significance Index: -7.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2025
    Cell Significance Index: -3.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2128
    Cell Significance Index: -7.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2150
    Cell Significance Index: -8.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2204
    Cell Significance Index: -3.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2210
    Cell Significance Index: -7.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2217
    Cell Significance Index: -5.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2311
    Cell Significance Index: -7.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2337
    Cell Significance Index: -6.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2366
    Cell Significance Index: -6.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2378
    Cell Significance Index: -5.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2430
    Cell Significance Index: -6.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2497
    Cell Significance Index: -6.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2501
    Cell Significance Index: -8.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The OASL gene exhibits several key characteristics that highlight its role in the immune response: 1. **Structural similarity**: OASL shares a high degree of structural similarity with OAS, which is a key enzyme in the production of secondary messengers that activate ISGs. 2. **Antiviral function**: The OASL protein has been shown to have antiviral activity, suggesting its role in the defense against viral infections. 3. **Widespread expression**: OASL is expressed in various cell types, including immune cells, epithelial cells, and neural cells, indicating its broad involvement in the immune response. 4. **Regulation of viral genome replication**: OASL has been shown to negatively regulate viral genome replication, suggesting its role in limiting viral replication. **Pathways and Functions** The OASL gene is involved in several key pathways and functions: 1. **Interferon signaling**: OASL is part of the interferon signaling pathway, which is a key mechanism by which the immune system responds to viral infections. 2. **Antiviral mechanisms**: OASL has been shown to have antiviral activity, suggesting its role in the defense against viral infections. 3. **Cytokine signaling**: OASL is involved in cytokine signaling, which is a key mechanism by which the immune system coordinates its response to infection. 4. **Regulation of ribonuclease activity**: OASL has been shown to regulate ribonuclease activity, which is a key mechanism by which the immune system degrades viral RNA. **Clinical Significance** The OASL gene has several clinical implications: 1. **Viral infections**: OASL's antiviral activity suggests its potential role in the treatment of viral infections, such as influenza and HIV. 2. **Autoimmune diseases**: OASL's involvement in cytokine signaling and immune response regulation suggests its potential role in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: OASL's role in regulating ribonuclease activity suggests its potential role in cancer, where dysregulation of ribonuclease activity can contribute to tumorigenesis. 4. **Neurological disorders**: OASL's expression in neural cells suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the OASL gene plays a crucial role in the innate immune response against viral infections, and its clinical significance extends to the treatment of viral infections, autoimmune diseases, cancer, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which OASL regulates immune responses and to explore its potential therapeutic applications.

Genular Protein ID: 3269379460

Symbol: OASL_HUMAN

Name: 2'-5'-oligoadenylate synthase-like protein

UniProtKB Accession Codes:

Q15646 B2RAZ2 I1YDD2 O75686 Q17R95 Q9Y6K6 Q9Y6K7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722630

Title: p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family.

PubMed ID: 9722630

DOI: 10.1093/nar/26.18.4121

PubMed ID: 9826176

Title: Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase.

PubMed ID: 9826176

DOI: 10.1046/j.1432-1327.1998.2570319.x

PubMed ID: 22531715

Title: Identification of OASL d, a splice variant of human OASL, with antiviral activity.

PubMed ID: 22531715

DOI: 10.1016/j.biocel.2012.04.001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7776974

Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

PubMed ID: 7776974

DOI: 10.1210/mend.9.2.7776974

PubMed ID: 14728690

Title: Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1.

PubMed ID: 14728690

DOI: 10.1046/j.1432-1033.2003.03966.x

PubMed ID: 17408844

Title: The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.

PubMed ID: 17408844

DOI: 10.1016/j.biochi.2007.02.003

PubMed ID: 18931074

Title: The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.

PubMed ID: 18931074

DOI: 10.1099/vir.0.2008/003558-0

PubMed ID: 19203244

Title: Differential regulation of the OASL and OAS1 genes in response to viral infections.

PubMed ID: 19203244

DOI: 10.1089/jir.2008.0050

PubMed ID: 19904482

Title: Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria.

PubMed ID: 19904482

DOI: 10.1007/s00239-009-9299-1

PubMed ID: 20074559

Title: 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro.

PubMed ID: 20074559

DOI: 10.1016/j.bbrc.2010.01.034

PubMed ID: 21142819

Title: The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.

PubMed ID: 21142819

DOI: 10.1089/jir.2010.0107

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 514
  • Mass: 59226
  • Checksum: 4D8BB655D9EA003E
  • Sequence:
    • MALMQELYST PASRLDSFVA QWLQPHREWK EEVLDAVRTV EEFLRQEHFQ GKRGLDQDVR 
VLKVVKVGSF GNGTVLRSTR EVELVAFLSC FHSFQEAAKH HKDVLRLIWK TMWQSQDLLD 
LGLEDLRMEQ RVPDALVFTI QTRGTAEPIT VTIVPAYRAL GPSLPNSQPP PEVYVSLIKA 
CGGPGNFCPS FSELQRNFVK HRPTKLKSLL RLVKHWYQQY VKARSPRANL PPLYALELLT 
IYAWEMGTEE DENFMLDEGF TTVMDLLLEY EVICIYWTKY YTLHNAIIED CVRKQLKKER 
PIILDPADPT LNVAEGYRWD IVAQRASQCL KQDCCYDNRE NPISSWNVKR ARDIHLTVEQ 
RGYPDFNLIV NPYEPIRKVK EKIRRTRGYS GLQRLSFQVP GSERQLLSSR CSLAKYGIFS 
HTHIYLLETI PSEIQVFVKN PDGGSYAYAI NPNSFILGLK QQIEDQQGLP KKQQQLEFQG 
QVLQDWLGLG IYGIQDSDTL ILSKKKGEAL FPAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.