Details for: KCNK5

Gene ID: 8645

Symbol: KCNK5

Ensembl ID: ENSG00000164626

Description: potassium two pore domain channel subfamily K member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.9808
    Cell Significance Index: -5.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.7378
    Cell Significance Index: -5.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.7413
    Cell Significance Index: -4.7700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 8.4236
    Cell Significance Index: 6.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.0694
    Cell Significance Index: -4.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.3473
    Cell Significance Index: -5.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.9074
    Cell Significance Index: 112.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.5562
    Cell Significance Index: 68.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5401
    Cell Significance Index: 55.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0931
    Cell Significance Index: 398.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9437
    Cell Significance Index: 134.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9038
    Cell Significance Index: -5.1000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.7448
    Cell Significance Index: 14.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3209
    Cell Significance Index: 59.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9839
    Cell Significance Index: 888.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8910
    Cell Significance Index: 53.4900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8716
    Cell Significance Index: 12.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8131
    Cell Significance Index: 94.7600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.7788
    Cell Significance Index: 8.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6334
    Cell Significance Index: 13.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5673
    Cell Significance Index: 92.2700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5583
    Cell Significance Index: 4.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5572
    Cell Significance Index: 7.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4708
    Cell Significance Index: 8.3200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.4348
    Cell Significance Index: 2.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3970
    Cell Significance Index: 10.6000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3725
    Cell Significance Index: 3.8400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3564
    Cell Significance Index: 4.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3412
    Cell Significance Index: 11.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3230
    Cell Significance Index: 4.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3013
    Cell Significance Index: 6.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2956
    Cell Significance Index: 4.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2775
    Cell Significance Index: 3.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2676
    Cell Significance Index: 13.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2393
    Cell Significance Index: 4.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2256
    Cell Significance Index: 22.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1528
    Cell Significance Index: 4.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1320
    Cell Significance Index: 3.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1207
    Cell Significance Index: 15.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1123
    Cell Significance Index: 1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1055
    Cell Significance Index: 20.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0959
    Cell Significance Index: 1.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0836
    Cell Significance Index: 10.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0768
    Cell Significance Index: 0.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0731
    Cell Significance Index: 3.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0704
    Cell Significance Index: 12.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0664
    Cell Significance Index: 3.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0650
    Cell Significance Index: 40.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0575
    Cell Significance Index: 31.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0505
    Cell Significance Index: 5.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0425
    Cell Significance Index: 0.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0288
    Cell Significance Index: 4.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0098
    Cell Significance Index: 7.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0087
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -2.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0040
    Cell Significance Index: -2.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0041
    Cell Significance Index: -6.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0042
    Cell Significance Index: -2.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0057
    Cell Significance Index: -1.2100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0065
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0083
    Cell Significance Index: -3.6600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0107
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0110
    Cell Significance Index: -4.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0133
    Cell Significance Index: -4.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0144
    Cell Significance Index: -4.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0145
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0152
    Cell Significance Index: -1.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0237
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0239
    Cell Significance Index: -4.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0264
    Cell Significance Index: -3.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0275
    Cell Significance Index: -3.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0292
    Cell Significance Index: -1.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0297
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0327
    Cell Significance Index: -3.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0331
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0334
    Cell Significance Index: -1.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0337
    Cell Significance Index: -4.9100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0403
    Cell Significance Index: -0.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0455
    Cell Significance Index: -5.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0474
    Cell Significance Index: -3.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0503
    Cell Significance Index: -0.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0513
    Cell Significance Index: -5.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0538
    Cell Significance Index: -0.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0564
    Cell Significance Index: -0.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0587
    Cell Significance Index: -3.0600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0598
    Cell Significance Index: -0.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0636
    Cell Significance Index: -2.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0644
    Cell Significance Index: -4.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0649
    Cell Significance Index: -4.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0719
    Cell Significance Index: -4.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0769
    Cell Significance Index: -5.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0772
    Cell Significance Index: -4.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0807
    Cell Significance Index: -3.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0824
    Cell Significance Index: -5.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0859
    Cell Significance Index: -5.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0980
    Cell Significance Index: -6.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ion Channel Function**: KCNK5 encodes a potassium two-pore domain channel that allows potassium ions to flow across the plasma membrane, influencing the resting membrane potential and muscle contraction. 2. **Tissue Expression**: KCNK5 is widely expressed in various tissues, including kidney proximal straight tubule epithelial cells, cardiac endothelial cells, pancreatic ductal cells, and cerebral cortex GABAergic interneurons. 3. **Regulatory Mechanisms**: KCNK5 is subject to regulation by various mechanisms, including acid sensitivity, voltage-dependent modulation, and interaction with other proteins. 4. **Subcellular Localization**: KCNK5 is primarily localized to the plasma membrane, where it regulates potassium ion transport and membrane potential. **Pathways and Functions** 1. **Cardiac Conduction**: KCNK5 plays a crucial role in maintaining the resting membrane potential and regulating cardiac muscle contraction through its potassium channel activity. 2. **Muscle Contraction**: KCNK5 is involved in regulating muscle contraction by modulating the resting membrane potential and potassium ion transport. 3. **Neurotransmitter Release**: KCNK5 is implicated in the regulation of neurotransmitter release in the brain, particularly in GABAergic interneurons, where it influences the resting membrane potential and potassium ion transport. 4. **Potassium Ion Transport**: KCNK5 regulates plasma membrane potassium ion transport, influencing the resting membrane potential and muscle contraction. 5. **Regulation of Resting Membrane Potential**: KCNK5 is involved in the regulation of the resting membrane potential in various cell types, including cardiac endothelial cells and pancreatic ductal cells. **Clinical Significance** 1. **Cardiac Arrhythmias**: Mutations in the KCNK5 gene have been associated with cardiac arrhythmias, highlighting the importance of KCNK5 in maintaining cardiac rhythm. 2. **Neurological Disorders**: KCNK5 has been implicated in various neurological disorders, including epilepsy and schizophrenia, where it regulates neurotransmitter release and membrane potential. 3. **Renal Function**: KCNK5 is involved in regulating renal function, particularly in the kidney proximal straight tubule epithelial cells, where it influences potassium ion transport and membrane potential. 4. **Pancreatic Function**: KCNK5 plays a role in regulating pancreatic function, particularly in the pancreatic ductal cells, where it influences potassium ion transport and membrane potential. In conclusion, the KCNK5 gene encodes a critical component of various ion channels that regulate membrane potential and potassium ion transport in different cell types. Its significant expression in various tissues and involvement in various physiological and pathological processes make it an important target for further research and potential therapeutic applications.

Genular Protein ID: 1951128460

Symbol: KCNK5_HUMAN

Name: Acid-sensitive potassium channel protein TASK-2

UniProtKB Accession Codes:

O95279 B2RAQ6 B5TJL2 Q5VV76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9812978

Title: Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.

PubMed ID: 9812978

DOI: 10.1074/jbc.273.47.30863

PubMed ID: 18516069

Title: Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.

PubMed ID: 18516069

DOI: 10.1038/bjp.2008.213

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12851074

Title: Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity.

PubMed ID: 12851074

DOI: 10.1080/0968768031000084181

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 499
  • Mass: 55130
  • Checksum: E871A7A4823DDA00
  • Sequence:
    • MVDRGPLLTS AIIFYLAIGA AIFEVLEEPH WKEAKKNYYT QKLHLLKEFP CLGQEGLDKI 
LEVVSDAAGQ GVAITGNQTF NNWNWPNAMI FAATVITTIG YGNVAPKTPA GRLFCVFYGL 
FGVPLCLTWI SALGKFFGGR AKRLGQFLTK RGVSLRKAQI TCTVIFIVWG VLVHLVIPPF 
VFMVTEGWNY IEGLYYSFIT ISTIGFGDFV AGVNPSANYH ALYRYFVELW IYLGLAWLSL 
FVNWKVSMFV EVHKAIKKRR RRRKESFESS PHSRKALQVK GSTASKDVNI FSFLSKKEET 
YNDLIKQIGK KAMKTSGGGE TGPGPGLGPQ GGGLPALPPS LVPLVVYSKN RVPTLEEVSQ 
TLRSKGHVSR SPDEEAVARA PEDSSPAPEV FMNQLDRISE ECEPWDAQDY HPLIFQDASI 
TFVNTEAGLS DEETSKSSLE DNLAGEESPQ QGAEAKAPLN MGEFPSSSES TFTSTESELS 
VPYEQLMNEY NKANSPKGT

Genular Protein ID: 2638212873

Symbol: A0A0B6VPR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B6VPR3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 317
  • Mass: 35039
  • Checksum: CA8E6623E7AEF805
  • Sequence:
    • MVTEGWNYIE GLYYSFITIS TIGFGDFVAG VNPSANYHAL YRYFVELWIY LGLAWLSLFV 
NWKVSMFVEV HKAIKKRRRR RKESFESSPH SRKALQVKGS TASKDVNIFS FLSKKEETYN 
DLIKQIGKKA MKTSGGGETG PGPGLGPQGG GLPALPPSLV PLVVYSKNRV PTLEEVSQTL 
RSKGHVSRSP DEEAVARAPE DSSPAPEVFM NQLDRISEEC EPWDAQDYHP LIFQDASITF 
VNTEAGLSDE ETSKSSLEDN LAGEESPQQG AEAKAPLNMG EFPSSSESTF TSTESELSVP 
YEQLMNEYNK ANSPKGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.