Details for: EIF3B

Gene ID: 8662

Symbol: EIF3B

Ensembl ID: ENSG00000106263

Description: eukaryotic translation initiation factor 3 subunit B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 254.3312
    Cell Significance Index: -39.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.8701
    Cell Significance Index: -40.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.5338
    Cell Significance Index: -36.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.0810
    Cell Significance Index: -43.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.5521
    Cell Significance Index: -46.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.0472
    Cell Significance Index: -37.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.3703
    Cell Significance Index: -43.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6820
    Cell Significance Index: -42.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4241
    Cell Significance Index: -45.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.0771
    Cell Significance Index: -27.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4072
    Cell Significance Index: -18.4000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.2533
    Cell Significance Index: 5.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9818
    Cell Significance Index: 31.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9738
    Cell Significance Index: 26.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.9051
    Cell Significance Index: 50.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8886
    Cell Significance Index: 52.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7681
    Cell Significance Index: 47.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6490
    Cell Significance Index: 1488.9200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.5295
    Cell Significance Index: 23.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5185
    Cell Significance Index: 43.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4752
    Cell Significance Index: 95.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4462
    Cell Significance Index: 287.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3239
    Cell Significance Index: 62.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0718
    Cell Significance Index: 48.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0145
    Cell Significance Index: 139.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9649
    Cell Significance Index: 526.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9454
    Cell Significance Index: 44.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8810
    Cell Significance Index: 23.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8692
    Cell Significance Index: 156.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8533
    Cell Significance Index: 24.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8454
    Cell Significance Index: 109.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8213
    Cell Significance Index: 100.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7821
    Cell Significance Index: 55.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7814
    Cell Significance Index: 345.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7322
    Cell Significance Index: 125.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6797
    Cell Significance Index: 136.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6244
    Cell Significance Index: 32.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6216
    Cell Significance Index: 32.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6148
    Cell Significance Index: 60.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5705
    Cell Significance Index: 42.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3728
    Cell Significance Index: 60.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3690
    Cell Significance Index: 132.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2143
    Cell Significance Index: 25.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1808
    Cell Significance Index: 1.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1694
    Cell Significance Index: 4.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1221
    Cell Significance Index: 84.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0862
    Cell Significance Index: 16.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0747
    Cell Significance Index: 9.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0666
    Cell Significance Index: 2.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0604
    Cell Significance Index: 3.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0226
    Cell Significance Index: 42.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0189
    Cell Significance Index: 34.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0185
    Cell Significance Index: 1.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0158
    Cell Significance Index: 24.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0151
    Cell Significance Index: 0.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0136
    Cell Significance Index: 0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0151
    Cell Significance Index: -11.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0195
    Cell Significance Index: -1.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0361
    Cell Significance Index: -20.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0399
    Cell Significance Index: -24.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0573
    Cell Significance Index: -3.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0644
    Cell Significance Index: -6.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0745
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1276
    Cell Significance Index: -26.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1307
    Cell Significance Index: -37.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1521
    Cell Significance Index: -4.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1604
    Cell Significance Index: -23.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1908
    Cell Significance Index: -21.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1966
    Cell Significance Index: -13.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2053
    Cell Significance Index: -23.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2346
    Cell Significance Index: -2.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2610
    Cell Significance Index: -16.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2695
    Cell Significance Index: -4.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3033
    Cell Significance Index: -3.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3604
    Cell Significance Index: -37.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3827
    Cell Significance Index: -8.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3917
    Cell Significance Index: -13.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3942
    Cell Significance Index: -45.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4320
    Cell Significance Index: -9.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4342
    Cell Significance Index: -34.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4460
    Cell Significance Index: -11.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4514
    Cell Significance Index: -8.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4524
    Cell Significance Index: -14.4900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.4573
    Cell Significance Index: -3.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4723
    Cell Significance Index: -12.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4861
    Cell Significance Index: -21.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4871
    Cell Significance Index: -8.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5353
    Cell Significance Index: -13.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5619
    Cell Significance Index: -29.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5645
    Cell Significance Index: -34.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6083
    Cell Significance Index: -23.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6092
    Cell Significance Index: -30.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6646
    Cell Significance Index: -11.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6987
    Cell Significance Index: -19.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7527
    Cell Significance Index: -13.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The EIF3B gene exhibits several key characteristics that highlight its significance in translation initiation: 1. **Cap-dependent translation initiation**: EIF3B is essential for binding to the mRNA cap, a crucial step in the initiation of translation. 2. **Ribosomal subunit recruitment**: EIF3B helps recruit the 40S ribosomal subunit, which is necessary for the initiation of translation. 3. **Regulation of translational initiation**: EIF3B modulates the efficiency of translation initiation, influencing the expression of various genes. 4. **Adaptor activity**: EIF3B acts as a molecular adaptor, facilitating the interaction between eIF3 and other translation initiation factors. **Pathways and Functions** EIF3B is involved in various cellular processes, including: 1. **Activation of mRNA upon binding of the cap-binding complex and eIFs**: EIF3B enables the binding of the cap-binding complex and eIFs to the mRNA cap, initiating translation. 2. **Binding to 43S**: EIF3B interacts with the 43S ribosomal subunit, facilitating the recruitment of the 60S ribosomal subunit and the initiation of translation. 3. **Formation of cytoplasmic stress granules**: EIF3B is involved in the formation of cytoplasmic stress granules, which are involved in the regulation of translation in response to stress. 4. **Regulation of translational initiation**: EIF3B modulates the efficiency of translation initiation, influencing the expression of various genes. **Clinical Significance** Dysregulation of EIF3B has been implicated in various diseases, including: 1. **Neuropathic disorders**: Mutations in EIF3B have been associated with neurodegenerative diseases, such as Charcot-Marie-Tooth disease and spinocerebellar ataxia. 2. **Cancer**: Alterations in EIF3B expression have been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Muscular dystrophy**: EIF3B mutations have been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. In conclusion, EIF3B plays a critical role in the regulation of translation initiation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which EIF3B influences cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 3876678635

Symbol: EIF3B_HUMAN

Name: Prt1 homolog

UniProtKB Accession Codes:

P55884 A4D208 Q2NL77 Q9UMF9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9388245

Title: Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1.

PubMed ID: 9388245

DOI: 10.1074/jbc.272.49.30975

PubMed ID: 8995410

Title: The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170.

PubMed ID: 8995410

DOI: 10.1074/jbc.272.2.1110

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11457827

Title: Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.

PubMed ID: 11457827

DOI: 10.1074/jbc.m102161200

PubMed ID: 11169732

Title: Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7.

PubMed ID: 11169732

DOI: 10.1002/1097-4644(20010315)80:4<483::aid-jcb1002>3.0.co;2-b

PubMed ID: 14519125

Title: Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3.

PubMed ID: 14519125

DOI: 10.1046/j.1432-1033.2003.03807.x

PubMed ID: 14688252

Title: The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro.

PubMed ID: 14688252

DOI: 10.1074/jbc.m312745200

PubMed ID: 16286006

Title: mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.

PubMed ID: 16286006

DOI: 10.1016/j.cell.2005.10.024

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 17581632

Title: Reconstitution reveals the functional core of mammalian eIF3.

PubMed ID: 17581632

DOI: 10.1038/sj.emboj.7601765

PubMed ID: 18056426

Title: The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation.

PubMed ID: 18056426

DOI: 10.1101/gad.439507

PubMed ID: 17468741

Title: Human INT6/eIF3e is required for nonsense-mediated mRNA decay.

PubMed ID: 17468741

DOI: 10.1038/sj.embor.7400955

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 17984221

Title: Proline-rich transcript in brain protein induces stress granule formation.

PubMed ID: 17984221

DOI: 10.1128/mcb.01226-07

PubMed ID: 18628297

Title: Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.

PubMed ID: 18628297

DOI: 10.1093/nar/gkn454

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24423872

Title: AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.

PubMed ID: 24423872

DOI: 10.1093/nar/gkt1379

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 27117702

Title: The m(6)A methyltransferase METTL3 promotes translation in human cancer cells.

PubMed ID: 27117702

DOI: 10.1016/j.molcel.2016.03.021

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

PubMed ID: 17190833

Title: Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit.

PubMed ID: 17190833

DOI: 10.1074/jbc.m610860200

Sequence Information:

  • Length: 814
  • Mass: 92482
  • Checksum: C687A986EDAE0F5E
  • Sequence:
    • MQDAENVAVP EAAEERAEPG QQQPAAEPPP AEGLLRPAGP GAPEAAGTEA SSEEVGIAEA 
GPESEVRTEP AAEAEAASGP SESPSPPAAE ELPGSHAEPP VPAQGEAPGE QARDERSDSR 
AQAVSEDAGG NEGRAAEAEP RALENGDADE PSFSDPEDFV DDVSEEELLG DVLKDRPQEA 
DGIDSVIVVD NVPQVGPDRL EKLKNVIHKI FSKFGKITND FYPEEDGKTK GYIFLEYASP 
AHAVDAVKNA DGYKLDKQHT FRVNLFTDFD KYMTISDEWD IPEKQPFKDL GNLRYWLEEA 
ECRDQYSVIF ESGDRTSIFW NDVKDPVSIE ERARWTETYV RWSPKGTYLA TFHQRGIALW 
GGEKFKQIQR FSHQGVQLID FSPCERYLVT FSPLMDTQDD PQAIIIWDIL TGHKKRGFHC 
ESSAHWPIFK WSHDGKFFAR MTLDTLSIYE TPSMGLLDKK SLKISGIKDF SWSPGGNIIA 
FWVPEDKDIP ARVTLMQLPT RQEIRVRNLF NVVDCKLHWQ KNGDYLCVKV DRTPKGTQGV 
VTNFEIFRMR EKQVPVDVVE MKETIIAFAW EPNGSKFAVL HGEAPRISVS FYHVKNNGKI 
ELIKMFDKQQ ANTIFWSPQG QFVVLAGLRS MNGALAFVDT SDCTVMNIAE HYMASDVEWD 
PTGRYVVTSV SWWSHKVDNA YWLWTFQGRL LQKNNKDRFC QLLWRPRPPT LLSQEQIKQI 
KKDLKKYSKI FEQKDRLSQS KASKELVERR RTMMEDFRKY RKMAQELYME QKNERLELRG 
GVDTDELDSN VDDWEEETIE FFVTEEIIPL GNQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.