Details for: TRADD

Gene ID: 8717

Symbol: TRADD

Ensembl ID: ENSG00000102871

Description: TNFRSF1A associated via death domain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.6431
    Cell Significance Index: -17.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.1021
    Cell Significance Index: -17.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.9594
    Cell Significance Index: -19.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.6808
    Cell Significance Index: -21.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.6115
    Cell Significance Index: -19.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8586
    Cell Significance Index: -18.3200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.4602
    Cell Significance Index: 87.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8314
    Cell Significance Index: -19.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5646
    Cell Significance Index: -14.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5295
    Cell Significance Index: -9.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3263
    Cell Significance Index: -7.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0566
    Cell Significance Index: 89.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.1419
    Cell Significance Index: 148.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0292
    Cell Significance Index: 236.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.9892
    Cell Significance Index: 42.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7378
    Cell Significance Index: 282.6400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.5520
    Cell Significance Index: 4.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4388
    Cell Significance Index: 19.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1246
    Cell Significance Index: 122.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0864
    Cell Significance Index: 65.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7602
    Cell Significance Index: 39.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7052
    Cell Significance Index: 11.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6908
    Cell Significance Index: 32.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6214
    Cell Significance Index: 339.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5851
    Cell Significance Index: 57.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5822
    Cell Significance Index: 13.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5372
    Cell Significance Index: 25.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4804
    Cell Significance Index: 86.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4478
    Cell Significance Index: 12.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4438
    Cell Significance Index: 12.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3654
    Cell Significance Index: 44.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3288
    Cell Significance Index: 21.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2644
    Cell Significance Index: 116.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2388
    Cell Significance Index: 32.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2364
    Cell Significance Index: 30.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2341
    Cell Significance Index: 10.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2305
    Cell Significance Index: 4.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2268
    Cell Significance Index: 204.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2259
    Cell Significance Index: 2.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1951
    Cell Significance Index: 37.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1771
    Cell Significance Index: 13.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1690
    Cell Significance Index: 1.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1579
    Cell Significance Index: 11.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1322
    Cell Significance Index: 3.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1240
    Cell Significance Index: 3.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1106
    Cell Significance Index: 3.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0914
    Cell Significance Index: 2.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0748
    Cell Significance Index: 1.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0626
    Cell Significance Index: 3.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0544
    Cell Significance Index: 7.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0538
    Cell Significance Index: 10.6900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0496
    Cell Significance Index: 0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0098
    Cell Significance Index: 7.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0013
    Cell Significance Index: 0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0043
    Cell Significance Index: -0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0085
    Cell Significance Index: -5.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0095
    Cell Significance Index: -3.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0221
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0265
    Cell Significance Index: -19.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0357
    Cell Significance Index: -22.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0364
    Cell Significance Index: -16.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0571
    Cell Significance Index: -16.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0850
    Cell Significance Index: -12.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0892
    Cell Significance Index: -10.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1099
    Cell Significance Index: -23.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1268
    Cell Significance Index: -3.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1520
    Cell Significance Index: -6.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1627
    Cell Significance Index: -4.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1718
    Cell Significance Index: -13.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1746
    Cell Significance Index: -3.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1784
    Cell Significance Index: -18.5800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1834
    Cell Significance Index: -1.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1931
    Cell Significance Index: -10.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2114
    Cell Significance Index: -6.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2131
    Cell Significance Index: -13.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2158
    Cell Significance Index: -13.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2192
    Cell Significance Index: -17.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2308
    Cell Significance Index: -15.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3309
    Cell Significance Index: -8.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3314
    Cell Significance Index: -20.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3856
    Cell Significance Index: -9.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4051
    Cell Significance Index: -22.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4067
    Cell Significance Index: -17.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4349
    Cell Significance Index: -12.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4379
    Cell Significance Index: -15.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4487
    Cell Significance Index: -16.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4524
    Cell Significance Index: -8.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4583
    Cell Significance Index: -3.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4615
    Cell Significance Index: -15.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4700
    Cell Significance Index: -12.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4822
    Cell Significance Index: -8.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4851
    Cell Significance Index: -18.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4909
    Cell Significance Index: -10.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Molecular Adaptor Function:** TRADD acts as a scaffold protein, binding to multiple partners and modulating their activities. This function enables it to integrate signals from various pathways, including the TNF receptor superfamily, NF-κB, and caspase activation. 2. **Apoptosis Regulation:** TRADD is involved in the regulation of apoptosis, particularly in the context of TNF receptor signaling. It interacts with FADD (Fas-associated death domain protein) and caspase-8, facilitating the activation of caspase-8 and subsequent apoptosis. 3. **Inflammation and Immune Response:** TRADD is a key regulator of inflammatory responses, particularly in the context of the TNF receptor superfamily. It modulates the activity of NF-κB, a transcription factor that regulates the expression of pro-inflammatory genes. 4. **Cell Signaling Pathways:** TRADD interacts with various signaling proteins, including RIPK1 (receptor-interacting protein kinase 1), RIPK3 (receptor-interacting protein kinase 3), and caspases. These interactions modulate the activity of these proteins and influence the outcome of cellular signaling. **Pathways and Functions:** 1. **TNF Receptor Signaling:** TRADD interacts with TNF receptors, modulating the activity of NF-κB and caspase-8. 2. **NF-κB Signaling:** TRADD regulates the activity of NF-κB, a transcription factor that controls the expression of pro-inflammatory genes. 3. **Caspase Activation:** TRADD interacts with FADD and caspase-8, facilitating the activation of caspase-8 and subsequent apoptosis. 4. **RIPK1-Mediated Regulated Necrosis:** TRADD interacts with RIPK1, modulating the activity of RIPK3 and influencing the outcome of regulated necrosis. 5. **Extrinsic Apoptotic Signaling Pathway:** TRADD is involved in the regulation of apoptosis via the extrinsic apoptotic signaling pathway, which is triggered by death receptors. **Clinical Significance:** Dysregulation of TRADD has been implicated in various diseases, including: 1. **Autoimmune Disorders:** TRADD dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. 2. **Cancer:** TRADD is involved in the regulation of apoptosis and inflammation, and its dysregulation has been implicated in various types of cancer. 3. **Neurodegenerative Conditions:** TRADD has been implicated in the regulation of apoptosis and inflammation in neurodegenerative conditions, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRADD is a multifaceted protein that plays a critical role in regulating apoptosis, inflammation, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of TRADD in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 3128652025

Symbol: TRADD_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7758105

Title: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.

PubMed ID: 7758105

DOI: 10.1016/0092-8674(95)90070-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8612133

Title: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.

PubMed ID: 8612133

DOI: 10.1016/s1074-7613(00)80252-6

PubMed ID: 10356400

Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

PubMed ID: 10356400

DOI: 10.1093/emboj/18.11.3044

PubMed ID: 11032752

Title: The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.

PubMed ID: 11032752

DOI: 10.1006/bbrc.2000.3700

PubMed ID: 11684708

Title: Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD.

PubMed ID: 11684708

DOI: 10.1083/jcb.200103078

PubMed ID: 14585990

Title: TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.

PubMed ID: 14585990

DOI: 10.1128/mcb.23.22.8334-8344.2003

PubMed ID: 15310755

Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

PubMed ID: 15310755

DOI: 10.1074/jbc.m407617200

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21307340

Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.

PubMed ID: 21307340

DOI: 10.1091/mbc.e10-10-0827

PubMed ID: 23429285

Title: EVER2 protein binds TRADD to promote TNF-alpha-induced apoptosis.

PubMed ID: 23429285

DOI: 10.1038/cddis.2013.27

PubMed ID: 23955153

Title: Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.

PubMed ID: 23955153

DOI: 10.1038/nature12436

PubMed ID: 24130170

Title: SH3RF2 functions as an oncogene by mediating PAK4 protein stability.

PubMed ID: 24130170

DOI: 10.1093/carcin/bgt338

PubMed ID: 28069818

Title: SseK1 and SseK3 type III secretion system effectors inhibit NF-kappaB signaling and necroptotic cell death in salmonella-infected macrophages.

PubMed ID: 28069818

DOI: 10.1128/iai.00010-17

PubMed ID: 29449376

Title: Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3.

PubMed ID: 29449376

DOI: 10.1074/jbc.ra118.001796

PubMed ID: 30902834

Title: Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways.

PubMed ID: 30902834

DOI: 10.1074/mcp.ra118.001093

PubMed ID: 32766249

Title: Arg-GlcNAcylation on TRADD by NleB and SseK1 is crucial for bacterial pathogenesis.

PubMed ID: 32766249

DOI: 10.3389/fcell.2020.00641

PubMed ID: 10911999

Title: Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.

PubMed ID: 10911999

DOI: 10.1016/s1097-2765(00)80270-1

PubMed ID: 10892748

Title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.

PubMed ID: 10892748

DOI: 10.1016/s0092-8674(00)80889-2

PubMed ID: 30979585

Title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector.

PubMed ID: 30979585

DOI: 10.1016/j.molcel.2019.03.028

Sequence Information:

  • Length: 312
  • Mass: 34247
  • Checksum: 5645D7E63E5FF05A
  • Sequence:
  • MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA ESGGSPDVLQ 
    MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ RSLAAALAQH SVPLQLELRA 
    GAERLDALLA DEERCLSCIL AQQPDRLRDE ELAELEDALR NLKCGSGARG GDGEVASAPL 
    QPPVPSLSEV KPPPPPPPAQ TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG 
    CRALRDPALD SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED 
    LLGLTDPNGG LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.