Details for: TRADD
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 110.6431
Cell Significance Index: -17.2100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 67.1021
Cell Significance Index: -17.0200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 41.9594
Cell Significance Index: -19.8100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 41.6808
Cell Significance Index: -21.4400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 29.6115
Cell Significance Index: -19.8700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.8586
Cell Significance Index: -18.3200 - Cell Name: decidual cell (CL2000002)
Fold Change: 5.4602
Cell Significance Index: 87.6000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.8314
Cell Significance Index: -19.0700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.5646
Cell Significance Index: -14.0200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.5295
Cell Significance Index: -9.4600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.3263
Cell Significance Index: -7.2800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.0566
Cell Significance Index: 89.7700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.1419
Cell Significance Index: 148.1200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.0292
Cell Significance Index: 236.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.9892
Cell Significance Index: 42.3700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.7378
Cell Significance Index: 282.6400 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.5520
Cell Significance Index: 4.7300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.4388
Cell Significance Index: 19.6300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1246
Cell Significance Index: 122.3200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0864
Cell Significance Index: 65.2200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7602
Cell Significance Index: 39.4900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.7052
Cell Significance Index: 11.6200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6908
Cell Significance Index: 32.2100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6214
Cell Significance Index: 339.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5851
Cell Significance Index: 57.8800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5822
Cell Significance Index: 13.4500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5372
Cell Significance Index: 25.2500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4804
Cell Significance Index: 86.5900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4478
Cell Significance Index: 12.0000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4438
Cell Significance Index: 12.0800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3654
Cell Significance Index: 44.9300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3288
Cell Significance Index: 21.2200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2644
Cell Significance Index: 116.8800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2388
Cell Significance Index: 32.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2364
Cell Significance Index: 30.3100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2341
Cell Significance Index: 10.6100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2305
Cell Significance Index: 4.2600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2268
Cell Significance Index: 204.8100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2259
Cell Significance Index: 2.0800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1951
Cell Significance Index: 37.1200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1771
Cell Significance Index: 13.2000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1690
Cell Significance Index: 1.9200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1579
Cell Significance Index: 11.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1322
Cell Significance Index: 3.8100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1240
Cell Significance Index: 3.3100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1106
Cell Significance Index: 3.0900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0914
Cell Significance Index: 2.4500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0748
Cell Significance Index: 1.6200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0626
Cell Significance Index: 3.1700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0544
Cell Significance Index: 7.0300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0538
Cell Significance Index: 10.6900 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.0496
Cell Significance Index: 0.3100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0098
Cell Significance Index: 7.4400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0013
Cell Significance Index: 0.2700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0005
Cell Significance Index: 1.0000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0043
Cell Significance Index: -0.4400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0062
Cell Significance Index: -11.4400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0074
Cell Significance Index: -11.3700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0085
Cell Significance Index: -5.9000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0094
Cell Significance Index: -12.8100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0095
Cell Significance Index: -3.4200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0105
Cell Significance Index: -7.7200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0181
Cell Significance Index: -11.4700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0221
Cell Significance Index: -3.7700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0265
Cell Significance Index: -19.6600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0341
Cell Significance Index: -19.2400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0357
Cell Significance Index: -22.3200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0364
Cell Significance Index: -16.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0571
Cell Significance Index: -16.4200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0850
Cell Significance Index: -12.3600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0892
Cell Significance Index: -10.2200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1099
Cell Significance Index: -23.1400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1268
Cell Significance Index: -3.2400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1520
Cell Significance Index: -6.2300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1627
Cell Significance Index: -4.6700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1718
Cell Significance Index: -13.1900 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1746
Cell Significance Index: -3.0100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1784
Cell Significance Index: -18.5800 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.1834
Cell Significance Index: -1.0000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1931
Cell Significance Index: -10.1400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2114
Cell Significance Index: -6.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2131
Cell Significance Index: -13.0700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2158
Cell Significance Index: -13.6000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2192
Cell Significance Index: -17.3600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2308
Cell Significance Index: -15.5200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3309
Cell Significance Index: -8.7000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3314
Cell Significance Index: -20.3700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3856
Cell Significance Index: -9.6400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4051
Cell Significance Index: -22.7300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4067
Cell Significance Index: -17.9900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4349
Cell Significance Index: -12.8100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4379
Cell Significance Index: -15.3400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4487
Cell Significance Index: -16.4700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4524
Cell Significance Index: -8.0000 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.4583
Cell Significance Index: -3.8500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4615
Cell Significance Index: -15.1100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4700
Cell Significance Index: -12.0800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4822
Cell Significance Index: -8.0700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4851
Cell Significance Index: -18.3700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4909
Cell Significance Index: -10.1800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3128652025
Symbol: TRADD_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7758105
Title: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.
PubMed ID: 7758105
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8612133
Title: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
PubMed ID: 8612133
PubMed ID: 10356400
Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
PubMed ID: 10356400
PubMed ID: 11032752
Title: The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.
PubMed ID: 11032752
PubMed ID: 11684708
Title: Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD.
PubMed ID: 11684708
PubMed ID: 14585990
Title: TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.
PubMed ID: 14585990
PubMed ID: 15310755
Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
PubMed ID: 15310755
PubMed ID: 20628368
Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
PubMed ID: 20628368
DOI: 10.1038/cr.2010.103
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21307340
Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
PubMed ID: 21307340
PubMed ID: 23429285
Title: EVER2 protein binds TRADD to promote TNF-alpha-induced apoptosis.
PubMed ID: 23429285
PubMed ID: 23955153
Title: Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.
PubMed ID: 23955153
DOI: 10.1038/nature12436
PubMed ID: 24130170
Title: SH3RF2 functions as an oncogene by mediating PAK4 protein stability.
PubMed ID: 24130170
PubMed ID: 28069818
Title: SseK1 and SseK3 type III secretion system effectors inhibit NF-kappaB signaling and necroptotic cell death in salmonella-infected macrophages.
PubMed ID: 28069818
DOI: 10.1128/iai.00010-17
PubMed ID: 29449376
Title: Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3.
PubMed ID: 29449376
PubMed ID: 30902834
Title: Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways.
PubMed ID: 30902834
PubMed ID: 32766249
Title: Arg-GlcNAcylation on TRADD by NleB and SseK1 is crucial for bacterial pathogenesis.
PubMed ID: 32766249
PubMed ID: 10911999
Title: Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.
PubMed ID: 10911999
PubMed ID: 10892748
Title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.
PubMed ID: 10892748
PubMed ID: 30979585
Title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector.
PubMed ID: 30979585
Sequence Information:
- Length: 312
- Mass: 34247
- Checksum: 5645D7E63E5FF05A
- Sequence:
MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA ESGGSPDVLQ MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ RSLAAALAQH SVPLQLELRA GAERLDALLA DEERCLSCIL AQQPDRLRDE ELAELEDALR NLKCGSGARG GDGEVASAPL QPPVPSLSEV KPPPPPPPAQ TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG CRALRDPALD SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED LLGLTDPNGG LA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.