Details for: TNFSF14

Gene ID: 8740

Symbol: TNFSF14

Ensembl ID: ENSG00000125735

Description: TNF superfamily member 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.0965
    Cell Significance Index: -8.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.1030
    Cell Significance Index: -8.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9751
    Cell Significance Index: -8.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 6.2959
    Cell Significance Index: 221.2300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.7520
    Cell Significance Index: 12.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.0415
    Cell Significance Index: 76.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1110
    Cell Significance Index: 35.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8500
    Cell Significance Index: 161.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6129
    Cell Significance Index: 121.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5480
    Cell Significance Index: 54.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5339
    Cell Significance Index: 7.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4657
    Cell Significance Index: 420.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3975
    Cell Significance Index: 5.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2695
    Cell Significance Index: 43.8400
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.2634
    Cell Significance Index: 1.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1980
    Cell Significance Index: 5.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1967
    Cell Significance Index: 21.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1214
    Cell Significance Index: 6.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1014
    Cell Significance Index: 7.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0763
    Cell Significance Index: 1.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0530
    Cell Significance Index: 1.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0170
    Cell Significance Index: 0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0162
    Cell Significance Index: 1.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0151
    Cell Significance Index: 0.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0143
    Cell Significance Index: 0.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0013
    Cell Significance Index: -0.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0027
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -10.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -7.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0095
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0134
    Cell Significance Index: -0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -8.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0164
    Cell Significance Index: -9.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0170
    Cell Significance Index: -0.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0186
    Cell Significance Index: -0.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0196
    Cell Significance Index: -7.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0198
    Cell Significance Index: -8.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0200
    Cell Significance Index: -0.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0230
    Cell Significance Index: -6.6300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0260
    Cell Significance Index: -0.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0311
    Cell Significance Index: -4.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0312
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0364
    Cell Significance Index: -6.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0395
    Cell Significance Index: -7.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0417
    Cell Significance Index: -8.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0592
    Cell Significance Index: -8.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0598
    Cell Significance Index: -7.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0635
    Cell Significance Index: -7.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0640
    Cell Significance Index: -6.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0665
    Cell Significance Index: -8.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0707
    Cell Significance Index: -9.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0712
    Cell Significance Index: -8.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0832
    Cell Significance Index: -8.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0838
    Cell Significance Index: -3.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0880
    Cell Significance Index: -2.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1030
    Cell Significance Index: -4.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1143
    Cell Significance Index: -1.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1215
    Cell Significance Index: -9.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1287
    Cell Significance Index: -9.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1298
    Cell Significance Index: -8.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1299
    Cell Significance Index: -2.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1449
    Cell Significance Index: -9.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1494
    Cell Significance Index: -6.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1585
    Cell Significance Index: -4.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1611
    Cell Significance Index: -9.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1659
    Cell Significance Index: -2.7900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1737
    Cell Significance Index: -1.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1774
    Cell Significance Index: -11.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1823
    Cell Significance Index: -10.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1891
    Cell Significance Index: -9.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1917
    Cell Significance Index: -3.0800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1996
    Cell Significance Index: -2.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2213
    Cell Significance Index: -9.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2298
    Cell Significance Index: -8.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2324
    Cell Significance Index: -8.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2325
    Cell Significance Index: -3.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2413
    Cell Significance Index: -7.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2591
    Cell Significance Index: -9.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2604
    Cell Significance Index: -8.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2726
    Cell Significance Index: -4.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2959
    Cell Significance Index: -4.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3039
    Cell Significance Index: -7.9900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3054
    Cell Significance Index: -2.4300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3059
    Cell Significance Index: -3.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3068
    Cell Significance Index: -8.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3085
    Cell Significance Index: -7.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3098
    Cell Significance Index: -8.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3118
    Cell Significance Index: -9.1900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3193
    Cell Significance Index: -10.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3202
    Cell Significance Index: -8.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3213
    Cell Significance Index: -8.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3217
    Cell Significance Index: -6.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3300
    Cell Significance Index: -5.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3375
    Cell Significance Index: -8.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFSF14 is a type II transmembrane protein, consisting of a soluble extracellular domain and a transmembrane domain. The protein has a unique structure, with a characteristic "V" shape, which allows it to bind to its receptor, TNFR2, with high affinity. TNFSF14 is a ligand of TNFR2, which is a member of the TNF receptor family. The interaction between TNFSF14 and TNFR2 triggers a signaling cascade that involves the activation of various kinases and transcription factors, leading to the regulation of cellular processes. **Pathways and Functions** TNFSF14 belongs to several signaling pathways, including: 1. **Apoptotic process**: TNFSF14 can induce apoptosis in certain cell types, including activated T cells and cancer cells, by triggering the activation of caspases and the downregulation of anti-apoptotic proteins. 2. **Cellular response to mechanical stimulus**: TNFSF14 can regulate the response of cells to mechanical stress, such as cell migration and proliferation. 3. **Cytokine activity**: TNFSF14 can modulate the activity of immune cells, including T cells and dendritic cells, by regulating the expression of cytokines and chemokines. 4. **Immune response**: TNFSF14 can regulate the immune response by modulating the activity of immune cells, including T cells, B cells, and macrophages. 5. **T cell activation**: TNFSF14 can activate T cells by regulating the expression of costimulatory molecules and cytokines. 6. **T cell homeostasis**: TNFSF14 can regulate the homeostasis of T cells by modulating the expression of cytokines and chemokines. **Clinical Significance** TNFSF14 has been implicated in various diseases, including: 1. **Autoimmune disorders**: TNFSF14 has been shown to contribute to the development of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, by regulating the activity of immune cells. 2. **Cancer**: TNFSF14 has been implicated in the development and progression of cancer, including colorectal cancer, by regulating the activity of immune cells and promoting tumor growth and metastasis. 3. **Neurological disorders**: TNFSF14 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, by regulating the activity of immune cells and promoting neuroinflammation. 4. **Inflammatory disorders**: TNFSF14 has been implicated in various inflammatory disorders, including psoriasis and inflammatory bowel disease, by regulating the activity of immune cells and promoting inflammation. In summary, TNFSF14 is a member of the TNF superfamily that plays a crucial role in regulating immune responses, cell differentiation, and tissue homeostasis. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, neurological disorders, and inflammatory disorders. Further research is needed to fully understand the mechanisms of TNFSF14 and its role in human health and disease.

Genular Protein ID: 3413089930

Symbol: TNF14_HUMAN

Name: Tumor necrosis factor ligand superfamily member 14

UniProtKB Accession Codes:

O43557 A8K7M2 C9J5H4 O75476 Q6FHA1 Q8WVF8 Q96LD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9462508

Title: LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.

PubMed ID: 9462508

DOI: 10.1016/s1074-7613(00)80455-0

PubMed ID: 9765287

Title: Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth.

PubMed ID: 9765287

DOI: 10.1074/jbc.273.42.27548

PubMed ID: 11673523

Title: Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis.

PubMed ID: 11673523

DOI: 10.4049/jimmunol.167.9.5122

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 10754304

Title: LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response.

PubMed ID: 10754304

DOI: 10.4049/jimmunol.164.8.4105

Sequence Information:

  • Length: 240
  • Mass: 26350
  • Checksum: 49D0B1870F390B39
  • Sequence:
    • MEESVVRPSV FVVDGQTDIP FTRLGRSHRR QSCSVARVGL GLLLLLMGAG LAVQGWFLLQ 
LHWRLGEMVT RLPDGPAGSW EQLIQERRSH EVNPAAHLTG ANSSLTGSGG PLLWETQLGL 
AFLRGLSYHD GALVVTKAGY YYIYSKVQLG GVGCPLGLAS TITHGLYKRT PRYPEELELL 
VSQQSPCGRA TSSSRVWWDS SFLGGVVHLE AGEKVVVRVL DERLVRLRDG TRSYFGAFMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.