Details for: CDS2

Gene ID: 8760

Symbol: CDS2

Ensembl ID: ENSG00000101290

Description: CDP-diacylglycerol synthase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 257.6743
    Cell Significance Index: -40.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.8327
    Cell Significance Index: -38.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 95.7161
    Cell Significance Index: -39.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.5523
    Cell Significance Index: -35.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.3168
    Cell Significance Index: -40.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.7798
    Cell Significance Index: -36.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.8455
    Cell Significance Index: -41.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3942
    Cell Significance Index: -38.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6448
    Cell Significance Index: -42.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5176
    Cell Significance Index: -20.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5997
    Cell Significance Index: 317.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5864
    Cell Significance Index: 318.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5416
    Cell Significance Index: 179.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2829
    Cell Significance Index: 460.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1283
    Cell Significance Index: 780.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1266
    Cell Significance Index: 86.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0966
    Cell Significance Index: 178.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8302
    Cell Significance Index: 21.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7800
    Cell Significance Index: 52.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6043
    Cell Significance Index: 7.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5550
    Cell Significance Index: 35.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5368
    Cell Significance Index: 32.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4425
    Cell Significance Index: 399.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4227
    Cell Significance Index: 26.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4184
    Cell Significance Index: 75.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3962
    Cell Significance Index: 24.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3619
    Cell Significance Index: 19.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3413
    Cell Significance Index: 41.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3313
    Cell Significance Index: 623.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2610
    Cell Significance Index: 142.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2554
    Cell Significance Index: 17.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2225
    Cell Significance Index: 6.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2136
    Cell Significance Index: 96.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2130
    Cell Significance Index: 9.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2014
    Cell Significance Index: 4.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1805
    Cell Significance Index: 17.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1754
    Cell Significance Index: 9.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1718
    Cell Significance Index: 4.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1586
    Cell Significance Index: 21.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1517
    Cell Significance Index: 4.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1495
    Cell Significance Index: 5.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1459
    Cell Significance Index: 3.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1429
    Cell Significance Index: 63.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1055
    Cell Significance Index: 12.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0934
    Cell Significance Index: 11.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0427
    Cell Significance Index: 65.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0407
    Cell Significance Index: 7.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0389
    Cell Significance Index: 2.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0334
    Cell Significance Index: 45.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0333
    Cell Significance Index: 61.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0312
    Cell Significance Index: 19.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0286
    Cell Significance Index: 4.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0210
    Cell Significance Index: 0.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0021
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0287
    Cell Significance Index: -17.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0319
    Cell Significance Index: -23.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0337
    Cell Significance Index: -25.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0390
    Cell Significance Index: -1.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0446
    Cell Significance Index: -2.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0492
    Cell Significance Index: -27.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0721
    Cell Significance Index: -7.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0725
    Cell Significance Index: -3.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0730
    Cell Significance Index: -1.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0732
    Cell Significance Index: -2.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0870
    Cell Significance Index: -11.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1068
    Cell Significance Index: -22.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1207
    Cell Significance Index: -34.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1321
    Cell Significance Index: -19.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1470
    Cell Significance Index: -15.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1506
    Cell Significance Index: -4.2100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1554
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1585
    Cell Significance Index: -18.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1907
    Cell Significance Index: -8.9700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2241
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2435
    Cell Significance Index: -27.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3008
    Cell Significance Index: -6.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3143
    Cell Significance Index: -5.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3212
    Cell Significance Index: -6.8400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3448
    Cell Significance Index: -4.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3533
    Cell Significance Index: -24.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3607
    Cell Significance Index: -5.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3694
    Cell Significance Index: -19.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4173
    Cell Significance Index: -9.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4401
    Cell Significance Index: -9.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4785
    Cell Significance Index: -37.9000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4930
    Cell Significance Index: -3.8000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5570
    Cell Significance Index: -7.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5826
    Cell Significance Index: -15.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5956
    Cell Significance Index: -18.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6147
    Cell Significance Index: -9.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6224
    Cell Significance Index: -13.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6333
    Cell Significance Index: -16.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6380
    Cell Significance Index: -16.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6399
    Cell Significance Index: -10.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6898
    Cell Significance Index: -42.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7114
    Cell Significance Index: -8.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7183
    Cell Significance Index: -24.9600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.7190
    Cell Significance Index: -7.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7224
    Cell Significance Index: -23.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** CDS2 is a phosphatidate cytidylyltransferase, which catalyzes the conversion of phosphatidate to CDP-diacylglycerol. 2. **Lipid Metabolism:** The gene is involved in the synthesis of glycerophospholipids, which are essential components of cellular membranes. 3. **Cellular Expression:** CDS2 is expressed in various cell types, including ciliary muscle cells, pigmented epithelial cells, and smooth muscle cells of the sphincter of pupil. 4. **Tissue Distribution:** The gene is widely distributed across different tissues, suggesting a critical role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Glycerophospholipid Biosynthesis:** CDS2 is involved in the synthesis of glycerophospholipids, including phosphatidate, phosphatidylglycerol, and phosphatidylserine. 2. **Endoplasmic Reticulum (ER) Membrane:** The gene is localized to the ER membrane, suggesting a role in regulating lipid metabolism within this organelle. 3. **Lipid Droplet Formation:** CDS2 may contribute to the formation of lipid droplets, which are essential for lipid storage and metabolism. 4. **Protein Binding:** The gene product interacts with various proteins, including enzymes and receptors, to regulate lipid metabolism and cellular signaling. **Clinical Significance:** 1. **Lipid Metabolic Disorders:** Abnormalities in CDS2 expression or function may contribute to lipid metabolic disorders, such as hyperlipidemia and atherosclerosis. 2. **Neurological Disorders:** The gene's expression in neurons suggests a potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** Altered CDS2 expression has been linked to various types of cancer, including colorectal and breast cancer. 4. **Regenerative Medicine:** Understanding the role of CDS2 in lipid metabolism may provide insights into regenerative medicine approaches for tissue engineering and organ transplantation. In conclusion, CDS2 is a vital enzyme involved in lipid metabolism, with significant implications for our understanding of various diseases. Further research is necessary to elucidate the molecular mechanisms underlying CDS2's functions and to explore its therapeutic potential in lipid metabolic disorders and other diseases.

Genular Protein ID: 3432845009

Symbol: CDS2_HUMAN

Name: CDP-DAG synthase 2

UniProtKB Accession Codes:

O95674 B2RDC6 D3DW04 Q5TDY2 Q5TDY3 Q5TDY4 Q5TDY5 Q9BYK5 Q9NTT2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 45 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 2 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 18 SIGNOR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9889000

Title: Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene.

PubMed ID: 9889000

DOI: 10.1006/geno.1998.5610

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9806839

Title: Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes.

PubMed ID: 9806839

DOI: 10.1006/geno.1998.5547

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25375833

Title: Distinct properties of the two isoforms of CDP-diacylglycerol synthase.

PubMed ID: 25375833

DOI: 10.1021/bi501250m

PubMed ID: 26946540

Title: CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.

PubMed ID: 26946540

DOI: 10.1194/jlr.m060574

PubMed ID: 31548309

Title: CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms.

PubMed ID: 31548309

DOI: 10.1074/jbc.ra119.009992

Sequence Information:

  • Length: 445
  • Mass: 51418
  • Checksum: 7DAD6A3C1D5587D6
  • Sequence:
    • MTELRQRVAH EPVAPPEDKE SESEAKVDGE TASDSESRAE SAPLPVSADD TPEVLNRALS 
NLSSRWKNWW VRGILTLAMI AFFFIIIYLG PMVLMIIVMC VQIKCFHEII TIGYNVYHSY 
DLPWFRTLSW YFLLCVNYFF YGETVTDYFF TLVQREEPLR ILSKYHRFIS FTLYLIGFCM 
FVLSLVKKHY RLQFYMFGWT HVTLLIVVTQ SHLVIHNLFE GMIWFIVPIS CVICNDIMAY 
MFGFFFGRTP LIKLSPKKTW EGFIGGFFAT VVFGLLLSYV MSGYRCFVCP VEYNNDTNSF 
TVDCEPSDLF RLQEYNIPGV IQSVIGWKTV RMYPFQIHSI ALSTFASLIG PFGGFFASGF 
KRAFKIKDFA NTIPGHGGIM DRFDCQYLMA TFVNVYIASF IRGPNPSKLI QQFLTLRPDQ 
QLHIFNTLRS HLIDKGMLTS TTEDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.