Details for: FPGT

Gene ID: 8790

Symbol: FPGT

Ensembl ID: ENSG00000254685

Description: fucose-1-phosphate guanylyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.0142
    Cell Significance Index: -16.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.8906
    Cell Significance Index: -17.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9097
    Cell Significance Index: -17.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9204
    Cell Significance Index: -15.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5286
    Cell Significance Index: -17.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1624
    Cell Significance Index: 114.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9544
    Cell Significance Index: 861.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8511
    Cell Significance Index: 170.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7342
    Cell Significance Index: 44.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7184
    Cell Significance Index: 78.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6853
    Cell Significance Index: 52.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6416
    Cell Significance Index: 104.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4284
    Cell Significance Index: 153.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3844
    Cell Significance Index: 26.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3232
    Cell Significance Index: 16.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3008
    Cell Significance Index: 18.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2954
    Cell Significance Index: 6.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2950
    Cell Significance Index: 34.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2411
    Cell Significance Index: 9.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1873
    Cell Significance Index: 33.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1864
    Cell Significance Index: 4.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1646
    Cell Significance Index: 8.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1553
    Cell Significance Index: 7.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1193
    Cell Significance Index: 34.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1173
    Cell Significance Index: 5.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1112
    Cell Significance Index: 3.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1105
    Cell Significance Index: 2.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1094
    Cell Significance Index: 6.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1016
    Cell Significance Index: 55.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0954
    Cell Significance Index: 4.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0904
    Cell Significance Index: 62.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0845
    Cell Significance Index: 10.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0774
    Cell Significance Index: 14.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0670
    Cell Significance Index: 4.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0567
    Cell Significance Index: 25.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0474
    Cell Significance Index: 1.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0471
    Cell Significance Index: 6.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0430
    Cell Significance Index: 5.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0066
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0094
    Cell Significance Index: -17.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0130
    Cell Significance Index: -23.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0156
    Cell Significance Index: -24.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0177
    Cell Significance Index: -24.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0205
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0222
    Cell Significance Index: -16.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0236
    Cell Significance Index: -14.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0273
    Cell Significance Index: -4.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0320
    Cell Significance Index: -18.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0387
    Cell Significance Index: -24.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0403
    Cell Significance Index: -18.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0449
    Cell Significance Index: -4.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0683
    Cell Significance Index: -3.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0686
    Cell Significance Index: -4.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0738
    Cell Significance Index: -8.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0760
    Cell Significance Index: -9.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0969
    Cell Significance Index: -19.2400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0980
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1021
    Cell Significance Index: -21.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1042
    Cell Significance Index: -3.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1141
    Cell Significance Index: -13.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1156
    Cell Significance Index: -16.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1167
    Cell Significance Index: -8.7000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1217
    Cell Significance Index: -2.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1416
    Cell Significance Index: -3.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1614
    Cell Significance Index: -10.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1696
    Cell Significance Index: -13.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1734
    Cell Significance Index: -18.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2023
    Cell Significance Index: -1.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2075
    Cell Significance Index: -12.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2244
    Cell Significance Index: -3.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2282
    Cell Significance Index: -2.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2402
    Cell Significance Index: -3.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2472
    Cell Significance Index: -8.5900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2497
    Cell Significance Index: -3.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2569
    Cell Significance Index: -13.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2852
    Cell Significance Index: -3.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2896
    Cell Significance Index: -19.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2932
    Cell Significance Index: -7.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3028
    Cell Significance Index: -8.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3277
    Cell Significance Index: -10.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3368
    Cell Significance Index: -7.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3370
    Cell Significance Index: -5.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3514
    Cell Significance Index: -4.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4018
    Cell Significance Index: -14.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4023
    Cell Significance Index: -8.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4217
    Cell Significance Index: -4.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4230
    Cell Significance Index: -13.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4305
    Cell Significance Index: -8.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4540
    Cell Significance Index: -15.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4542
    Cell Significance Index: -13.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4594
    Cell Significance Index: -14.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4605
    Cell Significance Index: -12.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4797
    Cell Significance Index: -13.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4834
    Cell Significance Index: -12.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4867
    Cell Significance Index: -7.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5233
    Cell Significance Index: -4.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5330
    Cell Significance Index: -11.1300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5351
    Cell Significance Index: -7.5100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5430
    Cell Significance Index: -3.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FPGT is a unique enzyme that exhibits characteristics of both glycosyltransferases and phosphotransferases. It is a cytosolic enzyme that requires GTP as a cofactor and exhibits GTP-binding activity. The enzyme has a high specificity for fucose-1-phosphate and exhibits a low affinity for other substrates. FPGT is also a key enzyme in the biosynthesis of glycosphingolipids and glycoproteins, which are essential components of the neuronal cell membrane. **Pathways and Functions** FPGT is involved in several key pathways, including: 1. **Asparagine n-linked glycosylation**: FPGT is required for the transfer of GDP-l-fucose to the asparagine residue in the nascent protein chain, resulting in the formation of a glycosylated protein. 2. **Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo)**: FPGT is involved in the biosynthesis of the llo precursor, which is a key component of the n-glycan biosynthesis pathway. 3. **Gdp-fucose biosynthesis**: FPGT is a key enzyme in the biosynthesis of GDP-l-fucose, which is a critical component of the glycosphingolipid biosynthesis pathway. 4. **Metabolism of proteins**: FPGT is involved in the post-translational modification of proteins, resulting in the formation of glycosylated proteins. 5. **Post-translational protein modification**: FPGT is involved in the modification of proteins, resulting in the formation of glycosylated proteins. **Clinical Significance** Dysregulation of FPGT has been implicated in several neurological disorders, including: 1. **Neurodegenerative diseases**: FPGT dysregulation has been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 2. **Cognitive impairment**: FPGT dysregulation has been implicated in cognitive impairment and dementia. 3. **Neurodevelopmental disorders**: FPGT dysregulation has been linked to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. In conclusion, FPGT is a critical enzyme involved in the biosynthesis of glycosphingolipids and glycoproteins in the brain. Its dysregulation has been implicated in several neurological disorders, highlighting the importance of this enzyme in maintaining neuronal function and development. Further research is needed to fully elucidate the role of FPGT in neurological disorders and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 2686800309

Symbol: FPGT_HUMAN

Name: GDP-L-fucose diphosphorylase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9804772

Title: GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme.

PubMed ID: 9804772

DOI: 10.1074/jbc.273.46.30165

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 607
  • Mass: 68010
  • Checksum: 5175BB73A69255F1
  • Sequence:
  • MRAVRRGLRE GGAMAAARDP PEVSLREATQ RKLRRFSELR GKLVARGEFW DIVAITAADE 
    KQELAYNQQL SEKLKRKELP LGVQYHVFVD PAGAKIGNGG STLCALQCLE KLYGDKWNSF 
    TILLIHSGGY SQRLPNASAL GKIFTALPLG NPIYQMLELK LAMYIDFPLN MNPGILVTCA 
    DDIELYSIGE FEFIRFDKPG FTALAHPSSL TIGTTHGVFV LDPFDDLKHR DLEYRSCHRF 
    LHKPSIEKMY QFNAVCRPGN FCQQDFAGGD IADLKLDSDY VYTDSLFYMD HKSAKMLLAF 
    YEKIGTLSCE IDAYGDFLQA LGPGATVEYT RNTSNVIKEE SELVEMRQRI FHLLKGTSLN 
    VVVLNNSKFY HIGTTEEYLF YFTSDNSLKS ELGLQSITFS IFPDIPECSG KTSCIIQSIL 
    DSRCSVAPGS VVEYSRLGPD VSVGENCIIS GSYILTKAAL PAHSFVCSLS LKMNRCLKYA 
    TMAFGVQDNL KKSVKTLSDI KLLQFFGVCF LSCLDVWNLK VTEELFSGNK TCLSLWTARI 
    FPVCSSLSDS VITSLKMLNA VKNKSAFSLN SYKLLSIEEM LIYKDVEDMI TYREQIFLEI 
    SLKSSLM

Genular Protein ID: 2002096693

Symbol: A0A0S2Z4P4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 169
  • Mass: 19170
  • Checksum: E8D68424A3C4D277
  • Sequence:
  • MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 
    LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSVSFQIY 
    QNALAKHPVS FKAYWIQDVL WHLAQLWSIP DWGLMFQLGK TALLVVLTS

Genular Protein ID: 3010292816

Symbol: A0A0S2Z5C6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 594
  • Mass: 66599
  • Checksum: 15BA9CB906C70CC7
  • Sequence:
  • MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 
    LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSGGYSQR 
    LPNASALGKI FTALPLGNPI YQMLELKLAM YIDFPLNMNP GILVTCADDI ELYSIGEFEF 
    IRFDKPGFTA LAHPSSLTIG TTHGVFVLDP FDDLKHRDLE YRSCHRFLHK PSIEKMYQFN 
    AVCRPGNFCQ QDFAGGDIAD LKLDSDYVYT DSLFYMDHKS AKMLLAFYEK IGTLSCEIDA 
    YGDFLQALGP GATVEYTRNT SNVIKEESEL VEMRQRIFHL LKGTSLNVVV LNNSKFYHIG 
    TTEEYLFYFT SDNSLKSELG LQSITFSIFP DIPECSGKTS CIIQSILDSR CSVAPGSVVE 
    YSRLGPDVSV GENCIISGSY ILTKAALPAH SFVCSLSLKM NRCLKYATMA FGVQDNLKKS 
    VKTLSDIKLL QFFGVCFLSC LDVWNLKVTE ELFSGNKTCL SLWTARIFPV CSSLSDSVIT 
    SLKMLNAVKN KSAFSLNSYK LLSIEEMLIY KDVEDMITYR EQIFLEISLK SSLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.