Details for: TNFRSF10B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 134.1089
Cell Significance Index: -20.8600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 80.1913
Cell Significance Index: -20.3400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 42.5100
Cell Significance Index: -17.2700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 38.9397
Cell Significance Index: -20.0300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 18.1201
Cell Significance Index: -17.3000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.9268
Cell Significance Index: -20.8700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.1784
Cell Significance Index: -19.2300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.5511
Cell Significance Index: -17.0500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.3116
Cell Significance Index: -20.9600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.9705
Cell Significance Index: 154.3100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.1604
Cell Significance Index: 61.9300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.0080
Cell Significance Index: 28.8800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.0023
Cell Significance Index: 43.3800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8969
Cell Significance Index: 376.4500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.8667
Cell Significance Index: 50.0200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.8368
Cell Significance Index: 181.7100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.7566
Cell Significance Index: 285.7000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.6224
Cell Significance Index: 44.1600 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.5702
Cell Significance Index: 26.4100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.2247
Cell Significance Index: 20.6300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.1162
Cell Significance Index: 19.7300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1137
Cell Significance Index: 50.4800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0159
Cell Significance Index: 917.2500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6652
Cell Significance Index: 18.5900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6355
Cell Significance Index: 29.8700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.5079
Cell Significance Index: 7.6100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4824
Cell Significance Index: 263.4300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4814
Cell Significance Index: 13.8700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4659
Cell Significance Index: 57.2900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4159
Cell Significance Index: 28.7700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3689
Cell Significance Index: 47.6700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3107
Cell Significance Index: 3.5300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2944
Cell Significance Index: 6.2700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2814
Cell Significance Index: 50.7200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2744
Cell Significance Index: 20.4500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2718
Cell Significance Index: 51.7300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2712
Cell Significance Index: 9.5300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.2567
Cell Significance Index: 1.5800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2355
Cell Significance Index: 18.0800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1774
Cell Significance Index: 20.2500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1721
Cell Significance Index: 1.0400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1535
Cell Significance Index: 21.0800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1380
Cell Significance Index: 2.5500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1026
Cell Significance Index: 17.5200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0868
Cell Significance Index: 38.3600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0854
Cell Significance Index: 4.3200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0812
Cell Significance Index: 124.9800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0740
Cell Significance Index: 136.4000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0716
Cell Significance Index: 45.4700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0693
Cell Significance Index: 3.2300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0611
Cell Significance Index: 12.2600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0550
Cell Significance Index: 34.3600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0543
Cell Significance Index: 1.0600 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.0473
Cell Significance Index: 0.3400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0379
Cell Significance Index: 2.6800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0271
Cell Significance Index: 1.4100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0198
Cell Significance Index: 37.2800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0143
Cell Significance Index: 19.4000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0032
Cell Significance Index: 1.4400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0008
Cell Significance Index: -0.1000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0013
Cell Significance Index: -1.0000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0043
Cell Significance Index: -0.0400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0082
Cell Significance Index: -0.2200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0129
Cell Significance Index: -9.5700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0150
Cell Significance Index: -2.1800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0154
Cell Significance Index: -11.3100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0210
Cell Significance Index: -2.1500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0229
Cell Significance Index: -12.9400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0278
Cell Significance Index: -3.2800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0443
Cell Significance Index: -15.8800 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0456
Cell Significance Index: -0.4600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0481
Cell Significance Index: -10.1400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0491
Cell Significance Index: -0.6700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0560
Cell Significance Index: -16.1100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0752
Cell Significance Index: -8.6200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0815
Cell Significance Index: -2.6100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0868
Cell Significance Index: -2.1700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0960
Cell Significance Index: -11.1900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1084
Cell Significance Index: -1.6000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1548
Cell Significance Index: -4.0700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1616
Cell Significance Index: -9.0700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1797
Cell Significance Index: -1.8600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1802
Cell Significance Index: -18.7600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1826
Cell Significance Index: -11.7800 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1848
Cell Significance Index: -2.6300 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1861
Cell Significance Index: -4.3000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1932
Cell Significance Index: -6.7200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2001
Cell Significance Index: -5.3500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2343
Cell Significance Index: -18.5600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2482
Cell Significance Index: -6.3800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2579
Cell Significance Index: -7.3600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2635
Cell Significance Index: -16.1600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2638
Cell Significance Index: -17.7400 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.2930
Cell Significance Index: -2.4900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3192
Cell Significance Index: -19.6200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3192
Cell Significance Index: -20.1200 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.3373
Cell Significance Index: -4.6800 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.3830
Cell Significance Index: -2.3800 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.4003
Cell Significance Index: -6.0900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4147
Cell Significance Index: -6.9400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 66532789
Symbol: TR10B_HUMAN
Name: Tumor necrosis factor receptor superfamily member 10B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9285725
Title: TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.
PubMed ID: 9285725
PubMed ID: 9311998
Title: TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.
PubMed ID: 9311998
PubMed ID: 9373179
Title: Characterization of two receptors for TRAIL.
PubMed ID: 9373179
PubMed ID: 9430227
Title: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.
PubMed ID: 9430227
PubMed ID: 9325248
Title: Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
PubMed ID: 9325248
PubMed ID: 9326928
Title: KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.
PubMed ID: 9326928
DOI: 10.1038/ng1097-141
PubMed ID: 9242610
Title: An antagonist decoy receptor and a death domain-containing receptor for TRAIL.
PubMed ID: 9242610
PubMed ID: 9242611
Title: Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
PubMed ID: 9242611
PubMed ID: 10072170
Title: Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.
PubMed ID: 10072170
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14759258
PubMed ID: 15322075
Title: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.
PubMed ID: 15322075
PubMed ID: 18846110
Title: Identification of an antiapoptotic protein complex at death receptors.
PubMed ID: 18846110
DOI: 10.1038/cdd.2008.124
PubMed ID: 23498957
Title: Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
PubMed ID: 23498957
PubMed ID: 30902834
Title: Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways.
PubMed ID: 30902834
PubMed ID: 10549288
Title: Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
PubMed ID: 10549288
PubMed ID: 10542098
Title: Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.
PubMed ID: 10542098
DOI: 10.1038/14935
PubMed ID: 23555243
Title: Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.
PubMed ID: 23555243
Sequence Information:
- Length: 440
- Mass: 47878
- Checksum: 60358EAF2A835870
- Sequence:
MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED HLLSSGKFMY LEGNADSAMS
Genular Protein ID: 1263203466
Symbol: Q7Z2I8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 205
- Mass: 22612
- Checksum: 34965B14AFC0313F
- Sequence:
MGPSLPAKET ASFLGGGGDP ERVDRSSQRP GAEDNVLNEI VSILQPTQVP EQEMEVQEPA EPTGVNMLSP GESEHLLEPA EAERSQRRRL LVPANEGDPT ETLRQCFDDF ADLVPFDSWE PLMRKLGLMD NEIKVAKAEA AGHRDTLYTM LIKWVNKTGR DASVHTLLDA LETLGERLAK QKIEDHLLSS GKFMYLEGNA DSAMS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.