Details for: TNFRSF10B

Gene ID: 8795

Symbol: TNFRSF10B

Ensembl ID: ENSG00000120889

Description: TNF receptor superfamily member 10b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.1089
    Cell Significance Index: -20.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.1913
    Cell Significance Index: -20.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.5100
    Cell Significance Index: -17.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9397
    Cell Significance Index: -20.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.1201
    Cell Significance Index: -17.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.9268
    Cell Significance Index: -20.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1784
    Cell Significance Index: -19.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5511
    Cell Significance Index: -17.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3116
    Cell Significance Index: -20.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9705
    Cell Significance Index: 154.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1604
    Cell Significance Index: 61.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.0080
    Cell Significance Index: 28.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0023
    Cell Significance Index: 43.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8969
    Cell Significance Index: 376.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.8667
    Cell Significance Index: 50.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8368
    Cell Significance Index: 181.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7566
    Cell Significance Index: 285.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6224
    Cell Significance Index: 44.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.5702
    Cell Significance Index: 26.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2247
    Cell Significance Index: 20.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1162
    Cell Significance Index: 19.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1137
    Cell Significance Index: 50.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0159
    Cell Significance Index: 917.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6652
    Cell Significance Index: 18.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6355
    Cell Significance Index: 29.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5079
    Cell Significance Index: 7.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4824
    Cell Significance Index: 263.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4814
    Cell Significance Index: 13.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4659
    Cell Significance Index: 57.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4159
    Cell Significance Index: 28.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3689
    Cell Significance Index: 47.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3107
    Cell Significance Index: 3.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2944
    Cell Significance Index: 6.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2814
    Cell Significance Index: 50.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2744
    Cell Significance Index: 20.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2718
    Cell Significance Index: 51.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2712
    Cell Significance Index: 9.5300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2567
    Cell Significance Index: 1.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2355
    Cell Significance Index: 18.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1774
    Cell Significance Index: 20.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1721
    Cell Significance Index: 1.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1535
    Cell Significance Index: 21.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1380
    Cell Significance Index: 2.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1026
    Cell Significance Index: 17.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0868
    Cell Significance Index: 38.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0854
    Cell Significance Index: 4.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0812
    Cell Significance Index: 124.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0740
    Cell Significance Index: 136.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0716
    Cell Significance Index: 45.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0693
    Cell Significance Index: 3.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0611
    Cell Significance Index: 12.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0550
    Cell Significance Index: 34.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0543
    Cell Significance Index: 1.0600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0473
    Cell Significance Index: 0.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0379
    Cell Significance Index: 2.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0271
    Cell Significance Index: 1.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0198
    Cell Significance Index: 37.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0143
    Cell Significance Index: 19.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0032
    Cell Significance Index: 1.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0008
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -1.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0150
    Cell Significance Index: -2.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0210
    Cell Significance Index: -2.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0278
    Cell Significance Index: -3.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0443
    Cell Significance Index: -15.8800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0456
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0481
    Cell Significance Index: -10.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0491
    Cell Significance Index: -0.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0560
    Cell Significance Index: -16.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0752
    Cell Significance Index: -8.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0815
    Cell Significance Index: -2.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0868
    Cell Significance Index: -2.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0960
    Cell Significance Index: -11.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1084
    Cell Significance Index: -1.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1548
    Cell Significance Index: -4.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1616
    Cell Significance Index: -9.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1797
    Cell Significance Index: -1.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1802
    Cell Significance Index: -18.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1826
    Cell Significance Index: -11.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1848
    Cell Significance Index: -2.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1861
    Cell Significance Index: -4.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1932
    Cell Significance Index: -6.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2001
    Cell Significance Index: -5.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2343
    Cell Significance Index: -18.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2482
    Cell Significance Index: -6.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2579
    Cell Significance Index: -7.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2635
    Cell Significance Index: -16.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2638
    Cell Significance Index: -17.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2930
    Cell Significance Index: -2.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3192
    Cell Significance Index: -19.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3192
    Cell Significance Index: -20.1200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3373
    Cell Significance Index: -4.6800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3830
    Cell Significance Index: -2.3800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4003
    Cell Significance Index: -6.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4147
    Cell Significance Index: -6.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFRSF10B is a type II transmembrane receptor that belongs to the tumor necrosis factor receptor superfamily. It is characterized by the presence of a death domain in its cytoplasmic tail, which is essential for its ability to induce apoptosis in response to ligand binding. The receptor is also known as TR10B and is specifically expressed in various cell types, including those of the mammary gland, bladder, and vascular tree. **Pathways and Functions** TNFRSF10B is involved in several signaling pathways that regulate cellular responses to external stimuli. These pathways include: 1. **Apoptosis**: TNFRSF10B can induce apoptosis in response to ligand binding, which is mediated by the activation of caspases. 2. **Activation of NF-κB**: The receptor can activate the NF-κB signaling pathway, which regulates the expression of genes involved in inflammation and cell growth. 3. **Extrinsic Apoptotic Signaling**: TNFRSF10B can also induce apoptosis through the extrinsic apoptotic signaling pathway, which involves the activation of caspases. 4. **Intrinsic Apoptotic Signaling**: The receptor can induce apoptosis in response to endoplasmic reticulum stress, which involves the activation of caspases. 5. **Regulation of Cell Growth**: TNFRSF10B can regulate cell growth by modulating the expression of genes involved in cell proliferation and differentiation. **Clinical Significance** TNFRSF10B has been implicated in various diseases, including: 1. **Cancer**: The receptor is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Inflammatory Diseases**: TNFRSF10B is involved in the regulation of inflammation and has been implicated in diseases such as rheumatoid arthritis and multiple sclerosis. 3. **Cardiovascular Disease**: The receptor is involved in the regulation of vascular tone and has been implicated in the development of cardiovascular disease. 4. **Neurological Disorders**: TNFRSF10B has been implicated in the regulation of neuronal survival and has been studied in the context of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In conclusion, TNFRSF10B is a critical regulator of cellular processes, including apoptosis, inflammation, and cell growth. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 66532789

Symbol: TR10B_HUMAN

Name: Tumor necrosis factor receptor superfamily member 10B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9285725

Title: TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.

PubMed ID: 9285725

DOI: 10.1016/s0960-9822(06)00297-1

PubMed ID: 9311998

Title: TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

PubMed ID: 9311998

DOI: 10.1093/emboj/16.17.5386

PubMed ID: 9373179

Title: Characterization of two receptors for TRAIL.

PubMed ID: 9373179

DOI: 10.1016/s0014-5793(97)01231-3

PubMed ID: 9430227

Title: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.

PubMed ID: 9430227

DOI: 10.1016/s1074-7613(00)80400-8

PubMed ID: 9325248

Title: Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.

PubMed ID: 9325248

DOI: 10.1074/jbc.272.41.25417

PubMed ID: 9326928

Title: KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.

PubMed ID: 9326928

DOI: 10.1038/ng1097-141

PubMed ID: 9242610

Title: An antagonist decoy receptor and a death domain-containing receptor for TRAIL.

PubMed ID: 9242610

DOI: 10.1126/science.277.5327.815

PubMed ID: 9242611

Title: Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

PubMed ID: 9242611

DOI: 10.1126/science.277.5327.818

PubMed ID: 10072170

Title: Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.

PubMed ID: 10072170

DOI: 10.1016/s0304-3835(98)00230-4

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15322075

Title: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.

PubMed ID: 15322075

DOI: 10.1074/jbc.m406933200

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 23498957

Title: Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

PubMed ID: 23498957

DOI: 10.1016/j.chom.2013.02.003

PubMed ID: 30902834

Title: Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways.

PubMed ID: 30902834

DOI: 10.1074/mcp.ra118.001093

PubMed ID: 10549288

Title: Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

PubMed ID: 10549288

DOI: 10.1016/s1097-2765(00)80207-5

PubMed ID: 10542098

Title: Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.

PubMed ID: 10542098

DOI: 10.1038/14935

PubMed ID: 23555243

Title: Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.

PubMed ID: 23555243

DOI: 10.1371/journal.ppat.1003224

Sequence Information:

  • Length: 440
  • Mass: 47878
  • Checksum: 60358EAF2A835870
  • Sequence:
  • MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD 
    LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 
    SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 
    KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV 
    LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 
    NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK 
    LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED 
    HLLSSGKFMY LEGNADSAMS

Genular Protein ID: 1263203466

Symbol: Q7Z2I8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 205
  • Mass: 22612
  • Checksum: 34965B14AFC0313F
  • Sequence:
  • MGPSLPAKET ASFLGGGGDP ERVDRSSQRP GAEDNVLNEI VSILQPTQVP EQEMEVQEPA 
    EPTGVNMLSP GESEHLLEPA EAERSQRRRL LVPANEGDPT ETLRQCFDDF ADLVPFDSWE 
    PLMRKLGLMD NEIKVAKAEA AGHRDTLYTM LIKWVNKTGR DASVHTLLDA LETLGERLAK 
    QKIEDHLLSS GKFMYLEGNA DSAMS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.