Details for: TNFRSF10B

Gene ID: 8795

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TNFRSF10B

Ensembl ID: ENSG00000120889

Description: TNF receptor superfamily member 10b

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cardiac endothelial cell CL0010008
    CSI 9.58
    rCSI 38.65%
    PRS 66.39
  • paneth cell of epithelium of small intestine CL1000343
    CSI 6.61
    rCSI 18.51%
    PRS 77.15
  • retinal blood vessel endothelial cell CL0002585
    CSI 6.15
    rCSI 9.82%
    PRS 71.53
  • conjunctival epithelial cell CL1000432
    CSI 5.02
    rCSI 7.67%
    PRS 68
  • respiratory suprabasal cell CL4033048
    CSI 4.37
    rCSI 5.6%
    PRS 71.67
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 3.79
    rCSI 2.66%
    PRS 84.67
  • enterocyte CL0000584
    CSI 3.44
    rCSI 5.55%
    PRS 69.47
  • secretory cell CL0000151
    CSI 3.18
    rCSI 3.32%
    PRS 67.19
  • inflammatory macrophage CL0000863
    CSI 3.17
    rCSI 5.41%
    PRS 87.54
  • BEST4+ enteroycte CL4030026
    CSI 2.98
    rCSI 3.71%
    PRS 68.84
  • brush cell of tracheobronchial tree CL0002075
    CSI 2.95
    rCSI 8.74%
    PRS 76.94
  • hepatic stellate cell CL0000632
    CSI 2.93
    rCSI 10.97%
    PRS 59.17
  • epithelial cell of lung CL0000082
    CSI 2.86
    rCSI 2.37%
    PRS 66.83
  • Kupffer cell CL0000091
    CSI 2.83
    rCSI 6.47%
    PRS 67.54
  • neural crest cell CL0011012
    CSI 2.66
    rCSI 2.1%
    PRS 54.26
  • hepatocyte CL0000182
    CSI 2.58
    rCSI 4.61%
    PRS 66.67
  • midzonal region hepatocyte CL0019028
    CSI 2.57
    rCSI 6.04%
    PRS 70.38
  • lung macrophage CL1001603
    CSI 2.49
    rCSI 5.57%
    PRS 74.81
  • naive B cell CL0000788
    CSI 2.49
    rCSI 2.14%
    PRS 74.95
  • respiratory basal cell CL0002633
    CSI 2.4
    rCSI 2.49%
    PRS 73.05
  • lung ciliated cell CL1000271
    CSI 2.4
    rCSI 2.78%
    PRS 57.89
  • fibroblast of lung CL0002553
    CSI 2.39
    rCSI 2.22%
    PRS 67.9
  • endothelial cell of placenta CL0009092
    CSI 2.37
    rCSI 11.68%
    PRS 77.75
  • blood vessel endothelial cell CL0000071
    CSI 2.33
    rCSI 4.84%
    PRS 64.21
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.32
    rCSI 3.59%
    PRS 73.89
  • lung endothelial cell CL1001567
    CSI 2.31
    rCSI 5.39%
    PRS 83.51
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.28
    rCSI 4.35%
    PRS 80.86
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.28
    rCSI 1.77%
    PRS 70.12
  • epithelial cell CL0000066
    CSI 2.22
    rCSI 3.41%
    PRS 60.77
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.19
    rCSI 5.57%
    PRS 56.73
  • chondrocyte CL0000138
    CSI 2.17
    rCSI 3.46%
    PRS 59.89
  • myeloid leukocyte CL0000766
    CSI 2.07
    rCSI 1.91%
    PRS 68.91
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.07
    rCSI 5.58%
    PRS 73.72
  • stem cell CL0000034
    CSI 1.94
    rCSI 1.87%
    PRS 58.48
  • Hofbauer cell CL3000001
    CSI 1.93
    rCSI 3.64%
    PRS 77.33
  • CD14-positive monocyte CL0001054
    CSI 1.89
    rCSI 2.35%
    PRS 77.8
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 1.88
    rCSI 4.91%
    PRS 67.14
  • centrilobular region hepatocyte CL0019029
    CSI 1.85
    rCSI 4.83%
    PRS 69.27
  • radial glial cell CL0000681
    CSI 1.84
    rCSI 2.56%
    PRS 65.88
  • myeloid dendritic cell CL0000782
    CSI 1.83
    rCSI 2.65%
    PRS 82.37
  • M cell of gut CL0000682
    CSI 1.81
    rCSI 1.93%
    PRS 75.69
  • bronchus fibroblast of lung CL2000093
    CSI 1.81
    rCSI 1.47%
    PRS 67.61
  • pancreatic acinar cell CL0002064
    CSI 1.8
    rCSI 2.39%
    PRS 73.5
  • keratinocyte CL0000312
    CSI 1.71
    rCSI 1.43%
    PRS 70.91
  • renal beta-intercalated cell CL0002201
    CSI 1.7
    rCSI 4.06%
    PRS 67.7
  • keratocyte CL0002363
    CSI 1.69
    rCSI 4.07%
    PRS 73.91
  • renal principal cell CL0005009
    CSI 1.69
    rCSI 4.39%
    PRS 70.21
  • colon epithelial cell CL0011108
    CSI 1.69
    rCSI 1.77%
    PRS 63.82
  • intestinal tuft cell CL0019032
    CSI 1.68
    rCSI 2.57%
    PRS 71.46
  • intestinal crypt stem cell of colon CL0009043
    CSI 1.68
    rCSI 12.6%
    PRS 81.33
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.67
    rCSI 2.37%
    PRS 63.6
  • periportal region hepatocyte CL0019026
    CSI 1.67
    rCSI 6.48%
    PRS 70.3
  • elicited macrophage CL0000861
    CSI 1.66
    rCSI 1.52%
    PRS 76.19
  • tissue-resident macrophage CL0000864
    CSI 1.63
    rCSI 7.63%
    PRS 82.13
  • enterocyte of epithelium of large intestine CL0002071
    CSI 1.62
    rCSI 8.49%
    PRS 75.49
  • glandular epithelial cell CL0000150
    CSI 1.59
    rCSI 4.19%
    PRS 83.64
  • respiratory hillock cell CL4030023
    CSI 1.58
    rCSI 2.82%
    PRS 79.58
  • granulocyte CL0000094
    CSI 1.58
    rCSI 2.42%
    PRS 76.23
  • extravillous trophoblast CL0008036
    CSI 1.58
    rCSI 1.95%
    PRS 64.05
  • cerebral cortex endothelial cell CL1001602
    CSI 1.56
    rCSI 2.7%
    PRS 57.55
  • adventitial cell CL0002503
    CSI 1.55
    rCSI 3.71%
    PRS 74.97
  • alveolar macrophage CL0000583
    CSI 1.53
    rCSI 2.52%
    PRS 72.5
  • goblet cell CL0000160
    CSI 1.53
    rCSI 1.44%
    PRS 66.2
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.5
    rCSI 1.96%
    PRS 80.18
  • epithelial cell of proximal tubule CL0002306
    CSI 1.45
    rCSI 3.55%
    PRS 60.21
  • mononuclear phagocyte CL0000113
    CSI 1.44
    rCSI 3.17%
    PRS 71.22
  • endocardial cell CL0002350
    CSI 1.41
    rCSI 6.77%
    PRS 65.27
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.41
    rCSI 2.57%
    PRS 81.12
  • intermediate monocyte CL0002393
    CSI 1.4
    rCSI 2.12%
    PRS 72.04
  • small intestine goblet cell CL1000495
    CSI 1.39
    rCSI 3.04%
    PRS 74.42
  • intestine goblet cell CL0019031
    CSI 1.35
    rCSI 1.2%
    PRS 64.91
  • cholangiocyte CL1000488
    CSI 1.34
    rCSI 8.05%
    PRS 72.75
  • corneal epithelial cell CL0000575
    CSI 1.34
    rCSI 3.84%
    PRS 77.68
  • endothelial cell of lymphatic vessel CL0002138
    CSI 1.32
    rCSI 2.62%
    PRS 78.88
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 1.3
    rCSI 3.99%
    PRS 74.44
  • alveolar adventitial fibroblast CL4028006
    CSI 1.29
    rCSI 2.03%
    PRS 69.72
  • transit amplifying cell of small intestine CL0009012
    CSI 1.27
    rCSI 5.58%
    PRS 80.02
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.25
    rCSI 1.51%
    PRS 76.01
  • choroid plexus epithelial cell CL0000706
    CSI 1.21
    rCSI 1.99%
    PRS 56.31
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.21
    rCSI 3.14%
    PRS 62.16
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.15
    rCSI 0.88%
    PRS 68.48
  • basal cell of prostate epithelium CL0002341
    CSI 1.12
    rCSI 3.23%
    PRS 77.56
  • colonocyte CL1000347
    CSI 1.11
    rCSI 1.59%
    PRS 69.86
  • lung secretory cell CL1000272
    CSI 1.07
    rCSI 2.65%
    PRS 65.94
  • pancreatic ductal cell CL0002079
    CSI 0.96
    rCSI 1.87%
    PRS 70.27
  • parietal epithelial cell CL1000452
    CSI 0.83
    rCSI 2.21%
    PRS 58.06
  • colon macrophage CL0009038
    CSI 0.79
    rCSI 3.66%
    PRS 83.92
  • luminal cell of prostate epithelium CL0002340
    CSI 0.75
    rCSI 4.06%
    PRS 77.72
  • podocyte CL0000653
    CSI 0.75
    rCSI 3.34%
    PRS 67.32
  • endothelial cell of uterus CL0009095
    CSI 0.66
    rCSI 4.83%
    PRS 81.76
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.53
    rCSI 3.67%
    PRS 78.7
  • blood vessel smooth muscle cell CL0019018
    CSI 0.37
    rCSI 3.02%
    PRS 60.68
  • pancreatic stellate cell CL0002410
    CSI 0.33
    rCSI 1.9%
    PRS 74.83
  • respiratory goblet cell CL0002370
    CSI 0.3
    rCSI 3.3%
    PRS 79.9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TNFRSF10B](/details-gene/8795), also known as Tumor necrosis factor receptor superfamily member 10b, is a protein-coding gene located on chromosome 8p21.3. It functions as a cell surface death receptor that, upon binding its ligand TRAIL (TNF-related apoptosis-inducing ligand), initiates the extrinsic apoptotic pathway. This process is critical for programmed cell death and immune-mediated clearance of transformed or infected cells ([Link](https://doi.org/10.1126/science.277.5327.818)). Expression data from the **Overall** context indicates that [TNFRSF10B](/details-gene/8795) is particularly significant in vascular endothelial cells, such as `[cardiac endothelial cell](/details-cell/CL0010008)` and `[retinal blood vessel endothelial cell](/details-cell/CL0002585)`, as well as in specialized epithelial and secretory cells like `[paneth cell of epithelium of small intestine](/details-cell/CL1000343)` and `[conjunctival epithelial cell](/details-cell/CL1000432)`. Its role extends to immune surveillance, with notable expression in `[naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900)` and `[inflammatory macrophage](/details-cell/CL0000863)`. ## Cellular Roles and Expression Landscape The expression profile of [TNFRSF10B](/details-gene/8795) suggests a multifaceted role in tissue homeostasis, vascular biology, and immunity. In the **Overall** context, its highest significance is observed in `[cardiac endothelial cell](/details-cell/CL0010008)` (CSI: 9.58), indicating a potentially crucial function in regulating the apoptosis of cells lining the heart and blood vessels. This is further supported by its high rank in `[retinal blood vessel endothelial cell](/details-cell/CL0002585)` (CSI: 6.15), suggesting a conserved role in vascular beds across different organs. Beyond the endothelium, [TNFRSF10B](/details-gene/8795) demonstrates high significance in various epithelial and secretory cell populations. Its expression in `[paneth cell of epithelium of small intestine](/details-cell/CL1000343)` (CSI: 6.61), `[enterocyte](/details-cell/CL0000584)` (CSI: 3.44), and `[conjunctival epithelial cell](/details-cell/CL1000432)` (CSI: 5.02) points towards a function in the rapid turnover and maintenance of mucosal barriers. Its presence in immune cell types, including `[inflammatory macrophage](/details-cell/CL0000863)` (CSI: 3.17) and `[naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900)` (CSI: 3.79), is consistent with its established role as a death receptor utilized by the immune system to eliminate target cells. ## Pathways and Molecular Function Functionally, [TNFRSF10B](/details-gene/8795) is a key component of the cell death machinery. Its molecular function is defined by `[TRAIL receptor activity](/details-gene/GO:0036463)` and `[TRAIL binding](/details-gene/GO:0045569)`, which directly initiates the `[extrinsic apoptotic signaling pathway via death domain receptors](/details-gene/GO:0008625)`. This is corroborated by its central role in Reactome pathways such as `[TRAIL signaling](/details-gene/R-HSA-75158)` and `[Death receptor signaling](/details-gene/R-HSA-73887)`. Upon ligand binding, [TNFRSF10B](/details-gene/8795) recruits adaptor proteins like FADD, leading to the activation of initiator caspases (caspase-8) and the subsequent execution of apoptosis, as detailed in the `[Caspase activation via death receptors in the presence of ligand](/details-gene/R-HSA-140534)` pathway. The regulation of [TNFRSF10B](/details-gene/8795) expression is also clinically relevant. It is implicated in the `[Defense response to tumor cell](/details-gene/GO:0002357)`, and its transcription can be induced by the tumor suppressor TP53 in response to DNA damage ([Link](https://doi.org/10.1038/ng1097-141)), a process annotated in the Reactome pathway `[Tp53 regulates transcription of death receptors and ligands](/details-gene/R-HSA-6803211)`. Furthermore, its expression is linked to cellular stress responses, particularly the `[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress](/details-gene/GO:0070059)` ([Link](https://doi.org/10.1074/jbc.m406933200)), highlighting its role as a sensor for cellular damage that can trigger apoptosis. ## Research Directions The widespread yet specific expression pattern of [TNFRSF10B](/details-gene/8795) suggests multiple avenues for future research into its role in physiology and disease. Based on the available data, the following hypotheses can be proposed: 1. **Hypothesis 1:** In vascular tissues, [TNFRSF10B](/details-gene/8795) signaling in `[cardiac endothelial cell](/details-cell/CL0010008)` is a critical regulator of vascular homeostasis, mediating the removal of senescent or damaged endothelial cells during angiogenesis, inflammation, or atherosclerotic plaque development. Aberrant regulation of this pathway could contribute to cardiovascular pathologies. 2. **Hypothesis 2:** In the gastrointestinal tract, [TNFRSF10B](/details-gene/8795) expression in `[paneth cell of epithelium of small intestine](/details-cell/CL1000343)` and `[enterocyte](/details-cell/CL0000584)` is essential for maintaining epithelial barrier integrity. It may mediate the selective apoptosis of cells infected with intracellular pathogens or those that have sustained DNA damage, thereby preventing microbial translocation and inflammation. **Experimental Approach:** To test the first hypothesis, a robust experimental plan could be implemented. CRISPR-Cas9-mediated knockout or siRNA-mediated knockdown of [TNFRSF10B](/details-gene/8795) could be performed in primary human cardiac microvascular endothelial cells (HCMECs). These modified cells, along with wild-type controls, would then be subjected to pro-inflammatory stimuli (e.g., TNF-α, LPS) or oxidative stress (e.g., H₂O₂). The functional consequences would be assessed by quantifying apoptosis using flow cytometry for Annexin V/PI staining and by measuring caspase-3/7 activity. Furthermore, endothelial barrier function could be evaluated using a transendothelial electrical resistance (TEER) assay to determine if loss of [TNFRSF10B](/details-gene/8795) affects the integrity of the endothelial monolayer under stress. **Therapeutic Potential:** As a pro-apoptotic death receptor, [TNFRSF10B](/details-gene/8795) represents a compelling target for cancer therapy. The primary strategy would involve **activation**, not inhibition, of its signaling pathway to selectively induce apoptosis in malignant cells. Recombinant TRAIL protein or agonistic antibodies that specifically bind and activate [TNFRSF10B](/details-gene/8795) have been explored clinically. This approach is particularly promising for tumors that retain sensitivity to TRAIL-mediated apoptosis. Its high expression on various epithelial cells suggests potential utility in treating carcinomas, though careful consideration of on-target, off-tumor toxicity would be essential for therapeutic development.

Genular Protein ID: 66532789

Symbol: TR10B_HUMAN

Name: Tumor necrosis factor receptor superfamily member 10B

UniProtKB Accession Codes:

O14763 O14720 O15508 O15517 O15531 Q6UXM8 Q7Z360 Q9BVE0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 16 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9285725

Title: TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.

PubMed ID: 9285725

DOI: 10.1016/s0960-9822(06)00297-1

PubMed ID: 9311998

Title: TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

PubMed ID: 9311998

DOI: 10.1093/emboj/16.17.5386

PubMed ID: 9373179

Title: Characterization of two receptors for TRAIL.

PubMed ID: 9373179

DOI: 10.1016/s0014-5793(97)01231-3

PubMed ID: 9430227

Title: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.

PubMed ID: 9430227

DOI: 10.1016/s1074-7613(00)80400-8

PubMed ID: 9325248

Title: Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.

PubMed ID: 9325248

DOI: 10.1074/jbc.272.41.25417

PubMed ID: 9326928

Title: KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.

PubMed ID: 9326928

DOI: 10.1038/ng1097-141

PubMed ID: 9242610

Title: An antagonist decoy receptor and a death domain-containing receptor for TRAIL.

PubMed ID: 9242610

DOI: 10.1126/science.277.5327.815

PubMed ID: 9242611

Title: Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

PubMed ID: 9242611

DOI: 10.1126/science.277.5327.818

PubMed ID: 10072170

Title: Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.

PubMed ID: 10072170

DOI: 10.1016/s0304-3835(98)00230-4

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15322075

Title: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.

PubMed ID: 15322075

DOI: 10.1074/jbc.m406933200

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 23498957

Title: Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

PubMed ID: 23498957

DOI: 10.1016/j.chom.2013.02.003

PubMed ID: 30902834

Title: Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways.

PubMed ID: 30902834

DOI: 10.1074/mcp.ra118.001093

PubMed ID: 10549288

Title: Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

PubMed ID: 10549288

DOI: 10.1016/s1097-2765(00)80207-5

PubMed ID: 10542098

Title: Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.

PubMed ID: 10542098

DOI: 10.1038/14935

PubMed ID: 23555243

Title: Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.

PubMed ID: 23555243

DOI: 10.1371/journal.ppat.1003224

Sequence Information:

  • Length: 440
  • Mass: 47878
  • Checksum: 60358EAF2A835870
  • Sequence:
    • MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD 
LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 
SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 
KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV 
LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 
NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK 
LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED 
HLLSSGKFMY LEGNADSAMS

Genular Protein ID: 1263203466

Symbol: Q7Z2I8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z2I8

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 2 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 205
  • Mass: 22612
  • Checksum: 34965B14AFC0313F
  • Sequence:
    • MGPSLPAKET ASFLGGGGDP ERVDRSSQRP GAEDNVLNEI VSILQPTQVP EQEMEVQEPA 
EPTGVNMLSP GESEHLLEPA EAERSQRRRL LVPANEGDPT ETLRQCFDDF ADLVPFDSWE 
PLMRKLGLMD NEIKVAKAEA AGHRDTLYTM LIKWVNKTGR DASVHTLLDA LETLGERLAK 
QKIEDHLLSS GKFMYLEGNA DSAMS