Details for: PEX11B

Gene ID: 8799

Symbol: PEX11B

Ensembl ID: ENSG00000131779

Description: peroxisomal biogenesis factor 11 beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.38
    Marker Score: 4,156
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.86
    Marker Score: 1,492
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,548
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.24
    Marker Score: 1,782
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.05
    Marker Score: 13,932
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.02
    Marker Score: 908
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,958
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.96
    Marker Score: 1,199
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.91
    Marker Score: 3,573
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,714
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.89
    Marker Score: 6,620
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.88
    Marker Score: 354
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,249
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,913
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 926
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.84
    Marker Score: 1,050
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.84
    Marker Score: 11,246
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1,349
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.83
    Marker Score: 503
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.83
    Marker Score: 5,299
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 794
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.81
    Marker Score: 200
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.77
    Marker Score: 8,990
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.76
    Marker Score: 421
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.75
    Marker Score: 6,458
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 567
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 211
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.73
    Marker Score: 776
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.71
    Marker Score: 744
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.7
    Marker Score: 470
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.7
    Marker Score: 934
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,933
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 636
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.68
    Marker Score: 378
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.67
    Marker Score: 6,786
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.66
    Marker Score: 1,012
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.65
    Marker Score: 359
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.64
    Marker Score: 1,738
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.64
    Marker Score: 370
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 637
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.63
    Marker Score: 4,088
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.63
    Marker Score: 5,376
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.62
    Marker Score: 291
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.62
    Marker Score: 252
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.62
    Marker Score: 9,655
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.61
    Marker Score: 1,820
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.61
    Marker Score: 322
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.61
    Marker Score: 304
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.61
    Marker Score: 205
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.61
    Marker Score: 1,188
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.6
    Marker Score: 402
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.59
    Marker Score: 830
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.58
    Marker Score: 276
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.58
    Marker Score: 1,570
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.56
    Marker Score: 381
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.56
    Marker Score: 465
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.56
    Marker Score: 1,748
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.56
    Marker Score: 5,278
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.55
    Marker Score: 576
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.55
    Marker Score: 1,381
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 365
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.55
    Marker Score: 904
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.55
    Marker Score: 268
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.54
    Marker Score: 363
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.54
    Marker Score: 299
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.54
    Marker Score: 574
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.54
    Marker Score: 267
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 560
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.54
    Marker Score: 392
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.54
    Marker Score: 1,123
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.53
    Marker Score: 515
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.53
    Marker Score: 376
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.53
    Marker Score: 124
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.53
    Marker Score: 255
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.53
    Marker Score: 2,533
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.53
    Marker Score: 1,072
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.53
    Marker Score: 484
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.52
    Marker Score: 150
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 167
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.52
    Marker Score: 3,289
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.51
    Marker Score: 250
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.51
    Marker Score: 2,704
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.51
    Marker Score: 31,578
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.51
    Marker Score: 1,219
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.51
    Marker Score: 2,142
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.51
    Marker Score: 575
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.51
    Marker Score: 960
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.5
    Marker Score: 365
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.5
    Marker Score: 800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 485

Other Information

**Key Characteristics:** PEX11B is a protein that belongs to the PEX family of proteins, which are essential for peroxisomal biogenesis and function. The protein is composed of two main domains: a C-terminal domain that interacts with the peroxisomal membrane and an N-terminal domain that interacts with the cytoskeleton. PEX11B is highly expressed in various cell types, including germ cells, pulmonary interstitial fibroblasts, and cardiac muscle cells. **Pathways and Functions:** PEX11B plays a critical role in the regulation of peroxisome size and function through the following pathways: 1. **Peroxisome organization:** PEX11B interacts with the peroxisomal membrane and regulates the expansion and contraction of peroxisomes in response to changes in cellular energy levels. 2. **Peroxisome fission:** PEX11B is involved in the regulation of peroxisome fission, which is the process by which peroxisomes divide to maintain cellular homeostasis. 3. **Signal transduction:** PEX11B interacts with other signaling molecules, such as PEX5 and PEX14, to regulate peroxisome biogenesis and function. The functions of PEX11B include: 1. **Regulation of peroxisome size:** PEX11B regulates the size of peroxisomes in response to changes in cellular energy levels. 2. **Regulation of peroxisome function:** PEX11B regulates the function of peroxisomes, including the breakdown of fatty acids and amino acids. 3. **Maintenance of cellular homeostasis:** PEX11B helps to maintain cellular homeostasis by regulating peroxisome size and function. **Clinical Significance:** Dysregulation of PEX11B has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Mutations in PEX11B have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Metabolic disorders:** Dysregulation of PEX11B has been linked to metabolic disorders, such as fatty liver disease and hyperlipidemia. 3. **Cancer:** PEX11B has been implicated in cancer development and progression, particularly in the context of peroxisome dysfunction. In conclusion, PEX11B is a critical regulator of peroxisome organization and function, and its dysregulation has significant implications for human health. Further research is needed to fully understand the mechanisms by which PEX11B regulates peroxisome biogenesis and function, and to develop therapeutic strategies for the treatment of diseases associated with PEX11B dysfunction.

Genular Protein ID: 1600831541

Symbol: PX11B_HUMAN

Name: Peroxisomal membrane protein 11B

UniProtKB Accession Codes:

O96011 B3KN85 B4DXH9 Q96ET2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9826565

Title: cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p.

PubMed ID: 9826565

DOI: 10.1006/bbrc.1998.9684

PubMed ID: 9792670

Title: Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli.

PubMed ID: 9792670

DOI: 10.1074/jbc.273.45.29607

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 12618434

Title: The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11.

PubMed ID: 12618434

DOI: 10.1074/jbc.m212031200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20826455

Title: PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance.

PubMed ID: 20826455

DOI: 10.1242/jcs.064907

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22581968

Title: A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11beta gene.

PubMed ID: 22581968

DOI: 10.1136/jmedgenet-2012-100778

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 259
  • Mass: 28431
  • Checksum: DC26CE30021C7B8D
  • Sequence:
    • MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES HLSLGRKLLR 
LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD NVLWAGKSGL APRVDQEKWA 
QRSFRYYLFS LIMNLSRDAY EIRLLMEQES SACSRRLKGS GGGVPGGSET GGLGGPGTPG 
GGLPQLALKL RLQVLLLARV LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL 
VSSILSILTL IYPWLRLKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.