Details for: PEX11B

Gene ID: 8799

Symbol: PEX11B

Ensembl ID: ENSG00000131779

Description: peroxisomal biogenesis factor 11 beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.9060
    Cell Significance Index: -14.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.8194
    Cell Significance Index: -12.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.9742
    Cell Significance Index: -16.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.1294
    Cell Significance Index: -14.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2443
    Cell Significance Index: -11.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9428
    Cell Significance Index: -12.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8494
    Cell Significance Index: -15.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0225
    Cell Significance Index: -6.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.8297
    Cell Significance Index: 46.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9234
    Cell Significance Index: 133.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1833
    Cell Significance Index: 71.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1140
    Cell Significance Index: 181.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9176
    Cell Significance Index: 12.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9107
    Cell Significance Index: 822.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9042
    Cell Significance Index: 98.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6374
    Cell Significance Index: 18.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5582
    Cell Significance Index: 15.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3414
    Cell Significance Index: 61.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3385
    Cell Significance Index: 64.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3381
    Cell Significance Index: 39.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3064
    Cell Significance Index: 61.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3059
    Cell Significance Index: 15.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2769
    Cell Significance Index: 6.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2596
    Cell Significance Index: 162.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2432
    Cell Significance Index: 132.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2387
    Cell Significance Index: 11.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2278
    Cell Significance Index: 28.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1954
    Cell Significance Index: 38.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1877
    Cell Significance Index: 5.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1837
    Cell Significance Index: 81.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1811
    Cell Significance Index: 24.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1615
    Cell Significance Index: 23.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1561
    Cell Significance Index: 56.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1554
    Cell Significance Index: 3.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1446
    Cell Significance Index: 14.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1441
    Cell Significance Index: 1.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1296
    Cell Significance Index: 8.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1152
    Cell Significance Index: 6.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1024
    Cell Significance Index: 1.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1012
    Cell Significance Index: 2.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0960
    Cell Significance Index: 6.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0913
    Cell Significance Index: 2.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0751
    Cell Significance Index: 9.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0742
    Cell Significance Index: 5.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0627
    Cell Significance Index: 43.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0396
    Cell Significance Index: 5.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0371
    Cell Significance Index: 6.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0290
    Cell Significance Index: 54.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0238
    Cell Significance Index: 0.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0205
    Cell Significance Index: 1.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0190
    Cell Significance Index: 1.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0170
    Cell Significance Index: 26.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0153
    Cell Significance Index: 0.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0145
    Cell Significance Index: 26.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0124
    Cell Significance Index: 0.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0048
    Cell Significance Index: 3.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0032
    Cell Significance Index: 4.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0002
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0064
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0067
    Cell Significance Index: -0.1400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0123
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0126
    Cell Significance Index: -0.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0152
    Cell Significance Index: -1.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0162
    Cell Significance Index: -9.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0165
    Cell Significance Index: -0.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0173
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0188
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0223
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0228
    Cell Significance Index: -2.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0272
    Cell Significance Index: -0.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0384
    Cell Significance Index: -0.8400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0404
    Cell Significance Index: -0.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0540
    Cell Significance Index: -15.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0687
    Cell Significance Index: -8.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0690
    Cell Significance Index: -3.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0727
    Cell Significance Index: -1.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0834
    Cell Significance Index: -1.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0945
    Cell Significance Index: -3.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0977
    Cell Significance Index: -5.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0980
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1171
    Cell Significance Index: -2.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1243
    Cell Significance Index: -1.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1326
    Cell Significance Index: -13.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1370
    Cell Significance Index: -3.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1559
    Cell Significance Index: -12.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1708
    Cell Significance Index: -4.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2045
    Cell Significance Index: -12.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2045
    Cell Significance Index: -5.4700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2189
    Cell Significance Index: -3.0700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2377
    Cell Significance Index: -3.5100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2514
    Cell Significance Index: -2.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2540
    Cell Significance Index: -5.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2560
    Cell Significance Index: -7.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2661
    Cell Significance Index: -13.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2707
    Cell Significance Index: -8.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2727
    Cell Significance Index: -6.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2777
    Cell Significance Index: -2.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PEX11B is a protein that belongs to the PEX family of proteins, which are essential for peroxisomal biogenesis and function. The protein is composed of two main domains: a C-terminal domain that interacts with the peroxisomal membrane and an N-terminal domain that interacts with the cytoskeleton. PEX11B is highly expressed in various cell types, including germ cells, pulmonary interstitial fibroblasts, and cardiac muscle cells. **Pathways and Functions:** PEX11B plays a critical role in the regulation of peroxisome size and function through the following pathways: 1. **Peroxisome organization:** PEX11B interacts with the peroxisomal membrane and regulates the expansion and contraction of peroxisomes in response to changes in cellular energy levels. 2. **Peroxisome fission:** PEX11B is involved in the regulation of peroxisome fission, which is the process by which peroxisomes divide to maintain cellular homeostasis. 3. **Signal transduction:** PEX11B interacts with other signaling molecules, such as PEX5 and PEX14, to regulate peroxisome biogenesis and function. The functions of PEX11B include: 1. **Regulation of peroxisome size:** PEX11B regulates the size of peroxisomes in response to changes in cellular energy levels. 2. **Regulation of peroxisome function:** PEX11B regulates the function of peroxisomes, including the breakdown of fatty acids and amino acids. 3. **Maintenance of cellular homeostasis:** PEX11B helps to maintain cellular homeostasis by regulating peroxisome size and function. **Clinical Significance:** Dysregulation of PEX11B has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Mutations in PEX11B have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Metabolic disorders:** Dysregulation of PEX11B has been linked to metabolic disorders, such as fatty liver disease and hyperlipidemia. 3. **Cancer:** PEX11B has been implicated in cancer development and progression, particularly in the context of peroxisome dysfunction. In conclusion, PEX11B is a critical regulator of peroxisome organization and function, and its dysregulation has significant implications for human health. Further research is needed to fully understand the mechanisms by which PEX11B regulates peroxisome biogenesis and function, and to develop therapeutic strategies for the treatment of diseases associated with PEX11B dysfunction.

Genular Protein ID: 1600831541

Symbol: PX11B_HUMAN

Name: Peroxisomal membrane protein 11B

UniProtKB Accession Codes:

O96011 B3KN85 B4DXH9 Q96ET2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 14 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9826565

Title: cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p.

PubMed ID: 9826565

DOI: 10.1006/bbrc.1998.9684

PubMed ID: 9792670

Title: Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli.

PubMed ID: 9792670

DOI: 10.1074/jbc.273.45.29607

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 12618434

Title: The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11.

PubMed ID: 12618434

DOI: 10.1074/jbc.m212031200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20826455

Title: PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance.

PubMed ID: 20826455

DOI: 10.1242/jcs.064907

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22581968

Title: A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11beta gene.

PubMed ID: 22581968

DOI: 10.1136/jmedgenet-2012-100778

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 259
  • Mass: 28431
  • Checksum: DC26CE30021C7B8D
  • Sequence:
    • MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES HLSLGRKLLR 
LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD NVLWAGKSGL APRVDQEKWA 
QRSFRYYLFS LIMNLSRDAY EIRLLMEQES SACSRRLKGS GGGVPGGSET GGLGGPGTPG 
GGLPQLALKL RLQVLLLARV LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL 
VSSILSILTL IYPWLRLKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.