Details for: SUCLG2

Gene ID: 8801

Symbol: SUCLG2

Ensembl ID: ENSG00000172340

Description: succinate-CoA ligase GDP-forming subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 327.9111
    Cell Significance Index: -51.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.8078
    Cell Significance Index: -53.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 123.1467
    Cell Significance Index: -50.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.4088
    Cell Significance Index: -54.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.3057
    Cell Significance Index: -45.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.2106
    Cell Significance Index: -53.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 80.7201
    Cell Significance Index: -54.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.1281
    Cell Significance Index: -45.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.0997
    Cell Significance Index: -53.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2756
    Cell Significance Index: -43.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5984
    Cell Significance Index: -53.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.4204
    Cell Significance Index: -41.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.5606
    Cell Significance Index: -27.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 6.3393
    Cell Significance Index: 106.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 6.1979
    Cell Significance Index: 428.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3128
    Cell Significance Index: 59.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2671
    Cell Significance Index: 449.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1175
    Cell Significance Index: 28.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8937
    Cell Significance Index: 145.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6503
    Cell Significance Index: 32.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6095
    Cell Significance Index: 44.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3534
    Cell Significance Index: 29.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3533
    Cell Significance Index: 38.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3280
    Cell Significance Index: 1199.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1813
    Cell Significance Index: 212.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0965
    Cell Significance Index: 16.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0460
    Cell Significance Index: 47.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9555
    Cell Significance Index: 44.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9259
    Cell Significance Index: 24.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8593
    Cell Significance Index: 44.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8269
    Cell Significance Index: 46.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8177
    Cell Significance Index: 100.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8074
    Cell Significance Index: 110.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7231
    Cell Significance Index: 394.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6839
    Cell Significance Index: 5.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6342
    Cell Significance Index: 5.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6168
    Cell Significance Index: 13.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6029
    Cell Significance Index: 42.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5886
    Cell Significance Index: 29.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5629
    Cell Significance Index: 91.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5307
    Cell Significance Index: 234.6400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.5065
    Cell Significance Index: 5.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4546
    Cell Significance Index: 86.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4414
    Cell Significance Index: 10.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4134
    Cell Significance Index: 40.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4074
    Cell Significance Index: 30.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3200
    Cell Significance Index: 41.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3046
    Cell Significance Index: 52.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2990
    Cell Significance Index: 38.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2319
    Cell Significance Index: 10.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2300
    Cell Significance Index: 433.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2148
    Cell Significance Index: 97.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2029
    Cell Significance Index: 7.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1973
    Cell Significance Index: 125.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1536
    Cell Significance Index: 106.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1319
    Cell Significance Index: 243.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1211
    Cell Significance Index: 3.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1139
    Cell Significance Index: 22.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1080
    Cell Significance Index: 166.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0696
    Cell Significance Index: 51.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0647
    Cell Significance Index: 0.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0150
    Cell Significance Index: 1.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0060
    Cell Significance Index: 8.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0233
    Cell Significance Index: -14.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0259
    Cell Significance Index: -14.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0583
    Cell Significance Index: -0.8600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0688
    Cell Significance Index: -0.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0723
    Cell Significance Index: -7.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0971
    Cell Significance Index: -34.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1350
    Cell Significance Index: -2.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1387
    Cell Significance Index: -8.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1407
    Cell Significance Index: -2.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1410
    Cell Significance Index: -20.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1473
    Cell Significance Index: -17.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1487
    Cell Significance Index: -31.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1567
    Cell Significance Index: -45.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1706
    Cell Significance Index: -19.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1956
    Cell Significance Index: -4.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2507
    Cell Significance Index: -3.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2764
    Cell Significance Index: -28.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2833
    Cell Significance Index: -22.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3425
    Cell Significance Index: -39.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3866
    Cell Significance Index: -13.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4066
    Cell Significance Index: -21.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4447
    Cell Significance Index: -12.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5025
    Cell Significance Index: -30.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5284
    Cell Significance Index: -5.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5983
    Cell Significance Index: -17.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6068
    Cell Significance Index: -15.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6436
    Cell Significance Index: -39.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6971
    Cell Significance Index: -46.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7222
    Cell Significance Index: -16.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7830
    Cell Significance Index: -48.1300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.8010
    Cell Significance Index: -7.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8154
    Cell Significance Index: -51.3900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.9193
    Cell Significance Index: -7.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9348
    Cell Significance Index: -49.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SUCLG2 is a subunit of the succinate-CoA ligase complex, which is responsible for the conversion of succinyl-CoA to succinate, a critical step in the TCA cycle. This reaction is reversible, with the GDP-forming subunit (SUCLG2) catalyzing the GDP-dependent reaction, while the ADP-forming subunit (SUCLG1) catalyzes the ADP-dependent reaction. The complex is composed of two subunits, SUCLG1 and SUCLG2, which are encoded by separate genes. SUCLG2 is a beta-subunit, which is distinct from the alpha-subunit (SUCLG1) that is encoded by a separate gene. **Pathways and Functions:** SUCLG2 is involved in several key metabolic pathways, including: 1. **Citric Acid Cycle (TCA Cycle):** SUCLG2 is a crucial component of the TCA cycle, which is a central metabolic pathway that generates energy for the cell through the oxidation of acetyl-CoA. 2. **ATP Production:** The succinate-CoA ligase complex is responsible for the production of ATP through the conversion of succinyl-CoA to succinate, which is then fed into the electron transport chain to generate ATP. 3. **Metabolic Regulation:** SUCLG2 plays a regulatory role in metabolism, as it is involved in the control of the TCA cycle and the production of ATP. 4. **Protein Degradation:** SUCLG2 is also involved in the regulation of protein degradation, as it is a component of the mitochondrial matrix, where protein degradation occurs. **Clinical Significance:** Dysregulation of SUCLG2 has been implicated in several diseases, including: 1. **Mitochondrial Diseases:** Mutations in the SUCLG1 gene, which encodes the alpha-subunit of the succinate-CoA ligase complex, have been linked to mitochondrial diseases, such as Kearns-Sayre syndrome and MERRF syndrome. 2. **Cancer:** SUCLG2 has been shown to be overexpressed in certain types of cancer, including colon cancer, suggesting a potential role in tumorigenesis. 3. **Metabolic Disorders:** SUCLG2 has been implicated in metabolic disorders, such as type 2 diabetes and metabolic syndrome, where impaired mitochondrial function is a key contributor to disease pathogenesis. In conclusion, SUCLG2 is a critical component of the succinate-CoA ligase complex, playing a central role in the regulation of the TCA cycle and the production of ATP. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health.

Genular Protein ID: 2142552510

Symbol: SUCB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96I99 C9JVT2 O95195 Q6NUH7 Q86VX8 Q8WUQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 2 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9765291

Title: Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes.

PubMed ID: 9765291

DOI: 10.1074/jbc.273.42.27580

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 432
  • Mass: 46511
  • Checksum: 56A977A3E50713A1
  • Sequence:
    • MASPVAAQAG KLLRALALRP RFLAAGSQAV QLTSRRWLNL QEYQSKKLMS DNGVRVQRFF 
VADTANEALE AAKRLNAKEI VLKAQILAGG RGKGVFNSGL KGGVHLTKDP NVVGQLAKQM 
IGYNLATKQT PKEGVKVNKV MVAEALDISR ETYLAILMDR SCNGPVLVGS PQGGVDIEEV 
AASNPELIFK EQIDIFEGIK DSQAQRMAEN LGFVGPLKSQ AADQITKLYN LFLKIDATQV 
EVNPFGETPE GQVVCFDAKI NFDDNAEFRQ KDIFAMDDKS ENEPIENEAA KYDLKYIGLD 
GNIACFVNGA GLAMATCDII FLNGGKPANF LDLGGGVKEA QVYQAFKLLT ADPKVEAILV 
NIFGGIVNCA IIANGITKAC RELELKVPLV VRLEGTNVQE AQKILNNSGL PITSAIDLED 
AAKKAVASVA KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.