Details for: CREG1

Gene ID: 8804

Symbol: CREG1

Ensembl ID: ENSG00000143162

Description: cellular repressor of E1A stimulated genes 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.4924
    Cell Significance Index: -32.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 120.8390
    Cell Significance Index: -30.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 102.1975
    Cell Significance Index: -42.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.5620
    Cell Significance Index: -41.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.2087
    Cell Significance Index: -39.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.5479
    Cell Significance Index: -41.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.3108
    Cell Significance Index: -32.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4464
    Cell Significance Index: -38.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6527
    Cell Significance Index: -38.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0255
    Cell Significance Index: -24.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7862
    Cell Significance Index: 324.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.7320
    Cell Significance Index: 50.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5363
    Cell Significance Index: 71.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3777
    Cell Significance Index: 248.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2144
    Cell Significance Index: 149.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2137
    Cell Significance Index: 32.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0651
    Cell Significance Index: 470.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0561
    Cell Significance Index: 74.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0342
    Cell Significance Index: 29.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9170
    Cell Significance Index: 24.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8896
    Cell Significance Index: 46.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8580
    Cell Significance Index: 139.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8344
    Cell Significance Index: 107.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8305
    Cell Significance Index: 166.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7835
    Cell Significance Index: 7.2200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.7672
    Cell Significance Index: 5.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7192
    Cell Significance Index: 33.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6839
    Cell Significance Index: 47.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6564
    Cell Significance Index: 358.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5300
    Cell Significance Index: 13.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4900
    Cell Significance Index: 62.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4757
    Cell Significance Index: 90.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4703
    Cell Significance Index: 168.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4449
    Cell Significance Index: 11.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4227
    Cell Significance Index: 72.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3875
    Cell Significance Index: 24.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3411
    Cell Significance Index: 37.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3397
    Cell Significance Index: 25.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3211
    Cell Significance Index: 44.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2896
    Cell Significance Index: 6.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2096
    Cell Significance Index: 6.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1940
    Cell Significance Index: 4.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1894
    Cell Significance Index: 6.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1812
    Cell Significance Index: 17.9200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1633
    Cell Significance Index: 2.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1513
    Cell Significance Index: 30.0200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0716
    Cell Significance Index: 1.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0553
    Cell Significance Index: 38.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0529
    Cell Significance Index: 2.4000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0454
    Cell Significance Index: 0.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0425
    Cell Significance Index: 32.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0364
    Cell Significance Index: 0.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0246
    Cell Significance Index: 46.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0107
    Cell Significance Index: 1.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0063
    Cell Significance Index: -9.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0112
    Cell Significance Index: -7.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0122
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0176
    Cell Significance Index: -12.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0196
    Cell Significance Index: -1.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0277
    Cell Significance Index: -17.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0311
    Cell Significance Index: -17.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0323
    Cell Significance Index: -43.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0488
    Cell Significance Index: -3.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0651
    Cell Significance Index: -29.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0702
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1030
    Cell Significance Index: -21.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1076
    Cell Significance Index: -30.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1124
    Cell Significance Index: -6.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1195
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1449
    Cell Significance Index: -16.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1471
    Cell Significance Index: -4.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1609
    Cell Significance Index: -18.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1913
    Cell Significance Index: -27.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2339
    Cell Significance Index: -26.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2354
    Cell Significance Index: -3.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3031
    Cell Significance Index: -20.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3283
    Cell Significance Index: -25.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3364
    Cell Significance Index: -4.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3512
    Cell Significance Index: -36.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3720
    Cell Significance Index: -8.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3856
    Cell Significance Index: -7.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4171
    Cell Significance Index: -7.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4470
    Cell Significance Index: -35.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4671
    Cell Significance Index: -26.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4763
    Cell Significance Index: -9.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5214
    Cell Significance Index: -13.3200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5295
    Cell Significance Index: -8.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5987
    Cell Significance Index: -30.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6230
    Cell Significance Index: -5.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6252
    Cell Significance Index: -13.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6598
    Cell Significance Index: -40.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7148
    Cell Significance Index: -8.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7181
    Cell Significance Index: -21.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7483
    Cell Significance Index: -27.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7506
    Cell Significance Index: -7.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7629
    Cell Significance Index: -19.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7802
    Cell Significance Index: -9.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CREG1 is a transcriptional corepressor that belongs to the CREB (cAMP response element-binding) family of proteins. It is characterized by its ability to repress transcriptional activity by binding to specific DNA sequences, thereby inhibiting the expression of target genes. CREG1 is highly expressed in cells of the immune system, including macrophages, dendritic cells, and neutrophils, making it an essential regulator of immune responses. **Pathways and Functions:** CREG1 is involved in various cellular pathways, including: 1. **Autophagy**: CREG1 regulates the autophagic process by modulating the expression of autophagy-related genes. 2. **Immune system**: CREG1 plays a critical role in regulating the immune response by modulating the expression of genes involved in inflammation, cytokine production, and immune cell activation. 3. **Transcriptional regulation**: CREG1 acts as a transcriptional corepressor by binding to specific DNA sequences, thereby inhibiting the expression of target genes. 4. **Endocytosis and extracellular vesicle formation**: CREG1 is involved in the regulation of endocytosis and extracellular vesicle formation, which are critical processes in immune cell function. **Significantly Expressed Cells:** CREG1 is highly expressed in cells of the immune system, including: 1. **Macrophages**: CREG1 is highly expressed in macrophages, which are key players in immune responses. 2. **Dendritic cells**: CREG1 is also expressed in dendritic cells, which are essential for antigen presentation and immune cell activation. 3. **Neutrophils**: CREG1 is expressed in neutrophils, which are critical for the elimination of pathogens and foreign substances. **Clinical Significance:** Dysregulation of CREG1 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: CREG1 dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: CREG1 has been shown to play a role in cancer progression and metastasis. 3. **Infectious diseases**: CREG1 dysregulation has been implicated in infectious diseases, such as tuberculosis and sepsis. In conclusion, CREG1 is a critical gene involved in regulating immune responses, autophagy, and transcriptional control. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of CREG1 in maintaining cellular homeostasis and immune system function. Further research is needed to fully elucidate the role of CREG1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3525319085

Symbol: CREG1_HUMAN

Name: Protein CREG1

UniProtKB Accession Codes:

O75629 B2RDD4 Q8N9A3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9710587

Title: A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.

PubMed ID: 9710587

DOI: 10.1128/mcb.18.9.5032

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10815803

Title: The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells.

PubMed ID: 10815803

DOI: 10.1038/sj.onc.1203529

PubMed ID: 12934103

Title: The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor.

PubMed ID: 12934103

DOI: 10.1038/sj.onc.1206670

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16344469

Title: The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.

PubMed ID: 16344469

DOI: 10.1073/pnas.0505071102

Sequence Information:

  • Length: 220
  • Mass: 24075
  • Checksum: 0DB95A1E4149CD7C
  • Sequence:
    • MAGLSRGSAR ALLAALLAST LLALLVSPAR GRGGRDHGDW DEASRLPPLP PREDAARVAR 
FVTHVSDWGA LATISTLEAV RGRPFADVLS LSDGPPGAGS GVPYFYLSPL QLSVSNLQEN 
PYATLTMTLA QTNFCKKHGF DPQSPLCVHI MLSGTVTKVN ETEMDIAKHS LFIRHPEMKT 
WPSSHNWFFA KLNITNIWVL DYFGGPKIVT PEEYYNVTVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.