CCNK | ENSG00000090061 | NCBI 8812

Details for: CCNK

Associated with

Disease
(R-HSA-1643685)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Cell division
(GO:0051301)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin/cdk positive transcription elongation factor complex
(GO:0008024)
Cyclin k-cdk12 complex
(GO:0002944)
Cyclin k-cdk13 complex
(GO:0002945)
Dna damage response
(GO:0006974)
Negative regulation by host of viral genome replication
(GO:0044828)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription, elongation
(GO:0032786)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of signal transduction
(GO:0009966)
Rna polymerase ii ctd heptapeptide repeat kinase activity
(GO:0008353)
Transcription by rna polymerase ii
(GO:0006366)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

fallopian tube secretory epithelial cell CL4030006

CSI 6.59

rCSI 6.35%

PRS 29.25
megakaryocyte-erythroid progenitor cell CL0000050

CSI 6.41

rCSI 5.79%

PRS 25.85
respiratory suprabasal cell CL4033048

CSI 5.86

rCSI 7.52%

PRS 32.56
endothelial cell of placenta CL0009092

CSI 5.16

rCSI 25.42%

PRS 37.7
helper T cell CL0000912

CSI 4.29

rCSI 6.06%

PRS 38.1
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.29

rCSI 3.26%

PRS 37.07
paneth cell CL0000510

CSI 3.96

rCSI 5.85%

PRS 42.92
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 3.94

rCSI 6.95%

PRS 17.03
hematopoietic multipotent progenitor cell CL0000837

CSI 3.85

rCSI 9.26%

PRS 43.23
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.82

rCSI 19.15%

PRS 36.98
kidney connecting tubule epithelial cell CL1000768

CSI 3.46

rCSI 8.78%

PRS 21.85
luminal cell of prostate epithelium CL0002340

CSI 3.29

rCSI 17.69%

PRS 45.23
T-helper 17 cell CL0000899

CSI 3.24

rCSI 2.57%

PRS 47.86
regular ventricular cardiac myocyte CL0002131

CSI 3.2

rCSI 19.96%

PRS 22.87
cardiac endothelial cell CL0010008

CSI 2.98

rCSI 12.01%

PRS 26.83
sncg GABAergic cortical interneuron CL4023015

CSI 2.89

rCSI 4.65%

PRS 19.04
pro-B cell CL0000826

CSI 2.81

rCSI 2.33%

PRS 28.78
immature B cell CL0000816

CSI 2.79

rCSI 2.07%

PRS 40.05
class switched memory B cell CL0000972

CSI 2.71

rCSI 2.03%

PRS 45.23
hematopoietic precursor cell CL0008001

CSI 2.49

rCSI 2.56%

PRS 43.57
cerebellar granule cell CL0001031

CSI 2.48

rCSI 3.65%

PRS 26.26
naive T cell CL0000898

CSI 2.43

rCSI 1.69%

PRS 39.05
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.33

rCSI 1.57%

PRS 35.23
vascular leptomeningeal cell CL4023051

CSI 2.32

rCSI 4.06%

PRS 22.39
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.3

rCSI 2.25%

PRS 42.13
unswitched memory B cell CL0000970

CSI 2.29

rCSI 1.92%

PRS 43.2
interneuron CL0000099

CSI 2.28

rCSI 4.58%

PRS 21.19
mature T cell CL0002419

CSI 2.28

rCSI 1.78%

PRS 41.16
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.25

rCSI 1.61%

PRS 38.36
lung secretory cell CL1000272

CSI 2.25

rCSI 5.57%

PRS 26.53
ciliated cell CL0000064

CSI 2.24

rCSI 3.63%

PRS 28.16
epithelial cell of lung CL0000082

CSI 2.22

rCSI 1.84%

PRS 27.03
neural crest cell CL0011012

CSI 2.18

rCSI 1.72%

PRS 19.7
double negative thymocyte CL0002489

CSI 2.14

rCSI 1.49%

PRS 34.19
pulmonary ionocyte CL0017000

CSI 2.12

rCSI 2.58%

PRS 34.81
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 2.07

rCSI 2.47%

PRS 46.5
epithelial cell of lower respiratory tract CL0002632

CSI 2.06

rCSI 1.6%

PRS 27.77
T follicular helper cell CL0002038

CSI 2.04

rCSI 1.53%

PRS 42.29
multi-ciliated epithelial cell CL0005012

CSI 2.04

rCSI 2.04%

PRS 24.28
plasmablast CL0000980

CSI 2.03

rCSI 1.6%

PRS 33.78
Kupffer cell CL0000091

CSI 2

rCSI 4.58%

PRS 27.74
precursor B cell CL0000817

CSI 1.99

rCSI 1.74%

PRS 36.59
melanocyte CL0000148

CSI 1.98

rCSI 1.47%

PRS 24.37
secretory cell CL0000151

CSI 1.95

rCSI 2.03%

PRS 29.05
CD14-low, CD16-positive monocyte CL0002396

CSI 1.94

rCSI 1.5%

PRS 26.72
microcirculation associated smooth muscle cell CL0008035

CSI 1.94

rCSI 5.61%

PRS 31.35
cerebral cortex GABAergic interneuron CL0010011

CSI 1.94

rCSI 5.72%

PRS 32.92
brush cell of tracheobronchial tree CL0002075

CSI 1.94

rCSI 5.74%

PRS 38.11
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.92

rCSI 1.77%

PRS 47.75
pvalb GABAergic cortical interneuron CL4023018

CSI 1.91

rCSI 2.38%

PRS 16.46
common myeloid progenitor CL0000049

CSI 1.91

rCSI 1.54%

PRS 28.5
blood vessel endothelial cell CL0000071

CSI 1.88

rCSI 3.89%

PRS 27.81
VIP GABAergic cortical interneuron CL4023016

CSI 1.86

rCSI 2.23%

PRS 17.32
mesodermal cell CL0000222

CSI 1.85

rCSI 2.22%

PRS 27.45
keratinocyte CL0000312

CSI 1.83

rCSI 1.53%

PRS 33.01
goblet cell CL0000160

CSI 1.83

rCSI 1.73%

PRS 29.56
alpha-beta T cell CL0000789

CSI 1.82

rCSI 2.13%

PRS 39.69
alternatively activated macrophage CL0000890

CSI 1.82

rCSI 2.28%

PRS 41.05
granulocyte CL0000094

CSI 1.82

rCSI 2.77%

PRS 35.92
retinal bipolar neuron CL0000748

CSI 1.81

rCSI 3.4%

PRS 21.04
perivascular cell CL4033054

CSI 1.8

rCSI 2.46%

PRS 31.93
double-positive, alpha-beta thymocyte CL0000809

CSI 1.8

rCSI 1.83%

PRS 39.42
pulmonary capillary endothelial cell CL4028001

CSI 1.79

rCSI 3.41%

PRS 43.45
fibroblast of lung CL0002553

CSI 1.79

rCSI 1.66%

PRS 28.36
duct epithelial cell CL0000068

CSI 1.77

rCSI 2.59%

PRS 30.2
activated type II NK T cell CL0000931

CSI 1.76

rCSI 1.99%

PRS 43.24
colon epithelial cell CL0011108

CSI 1.76

rCSI 1.84%

PRS 26.45
lung ciliated cell CL1000271

CSI 1.74

rCSI 2.02%

PRS 21.17
Mueller cell CL0000636

CSI 1.74

rCSI 3.96%

PRS 24.33
CD4-positive helper T cell CL0000492

CSI 1.73

rCSI 1.31%

PRS 38.07
dendritic cell, human CL0001056

CSI 1.73

rCSI 2.66%

PRS 33.64
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.72

rCSI 1.02%

PRS 39.46
bronchus fibroblast of lung CL2000093

CSI 1.72

rCSI 1.4%

PRS 29.42
plasmacytoid dendritic cell, human CL0001058

CSI 1.7

rCSI 1.19%

PRS 29.93
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.69

rCSI 2.83%

PRS 17.5
elicited macrophage CL0000861

CSI 1.68

rCSI 1.54%

PRS 33.67
transit amplifying cell CL0009010

CSI 1.68

rCSI 2.57%

PRS 43.8
neuroblast (sensu Vertebrata) CL0000031

CSI 1.65

rCSI 2.12%

PRS 27.1
intestinal tuft cell CL0019032

CSI 1.64

rCSI 2.51%

PRS 32.19
granulocyte monocyte progenitor cell CL0000557

CSI 1.64

rCSI 1.42%

PRS 31.53
hematopoietic stem cell CL0000037

CSI 1.61

rCSI 1.07%

PRS 32.88
radial glial cell CL0000681

CSI 1.6

rCSI 2.22%

PRS 28.54
mesenchymal cell CL0008019

CSI 1.59

rCSI 4.04%

PRS 27.44
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.59

rCSI 3.16%

PRS 45.21
hepatic stellate cell CL0000632

CSI 1.58

rCSI 5.92%

PRS 23.92
pancreatic acinar cell CL0002064

CSI 1.56

rCSI 2.08%

PRS 31.24
peripheral nervous system neuron CL2000032

CSI 1.56

rCSI 2.13%

PRS 24.64
astrocyte of the cerebral cortex CL0002605

CSI 1.56

rCSI 3.5%

PRS 18.12
cerebral cortex endothelial cell CL1001602

CSI 1.56

rCSI 2.7%

PRS 21.82
blood vessel smooth muscle cell CL0019018

CSI 1.53

rCSI 12.42%

PRS 26.47
myeloid leukocyte CL0000766

CSI 1.49

rCSI 1.37%

PRS 29.4
CD14-positive monocyte CL0001054

CSI 1.47

rCSI 1.83%

PRS 38.17
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.47

rCSI 1.34%

PRS 41.57
erythrocyte CL0000232

CSI 1.45

rCSI 3.3%

PRS 35.36
intestine goblet cell CL0019031

CSI 1.44

rCSI 1.28%

PRS 28.27
placental villous trophoblast CL2000060

CSI 1.44

rCSI 2.23%

PRS 26.71
ciliated epithelial cell CL0000067

CSI 1.41

rCSI 1.24%

PRS 20.84
common dendritic progenitor CL0001029

CSI 1.4

rCSI 1.75%

PRS 36.28
mature B cell CL0000785

CSI 1.39

rCSI 1.21%

PRS 35.24
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.35

rCSI 3.5%

PRS 61.4

L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.3

rCSI 1.0%

PRS 16.6%
foveolar cell of stomach CL0002179

CSI 0.4

rCSI 0.8%

PRS 42.6%
primitive red blood cell CL0002355

CSI 0.4

rCSI 1.9%

PRS 43.9%
erythroid progenitor cell CL0000038

CSI 0.4

rCSI 2.1%

PRS 39.6%
small pre-B-II cell CL0000954

CSI 0.5

rCSI 0.5%

PRS 52.0%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.5

rCSI 2.6%

PRS 51.0%
intestinal crypt stem cell of colon CL0009043

CSI 0.6

rCSI 4.2%

PRS 48.2%
enterocyte of epithelium of large intestine CL0002071

CSI 0.6

rCSI 3.0%

PRS 44.6%
megakaryocyte CL0000556

CSI 0.6

rCSI 2.7%

PRS 45.0%
intermediate monocyte CL0002393

CSI 0.6

rCSI 0.9%

PRS 29.1%
L6b glutamatergic cortical neuron CL4023038

CSI 0.6

rCSI 1.9%

PRS 18.3%
CD1c-positive myeloid dendritic cell CL0002399

CSI 0.6

rCSI 0.8%

PRS 33.9%
squamous epithelial cell CL0000076

CSI 0.7

rCSI 1.6%

PRS 34.0%
neural progenitor cell CL0011020

CSI 0.7

rCSI 2.9%

PRS 25.2%
transit amplifying cell of small intestine CL0009012

CSI 0.7

rCSI 3.0%

PRS 48.0%
large pre-B-II cell CL0000957

CSI 0.7

rCSI 2.0%

PRS 43.6%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.7

rCSI 1.7%

PRS 17.1%
retinal cone cell CL0000573

CSI 0.7

rCSI 1.1%

PRS 21.9%
glandular epithelial cell CL0000150

CSI 0.7

rCSI 1.8%

PRS 50.7%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.8

rCSI 2.0%

PRS 36.3%
paneth cell of epithelium of small intestine CL1000343

CSI 0.8

rCSI 2.3%

PRS 42.4%
colon goblet cell CL0009039

CSI 0.8

rCSI 2.0%

PRS 40.2%
forebrain radial glial cell CL0013000

CSI 0.8

rCSI 2.7%

PRS 37.6%
small intestine goblet cell CL1000495

CSI 0.9

rCSI 1.9%

PRS 37.1%
nasal mucosa goblet cell CL0002480

CSI 0.9

rCSI 1.0%

PRS 39.2%
colonocyte CL1000347

CSI 0.9

rCSI 1.3%

PRS 36.6%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 0.9

rCSI 2.7%

PRS 41.8%
BEST4+ enteroycte CL4030026

CSI 0.9

rCSI 1.2%

PRS 30.3%
ionocyte CL0005006

CSI 1.0

rCSI 1.1%

PRS 26.3%
conjunctival epithelial cell CL1000432

CSI 1.0

rCSI 1.6%

PRS 28.6%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.0

rCSI 6.1%

PRS 18.4%
promonocyte CL0000559

CSI 1.0

rCSI 1.8%

PRS 37.1%
basal cell CL0000646

CSI 1.1

rCSI 1.4%

PRS 30.5%
hepatocyte CL0000182

CSI 1.1

rCSI 1.9%

PRS 26.5%
enteroendocrine cell CL0000164

CSI 1.1

rCSI 1.5%

PRS 31.1%
sst GABAergic cortical interneuron CL4023017

CSI 1.1

rCSI 1.4%

PRS 18.1%
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.1

rCSI 4.3%

PRS 45.3%
glioblast CL0000030

CSI 1.1

rCSI 1.8%

PRS 24.3%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.2

rCSI 1.6%

PRS 49.2%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.2

rCSI 1.6%

PRS 39.4%
promyelocyte CL0000836

CSI 1.2

rCSI 1.8%

PRS 37.8%
common lymphoid progenitor CL0000051

CSI 1.2

rCSI 1.6%

PRS 49.7%
acinar cell CL0000622

CSI 1.2

rCSI 1.8%

PRS 36.9%
respiratory basal cell CL0002633

CSI 1.3

rCSI 1.3%

PRS 33.3%
extravillous trophoblast CL0008036

CSI 1.3

rCSI 1.6%

PRS 25.1%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.3

rCSI 1.5%

PRS 24.6%
lung macrophage CL1001603

CSI 1.3

rCSI 2.9%

PRS 33.1%
corneal epithelial cell CL0000575

CSI 1.3

rCSI 3.7%

PRS 46.1%
transit amplifying cell of colon CL0009011

CSI 1.3

rCSI 1.5%

PRS 32.2%
Langerhans cell CL0000453

CSI 1.3

rCSI 2.0%

PRS 46.1%
retinal blood vessel endothelial cell CL0002585

CSI 1.3

rCSI 2.1%

PRS 31.0%
retinal rod cell CL0000604

CSI 1.3

rCSI 2.3%

PRS 27.6%
chondrocyte CL0000138

CSI 1.3

rCSI 2.1%

PRS 23.9%
stem cell CL0000034

CSI 1.3

rCSI 1.3%

PRS 21.3%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.4

rCSI 2.3%

PRS 49.3%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.4

rCSI 3.5%

PRS 61.4%
mature B cell CL0000785

CSI 1.4

rCSI 1.2%

PRS 35.2%
common dendritic progenitor CL0001029

CSI 1.4

rCSI 1.8%

PRS 36.3%
ciliated epithelial cell CL0000067

CSI 1.4

rCSI 1.2%

PRS 20.8%
placental villous trophoblast CL2000060

CSI 1.4

rCSI 2.2%

PRS 26.7%
intestine goblet cell CL0019031

CSI 1.4

rCSI 1.3%

PRS 28.3%
erythrocyte CL0000232

CSI 1.5

rCSI 3.3%

PRS 35.4%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.5

rCSI 1.3%

PRS 41.6%
CD14-positive monocyte CL0001054

CSI 1.5

rCSI 1.8%

PRS 38.2%
myeloid leukocyte CL0000766

CSI 1.5

rCSI 1.4%

PRS 29.4%
blood vessel smooth muscle cell CL0019018

CSI 1.5

rCSI 12.4%

PRS 26.5%
cerebral cortex endothelial cell CL1001602

CSI 1.6

rCSI 2.7%

PRS 21.8%
astrocyte of the cerebral cortex CL0002605

CSI 1.6

rCSI 3.5%

PRS 18.1%
peripheral nervous system neuron CL2000032

CSI 1.6

rCSI 2.1%

PRS 24.6%
pancreatic acinar cell CL0002064

CSI 1.6

rCSI 2.1%

PRS 31.2%
hepatic stellate cell CL0000632

CSI 1.6

rCSI 5.9%

PRS 23.9%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.6

rCSI 3.2%

PRS 45.2%
mesenchymal cell CL0008019

CSI 1.6

rCSI 4.0%

PRS 27.4%
radial glial cell CL0000681

CSI 1.6

rCSI 2.2%

PRS 28.5%
hematopoietic stem cell CL0000037

CSI 1.6

rCSI 1.1%

PRS 32.9%
granulocyte monocyte progenitor cell CL0000557

CSI 1.6

rCSI 1.4%

PRS 31.5%
intestinal tuft cell CL0019032

CSI 1.6

rCSI 2.5%

PRS 32.2%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.7

rCSI 2.1%

PRS 27.1%
transit amplifying cell CL0009010

CSI 1.7

rCSI 2.6%

PRS 43.8%
elicited macrophage CL0000861

CSI 1.7

rCSI 1.5%

PRS 33.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.7

rCSI 2.8%

PRS 17.5%
plasmacytoid dendritic cell, human CL0001058

CSI 1.7

rCSI 1.2%

PRS 29.9%
bronchus fibroblast of lung CL2000093

CSI 1.7

rCSI 1.4%

PRS 29.4%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.7

rCSI 1.0%

PRS 39.5%
dendritic cell, human CL0001056

CSI 1.7

rCSI 2.7%

PRS 33.6%
CD4-positive helper T cell CL0000492

CSI 1.7

rCSI 1.3%

PRS 38.1%
Mueller cell CL0000636

CSI 1.7

rCSI 4.0%

PRS 24.3%
lung ciliated cell CL1000271

CSI 1.7

rCSI 2.0%

PRS 21.2%
colon epithelial cell CL0011108

CSI 1.8

rCSI 1.8%

PRS 26.5%
activated type II NK T cell CL0000931

CSI 1.8

rCSI 2.0%

PRS 43.2%
duct epithelial cell CL0000068

CSI 1.8

rCSI 2.6%

PRS 30.2%
fibroblast of lung CL0002553

CSI 1.8

rCSI 1.7%

PRS 28.4%
pulmonary capillary endothelial cell CL4028001

CSI 1.8

rCSI 3.4%

PRS 43.5%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.8

rCSI 1.8%

PRS 39.4%
perivascular cell CL4033054

CSI 1.8

rCSI 2.5%

PRS 31.9%
retinal bipolar neuron CL0000748

CSI 1.8

rCSI 3.4%

PRS 21.0%
granulocyte CL0000094

CSI 1.8

rCSI 2.8%

PRS 35.9%
alternatively activated macrophage CL0000890

CSI 1.8

rCSI 2.3%

PRS 41.1%
alpha-beta T cell CL0000789

CSI 1.8

rCSI 2.1%

PRS 39.7%
goblet cell CL0000160

CSI 1.8

rCSI 1.7%

PRS 29.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its specificity using the CSI (Z-SCORE), [CCNK](/details-gene/8812) is identified as a ubiquitously expressed gene essential for fundamental cellular processes rather than a specific marker for any single cell type. Its core function as a cyclin partner for cyclin-dependent kinases (CDKs) places it at the center of regulating RNA polymerase II-mediated transcription elongation. This broad, non-specific expression pattern across diverse lineages is consistent with its indispensable role in basal gene expression, cell division, and the DNA damage response. Mutations in [CCNK](/details-gene/8812) have been linked to syndromic neurodevelopmental disorders, underscoring its critical importance in organismal biology. ## Cellular Roles and Expression Landscape The expression profile of [CCNK](/details-gene/8812), when evaluated for cellular specificity, reveals its role as a housekeeping gene. Across the **Overall** context, [CCNK](/details-gene/8812) exhibits a CSI (Z-SCORE) of 0.00 and non-significant p-values (p > 0.3) in all top-ranked cell types. This lack of statistical significance, combined with low Percentile Rank Scores (PRS) and modest relative significance (rCSI), strongly indicates that [CCNK](/details-gene/8812) expression is not a defining characteristic of any particular cell lineage. Instead, the data highlights its broad and consistent expression across functionally and developmentally distinct cell types. These include epithelial cells like [fallopian tube secretory epithelial cell](/details-cell/CL4030006) and [luminal cell of prostate epithelium](/details-cell/CL0002340), hematopoietic progenitors such as [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), differentiated immune cells like [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050), and specialized cells such as [regular ventricular cardiac myocyte](/details-cell/CL0002131) and [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064). This widespread expression pattern is consistent with its fundamental role in cellular machinery required by nearly all cells. ## Pathways and Molecular Function The functional annotations for [CCNK](/details-gene/8812) align perfectly with its observed ubiquitous expression. As a cyclin, its primary molecular function is [cyclin-dependent protein serine/threonine kinase activator activity](/details-ontology/GO0061575). It forms crucial complexes, notably the [cyclin K-CDK12 complex](/details-ontology/GO0002944) and the [cyclin K-CDK13 complex](/details-ontology/GO0002945), which are key components of the positive transcription elongation factor (P-TEFb) machinery ([GO:0008024](https://www.ebi.ac.uk/QuickGO/term/GO:0008024)). This role is central to the biological process of [positive regulation of transcription elongation by RNA polymerase II](/details-ontology/GO0032968). By phosphorylating the C-terminal domain (CTD) of RNA polymerase II, the CCNK/CDK complexes facilitate the transition from paused to productive transcription elongation, a fundamental step in gene expression ([PubMed: 10574912](https://pubmed.ncbi.nlm.nih.gov/10574912/)). This is reflected in its heavy annotation in Reactome pathways such as [RNA polymerase II transcription elongation](/details-pathway/R-HSA-75955) and [Gene expression (transcription)](/details-pathway/R-HSA-74160). Furthermore, the CCNK/CDK12 complex is critical for maintaining genome integrity by regulating the expression of genes involved in the [DNA damage response](/details-ontology/GO0006974) ([PubMed: 22012619](https://pubmed.ncbi.nlm.nih.gov/22012619/)), linking transcriptional regulation directly to genomic stability. Its involvement in pathways related to the [HIV life cycle](/details-pathway/R-HSA-162587) suggests it is co-opted by viruses to promote the transcription of viral genes. ## Research Directions Given that [CCNK](/details-gene/8812) is a fundamental component of the transcriptional machinery, research should focus on how its dysregulation contributes to specific pathological states. Its ubiquitous nature makes it a challenging therapeutic target, but understanding its context-dependent interactions could reveal novel vulnerabilities. ### Testable Hypotheses: 1. **Neurodevelopmental Defects:** Given that *de novo* mutations in [CCNK](/details-gene/8812) cause a syndromic neurodevelopmental disorder ([PubMed: 30122539](https://pubmed.ncbi.nlm.nih.gov/30122539/)), it is hypothesized that these mutations disproportionately affect the transcriptional elongation of exceptionally long genes that are critical for neuronal development and function. Impaired processing of these transcripts in developing neurons, such as the [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064), may underlie the observed clinical phenotype. * **Experimental Approach:** Generate induced pluripotent stem cell (iPSC) lines from patients with [CCNK](/details-gene/8812) mutations and differentiate them into cortical interneurons. Perform long-read RNA sequencing and nascent transcript analysis (e.g., PRO-seq) to identify defects in transcriptional processivity, particularly for genes longer than 100 kb. 2. **Cancer Synthetic Lethality:** The role of the CCNK/CDK12 complex in regulating DNA damage response (DDR) genes ([PubMed: 22012619](https://pubmed.ncbi.nlm.nih.gov/22012619/)) suggests a potential synthetic lethal relationship. It is hypothesized that tumors with loss-of-function mutations in [CCNK](/details-gene/8812) or [CDK12](/details-gene/51755) develop a dependency on alternative DNA repair pathways, rendering them hypersensitive to inhibitors of ATR or PARP. * **Experimental Approach:** Using CRISPR-Cas9, knockout [CCNK](/details-gene/8812) in a panel of cancer cell lines (e.g., ovarian, prostate). Assess the expression of key homologous recombination genes (e.g., [BRCA1](/details-gene/672), [RAD51](/details-gene/5888)). Treat both wild-type and knockout cells with a gradient of ATR and PARP inhibitors to determine if CCNK loss confers sensitization. 3. **Broad-Spectrum Antiviral Host Factor:** The extensive involvement of [CCNK](/details-gene/8812) in HIV transcription pathways ([R-HSA-167172](https://reactome.org/content/detail/R-HSA-167172)) suggests it may be a common host dependency factor for other viruses that rely on host RNA Polymerase II. It is hypothesized that transient inhibition of the CCNK/CDK12 kinase activity could serve as a broad-spectrum antiviral strategy by suppressing viral gene transcription without inducing long-term host cell toxicity. * **Experimental Approach:** Utilize a selective small-molecule inhibitor of CDK12 to treat human cell lines (e.g., lung epithelial cells) prior to and during infection with various RNA and DNA viruses (e.g., Influenza A, SARS-CoV-2, Adenovirus). Measure viral replication and host cell viability over time to determine the therapeutic window and spectrum of activity.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-K

Genular Protein ID: 3988257636

Symbol: CCNK_HUMAN

Name: Cyclin-K

UniProtKB Accession Codes:

O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9

Database IDs:

Citations:

PubMed ID: 9632813

Title: Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity.

PubMed ID: 9632813

DOI: 10.1128/mcb.18.7.4291

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574912

Title: Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.

PubMed ID: 10574912

DOI: 10.1074/jbc.274.49.34527

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22012619

Title: The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

PubMed ID: 22012619

DOI: 10.1101/gad.16962311

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30122539

Title: De novo mutations of CCNK cause a syndromic neurodevelopmental disorder with distinctive facial dysmorphism.

PubMed ID: 30122539

DOI: 10.1016/j.ajhg.2018.07.019

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 17169370

Title: Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.

PubMed ID: 17169370

DOI: 10.1016/j.jmb.2006.11.057

PubMed ID: 24662513

Title: The structure and substrate specificity of human Cdk12/Cyclin K.

PubMed ID: 24662513

DOI: 10.1038/ncomms4505

Sequence Information:

Length: 580
Mass: 64240
Checksum: 8A945E90359AD9F8
Sequence:

MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR REGARFIFDV 
GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL FLAGKVEETP KKCKDIIKTA 
RSLLNDVQFG QFGDDPKEEV MVLERILLQT IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK 
LVQMAWTFVN DSLCTTLSLQ WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ 
DVPVDVLEDI CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPQVQQ SQPSQSSEPS 
QPQQKDPQQP AQQQQPAQQP KKPSPQPSSP RQVKRAVVVS PKEENKAAEP PPPKIPKIET 
THPPLPPAHP PPDRKPPLAA ALGEAEPPGP VDATDLPKVQ IPPPAHPAPV HQPPPLPHRP 
PPPPPSSYMT GMSTTSSYMS GEGYQSLQSM MKTEGPSYGA LPPAYGPPAH LPYHPHVYPP 
NPPPPPVPPP PASFPPPAIP PPTPGYPPPP PTYNPNFPPP PPRLPPTHAV PPHPPPGLGL 
PPASYPPPAV PPGGQPPVPP PIPPPGMPPV GGLGRAAWMR

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Basal cell carcinoma MONDO0020804
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Colon UBERON0001155
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461

Details for: CCNK

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. PubMed ID: 9632813

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. PubMed ID: 10574912

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. PubMed ID: 22012619

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

De novo mutations of CCNK cause a syndromic neurodevelopmental disorder with distinctive facial dysmorphism. PubMed ID: 30122539

HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation. PubMed ID: 34696162

Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. PubMed ID: 17169370

The structure and substrate specificity of human Cdk12/Cyclin K. PubMed ID: 24662513