Details for: CCNK

Gene ID: 8812

Symbol: CCNK

Ensembl ID: ENSG00000090061

Description: cyclin K

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 190.6198
    Cell Significance Index: -29.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.7243
    Cell Significance Index: -29.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.6938
    Cell Significance Index: -38.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.9495
    Cell Significance Index: -29.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.5734
    Cell Significance Index: -33.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.6758
    Cell Significance Index: -29.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8420
    Cell Significance Index: -33.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2216
    Cell Significance Index: -32.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5655
    Cell Significance Index: -33.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2317
    Cell Significance Index: -11.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8790
    Cell Significance Index: 39.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6527
    Cell Significance Index: 1492.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5702
    Cell Significance Index: 71.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3317
    Cell Significance Index: 79.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2897
    Cell Significance Index: 140.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1054
    Cell Significance Index: 57.4200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9424
    Cell Significance Index: 15.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9348
    Cell Significance Index: 24.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8861
    Cell Significance Index: 24.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8491
    Cell Significance Index: 24.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7175
    Cell Significance Index: 129.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7048
    Cell Significance Index: 86.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6145
    Cell Significance Index: 15.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5593
    Cell Significance Index: 112.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5413
    Cell Significance Index: 34.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5045
    Cell Significance Index: 100.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4959
    Cell Significance Index: 80.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4162
    Cell Significance Index: 57.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4114
    Cell Significance Index: 40.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3786
    Cell Significance Index: 26.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3649
    Cell Significance Index: 161.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3436
    Cell Significance Index: 40.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3414
    Cell Significance Index: 186.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3373
    Cell Significance Index: 9.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3347
    Cell Significance Index: 18.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3164
    Cell Significance Index: 14.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2789
    Cell Significance Index: 192.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2232
    Cell Significance Index: 80.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2218
    Cell Significance Index: 15.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2174
    Cell Significance Index: 27.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2113
    Cell Significance Index: 9.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2032
    Cell Significance Index: 5.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1922
    Cell Significance Index: 4.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1768
    Cell Significance Index: 33.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1409
    Cell Significance Index: 10.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0776
    Cell Significance Index: 146.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0440
    Cell Significance Index: 67.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0260
    Cell Significance Index: 16.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0208
    Cell Significance Index: 38.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0182
    Cell Significance Index: 1.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0157
    Cell Significance Index: 21.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0163
    Cell Significance Index: -2.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0169
    Cell Significance Index: -1.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0201
    Cell Significance Index: -14.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0297
    Cell Significance Index: -4.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0351
    Cell Significance Index: -26.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0374
    Cell Significance Index: -6.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0523
    Cell Significance Index: -5.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0542
    Cell Significance Index: -30.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0623
    Cell Significance Index: -38.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0810
    Cell Significance Index: -1.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0866
    Cell Significance Index: -5.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0897
    Cell Significance Index: -25.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0947
    Cell Significance Index: -2.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1012
    Cell Significance Index: -11.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1028
    Cell Significance Index: -3.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1075
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1153
    Cell Significance Index: -13.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1596
    Cell Significance Index: -3.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1771
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1835
    Cell Significance Index: -38.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2171
    Cell Significance Index: -1.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2559
    Cell Significance Index: -13.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2602
    Cell Significance Index: -27.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2658
    Cell Significance Index: -11.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2671
    Cell Significance Index: -6.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2685
    Cell Significance Index: -8.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2819
    Cell Significance Index: -17.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2966
    Cell Significance Index: -7.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3223
    Cell Significance Index: -8.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3325
    Cell Significance Index: -6.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3419
    Cell Significance Index: -7.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3421
    Cell Significance Index: -12.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3561
    Cell Significance Index: -18.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3625
    Cell Significance Index: -28.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3909
    Cell Significance Index: -4.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4165
    Cell Significance Index: -6.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4621
    Cell Significance Index: -5.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4625
    Cell Significance Index: -6.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4779
    Cell Significance Index: -29.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4866
    Cell Significance Index: -16.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5061
    Cell Significance Index: -12.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5370
    Cell Significance Index: -9.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5442
    Cell Significance Index: -27.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6443
    Cell Significance Index: -6.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6888
    Cell Significance Index: -25.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7506
    Cell Significance Index: -10.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Cyclin K is a member of the cyclin family, which are key regulators of the cell cycle. Unlike other cyclins, cyclin K is a kinase activator, rather than a kinase substrate, and its primary function is to regulate the activity of CDKs. Cyclin K is specifically involved in the regulation of CDK12 and CDK13, which are involved in transcription elongation and DNA damage response. The protein is also implicated in the regulation of signal transduction pathways, including those mediated by the TGF-β receptor complex and the Smad2/3/4 heterotrimer. **Pathways and Functions** Cyclin K is involved in several key cellular processes, including: 1. **Cell Cycle Regulation**: Cyclin K regulates the activity of CDK12 and CDK13, which are involved in the progression of the cell cycle. The protein is also implicated in the regulation of the G2/M checkpoint, a critical point in the cell cycle where cells prepare for mitosis. 2. **DNA Damage Response**: Cyclin K is involved in the regulation of the DNA damage response, including the activation of the TP53 tumor suppressor protein. TP53 is a key regulator of cell cycle arrest and apoptosis in response to DNA damage. 3. **Transcription Elongation**: Cyclin K is a kinase activator of CDK12 and CDK13, which are involved in the regulation of transcription elongation. The protein is also implicated in the regulation of the RNA polymerase II (RNAPII) transcription elongation complex. 4. **Signaling Pathways**: Cyclin K is involved in the regulation of various signaling pathways, including those mediated by the TGF-β receptor complex and the Smad2/3/4 heterotrimer. **Clinical Significance** Dysregulation of cyclin K has been implicated in various diseases, including: 1. **Cancer**: Cyclin K is overexpressed in several types of cancer, including breast, lung, and colon cancer. The protein is also implicated in the development of cancer stem cells. 2. **Neurological Disorders**: Cyclin K is involved in the regulation of cell cycle and transcription elongation, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Infectious Diseases**: Cyclin K is involved in the regulation of the HIV life cycle, and its dysregulation has been implicated in the pathogenesis of HIV infection. In summary, cyclin K is a critical regulator of cell cycle, DNA damage response, and transcription elongation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of cyclin K in disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 3988257636

Symbol: CCNK_HUMAN

Name: Cyclin-K

UniProtKB Accession Codes:

O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 9 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9632813

Title: Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity.

PubMed ID: 9632813

DOI: 10.1128/mcb.18.7.4291

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574912

Title: Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.

PubMed ID: 10574912

DOI: 10.1074/jbc.274.49.34527

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22012619

Title: The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

PubMed ID: 22012619

DOI: 10.1101/gad.16962311

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30122539

Title: De novo mutations of CCNK cause a syndromic neurodevelopmental disorder with distinctive facial dysmorphism.

PubMed ID: 30122539

DOI: 10.1016/j.ajhg.2018.07.019

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 17169370

Title: Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.

PubMed ID: 17169370

DOI: 10.1016/j.jmb.2006.11.057

PubMed ID: 24662513

Title: The structure and substrate specificity of human Cdk12/Cyclin K.

PubMed ID: 24662513

DOI: 10.1038/ncomms4505

Sequence Information:

  • Length: 580
  • Mass: 64240
  • Checksum: 8A945E90359AD9F8
  • Sequence:
    • MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR REGARFIFDV 
GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL FLAGKVEETP KKCKDIIKTA 
RSLLNDVQFG QFGDDPKEEV MVLERILLQT IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK 
LVQMAWTFVN DSLCTTLSLQ WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ 
DVPVDVLEDI CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPQVQQ SQPSQSSEPS 
QPQQKDPQQP AQQQQPAQQP KKPSPQPSSP RQVKRAVVVS PKEENKAAEP PPPKIPKIET 
THPPLPPAHP PPDRKPPLAA ALGEAEPPGP VDATDLPKVQ IPPPAHPAPV HQPPPLPHRP 
PPPPPSSYMT GMSTTSSYMS GEGYQSLQSM MKTEGPSYGA LPPAYGPPAH LPYHPHVYPP 
NPPPPPVPPP PASFPPPAIP PPTPGYPPPP PTYNPNFPPP PPRLPPTHAV PPHPPPGLGL 
PPASYPPPAV PPGGQPPVPP PIPPPGMPPV GGLGRAAWMR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.