Genular: Defining Cellular Identity and Function

Details for: AKT3

Gene ID: 10000

Symbol: AKT3

Ensembl ID: ENSG00000117020

Description: AKT serine/threonine kinase 3

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Adaptive immune system
(R-HSA-1280218)
Akt-mediated inactivation of foxo1a
(R-HSA-211163)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Apoptosis
(R-HSA-109581)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Downregulation of erbb2:erbb3 signaling
(R-HSA-1358803)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
G-protein beta:gamma signalling
(R-HSA-397795)
G1/s transition
(R-HSA-69206)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Membrane trafficking
(R-HSA-199991)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Programmed cell death
(R-HSA-5357801)
Pten regulation
(R-HSA-6807070)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab regulation of trafficking
(R-HSA-9007101)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in beta cells
(R-HSA-210745)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Regulation of tp53 activity through association with co-factors
(R-HSA-6804759)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates genes involved in cell migration
(R-HSA-8941332)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by erbb2
(R-HSA-1227986)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
S phase
(R-HSA-69242)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by tp53
(R-HSA-3700989)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Brain morphogenesis
(GO:0048854)
Homeostasis of number of cells within a tissue
(GO:0048873)
Intracellular signal transduction
(GO:0035556)
Mitochondrial genome maintenance
(GO:0000002)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of artery morphogenesis
(GO:1905653)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of cell size
(GO:0045793)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of tor signaling
(GO:0032008)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 5.9
Marker Score: 3,881
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 5.65
Marker Score: 4,250
Cell Name: cardiac neuron (CL0010022)
Fold Change: 5.47
Marker Score: 6,813
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 5.4
Marker Score: 18,105
Cell Name: contractile cell (CL0000183)
Fold Change: 4.74
Marker Score: 2,571
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.26
Marker Score: 22,326
Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.19
Marker Score: 5,642
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.99
Marker Score: 4,823
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 3.98
Marker Score: 2,215
Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.86
Marker Score: 5,426
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.71
Marker Score: 17,160
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.64
Marker Score: 6,996
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.63
Marker Score: 8,687
Cell Name: CNS interneuron (CL0000402)
Fold Change: 3.59
Marker Score: 1,727
Cell Name: skin fibroblast (CL0002620)
Fold Change: 3.51
Marker Score: 911
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.47
Marker Score: 3,990
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.37
Marker Score: 14,124
Cell Name: mature astrocyte (CL0002627)
Fold Change: 3.22
Marker Score: 2,117
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 3.21
Marker Score: 1,800
Cell Name: stellate neuron (CL0000122)
Fold Change: 3.19
Marker Score: 17,115
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.15
Marker Score: 67,134
Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.13
Marker Score: 105,840
Cell Name: renal principal cell (CL0005009)
Fold Change: 3.13
Marker Score: 2,413
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.09
Marker Score: 6,775
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 3.02
Marker Score: 1,762
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.01
Marker Score: 2,870
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.97
Marker Score: 1,478
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.92
Marker Score: 1,745
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.9
Marker Score: 2,569
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.85
Marker Score: 1,657
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.82
Marker Score: 8,044
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.81
Marker Score: 55,802
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.79
Marker Score: 814
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.74
Marker Score: 21,015
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.71
Marker Score: 40,455
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.7
Marker Score: 102,550
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.69
Marker Score: 1,572
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.65
Marker Score: 4,447
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.63
Marker Score: 832
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.63
Marker Score: 3,825
Cell Name: macroglial cell (CL0000126)
Fold Change: 2.62
Marker Score: 6,027
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 2.57
Marker Score: 1,140
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.55
Marker Score: 921
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.53
Marker Score: 2,079
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.53
Marker Score: 10,476
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.49
Marker Score: 1,042
Cell Name: granule cell (CL0000120)
Fold Change: 2.46
Marker Score: 18,535
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.41
Marker Score: 88,900
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.33
Marker Score: 740
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.25
Marker Score: 8,700
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.25
Marker Score: 2,779
Cell Name: astrocyte (CL0000127)
Fold Change: 2.18
Marker Score: 1,891
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.18
Marker Score: 1,884
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.18
Marker Score: 2,334
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.18
Marker Score: 20,481
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.16
Marker Score: 1,136
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.09
Marker Score: 1,082
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.08
Marker Score: 127,688
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 2.02
Marker Score: 669
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.02
Marker Score: 776
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.99
Marker Score: 8,297
Cell Name: neuron (CL0000540)
Fold Change: 1.98
Marker Score: 8,082
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.98
Marker Score: 719
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.98
Marker Score: 20,416
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.94
Marker Score: 1,932
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.92
Marker Score: 18,216
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.91
Marker Score: 486
Cell Name: podocyte (CL0000653)
Fold Change: 1.89
Marker Score: 700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.87
Marker Score: 16,028
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.86
Marker Score: 1,292
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.84
Marker Score: 503
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.79
Marker Score: 884
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.7
Marker Score: 968
Cell Name: fat cell (CL0000136)
Fold Change: 1.62
Marker Score: 905
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.61
Marker Score: 2,492
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.61
Marker Score: 2,007
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.61
Marker Score: 1,733
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.6
Marker Score: 1,713
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.55
Marker Score: 1,126
Cell Name: germ cell (CL0000586)
Fold Change: 1.52
Marker Score: 2,655
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.5
Marker Score: 469
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.49
Marker Score: 50,591
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.44
Marker Score: 490
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.44
Marker Score: 396
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.37
Marker Score: 518
Cell Name: neural cell (CL0002319)
Fold Change: 1.29
Marker Score: 622
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.29
Marker Score: 391
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.25
Marker Score: 450
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.25
Marker Score: 1,767
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.25
Marker Score: 433
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.23
Marker Score: 397
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.23
Marker Score: 295
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 1.22
Marker Score: 12,331
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.21
Marker Score: 1,084
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.19
Marker Score: 376
Cell Name: keratocyte (CL0002363)
Fold Change: 1.13
Marker Score: 261
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4,726
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.12
Marker Score: 3,961
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.08
Marker Score: 468
Cell Name: stromal cell (CL0000499)
Fold Change: 1.08
Marker Score: 1,271

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** AKT3 is a serine/threonine kinase that belongs to the AKT family, which consists of AKT1, AKT2, and AKT3. The three kinases share a high degree of sequence homology and similar substrate specificity. AKT3 is activated by phosphatidylinositol 3-kinase (PI3K) and phospholipase C (PLC) signaling pathways, which lead to the phosphorylation and activation of AKT3. The kinase is also subject to negative regulation by phosphatase and tensin homolog (PTEN) and tuberous sclerosis complex 2 (TSC2). **Pathways and Functions** AKT3 is involved in various signaling pathways, including: 1. **PI3K/AKT signaling pathway**: AKT3 is activated by PI3K, which leads to the phosphorylation and activation of AKT3, promoting cell survival and proliferation. 2. **Apoptosis**: AKT3 can inhibit apoptosis by phosphorylating and activating anti-apoptotic proteins, such as BCL-2 and BCL-XL. 3. **Cell cycle regulation**: AKT3 can regulate cell cycle progression by phosphorylating and activating cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 4. **Immune responses**: AKT3 can regulate immune responses by phosphorylating and activating immune-related proteins, such as CD28 and CTLA-4. 5. **Metabolic regulation**: AKT3 can regulate metabolic processes, including glucose and lipid metabolism, by phosphorylating and activating metabolic enzymes. **Clinical Significance** AKT3 has been implicated in various diseases, including: 1. **Cancer**: AKT3 overexpression has been observed in various types of cancer, including breast, lung, and colorectal cancer. 2. **Neurodegenerative diseases**: AKT3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Diabetes**: AKT3 has been implicated in diabetes, as it regulates insulin secretion and glucose metabolism. 4. **Infectious diseases**: AKT3 has been implicated in viral infections, such as SARS-CoV-2, which uses AKT3 as a host cell signaling platform. In summary, AKT3 is a serine/threonine kinase that plays a critical role in regulating various cellular processes, including cell survival, proliferation, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of AKT3 as a therapeutic target for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RAC-gamma serine/threonine-protein kinase

Genular Protein ID: 1406672817

Symbol: AKT3_HUMAN

Name: RAC-gamma serine/threonine-protein kinase

UniProtKB Accession Codes:

Q9Y243 Q0VAA6 Q5VTI1 Q5VTI2 Q96QV3 Q9UFP5

Database IDs:

Citations:

PubMed ID: 10092583

Title: A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain.

PubMed ID: 10092583

DOI: 10.1074/jbc.274.14.9133

PubMed ID: 10208883

Title: Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

PubMed ID: 10208883

DOI: 10.1006/bbrc.1999.0559

PubMed ID: 10491192

Title: Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3.

PubMed ID: 10491192

DOI: 10.1046/j.1432-1327.1999.00774.x

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 11387345

Title: Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain.

PubMed ID: 11387345

DOI: 10.1074/jbc.m104633200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9512493

Title: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

PubMed ID: 9512493

DOI: 10.1042/bj3310299

PubMed ID: 12162751

Title: Characterization of PDK2 activity against protein kinase B gamma.

PubMed ID: 12162751

DOI: 10.1021/bi026065r

PubMed ID: 11707444

Title: Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.

PubMed ID: 11707444

DOI: 10.1074/jbc.m107069200

PubMed ID: 11839817

Title: Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1.

PubMed ID: 11839817

DOI: 10.1128/mcb.22.5.1513-1525.2002

PubMed ID: 15466193

Title: Deregulated Akt3 activity promotes development of malignant melanoma.

PubMed ID: 15466193

DOI: 10.1158/0008-5472.can-04-1399

PubMed ID: 17178867

Title: A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition.

PubMed ID: 17178867

DOI: 10.1158/0008-5472.can-06-1968

PubMed ID: 16540465

Title: Kinetic mechanism of AKT/PKB enzyme family.

PubMed ID: 16540465

DOI: 10.1074/jbc.m601384200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18524868

Title: VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.

PubMed ID: 18524868

DOI: 10.1096/fj.08-106468

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 19713527

Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

PubMed ID: 19713527

DOI: 10.1126/science.1175065

PubMed ID: 20018949

Title: The Akt isoforms are present at distinct subcellular locations.

PubMed ID: 20018949

DOI: 10.1152/ajpcell.00375.2009

PubMed ID: 20167810

Title: Akt2 and Akt3 play a pivotal role in malignant gliomas.

PubMed ID: 20167810

DOI: 10.1093/neuonc/nop026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21191416

Title: Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-delta in normal human dermal fibroblasts.

PubMed ID: 21191416

DOI: 10.1038/jid.2010.361

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18813315

Title: A novel AKT3 mutation in melanoma tumours and cell lines.

PubMed ID: 18813315

DOI: 10.1038/sj.bjc.6604637

PubMed ID: 22729224

Title: De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.

PubMed ID: 22729224

DOI: 10.1038/ng.2331

PubMed ID: 22729223

Title: De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.

PubMed ID: 22729223

DOI: 10.1038/ng.2329

PubMed ID: 22500628

Title: Somatic activation of AKT3 causes hemispheric developmental brain malformations.

PubMed ID: 22500628

DOI: 10.1016/j.neuron.2012.03.010

PubMed ID: 23745724

Title: AKT3 and PIK3R2 mutations in two patients with megalencephaly-related syndromes: MCAP and MPPH.

PubMed ID: 23745724

DOI: 10.1111/cge.12188

Sequence Information:

Length: 479
Mass: 55775
Checksum: F08BDDE6502E78FB
Sequence:

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 
LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 
PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 
KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 
RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 
ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 
EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 
PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCM DNERRPHFPQ FSYSASGRE

Database document:

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Details for: AKT3

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Other Information

A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. PubMed ID: 10092583

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. PubMed ID: 10208883

Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. PubMed ID: 10491192

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain. PubMed ID: 11387345

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. PubMed ID: 9512493

Characterization of PDK2 activity against protein kinase B gamma. PubMed ID: 12162751

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. PubMed ID: 11707444

Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1. PubMed ID: 11839817

Deregulated Akt3 activity promotes development of malignant melanoma. PubMed ID: 15466193

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. PubMed ID: 17178867

Kinetic mechanism of AKT/PKB enzyme family. PubMed ID: 16540465

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. PubMed ID: 18524868

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. PubMed ID: 20059950

The E3 ligase TRAF6 regulates Akt ubiquitination and activation. PubMed ID: 19713527

The Akt isoforms are present at distinct subcellular locations. PubMed ID: 20018949

Akt2 and Akt3 play a pivotal role in malignant gliomas. PubMed ID: 20167810

Initial characterization of the human central proteome. PubMed ID: 21269460

Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-delta in normal human dermal fibroblasts. PubMed ID: 21191416

Akt signalling in health and disease. PubMed ID: 21620960

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

A novel AKT3 mutation in melanoma tumours and cell lines. PubMed ID: 18813315

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. PubMed ID: 22729224

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. PubMed ID: 22729223

Somatic activation of AKT3 causes hemispheric developmental brain malformations. PubMed ID: 22500628

AKT3 and PIK3R2 mutations in two patients with megalencephaly-related syndromes: MCAP and MPPH. PubMed ID: 23745724