AKT3 | ENSG00000117020 | NCBI 10000

Details for: AKT3

Gene ID: 10000

Symbol: AKT3

Ensembl ID: ENSG00000117020

Description: AKT serine/threonine kinase 3

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Adaptive immune system
(R-HSA-1280218)
Akt-mediated inactivation of foxo1a
(R-HSA-211163)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Apoptosis
(R-HSA-109581)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Downregulation of erbb2:erbb3 signaling
(R-HSA-1358803)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
G-protein beta:gamma signalling
(R-HSA-397795)
G1/s transition
(R-HSA-69206)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Membrane trafficking
(R-HSA-199991)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Programmed cell death
(R-HSA-5357801)
Pten regulation
(R-HSA-6807070)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab regulation of trafficking
(R-HSA-9007101)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in beta cells
(R-HSA-210745)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Regulation of tp53 activity through association with co-factors
(R-HSA-6804759)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates genes involved in cell migration
(R-HSA-8941332)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by erbb2
(R-HSA-1227986)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
S phase
(R-HSA-69242)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by tp53
(R-HSA-3700989)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Brain morphogenesis
(GO:0048854)
Chromatin remodeling
(GO:0006338)
Histone h2as1 kinase activity
(GO:0044024)
Homeostasis of number of cells within a tissue
(GO:0048873)
Intracellular signal transduction
(GO:0035556)
Mitochondrial genome maintenance
(GO:0000002)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell size
(GO:0045793)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of tor signaling
(GO:0032008)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 693.1103
Cell Significance Index: -107.8100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 423.5474
Cell Significance Index: -107.4300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 237.9678
Cell Significance Index: -112.3500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 202.4088
Cell Significance Index: -82.2300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 87.4403
Cell Significance Index: -107.8100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 34.2641
Cell Significance Index: -74.9900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.9583
Cell Significance Index: -101.2300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.5136
Cell Significance Index: -108.5700
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 10.9733
Cell Significance Index: 74.3500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 9.4237
Cell Significance Index: 528.8100
Cell Name: preadipocyte (CL0002334)
Fold Change: 5.6760
Cell Significance Index: 110.7800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.4203
Cell Significance Index: 686.1100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 3.3903
Cell Significance Index: 58.1000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.3471
Cell Significance Index: 1200.5300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 3.1313
Cell Significance Index: 2165.7500
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.4019
Cell Significance Index: 34.5500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.2142
Cell Significance Index: 83.8500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.2107
Cell Significance Index: 47.2600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.1916
Cell Significance Index: 96.9400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 1.9109
Cell Significance Index: 96.5700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.1058
Cell Significance Index: 1702.3100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.0563
Cell Significance Index: 1948.0500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.0308
Cell Significance Index: 1940.8500
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.9175
Cell Significance Index: 11.3800
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.8612
Cell Significance Index: 8.9200
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.7841
Cell Significance Index: 11.2600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7497
Cell Significance Index: 142.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.6928
Cell Significance Index: 942.0100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.6800
Cell Significance Index: 431.9000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.6330
Cell Significance Index: 16.2700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.5793
Cell Significance Index: 262.9100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2689
Cell Significance Index: 242.8400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1106
Cell Significance Index: 15.1900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0193
Cell Significance Index: -0.8800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0492
Cell Significance Index: -36.4300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0683
Cell Significance Index: -7.1100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0865
Cell Significance Index: -48.7800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1047
Cell Significance Index: -76.7600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1103
Cell Significance Index: -19.8800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1126
Cell Significance Index: -70.2900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1356
Cell Significance Index: -59.9600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1521
Cell Significance Index: -4.0600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1588
Cell Significance Index: -120.1900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1669
Cell Significance Index: -33.1200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1832
Cell Significance Index: -11.2300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1971
Cell Significance Index: -107.6200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2146
Cell Significance Index: -7.5400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2510
Cell Significance Index: -36.4900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2582
Cell Significance Index: -1.5600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.2899
Cell Significance Index: -47.1600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2963
Cell Significance Index: -62.4000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3236
Cell Significance Index: -93.1000
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.3596
Cell Significance Index: -5.4700
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.3763
Cell Significance Index: -4.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.3794
Cell Significance Index: -37.5400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.4233
Cell Significance Index: -52.0500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4808
Cell Significance Index: -15.4000
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4828
Cell Significance Index: -6.0200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.5393
Cell Significance Index: -92.0800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.6197
Cell Significance Index: -67.4000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.6323
Cell Significance Index: -81.0600
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.6499
Cell Significance Index: -8.6700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.6785
Cell Significance Index: -69.3100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.7299
Cell Significance Index: -94.3000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7874
Cell Significance Index: -25.7800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8022
Cell Significance Index: -25.5500
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.8490
Cell Significance Index: -14.6800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8493
Cell Significance Index: -21.2300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.8851
Cell Significance Index: -104.3800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8921
Cell Significance Index: -102.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8955
Cell Significance Index: -104.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.9055
Cell Significance Index: -26.0900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.9083
Cell Significance Index: -17.9600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.9286
Cell Significance Index: -25.9500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9502
Cell Significance Index: -108.4700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.9816
Cell Significance Index: -51.1300
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.9872
Cell Significance Index: -12.4600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.0637
Cell Significance Index: -81.6300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.1125
Cell Significance Index: -70.1200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1495
Cell Significance Index: -91.0400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.1629
Cell Significance Index: -80.4200
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.2009
Cell Significance Index: -24.1100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.2542
Cell Significance Index: -26.6200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.2775
Cell Significance Index: -60.0400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.3324
Cell Significance Index: -99.3000
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.3478
Cell Significance Index: -14.0400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.3586
Cell Significance Index: -81.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.4080
Cell Significance Index: -90.8400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.4499
Cell Significance Index: -102.5400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.4701
Cell Significance Index: -42.1400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.4892
Cell Significance Index: -78.1900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.6371
Cell Significance Index: -57.3500
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -1.7270
Cell Significance Index: -15.3300
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -1.8265
Cell Significance Index: -38.1200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -1.8393
Cell Significance Index: -45.8800
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -1.8679
Cell Significance Index: -13.5800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.8709
Cell Significance Index: -97.1900
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -2.1881
Cell Significance Index: -47.2800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -2.3725
Cell Significance Index: -51.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -2.4440
Cell Significance Index: -113.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** AKT3 is a serine/threonine kinase that belongs to the AKT family, which consists of AKT1, AKT2, and AKT3. The three kinases share a high degree of sequence homology and similar substrate specificity. AKT3 is activated by phosphatidylinositol 3-kinase (PI3K) and phospholipase C (PLC) signaling pathways, which lead to the phosphorylation and activation of AKT3. The kinase is also subject to negative regulation by phosphatase and tensin homolog (PTEN) and tuberous sclerosis complex 2 (TSC2). **Pathways and Functions** AKT3 is involved in various signaling pathways, including: 1. **PI3K/AKT signaling pathway**: AKT3 is activated by PI3K, which leads to the phosphorylation and activation of AKT3, promoting cell survival and proliferation. 2. **Apoptosis**: AKT3 can inhibit apoptosis by phosphorylating and activating anti-apoptotic proteins, such as BCL-2 and BCL-XL. 3. **Cell cycle regulation**: AKT3 can regulate cell cycle progression by phosphorylating and activating cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 4. **Immune responses**: AKT3 can regulate immune responses by phosphorylating and activating immune-related proteins, such as CD28 and CTLA-4. 5. **Metabolic regulation**: AKT3 can regulate metabolic processes, including glucose and lipid metabolism, by phosphorylating and activating metabolic enzymes. **Clinical Significance** AKT3 has been implicated in various diseases, including: 1. **Cancer**: AKT3 overexpression has been observed in various types of cancer, including breast, lung, and colorectal cancer. 2. **Neurodegenerative diseases**: AKT3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Diabetes**: AKT3 has been implicated in diabetes, as it regulates insulin secretion and glucose metabolism. 4. **Infectious diseases**: AKT3 has been implicated in viral infections, such as SARS-CoV-2, which uses AKT3 as a host cell signaling platform. In summary, AKT3 is a serine/threonine kinase that plays a critical role in regulating various cellular processes, including cell survival, proliferation, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of AKT3 as a therapeutic target for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RAC-gamma serine/threonine-protein kinase

Genular Protein ID: 1406672817

Symbol: AKT3_HUMAN

Name: RAC-gamma serine/threonine-protein kinase

UniProtKB Accession Codes:

Q9Y243 Q0VAA6 Q5VTI1 Q5VTI2 Q96QV3 Q9UFP5

Database IDs:

Citations:

PubMed ID: 10092583

Title: A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain.

PubMed ID: 10092583

DOI: 10.1074/jbc.274.14.9133

PubMed ID: 10208883

Title: Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

PubMed ID: 10208883

DOI: 10.1006/bbrc.1999.0559

PubMed ID: 10491192

Title: Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3.

PubMed ID: 10491192

DOI: 10.1046/j.1432-1327.1999.00774.x

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 11387345

Title: Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain.

PubMed ID: 11387345

DOI: 10.1074/jbc.m104633200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9512493

Title: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

PubMed ID: 9512493

DOI: 10.1042/bj3310299

PubMed ID: 12162751

Title: Characterization of PDK2 activity against protein kinase B gamma.

PubMed ID: 12162751

DOI: 10.1021/bi026065r

PubMed ID: 11707444

Title: Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.

PubMed ID: 11707444

DOI: 10.1074/jbc.m107069200

PubMed ID: 11839817

Title: Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1.

PubMed ID: 11839817

DOI: 10.1128/mcb.22.5.1513-1525.2002

PubMed ID: 15466193

Title: Deregulated Akt3 activity promotes development of malignant melanoma.

PubMed ID: 15466193

DOI: 10.1158/0008-5472.can-04-1399

PubMed ID: 17178867

Title: A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition.

PubMed ID: 17178867

DOI: 10.1158/0008-5472.can-06-1968

PubMed ID: 16540465

Title: Kinetic mechanism of AKT/PKB enzyme family.

PubMed ID: 16540465

DOI: 10.1074/jbc.m601384200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18524868

Title: VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.

PubMed ID: 18524868

DOI: 10.1096/fj.08-106468

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 19713527

Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

PubMed ID: 19713527

DOI: 10.1126/science.1175065

PubMed ID: 20018949

Title: The Akt isoforms are present at distinct subcellular locations.

PubMed ID: 20018949

DOI: 10.1152/ajpcell.00375.2009

PubMed ID: 20167810

Title: Akt2 and Akt3 play a pivotal role in malignant gliomas.

PubMed ID: 20167810

DOI: 10.1093/neuonc/nop026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21191416

Title: Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-delta in normal human dermal fibroblasts.

PubMed ID: 21191416

DOI: 10.1038/jid.2010.361

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18813315

Title: A novel AKT3 mutation in melanoma tumours and cell lines.

PubMed ID: 18813315

DOI: 10.1038/sj.bjc.6604637

PubMed ID: 22729224

Title: De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.

PubMed ID: 22729224

DOI: 10.1038/ng.2331

PubMed ID: 22729223

Title: De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.

PubMed ID: 22729223

DOI: 10.1038/ng.2329

PubMed ID: 22500628

Title: Somatic activation of AKT3 causes hemispheric developmental brain malformations.

PubMed ID: 22500628

DOI: 10.1016/j.neuron.2012.03.010

PubMed ID: 23745724

Title: AKT3 and PIK3R2 mutations in two patients with megalencephaly-related syndromes: MCAP and MPPH.

PubMed ID: 23745724

DOI: 10.1111/cge.12188

Sequence Information:

Length: 479
Mass: 55775
Checksum: F08BDDE6502E78FB
Sequence:

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 
LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 
PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 
KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 
RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 
ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 
EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 
PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCM DNERRPHFPQ FSYSASGRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AKT3

Associated with

Cells (max top 100)

Other Information

A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. PubMed ID: 10092583

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. PubMed ID: 10208883

Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. PubMed ID: 10491192

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain. PubMed ID: 11387345

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. PubMed ID: 9512493

Characterization of PDK2 activity against protein kinase B gamma. PubMed ID: 12162751

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. PubMed ID: 11707444

Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1. PubMed ID: 11839817

Deregulated Akt3 activity promotes development of malignant melanoma. PubMed ID: 15466193

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. PubMed ID: 17178867

Kinetic mechanism of AKT/PKB enzyme family. PubMed ID: 16540465

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. PubMed ID: 18524868

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. PubMed ID: 20059950

The E3 ligase TRAF6 regulates Akt ubiquitination and activation. PubMed ID: 19713527

The Akt isoforms are present at distinct subcellular locations. PubMed ID: 20018949

Akt2 and Akt3 play a pivotal role in malignant gliomas. PubMed ID: 20167810

Initial characterization of the human central proteome. PubMed ID: 21269460

Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-delta in normal human dermal fibroblasts. PubMed ID: 21191416

Akt signalling in health and disease. PubMed ID: 21620960

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

A novel AKT3 mutation in melanoma tumours and cell lines. PubMed ID: 18813315

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. PubMed ID: 22729224

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. PubMed ID: 22729223

Somatic activation of AKT3 causes hemispheric developmental brain malformations. PubMed ID: 22500628

AKT3 and PIK3R2 mutations in two patients with megalencephaly-related syndromes: MCAP and MPPH. PubMed ID: 23745724