Details for: GPC6

Gene ID: 10082

Symbol: GPC6

Ensembl ID: ENSG00000183098

Description: glypican 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 487.7681
    Cell Significance Index: -75.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 298.1745
    Cell Significance Index: -75.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 203.2783
    Cell Significance Index: -83.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.5756
    Cell Significance Index: -75.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.3145
    Cell Significance Index: -44.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.2547
    Cell Significance Index: -75.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 10.6792
    Cell Significance Index: 228.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.5577
    Cell Significance Index: 175.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.2270
    Cell Significance Index: 293.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.1845
    Cell Significance Index: 830.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.0617
    Cell Significance Index: 2117.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.9272
    Cell Significance Index: 1859.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.8186
    Cell Significance Index: 328.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5938
    Cell Significance Index: 98.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8168
    Cell Significance Index: 80.3600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.8021
    Cell Significance Index: 25.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.5594
    Cell Significance Index: 2936.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5315
    Cell Significance Index: 307.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5083
    Cell Significance Index: 92.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4521
    Cell Significance Index: 520.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9745
    Cell Significance Index: 23.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9274
    Cell Significance Index: 58.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8804
    Cell Significance Index: 14.8300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.8500
    Cell Significance Index: 3.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6953
    Cell Significance Index: 13.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5461
    Cell Significance Index: 6.5100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.4773
    Cell Significance Index: 6.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3960
    Cell Significance Index: 179.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3867
    Cell Significance Index: 73.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1809
    Cell Significance Index: 163.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0751
    Cell Significance Index: 10.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0429
    Cell Significance Index: 18.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0093
    Cell Significance Index: 0.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0051
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0329
    Cell Significance Index: -60.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0387
    Cell Significance Index: -59.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0396
    Cell Significance Index: -53.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0478
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0525
    Cell Significance Index: -38.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0961
    Cell Significance Index: -70.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1147
    Cell Significance Index: -86.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1313
    Cell Significance Index: -74.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1411
    Cell Significance Index: -77.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1705
    Cell Significance Index: -24.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1828
    Cell Significance Index: -32.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1870
    Cell Significance Index: -6.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1889
    Cell Significance Index: -2.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1999
    Cell Significance Index: -32.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2046
    Cell Significance Index: -3.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2346
    Cell Significance Index: -67.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2474
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2542
    Cell Significance Index: -53.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3095
    Cell Significance Index: -23.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3189
    Cell Significance Index: -40.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3261
    Cell Significance Index: -32.2600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3649
    Cell Significance Index: -5.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3802
    Cell Significance Index: -8.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3945
    Cell Significance Index: -67.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4082
    Cell Significance Index: -6.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4533
    Cell Significance Index: -27.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4759
    Cell Significance Index: -51.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.5106
    Cell Significance Index: -62.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6128
    Cell Significance Index: -63.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6155
    Cell Significance Index: -19.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6189
    Cell Significance Index: -63.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6192
    Cell Significance Index: -12.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.6315
    Cell Significance Index: -81.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6372
    Cell Significance Index: -18.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6944
    Cell Significance Index: -79.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7112
    Cell Significance Index: -50.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7173
    Cell Significance Index: -82.1800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.7469
    Cell Significance Index: -5.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8253
    Cell Significance Index: -20.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8564
    Cell Significance Index: -59.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9736
    Cell Significance Index: -51.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.0003
    Cell Significance Index: -60.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0290
    Cell Significance Index: -81.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0906
    Cell Significance Index: -73.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.1014
    Cell Significance Index: -82.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3068
    Cell Significance Index: -33.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.3197
    Cell Significance Index: -36.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.3811
    Cell Significance Index: -28.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.4366
    Cell Significance Index: -74.8300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.4801
    Cell Significance Index: -21.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4855
    Cell Significance Index: -52.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.5514
    Cell Significance Index: -80.5900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.6127
    Cell Significance Index: -17.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.6309
    Cell Significance Index: -27.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.6433
    Cell Significance Index: -26.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.6438
    Cell Significance Index: -77.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.6486
    Cell Significance Index: -11.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6741
    Cell Significance Index: -54.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.7687
    Cell Significance Index: -44.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.9845
    Cell Significance Index: -63.2100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -1.9869
    Cell Significance Index: -22.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.0060
    Cell Significance Index: -43.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0547
    Cell Significance Index: -60.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -2.0709
    Cell Significance Index: -90.0500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -2.1155
    Cell Significance Index: -28.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** GPC6 is a tetrasaccharide linker sequence required for gag synthesis, which is essential for the attachment and entry of viruses, such as SARS-CoV-2 and RSV. 2. **Expression:** GPC6 is expressed in various cell types, including cortical cells of the adrenal gland, photoreceptor cells, granule cells, macroglial cells, and sympathetic neurons. 3. **Function:** GPC6 regulates cell migration, attachment, and entry, as well as the localization of neurotransmitter receptors to postsynaptic specialization membranes. 4. **Pathways:** GPC6 is involved in several signaling pathways, including the regulation of signal transduction, glutamatergic synapse, and visual phototransduction. **Pathways and Functions:** 1. **Attachment and Entry:** GPC6 is required for the attachment and entry of viruses, such as SARS-CoV-2 and RSV, through the formation of a tetrasaccharide linker sequence. 2. **Cell Migration:** GPC6 regulates cell migration, which is essential for various biological processes, including immune responses and tissue development. 3. **Neurotransmitter Regulation:** GPC6 regulates the localization of neurotransmitter receptors to postsynaptic specialization membranes, which is essential for synaptic transmission and neuronal function. 4. **Signal Transduction:** GPC6 is involved in the regulation of signal transduction pathways, including those involved in immune responses and inflammation. 5. **Glycosaminoglycan Metabolism:** GPC6 is involved in the biosynthesis and degradation of heparan sulfate/heparin (hs-gag), which is essential for various biological processes, including cell signaling and immune responses. **Clinical Significance:** 1. **Infectious Diseases:** GPC6 dysfunction has been implicated in various infectious diseases, including SARS-CoV-2 and RSV infection. 2. **Cancer:** GPC6 is overexpressed in various types of cancer, including breast and lung cancer, and is associated with poor prognosis. 3. **Neurological Disorders:** GPC6 dysfunction has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders:** GPC6 is involved in the regulation of glycosaminoglycan metabolism, which is essential for various metabolic processes, including energy metabolism and lipid metabolism. In conclusion, the glypican 6 gene (GPC6) is a multifaceted regulator of various biological processes, including cell migration, attachment, and entry, as well as the regulation of neurotransmitter receptors and signal transduction. Its dysfunction has been implicated in various diseases, including infectious diseases, cancer, and neurological disorders. Further research is needed to understand the complex functions of GPC6 and its role in human disease.

Genular Protein ID: 3669305765

Symbol: GPC6_HUMAN

Name: Glypican-6

UniProtKB Accession Codes:

Q9Y625 A8K279 Q96SG5 Q96SG8 Q9H1P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 12 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10329016

Title: GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13.

PubMed ID: 10329016

DOI: 10.1006/geno.1999.5793

PubMed ID: 10480909

Title: Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans.

PubMed ID: 10480909

DOI: 10.1074/jbc.274.38.26968

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19481194

Title: Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.

PubMed ID: 19481194

DOI: 10.1016/j.ajhg.2009.05.002

PubMed ID: 21871017

Title: NFAT promotes carcinoma invasive migration through glypican-6.

PubMed ID: 21871017

DOI: 10.1042/bj20110530

Sequence Information:

  • Length: 555
  • Mass: 62736
  • Checksum: D3D01480FF9C4152
  • Sequence:
    • MPSWIGAVIL PLLGLLLSLP AGADVKARSC GEVRQAYGAK GFSLADIPYQ EIAGEHLRIC 
PQEYTCCTTE MEDKLSQQSK LEFENLVEET SHFVRTTFVS RHKKFDEFFR ELLENAEKSL 
NDMFVRTYGM LYMQNSEVFQ DLFTELKRYY TGGNVNLEEM LNDFWARLLE RMFQLINPQY 
HFSEDYLECV SKYTDQLKPF GDVPRKLKIQ VTRAFIAART FVQGLTVGRE VANRVSKVSP 
TPGCIRALMK MLYCPYCRGL PTVRPCNNYC LNVMKGCLAN QADLDTEWNL FIDAMLLVAE 
RLEGPFNIES VMDPIDVKIS EAIMNMQENS MQVSAKVFQG CGQPKPAPAL RSARSAPENF 
NTRFRPYNPE ERPTTAAGTS LDRLVTDIKE KLKLSKKVWS ALPYTICKDE SVTAGTSNEE 
ECWNGHSKAR YLPEIMNDGL TNQINNPEVD VDITRPDTFI RQQIMALRVM TNKLKNAYNG 
NDVNFQDTSD ESSGSGSGSG CMDDVCPTEF EFVTTEAPAV DPDRREVDSS AAQRGHSLLS 
WSLTCIVLAL QRLCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.