Details for: GPC6

Gene ID: 10082

Symbol: GPC6

Ensembl ID: ENSG00000183098

Description: glypican 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 10.21
    Marker Score: 181,190
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 10
    Marker Score: 7,531
  • Cell Name: granule cell (CL0000120)
    Fold Change: 9.98
    Marker Score: 75,226
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 9.64
    Marker Score: 50,575
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 8.76
    Marker Score: 20,147
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 7.58
    Marker Score: 40,706
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 6.18
    Marker Score: 20,259
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 4.71
    Marker Score: 1,555
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 4.29
    Marker Score: 1,567
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.94
    Marker Score: 2,041
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.89
    Marker Score: 2,180
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.71
    Marker Score: 3,204
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 3.5
    Marker Score: 1,320
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.22
    Marker Score: 940
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.17
    Marker Score: 1,763
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.95
    Marker Score: 764
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.8
    Marker Score: 9,393
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.79
    Marker Score: 2,656
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.64
    Marker Score: 2,110
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.63
    Marker Score: 52,288
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.62
    Marker Score: 1,521
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.57
    Marker Score: 779
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.5
    Marker Score: 1,235
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.38
    Marker Score: 9,945
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.33
    Marker Score: 3,583
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.29
    Marker Score: 3,223
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.18
    Marker Score: 1,183
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.16
    Marker Score: 28,477
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.14
    Marker Score: 7,589
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.09
    Marker Score: 4,581
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.07
    Marker Score: 2,587
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.07
    Marker Score: 2,564
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.07
    Marker Score: 993
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.05
    Marker Score: 21,141
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2
    Marker Score: 3,841
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.95
    Marker Score: 72,049
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.94
    Marker Score: 8,972
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.91
    Marker Score: 1,068
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.84
    Marker Score: 9,910
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.81
    Marker Score: 668
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.77
    Marker Score: 3,607
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.75
    Marker Score: 1,515
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.69
    Marker Score: 651
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.69
    Marker Score: 10,859
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.68
    Marker Score: 2,581
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.66
    Marker Score: 6,911
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.63
    Marker Score: 979
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.62
    Marker Score: 3,826
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,156
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.58
    Marker Score: 6,817
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.57
    Marker Score: 96,667
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.55
    Marker Score: 448
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.55
    Marker Score: 1,022
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.52
    Marker Score: 458
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.51
    Marker Score: 397
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.5
    Marker Score: 6,117
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.5
    Marker Score: 50,578
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2,289
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,180
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.42
    Marker Score: 937
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.42
    Marker Score: 1,002
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.4
    Marker Score: 1,082
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.39
    Marker Score: 3,471
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.36
    Marker Score: 463
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.35
    Marker Score: 5,230
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.29
    Marker Score: 676
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.28
    Marker Score: 1,416
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.27
    Marker Score: 1,371
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,878
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.23
    Marker Score: 313
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.22
    Marker Score: 11,455
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.19
    Marker Score: 537
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.19
    Marker Score: 1,273
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.17
    Marker Score: 1,440
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.16
    Marker Score: 364
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.16
    Marker Score: 793
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.16
    Marker Score: 1,242
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,780
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.13
    Marker Score: 752
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.11
    Marker Score: 6,641
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1
    Marker Score: 17,654
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.1
    Marker Score: 311
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.09
    Marker Score: 438
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.07
    Marker Score: 400
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 1.06
    Marker Score: 299
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.06
    Marker Score: 630
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.05
    Marker Score: 700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.05
    Marker Score: 363
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.05
    Marker Score: 508
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,725
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.04
    Marker Score: 420
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.03
    Marker Score: 308
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.03
    Marker Score: 3,824
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.03
    Marker Score: 1,157
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.03
    Marker Score: 261
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.02
    Marker Score: 489
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 425
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.02
    Marker Score: 535
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.01
    Marker Score: 440

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** GPC6 is a tetrasaccharide linker sequence required for gag synthesis, which is essential for the attachment and entry of viruses, such as SARS-CoV-2 and RSV. 2. **Expression:** GPC6 is expressed in various cell types, including cortical cells of the adrenal gland, photoreceptor cells, granule cells, macroglial cells, and sympathetic neurons. 3. **Function:** GPC6 regulates cell migration, attachment, and entry, as well as the localization of neurotransmitter receptors to postsynaptic specialization membranes. 4. **Pathways:** GPC6 is involved in several signaling pathways, including the regulation of signal transduction, glutamatergic synapse, and visual phototransduction. **Pathways and Functions:** 1. **Attachment and Entry:** GPC6 is required for the attachment and entry of viruses, such as SARS-CoV-2 and RSV, through the formation of a tetrasaccharide linker sequence. 2. **Cell Migration:** GPC6 regulates cell migration, which is essential for various biological processes, including immune responses and tissue development. 3. **Neurotransmitter Regulation:** GPC6 regulates the localization of neurotransmitter receptors to postsynaptic specialization membranes, which is essential for synaptic transmission and neuronal function. 4. **Signal Transduction:** GPC6 is involved in the regulation of signal transduction pathways, including those involved in immune responses and inflammation. 5. **Glycosaminoglycan Metabolism:** GPC6 is involved in the biosynthesis and degradation of heparan sulfate/heparin (hs-gag), which is essential for various biological processes, including cell signaling and immune responses. **Clinical Significance:** 1. **Infectious Diseases:** GPC6 dysfunction has been implicated in various infectious diseases, including SARS-CoV-2 and RSV infection. 2. **Cancer:** GPC6 is overexpressed in various types of cancer, including breast and lung cancer, and is associated with poor prognosis. 3. **Neurological Disorders:** GPC6 dysfunction has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders:** GPC6 is involved in the regulation of glycosaminoglycan metabolism, which is essential for various metabolic processes, including energy metabolism and lipid metabolism. In conclusion, the glypican 6 gene (GPC6) is a multifaceted regulator of various biological processes, including cell migration, attachment, and entry, as well as the regulation of neurotransmitter receptors and signal transduction. Its dysfunction has been implicated in various diseases, including infectious diseases, cancer, and neurological disorders. Further research is needed to understand the complex functions of GPC6 and its role in human disease.

Genular Protein ID: 3669305765

Symbol: GPC6_HUMAN

Name: Glypican-6

UniProtKB Accession Codes:

Q9Y625 A8K279 Q96SG5 Q96SG8 Q9H1P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10329016

Title: GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13.

PubMed ID: 10329016

DOI: 10.1006/geno.1999.5793

PubMed ID: 10480909

Title: Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans.

PubMed ID: 10480909

DOI: 10.1074/jbc.274.38.26968

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19481194

Title: Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.

PubMed ID: 19481194

DOI: 10.1016/j.ajhg.2009.05.002

PubMed ID: 21871017

Title: NFAT promotes carcinoma invasive migration through glypican-6.

PubMed ID: 21871017

DOI: 10.1042/bj20110530

Sequence Information:

  • Length: 555
  • Mass: 62736
  • Checksum: D3D01480FF9C4152
  • Sequence:
    • MPSWIGAVIL PLLGLLLSLP AGADVKARSC GEVRQAYGAK GFSLADIPYQ EIAGEHLRIC 
PQEYTCCTTE MEDKLSQQSK LEFENLVEET SHFVRTTFVS RHKKFDEFFR ELLENAEKSL 
NDMFVRTYGM LYMQNSEVFQ DLFTELKRYY TGGNVNLEEM LNDFWARLLE RMFQLINPQY 
HFSEDYLECV SKYTDQLKPF GDVPRKLKIQ VTRAFIAART FVQGLTVGRE VANRVSKVSP 
TPGCIRALMK MLYCPYCRGL PTVRPCNNYC LNVMKGCLAN QADLDTEWNL FIDAMLLVAE 
RLEGPFNIES VMDPIDVKIS EAIMNMQENS MQVSAKVFQG CGQPKPAPAL RSARSAPENF 
NTRFRPYNPE ERPTTAAGTS LDRLVTDIKE KLKLSKKVWS ALPYTICKDE SVTAGTSNEE 
ECWNGHSKAR YLPEIMNDGL TNQINNPEVD VDITRPDTFI RQQIMALRVM TNKLKNAYNG 
NDVNFQDTSD ESSGSGSGSG CMDDVCPTEF EFVTTEAPAV DPDRREVDSS AAQRGHSLLS 
WSLTCIVLAL QRLCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.