Details for: CDK3

Gene ID: 1018

Symbol: CDK3

Ensembl ID: ENSG00000250506

Description: cyclin dependent kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.2602
    Cell Significance Index: 104.4200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.9813
    Cell Significance Index: 28.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8609
    Cell Significance Index: 84.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3587
    Cell Significance Index: 258.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1532
    Cell Significance Index: 114.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0462
    Cell Significance Index: 22.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8436
    Cell Significance Index: 761.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7906
    Cell Significance Index: 16.4000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6463
    Cell Significance Index: 10.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5797
    Cell Significance Index: 94.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5276
    Cell Significance Index: 57.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4694
    Cell Significance Index: 13.5300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3548
    Cell Significance Index: 4.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3461
    Cell Significance Index: 68.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3331
    Cell Significance Index: 20.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2878
    Cell Significance Index: 19.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2077
    Cell Significance Index: 7.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1583
    Cell Significance Index: 1.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1186
    Cell Significance Index: 82.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0748
    Cell Significance Index: 3.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0731
    Cell Significance Index: 10.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0631
    Cell Significance Index: 12.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0587
    Cell Significance Index: 21.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0550
    Cell Significance Index: 3.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0548
    Cell Significance Index: 6.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0424
    Cell Significance Index: 1.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0407
    Cell Significance Index: 7.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0399
    Cell Significance Index: 17.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0206
    Cell Significance Index: 2.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0149
    Cell Significance Index: 0.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0109
    Cell Significance Index: 0.8400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0070
    Cell Significance Index: 0.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0024
    Cell Significance Index: 0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0078
    Cell Significance Index: -0.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0087
    Cell Significance Index: -0.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0096
    Cell Significance Index: -1.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0097
    Cell Significance Index: -5.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0098
    Cell Significance Index: -0.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0103
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0108
    Cell Significance Index: -1.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0116
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0182
    Cell Significance Index: -2.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0183
    Cell Significance Index: -2.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0205
    Cell Significance Index: -2.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0212
    Cell Significance Index: -6.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0261
    Cell Significance Index: -0.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0270
    Cell Significance Index: -0.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0298
    Cell Significance Index: -0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0320
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0322
    Cell Significance Index: -6.7800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0363
    Cell Significance Index: -0.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0381
    Cell Significance Index: -0.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0409
    Cell Significance Index: -4.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0546
    Cell Significance Index: -4.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0564
    Cell Significance Index: -2.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0674
    Cell Significance Index: -1.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0753
    Cell Significance Index: -5.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0792
    Cell Significance Index: -1.9000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0863
    Cell Significance Index: -1.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0931
    Cell Significance Index: -2.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0959
    Cell Significance Index: -6.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1030
    Cell Significance Index: -1.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1108
    Cell Significance Index: -1.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1204
    Cell Significance Index: -5.3300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1237
    Cell Significance Index: -1.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1401
    Cell Significance Index: -1.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1447
    Cell Significance Index: -5.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1491
    Cell Significance Index: -4.8800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1512
    Cell Significance Index: -1.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1544
    Cell Significance Index: -5.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1544
    Cell Significance Index: -6.3300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1606
    Cell Significance Index: -1.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1608
    Cell Significance Index: -5.1200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1683
    Cell Significance Index: -2.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1685
    Cell Significance Index: -3.6400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1714
    Cell Significance Index: -1.3100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.1728
    Cell Significance Index: -1.3100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1745
    Cell Significance Index: -2.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1887
    Cell Significance Index: -2.3400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1933
    Cell Significance Index: -2.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1958
    Cell Significance Index: -2.8900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1962
    Cell Significance Index: -1.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1981
    Cell Significance Index: -4.2100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1992
    Cell Significance Index: -2.8600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1996
    Cell Significance Index: -2.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2046
    Cell Significance Index: -6.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2078
    Cell Significance Index: -9.0400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2078
    Cell Significance Index: -5.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2115
    Cell Significance Index: -3.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2127
    Cell Significance Index: -4.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2130
    Cell Significance Index: -3.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2131
    Cell Significance Index: -5.2000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2140
    Cell Significance Index: -2.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2205
    Cell Significance Index: -2.7500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2205
    Cell Significance Index: -3.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDK3 exhibits the following key characteristics: 1. **Cyclin-dependent kinase activity**: CDK3 belongs to the CDK family, which is characterized by its ability to phosphorylate and activate downstream targets. 2. **Cell cycle regulation**: CDK3 is involved in the G1/S and G2/M transitions of the mitotic cell cycle, ensuring proper cell proliferation and differentiation. 3. **Specific expression in retinal cells**: CDK3 is highly expressed in various retinal cell types, including photoreceptor cells, bipolar neurons, and Müller cells. 4. **Negative regulation of Notch signaling**: CDK3 acts as a negative regulator of the Notch signaling pathway, which is involved in cell fate determination and differentiation. **Pathways and Functions** CDK3 is involved in various signaling pathways, including: 1. **Cell division**: CDK3 regulates the G1/S and G2/M transitions of the mitotic cell cycle, ensuring proper cell proliferation and differentiation. 2. **Cyclin-dependent protein kinase holoenzyme complex**: CDK3 forms a complex with cyclin-dependent kinases and other regulatory proteins to phosphorylate and activate downstream targets. 3. **Cyclin binding**: CDK3 interacts with cyclins to regulate its activity and specificity. 4. **Phosphorylation**: CDK3 phosphorylates and activates downstream targets, including other kinases, transcription factors, and proteins involved in cell cycle regulation. 5. **Negative regulation of Notch signaling**: CDK3 acts as a negative regulator of the Notch signaling pathway, which is involved in cell fate determination and differentiation. **Clinical Significance** The dysregulation of CDK3 has been implicated in various diseases, including: 1. **Visual impairments**: Mutations in the CDK3 gene have been associated with visual impairments and degenerative retinal diseases. 2. **Cancer**: CDK3 overexpression has been observed in various types of cancer, including pancreatic cancer. 3. **Neurodegenerative diseases**: CDK3 dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, CDK3 is a critical regulator of the cell cycle, particularly in the context of neuronal development and function. Its specific expression in retinal cells highlights its importance in the development and maintenance of the visual system. Further research is needed to fully understand the functions of CDK3 and its role in human disease.

Genular Protein ID: 2201615615

Symbol: CDK3_HUMAN

Name: Cyclin-dependent kinase 3

UniProtKB Accession Codes:

Q00526

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 ELM 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 8846921

Title: Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

PubMed ID: 8846921

DOI: 10.1101/gad.10.7.851

PubMed ID: 15084261

Title: Cyclin C/cdk3 promotes Rb-dependent G0 exit.

PubMed ID: 15084261

DOI: 10.1016/s0092-8674(04)00300-9

PubMed ID: 18794154

Title: Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.

PubMed ID: 18794154

DOI: 10.1158/0008-5472.can-08-1137

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 305
  • Mass: 35046
  • Checksum: 1128BE0096EA262A
  • Sequence:
    • MDMFQKVEKI GEGTYGVVYK AKNRETGQLV ALKKIRLDLE MEGVPSTAIR EISLLKELKH 
PNIVRLLDVV HNERKLYLVF EFLSQDLKKY MDSTPGSELP LHLIKSYLFQ LLQGVSFCHS 
HRVIHRDLKP QNLLINELGA IKLADFGLAR AFGVPLRTYT HEVVTLWYRA PEILLGSKFY 
TTAVDIWSIG CIFAEMVTRK ALFPGDSEID QLFRIFRMLG TPSEDTWPGV TQLPDYKGSF 
PKWTRKGLEE IVPNLEPEGR DLLMQLLQYD PSQRITAKTA LAHPYFSSPE PSPAARQYVL 
QRFRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.