Details for: HECW2 AS1

Gene ID: 101927482

Symbol: HECW2 AS1

Ensembl ID: ENSG00000229056

Description: HECW2 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.9512
    Cell Significance Index: 45.6600
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.4008
    Cell Significance Index: 10.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.0602
    Cell Significance Index: -2.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0228
    Cell Significance Index: 27.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.6707
    Cell Significance Index: -2.0600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5096
    Cell Significance Index: 5.1100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2406
    Cell Significance Index: 2.4900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1939
    Cell Significance Index: 2.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1256
    Cell Significance Index: 3.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0730
    Cell Significance Index: 1.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0492
    Cell Significance Index: 9.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0042
    Cell Significance Index: 0.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0050
    Cell Significance Index: -1.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0099
    Cell Significance Index: -3.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0102
    Cell Significance Index: -5.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0114
    Cell Significance Index: -6.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0116
    Cell Significance Index: -5.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0183
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0283
    Cell Significance Index: -5.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0294
    Cell Significance Index: -0.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0326
    Cell Significance Index: -3.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0343
    Cell Significance Index: -4.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0357
    Cell Significance Index: -0.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0377
    Cell Significance Index: -2.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0394
    Cell Significance Index: -1.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0401
    Cell Significance Index: -5.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0424
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0459
    Cell Significance Index: -7.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0467
    Cell Significance Index: -5.3500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0503
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0510
    Cell Significance Index: -0.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0526
    Cell Significance Index: -1.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0538
    Cell Significance Index: -1.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0542
    Cell Significance Index: -0.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0607
    Cell Significance Index: -7.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0687
    Cell Significance Index: -4.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0696
    Cell Significance Index: -4.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0702
    Cell Significance Index: -5.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0722
    Cell Significance Index: -2.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0727
    Cell Significance Index: -4.4700
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0735
    Cell Significance Index: -0.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0794
    Cell Significance Index: -3.7000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0795
    Cell Significance Index: -1.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0809
    Cell Significance Index: -4.9600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0855
    Cell Significance Index: -1.0800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0971
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1032
    Cell Significance Index: -2.1600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1088
    Cell Significance Index: -1.3400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1090
    Cell Significance Index: -1.3800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1096
    Cell Significance Index: -1.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1173
    Cell Significance Index: -6.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1238
    Cell Significance Index: -6.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1283
    Cell Significance Index: -3.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1300
    Cell Significance Index: -3.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1303
    Cell Significance Index: -2.0900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1305
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1310
    Cell Significance Index: -1.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1317
    Cell Significance Index: -2.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1356
    Cell Significance Index: -6.0000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1367
    Cell Significance Index: -1.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1376
    Cell Significance Index: -1.9700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.1387
    Cell Significance Index: -1.5000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1398
    Cell Significance Index: -1.6500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1449
    Cell Significance Index: -0.7900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1493
    Cell Significance Index: -1.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1565
    Cell Significance Index: -4.1800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1573
    Cell Significance Index: -1.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1584
    Cell Significance Index: -6.0000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1650
    Cell Significance Index: -1.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1676
    Cell Significance Index: -2.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1684
    Cell Significance Index: -3.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1704
    Cell Significance Index: -2.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1722
    Cell Significance Index: -3.7700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1753
    Cell Significance Index: -2.2700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1775
    Cell Significance Index: -1.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1798
    Cell Significance Index: -5.1300
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1798
    Cell Significance Index: -2.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1822
    Cell Significance Index: -6.6900
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1833
    Cell Significance Index: -1.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1849
    Cell Significance Index: -4.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1865
    Cell Significance Index: -4.0300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1880
    Cell Significance Index: -1.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1953
    Cell Significance Index: -2.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2006
    Cell Significance Index: -4.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2035
    Cell Significance Index: -4.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2062
    Cell Significance Index: -4.1400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2065
    Cell Significance Index: -3.0100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2084
    Cell Significance Index: -2.1200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2099
    Cell Significance Index: -2.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2107
    Cell Significance Index: -5.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antisense RNA**: HECW2 AS1 is a non-coding RNA that is transcribed from the opposite strand of the HECW2 gene, thereby regulating its expression. 2. **Cell-type specific expression**: HECW2 AS1 is significantly expressed in a range of cell types, including thymocytes, cardiac endothelial cells, and intestinal crypt stem cells. 3. **Diverse cellular contexts**: HECW2 AS1 is expressed in cells involved in immune function (thymocytes), cardiovascular health (cardiac endothelial cells), and intestinal homeostasis (intestinal crypt stem cells). 4. **Regulation of HECW2 expression**: HECW2 AS1 is believed to regulate the expression of HECW2, although the exact mechanisms remain unclear. **Pathways and Functions:** 1. **Cell signaling**: HECW2 AS1 may play a role in regulating cell signaling pathways, including those involved in immune function and cardiovascular health. 2. **Differentiation**: HECW2 AS1 may influence cellular differentiation processes, including the development of immune cells and intestinal epithelial cells. 3. **Apoptosis**: HECW2 AS1 may also be involved in regulating apoptosis, or programmed cell death, in various cell types. 4. **Gene expression regulation**: HECW2 AS1 may act as a transcriptional regulator, influencing the expression of other genes involved in cellular processes. **Clinical Significance:** 1. **Immune disorders**: Dysregulation of HECW2 AS1 expression may contribute to immune disorders, such as autoimmune diseases and immunodeficiency disorders. 2. **Cardiovascular disease**: Abnormal expression of HECW2 AS1 may also be linked to cardiovascular disease, including atherosclerosis and cardiac dysfunction. 3. **Intestinal health**: HECW2 AS1 expression may also be involved in maintaining intestinal homeostasis, and dysregulation of HECW2 AS1 expression may contribute to gastrointestinal disorders. 4. **Cancer**: Further investigation is needed to determine whether HECW2 AS1 plays a role in cancer development and progression. In conclusion, HECW2 AS1 is a complex gene that plays a multifaceted role in regulating cellular processes, including cell signaling, differentiation, and survival. Further research is needed to fully elucidate the mechanisms by which HECW2 AS1 regulates gene expression and to explore its clinical significance in immune disorders, cardiovascular disease, and intestinal health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.