Details for: ICAM4 AS1

Gene ID: 123706506

Symbol: ICAM4 AS1

Ensembl ID: ENSG00000267607

Description: ICAM4 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.3358
    Cell Significance Index: 18.4700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5441
    Cell Significance Index: 7.9000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.4250
    Cell Significance Index: 4.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1697
    Cell Significance Index: 2.1500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1493
    Cell Significance Index: 1.7200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1185
    Cell Significance Index: 1.5500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.0907
    Cell Significance Index: 0.8200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0775
    Cell Significance Index: 1.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0603
    Cell Significance Index: 3.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0580
    Cell Significance Index: 0.6600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0570
    Cell Significance Index: 0.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0324
    Cell Significance Index: 1.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0117
    Cell Significance Index: 2.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0103
    Cell Significance Index: 0.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0077
    Cell Significance Index: 0.1300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0048
    Cell Significance Index: 0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0028
    Cell Significance Index: 0.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0023
    Cell Significance Index: 0.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0015
    Cell Significance Index: -0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0017
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0023
    Cell Significance Index: -1.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.7100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0086
    Cell Significance Index: -1.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0093
    Cell Significance Index: -1.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0102
    Cell Significance Index: -1.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0106
    Cell Significance Index: -1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0117
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0149
    Cell Significance Index: -2.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0150
    Cell Significance Index: -1.1200
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0151
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0169
    Cell Significance Index: -1.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0176
    Cell Significance Index: -0.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0178
    Cell Significance Index: -2.1000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0204
    Cell Significance Index: -0.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0207
    Cell Significance Index: -0.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0233
    Cell Significance Index: -0.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0250
    Cell Significance Index: -1.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0293
    Cell Significance Index: -1.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0315
    Cell Significance Index: -1.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0319
    Cell Significance Index: -2.4500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0324
    Cell Significance Index: -0.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0345
    Cell Significance Index: -1.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0358
    Cell Significance Index: -1.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0391
    Cell Significance Index: -1.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0398
    Cell Significance Index: -0.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0398
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0443
    Cell Significance Index: -1.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0446
    Cell Significance Index: -1.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0463
    Cell Significance Index: -2.6000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0502
    Cell Significance Index: -0.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0514
    Cell Significance Index: -0.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0528
    Cell Significance Index: -1.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0528
    Cell Significance Index: -0.7200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0529
    Cell Significance Index: -0.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0543
    Cell Significance Index: -1.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0545
    Cell Significance Index: -2.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0553
    Cell Significance Index: -1.3800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0567
    Cell Significance Index: -0.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0605
    Cell Significance Index: -1.1800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0615
    Cell Significance Index: -0.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0626
    Cell Significance Index: -2.3700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0652
    Cell Significance Index: -1.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0652
    Cell Significance Index: -2.2900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0655
    Cell Significance Index: -0.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0656
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0676
    Cell Significance Index: -1.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0678
    Cell Significance Index: -1.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0687
    Cell Significance Index: -1.7500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0689
    Cell Significance Index: -0.8900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0696
    Cell Significance Index: -0.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0698
    Cell Significance Index: -2.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0702
    Cell Significance Index: -1.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0748
    Cell Significance Index: -1.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0756
    Cell Significance Index: -2.0300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0764
    Cell Significance Index: -0.4000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0780
    Cell Significance Index: -0.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0790
    Cell Significance Index: -1.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0799
    Cell Significance Index: -2.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0803
    Cell Significance Index: -1.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0807
    Cell Significance Index: -1.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0814
    Cell Significance Index: -1.6100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0815
    Cell Significance Index: -0.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0821
    Cell Significance Index: -1.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0825
    Cell Significance Index: -2.0600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0830
    Cell Significance Index: -1.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0846
    Cell Significance Index: -1.6700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0854
    Cell Significance Index: -1.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0854
    Cell Significance Index: -2.2800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0856
    Cell Significance Index: -0.9000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0857
    Cell Significance Index: -0.9600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0864
    Cell Significance Index: -1.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: ICAM4 AS1 is a long non-coding RNA (lncRNA) that lacks an open reading frame, making it unlikely to encode a protein. Instead, it regulates gene expression through various mechanisms, including transcriptional repression, epigenetic modification, and RNA interference. 2. **Diverse expression patterns**: ICAM4 AS1 is expressed in a wide range of cell types, including goblet cells, intestinal crypt stem cells, early T lineage precursors, and cerebral cortex GABAergic interneurons. This suggests that the gene plays a crucial role in maintaining tissue homeostasis and regulating cellular differentiation and proliferation. 3. **Antisense RNA**: ICAM4 AS1 is an antisense RNA, meaning that it is transcribed from the same DNA strand as the ICAM4 gene. Antisense RNAs can regulate gene expression by binding to specific mRNAs, thereby inhibiting their translation or promoting their degradation. **Pathways and Functions:** 1. **Immune regulation**: ICAM4 AS1 has been shown to modulate immune responses by regulating the expression of genes involved in inflammation and immune cell development. For example, it can suppress the expression of pro-inflammatory cytokines and promote the differentiation of regulatory T cells. 2. **Tissue homeostasis**: ICAM4 AS1 plays a crucial role in maintaining tissue homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. For example, it can promote the differentiation of intestinal epithelial cells and suppress the expression of genes involved in cancer. 3. **Neurodevelopment**: ICAM4 AS1 is also involved in neurodevelopment, where it regulates the expression of genes involved in neuronal differentiation and migration. For example, it can promote the differentiation of cerebral cortex GABAergic interneurons and suppress the expression of genes involved in neuronal degeneration. 4. **Epigenetic regulation**: ICAM4 AS1 can regulate epigenetic marks, such as DNA methylation and histone modification, to modulate gene expression. This suggests that the gene plays a crucial role in maintaining genome stability and regulating cellular differentiation and proliferation. **Clinical Significance:** 1. **Cancer**: ICAM4 AS1 has been identified as a potential biomarker for cancer diagnosis and prognosis. Its expression is often downregulated in cancerous tissues, suggesting that it may play a role in suppressing tumor growth and metastasis. 2. **Inflammatory diseases**: ICAM4 AS1 has been shown to regulate immune responses in inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. Its expression is often altered in these diseases, suggesting that it may play a role in modulating disease progression. 3. **Neurodegenerative diseases**: ICAM4 AS1 has been identified as a potential biomarker for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Its expression is often altered in these diseases, suggesting that it may play a role in regulating disease progression. In conclusion, ICAM4 AS1 is a complex gene with diverse functions across various cell types and tissues. Its regulation of immune responses, tissue homeostasis, and epigenetic marks highlights its potential as a biomarker and therapeutic target for various diseases. Further research is needed to fully understand the mechanisms by which ICAM4 AS1 regulates gene expression and its clinical significance in human diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.