Details for: ZNF280A

Gene ID: 129025

Symbol: ZNF280A

Ensembl ID: ENSG00000169548

Description: zinc finger protein 280A

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6748
    Cell Significance Index: 16.3500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.3169
    Cell Significance Index: 3.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1529
    Cell Significance Index: 2.1900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.1195
    Cell Significance Index: 0.8600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.1103
    Cell Significance Index: 2.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0634
    Cell Significance Index: 0.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0564
    Cell Significance Index: 0.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0396
    Cell Significance Index: 1.0100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.0367
    Cell Significance Index: 0.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0343
    Cell Significance Index: 0.9200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0305
    Cell Significance Index: 0.3900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0235
    Cell Significance Index: 0.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0195
    Cell Significance Index: 3.8600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0131
    Cell Significance Index: 0.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0116
    Cell Significance Index: 0.2900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.0086
    Cell Significance Index: 0.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0073
    Cell Significance Index: 0.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0053
    Cell Significance Index: 0.6800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0049
    Cell Significance Index: 0.0600
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0019
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0015
    Cell Significance Index: -0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0017
    Cell Significance Index: -0.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0023
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0033
    Cell Significance Index: -0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0034
    Cell Significance Index: -0.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0035
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0042
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0063
    Cell Significance Index: -0.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0066
    Cell Significance Index: -0.6700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0070
    Cell Significance Index: -0.7300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0071
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0071
    Cell Significance Index: -0.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0080
    Cell Significance Index: -0.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0080
    Cell Significance Index: -0.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0083
    Cell Significance Index: -0.2900
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0096
    Cell Significance Index: -0.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0101
    Cell Significance Index: -0.2900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0104
    Cell Significance Index: -0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0105
    Cell Significance Index: -0.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0114
    Cell Significance Index: -0.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0133
    Cell Significance Index: -0.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0134
    Cell Significance Index: -0.2900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0138
    Cell Significance Index: -0.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0139
    Cell Significance Index: -0.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0154
    Cell Significance Index: -0.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0160
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0162
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0172
    Cell Significance Index: -0.7600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0176
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0184
    Cell Significance Index: -0.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0192
    Cell Significance Index: -0.4200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0194
    Cell Significance Index: -0.2500
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0194
    Cell Significance Index: -0.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0195
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0198
    Cell Significance Index: -0.1900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0208
    Cell Significance Index: -0.2400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0208
    Cell Significance Index: -0.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0210
    Cell Significance Index: -0.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0219
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0220
    Cell Significance Index: -0.2300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0222
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0222
    Cell Significance Index: -0.2400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0226
    Cell Significance Index: -0.2000
  • Cell Name: airway submucosal gland duct basal cell (CL4033024)
    Fold Change: -0.0227
    Cell Significance Index: -0.2000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0228
    Cell Significance Index: -0.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0230
    Cell Significance Index: -0.4500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0240
    Cell Significance Index: -0.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0249
    Cell Significance Index: -0.5000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0250
    Cell Significance Index: -0.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0276
    Cell Significance Index: -0.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0278
    Cell Significance Index: -0.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0293
    Cell Significance Index: -0.8400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0295
    Cell Significance Index: -0.5800
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: -0.0299
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0299
    Cell Significance Index: -0.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0304
    Cell Significance Index: -0.3300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0304
    Cell Significance Index: -0.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0307
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0312
    Cell Significance Index: -0.5400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0312
    Cell Significance Index: -0.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0316
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulation**: ZNF280A is a DNA-binding transcription factor that regulates the expression of target genes through specific DNA sequences. 2. **Zinc Finger Domain**: The gene contains a highly conserved zinc finger domain, which is responsible for its DNA-binding activity. 3. **RNA Polymerase II-Specific**: ZNF280A is specifically associated with RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes. 4. **Metal Ion Binding**: The gene exhibits metal ion binding capabilities, which may be essential for its transcriptional regulatory function. **Pathways and Functions** 1. **Regulation of DNA-templated Transcription**: ZNF280A plays a crucial role in regulating the transcription of genes involved in immune responses, including the expression of cytokines, chemokines, and adhesion molecules. 2. **Regulation of Transcription by RNA Polymerase II**: ZNF280A is specifically associated with RNA polymerase II, influencing the transcription of protein-coding genes. 3. **Metal Ion Binding**: The gene's metal ion binding capabilities may be essential for its transcriptional regulatory function, allowing it to interact with other proteins and DNA sequences. 4. **Cellular Differentiation**: ZNF280A may also play a role in cellular differentiation, particularly in the development of immune cells. **Clinical Significance** 1. **Immune System Disorders**: Abnormalities in ZNF280A expression have been implicated in various immune system disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer**: ZNF280A has been identified as a potential tumor suppressor gene, with altered expression levels observed in certain types of cancer. 3. **Neurological Disorders**: The gene's expression in GABAergic interneurons has raised interest in its potential role in neurological disorders, such as epilepsy and schizophrenia. 4. **Gene Therapy**: ZNF280A may serve as a potential target for gene therapy, offering a novel approach to treating immune system disorders and other diseases. In conclusion, ZNF280A is a critical component of the immune system's transcriptional machinery, playing a pivotal role in regulating gene expression in various immune cells. Further research is needed to fully elucidate the gene's functions and its clinical significance, but its potential as a therapeutic target for immune system disorders and other diseases is undeniable.

Genular Protein ID: 1287398321

Symbol: Z280A_HUMAN

Name: Zinc finger protein 280A

UniProtKB Accession Codes:

P59817

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9074928

Title: One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

PubMed ID: 9074928

DOI: 10.1101/gr.7.3.250

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 542
  • Mass: 60584
  • Checksum: C594222D41A84DCB
  • Sequence:
    • MGDIFLCKKV ESPKKNLRES KQREEDDEDP DLIYVGVEHV HRDAEVLFVG MISNSKPVVS 
NILNRVTPGS NSRRKKGHFR QYPAHVSQPA NHVTSMAKAI MPVSLSEGRS TDSPVTMKSS 
SEPGYKMSSP QVVSPSSSDS LPPGTQCLVG AMVSGGGRNE SSPDSKRLST SDINSRDSKR 
VKLRDGIPGV PSLAVVPSDM SSTISTNTPS QGICNSSNHV QNGVTFPWPD ANGKAHFNLT 
DPERASESAL AMTDISSLAS QNKTFDPKKE NPIVLLSDFY YGQHKGDGQP EQKTHTTFKC 
LSCVKVLKNI KFMNHMKHHL EFEKQRNDSW EDHTTCQHCH RQFPTPFQLQ CHIDSVHIAM 
GPSAVCKICE LSFETDQVLL QHMKDHHKPG EMPYVCQVCH YRSSVFADVE THFRTCHENT 
KNLLCLFCLK LFKTAIPYMN HCWRHSRRRV LQCSKCRLQF LTLKEEIEHK TKDHQTFKKP 
EQLQGLPSET KVIIQTSVQP GSSGMASVIV SNTDPQSSPV KTKKKTAMNT RDSRLPCSKD 
SS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.