Details for: DAB2

Gene ID: 1601

Symbol: DAB2

Ensembl ID: ENSG00000153071

Description: DAB adaptor protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.31
    Marker Score: 3308
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.25
    Marker Score: 11544
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3
    Marker Score: 18205
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.71
    Marker Score: 1548
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.68
    Marker Score: 91190
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.44
    Marker Score: 62383
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.39
    Marker Score: 1316
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.39
    Marker Score: 2733
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.07
    Marker Score: 502
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.06
    Marker Score: 2838
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.04
    Marker Score: 36272
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.92
    Marker Score: 801
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.91
    Marker Score: 7501
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.9
    Marker Score: 437
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.84
    Marker Score: 1161
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.83
    Marker Score: 1905
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.81
    Marker Score: 587
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.79
    Marker Score: 20129
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.71
    Marker Score: 1402
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.65
    Marker Score: 1763
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.64
    Marker Score: 809
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.63
    Marker Score: 3309
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.61
    Marker Score: 4223
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.59
    Marker Score: 3898
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.58
    Marker Score: 6814
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.58
    Marker Score: 3721
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.45
    Marker Score: 327
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.38
    Marker Score: 535
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.36
    Marker Score: 910
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.36
    Marker Score: 586
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.28
    Marker Score: 2559
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.21
    Marker Score: 1417
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.21
    Marker Score: 3050
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.2
    Marker Score: 1294
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.19
    Marker Score: 295
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.19
    Marker Score: 1325
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.19
    Marker Score: 383
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.17
    Marker Score: 1103
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.14
    Marker Score: 265
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 472
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.12
    Marker Score: 358
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2110
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.11
    Marker Score: 348
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.11
    Marker Score: 794
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.1
    Marker Score: 448
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.08
    Marker Score: 307
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.07
    Marker Score: 258
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.07
    Marker Score: 249
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.07
    Marker Score: 234
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.06
    Marker Score: 5227.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.06
    Marker Score: 953
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.05
    Marker Score: 1063
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.01
    Marker Score: 2624
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2276
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71748
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47972
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.98
    Marker Score: 876
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.96
    Marker Score: 1326
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.93
    Marker Score: 583
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5319
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1511
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Marker Score: 1645
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.91
    Marker Score: 11977
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.9
    Marker Score: 868
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.9
    Marker Score: 229
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9
    Marker Score: 1517
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.88
    Marker Score: 948
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5258
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.87
    Marker Score: 316
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.84
    Marker Score: 1394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 637.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.83
    Marker Score: 2233
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.81
    Marker Score: 1152
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.8
    Marker Score: 961
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.79
    Marker Score: 791
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.79
    Marker Score: 1263
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.78
    Marker Score: 5090
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.78
    Marker Score: 1199
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.78
    Marker Score: 400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.78
    Marker Score: 516
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.78
    Marker Score: 205
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1191
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.74
    Marker Score: 1348
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.73
    Marker Score: 303
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3031
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.72
    Marker Score: 299
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.71
    Marker Score: 151
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.71
    Marker Score: 176
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.7
    Marker Score: 176
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.69
    Marker Score: 397

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Other Information

**Key characteristics:** * DAB2 is a transmembrane protein with a predicted molecular weight of approximately 150 kDa. * It is a member of the DAB family of adaptor proteins, which are involved in a variety of cellular processes, including endocytosis and cell signaling. * DAB2 is a key regulator of clathrin-mediated endocytosis, a process by which cells take in extracellular vesicles. * It is also involved in the regulation of gap junction trafficking, a process by which cells connect and form gap junctions with each other. * DAB2 is a negative regulator of transcription by RNA polymerase II. **Pathways and functions:** * DAB2 is involved in the regulation of endocytosis by binding to clathrin, a protein that is essential for the formation of clathrin-coated pits, which are the structures that are used for endocytosis. * It also regulates the activity of the transforming growth factor beta receptor (TGFR), a key regulator of cell growth and differentiation. * DAB2 is involved in the negative regulation of transcription by RNA polymerase II. * It does this by binding to the RNA polymerase II complex and blocking its access to the DNA. **Clinical significance:** * Mutations in the DAB2 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * In cancer, DAB2 mutations can lead to the activation of oncogenes and the formation of tumors. * DAB2 inhibitors are being investigated as potential treatments for cancer and other diseases that are characterized by abnormal endocytosis.

Genular Protein ID: 3171767950

Symbol: DAB2_HUMAN

Name: Disabled homolog 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8660969

Title: Sequence, genomic structure, and chromosomal assignment of human DOC-2.

PubMed ID: 8660969

DOI: 10.1006/geno.1996.0185

PubMed ID: 9620555

Title: DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer.

PubMed ID: 9620555

DOI: 10.1038/sj.onc.1201769

PubMed ID: 10340382

Title: Disabled-2 inactivation is an early step in ovarian tumorigenicity.

PubMed ID: 10340382

DOI: 10.1038/sj.onc.1202649

PubMed ID: 11161789

Title: Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2).

PubMed ID: 11161789

DOI: 10.1006/geno.2000.6383

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8314147

Title: Molecular cloning of differentially expressed genes in human epithelial ovarian cancer.

PubMed ID: 8314147

DOI: 10.1006/gyno.1994.1040

PubMed ID: 10769163

Title: Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin.

PubMed ID: 10769163

DOI: 10.1042/bj3470613

PubMed ID: 11387212

Title: The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.

PubMed ID: 11387212

DOI: 10.1093/emboj/20.11.2789

PubMed ID: 11967127

Title: Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton.

PubMed ID: 11967127

DOI: 10.1034/j.1600-0854.2002.30503.x

PubMed ID: 12805222

Title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2).

PubMed ID: 12805222

DOI: 10.1093/emboj/cdg286

PubMed ID: 14596919

Title: Dab2 links CIN85 with clathrin-mediated receptor internalization.

PubMed ID: 14596919

DOI: 10.1016/s0014-5793(03)01111-6

PubMed ID: 15134832

Title: The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin.

PubMed ID: 15134832

DOI: 10.1016/j.biochi.2004.03.001

PubMed ID: 16267015

Title: The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer.

PubMed ID: 16267015

DOI: 10.1158/0008-5472.can-05-1481

PubMed ID: 16984970

Title: The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH.

PubMed ID: 16984970

DOI: 10.1242/jcs.03217

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19306879

Title: Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins.

PubMed ID: 19306879

DOI: 10.1016/j.febslet.2009.03.037

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21097498

Title: Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis.

PubMed ID: 21097498

DOI: 10.1074/jbc.m110.161851

PubMed ID: 21995445

Title: Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator.

PubMed ID: 21995445

DOI: 10.1042/bj20111566

PubMed ID: 22491013

Title: Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin.

PubMed ID: 22491013

DOI: 10.1038/emboj.2012.83

PubMed ID: 22323290

Title: FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.

PubMed ID: 22323290

DOI: 10.1091/mbc.e11-09-0812

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 770
  • Mass: 82448
  • Checksum: 5B2F8B510A580A77
  • Sequence:
  • MSNEVETSAT NGQPDQQAAP KAPSKKEKKK GPEKTDEYLL ARFKGDGVKY KAKLIGIDDV 
    PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK 
    ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK 
    KIEEASKAVE NGSEALMILD DQTNKLKSGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN 
    SEIDTNQNSL RENPFLTNGI TSCSLPRPTP QASFLPENAF SANLNFFPTP NPDPFRDDPF 
    TQPDQSTPSS FDSLKSPDQK KENSSSSSTP LSNGPLNGDV DYFGQQFDQI SNRTGKQEAQ 
    AGPWPFSSSQ TQPAVRTQNG VSEREQNGFS VKSSPNPFVG SPPKGLSIQN GVKQDLESSV 
    QSSPHDSIAI IPPPQSTKPG RGRRTAKSSA NDLLASDIFA PPVSEPSGQA SPTGQPTALQ 
    PNPLDLFKTS APAPVGPLVG LGGVTVTLPQ AGPWNTASLV FNQSPSMAPG AMMGGQPSGF 
    SQPVIFGTSP AVSGWNQPSP FAASTPPPVP VVWGPSASVA PNAWSTTSPL GNPFQSNIFP 
    APAVSTQPPS MHSSLLVTPP QPPPRAGPPK DISSDAFTAL DPLGDKEIKD VKEMFKDFQL 
    RQPPAVPARK GEQTSSGTLS AFASYFNSKV GIPQENADHD DFDANQLLNK INEPPKPAPR 
    QVSLPVTKST DNAFENPFFK DSFGSSQASV ASSQPVSSEM YRDPFGNPFA

Genular Protein ID: 1310421438

Symbol: B2RAW0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 770
  • Mass: 82470
  • Checksum: 74F97161244AE6A7
  • Sequence:
  • MSNEVETSAT NGQPDQQAAP KAPSKKEKKK GPEKTDEYLL ARFKGDGVKY KAKLIGIDDV 
    PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK 
    ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK 
    KIEEASKAVE NGSEALMILD DQTNKLKSGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN 
    SEIDTNQNSL RENPFLTNGI TSCSLPRPTP QASFLPENAF SANLNFFPTP NPDPFRDDPF 
    TQPDQSTPSS FDSLKSPDQK KENSSSSSTP LSNGPLNGDV DYFGQQFDQI SNRTGKQEAQ 
    AGPWPFSSSQ TQPAVRTQNG VSEREQNGFS VKSSPNPFVG SPPKGLSIQN GVKQDLESSV 
    QSSPHDSIAI IPPPQSTKPG RGRRTAKSSA NDLLASDIFA PPVSEPSGQA SPTGQPTALQ 
    PNPLDLFKTS APAPVGPLVG LGGVIVTLPQ AGPWNTASLV FNQSPSMAPG AMMGGQPSGF 
    SQPVIFGTSP AVSGWNQPSP FAASTPPPVP VVWGPSASVA PNAWSTTSPL GNPFQSNIFP 
    APAVSTQPPS MHSPLLVTPP QPPPRAGPPK DISSDAFTAL DPLGDKEIKD VKEMFKDFQL 
    RQPPAVPARK GEQTSSGTLS AFASYFNSKV GIPQENADHD DFDANQLLNK INEPPKPAPR 
    QVSLPVTKST DNAFENPFFK DSFGSSQASV ASSQPVSSEM YRDPFGNPFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.