Details for: DAB2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.31
Marker Score: 3,308 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.25
Marker Score: 11,544 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 3
Marker Score: 18,205 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.71
Marker Score: 1,548 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.68
Marker Score: 91,190 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.44
Marker Score: 62,383 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.39
Marker Score: 1,316 - Cell Name: lung macrophage (CL1001603)
Fold Change: 2.39
Marker Score: 2,733 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 2.07
Marker Score: 502 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.06
Marker Score: 2,838 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.04
Marker Score: 36,272 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.92
Marker Score: 801 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.91
Marker Score: 7,501 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.9
Marker Score: 437 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.84
Marker Score: 1,161 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.83
Marker Score: 1,905 - Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 1.81
Marker Score: 587 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.79
Marker Score: 20,129 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.71
Marker Score: 1,402 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.65
Marker Score: 1,763 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.64
Marker Score: 809 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.63
Marker Score: 3,309 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.61
Marker Score: 4,223 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.59
Marker Score: 3,898 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.58
Marker Score: 6,814 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.58
Marker Score: 3,721 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.45
Marker Score: 327 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.38
Marker Score: 535 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.36
Marker Score: 910 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.36
Marker Score: 586 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.28
Marker Score: 2,559 - Cell Name: stromal cell (CL0000499)
Fold Change: 1.21
Marker Score: 1,417 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.21
Marker Score: 3,050 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.2
Marker Score: 1,294 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.19
Marker Score: 295 - Cell Name: macrophage (CL0000235)
Fold Change: 1.19
Marker Score: 1,325 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.19
Marker Score: 383 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.17
Marker Score: 1,103 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.14
Marker Score: 265 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.13
Marker Score: 472 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.12
Marker Score: 358 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.11
Marker Score: 2,110 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.11
Marker Score: 348 - Cell Name: theca cell (CL0000503)
Fold Change: 1.11
Marker Score: 794 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.1
Marker Score: 448 - Cell Name: preosteoblast (CL0007010)
Fold Change: 1.08
Marker Score: 307 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.07
Marker Score: 258 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.07
Marker Score: 249 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.07
Marker Score: 234 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.06
Marker Score: 5,228 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.06
Marker Score: 953 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.05
Marker Score: 1,063 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.01
Marker Score: 2,624 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1
Marker Score: 2,276 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,748 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,972 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.98
Marker Score: 876 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.96
Marker Score: 1,326 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,405 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.93
Marker Score: 583 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,319 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1,511 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.93
Marker Score: 1,645 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,736 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 365 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.91
Marker Score: 11,977 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.9
Marker Score: 868 - Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.9
Marker Score: 229 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9
Marker Score: 1,517 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.88
Marker Score: 948 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,258 - Cell Name: reticular cell (CL0000432)
Fold Change: 0.87
Marker Score: 316 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.84
Marker Score: 1,394 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 638 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.83
Marker Score: 2,233 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.81
Marker Score: 1,152 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.8
Marker Score: 961 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.79
Marker Score: 791 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.79
Marker Score: 1,263 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.78
Marker Score: 5,090 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.78
Marker Score: 1,199 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.78
Marker Score: 400 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.78
Marker Score: 516 - Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.78
Marker Score: 205 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1,191 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.74
Marker Score: 1,348 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.73
Marker Score: 303 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 466 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.72
Marker Score: 3,031 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.72
Marker Score: 299 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.71
Marker Score: 151 - Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 646 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.71
Marker Score: 176 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.7
Marker Score: 176 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.69
Marker Score: 397
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3171767950
Symbol: DAB2_HUMAN
Name: Disabled homolog 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8660969
Title: Sequence, genomic structure, and chromosomal assignment of human DOC-2.
PubMed ID: 8660969
PubMed ID: 9620555
Title: DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer.
PubMed ID: 9620555
PubMed ID: 10340382
Title: Disabled-2 inactivation is an early step in ovarian tumorigenicity.
PubMed ID: 10340382
PubMed ID: 11161789
Title: Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2).
PubMed ID: 11161789
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8314147
Title: Molecular cloning of differentially expressed genes in human epithelial ovarian cancer.
PubMed ID: 8314147
PubMed ID: 10769163
Title: Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin.
PubMed ID: 10769163
DOI: 10.1042/bj3470613
PubMed ID: 11387212
Title: The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.
PubMed ID: 11387212
PubMed ID: 11967127
Title: Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton.
PubMed ID: 11967127
PubMed ID: 12805222
Title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2).
PubMed ID: 12805222
DOI: 10.1093/emboj/cdg286
PubMed ID: 14596919
Title: Dab2 links CIN85 with clathrin-mediated receptor internalization.
PubMed ID: 14596919
PubMed ID: 15134832
Title: The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin.
PubMed ID: 15134832
PubMed ID: 16267015
Title: The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer.
PubMed ID: 16267015
PubMed ID: 16984970
Title: The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH.
PubMed ID: 16984970
DOI: 10.1242/jcs.03217
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19306879
Title: Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins.
PubMed ID: 19306879
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21097498
Title: Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis.
PubMed ID: 21097498
PubMed ID: 21995445
Title: Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator.
PubMed ID: 21995445
DOI: 10.1042/bj20111566
PubMed ID: 22491013
Title: Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin.
PubMed ID: 22491013
PubMed ID: 22323290
Title: FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.
PubMed ID: 22323290
PubMed ID: 22484487
Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
PubMed ID: 22484487
DOI: 10.1038/ncb2473
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 770
- Mass: 82448
- Checksum: 5B2F8B510A580A77
- Sequence:
MSNEVETSAT NGQPDQQAAP KAPSKKEKKK GPEKTDEYLL ARFKGDGVKY KAKLIGIDDV PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK KIEEASKAVE NGSEALMILD DQTNKLKSGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN SEIDTNQNSL RENPFLTNGI TSCSLPRPTP QASFLPENAF SANLNFFPTP NPDPFRDDPF TQPDQSTPSS FDSLKSPDQK KENSSSSSTP LSNGPLNGDV DYFGQQFDQI SNRTGKQEAQ AGPWPFSSSQ TQPAVRTQNG VSEREQNGFS VKSSPNPFVG SPPKGLSIQN GVKQDLESSV QSSPHDSIAI IPPPQSTKPG RGRRTAKSSA NDLLASDIFA PPVSEPSGQA SPTGQPTALQ PNPLDLFKTS APAPVGPLVG LGGVTVTLPQ AGPWNTASLV FNQSPSMAPG AMMGGQPSGF SQPVIFGTSP AVSGWNQPSP FAASTPPPVP VVWGPSASVA PNAWSTTSPL GNPFQSNIFP APAVSTQPPS MHSSLLVTPP QPPPRAGPPK DISSDAFTAL DPLGDKEIKD VKEMFKDFQL RQPPAVPARK GEQTSSGTLS AFASYFNSKV GIPQENADHD DFDANQLLNK INEPPKPAPR QVSLPVTKST DNAFENPFFK DSFGSSQASV ASSQPVSSEM YRDPFGNPFA
Genular Protein ID: 1310421438
Symbol: B2RAW0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 770
- Mass: 82470
- Checksum: 74F97161244AE6A7
- Sequence:
MSNEVETSAT NGQPDQQAAP KAPSKKEKKK GPEKTDEYLL ARFKGDGVKY KAKLIGIDDV PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK KIEEASKAVE NGSEALMILD DQTNKLKSGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN SEIDTNQNSL RENPFLTNGI TSCSLPRPTP QASFLPENAF SANLNFFPTP NPDPFRDDPF TQPDQSTPSS FDSLKSPDQK KENSSSSSTP LSNGPLNGDV DYFGQQFDQI SNRTGKQEAQ AGPWPFSSSQ TQPAVRTQNG VSEREQNGFS VKSSPNPFVG SPPKGLSIQN GVKQDLESSV QSSPHDSIAI IPPPQSTKPG RGRRTAKSSA NDLLASDIFA PPVSEPSGQA SPTGQPTALQ PNPLDLFKTS APAPVGPLVG LGGVIVTLPQ AGPWNTASLV FNQSPSMAPG AMMGGQPSGF SQPVIFGTSP AVSGWNQPSP FAASTPPPVP VVWGPSASVA PNAWSTTSPL GNPFQSNIFP APAVSTQPPS MHSPLLVTPP QPPPRAGPPK DISSDAFTAL DPLGDKEIKD VKEMFKDFQL RQPPAVPARK GEQTSSGTLS AFASYFNSKV GIPQENADHD DFDANQLLNK INEPPKPAPR QVSLPVTKST DNAFENPFFK DSFGSSQASV ASSQPVSSEM YRDPFGNPFA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.