Details for: DLAT

Gene ID: 1737

Symbol: DLAT

Ensembl ID: ENSG00000150768

Description: dihydrolipoamide S-acetyltransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.44
    Marker Score: 45727
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.43
    Marker Score: 1178
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.97
    Marker Score: 1762
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.69
    Marker Score: 2951
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168547
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.18
    Marker Score: 432
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.12
    Marker Score: 556
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.06
    Marker Score: 1642
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.03
    Marker Score: 702
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.03
    Marker Score: 23103.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1
    Marker Score: 36988
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47967
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1378
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14272
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5137
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9
    Marker Score: 717
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.88
    Marker Score: 54327
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.88
    Marker Score: 2353
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.87
    Marker Score: 8272.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.87
    Marker Score: 3094
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.86
    Marker Score: 7426
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.84
    Marker Score: 3479
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.84
    Marker Score: 886
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1354
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.82
    Marker Score: 7757
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.79
    Marker Score: 3055
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.78
    Marker Score: 977.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.72
    Marker Score: 169
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.7
    Marker Score: 26688.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7
    Marker Score: 741
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.7
    Marker Score: 522
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.69
    Marker Score: 5979
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.69
    Marker Score: 1138
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2871
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.68
    Marker Score: 13578
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.66
    Marker Score: 5741
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.66
    Marker Score: 439
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.66
    Marker Score: 1783
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.65
    Marker Score: 689
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.64
    Marker Score: 689
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.63
    Marker Score: 2485
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.63
    Marker Score: 9427.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.63
    Marker Score: 4800
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.63
    Marker Score: 1966
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.6
    Marker Score: 2896
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.6
    Marker Score: 1257.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.6
    Marker Score: 334
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.59
    Marker Score: 617
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.59
    Marker Score: 395.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.59
    Marker Score: 1344
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.59
    Marker Score: 1291
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.58
    Marker Score: 582
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 383
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.57
    Marker Score: 1361
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.57
    Marker Score: 575
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.57
    Marker Score: 12081
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.56
    Marker Score: 271.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.56
    Marker Score: 705
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.56
    Marker Score: 827
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.54
    Marker Score: 179
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.54
    Marker Score: 248
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1265
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.54
    Marker Score: 1350
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.53
    Marker Score: 309
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.53
    Marker Score: 1008
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.53
    Marker Score: 282
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.52
    Marker Score: 218
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.52
    Marker Score: 152
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.52
    Marker Score: 686
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.51
    Marker Score: 550
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.51
    Marker Score: 2371
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.51
    Marker Score: 17567
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.51
    Marker Score: 546
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.51
    Marker Score: 528
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.5
    Marker Score: 416
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.5
    Marker Score: 131
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.5
    Marker Score: 843
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.5
    Marker Score: 338
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.49
    Marker Score: 484
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.49
    Marker Score: 330
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.49
    Marker Score: 271
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.49
    Marker Score: 547

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Other Information

**Key characteristics** * DLAT is an enzyme of the acetyl-CoA biosynthetic process. * It is involved in the metabolism of pyruvate, dihydrolipoyllysine, and glycine. * It is a highly conserved enzyme with a wide expression pattern. **Pathways and functions** * DLAT is involved in the following metabolic pathways: * Acetyl-CoA biosynthetic process * Dihydrolipoyllysine-residue acetyltransferase activity * Glucose metabolic process * Glyoxylate metabolism and glycine degradation * Identical protein binding * Metabolism of amino acids and derivatives * Protein binding * Pyruvate dehydrogenase (nad+) activity * Pyruvate metabolism * Pyruvate metabolism and citric acid (tca) cycle * Regulation of pyruvate dehydrogenase (pdh) complex * Signaling by nuclear receptors * Signaling by retinoic acid * Signal transduction * The citric acid (tca) cycle and respiratory electron transport **Clinical significance** * DLAT is a potential therapeutic target for various diseases, including cancer and metabolic disorders. * Inhibition of DLAT has been shown to suppress tumor growth and metastasis in cancer cells. * It is a potential therapeutic target for disorders characterized by metabolic dysregulation, such as diabetes and obesity.

Genular Protein ID: 2143941255

Symbol: ODP2_HUMAN

Name: Pyruvate dehydrogenase complex component E2

UniProtKB Accession Codes:

P10515 Q16783 Q53EP3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 4 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 12 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 4 SABIO-RK 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 3174635

Title: Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.

PubMed ID: 3174635

DOI: 10.1073/pnas.85.19.7317

PubMed ID: 3191998

Title: Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydrogenase complex.

PubMed ID: 3191998

DOI: 10.1016/0014-5793(88)80337-5

PubMed ID: 14638692

Title: Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.

PubMed ID: 14638692

DOI: 10.1074/jbc.m308172200

PubMed ID: 20160912

Title: Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.

PubMed ID: 20160912

DOI: 10.1016/j.molcatb.2009.05.001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25525879

Title: Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.

PubMed ID: 25525879

DOI: 10.1016/j.cell.2014.11.046

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16049940

Title: Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency.

PubMed ID: 16049940

DOI: 10.1002/ana.20550

PubMed ID: 9649469

Title: Three-dimensional structure of the major autoantigen in primary biliary cirrhosis.

PubMed ID: 9649469

DOI: 10.1016/s0016-5085(98)70375-0

PubMed ID: 15861126

Title: Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.

PubMed ID: 15861126

DOI: 10.1038/sj.emboj.7600663

PubMed ID: 17532006

Title: Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications.

PubMed ID: 17532006

DOI: 10.1016/j.jmb.2007.04.083

PubMed ID: 17683942

Title: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

PubMed ID: 17683942

DOI: 10.1016/j.str.2007.07.001

PubMed ID: 18387944

Title: Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2.

PubMed ID: 18387944

DOI: 10.1074/jbc.m800311200

PubMed ID: 20361979

Title: Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.

PubMed ID: 20361979

DOI: 10.1016/j.jmb.2010.03.043

Sequence Information:

  • Length: 647
  • Mass: 68997
  • Checksum: DD93A8E666E377C2
  • Sequence:
    • MWRVCARRAQ NVAPWAGLEA RWTALQEVPG TPRVTSRSGP APARRNSVTT GYGGVRALCG 
WTPSSGATPR NRLLLQLLGS PGRRYYSLPP HQKVPLPSLS PTMQAGTIAR WEKKEGDKIN 
EGDLIAEVET DKATVGFESL EECYMAKILV AEGTRDVPIG AIICITVGKP EDIEAFKNYT 
LDSSAAPTPQ AAPAPTPAAT ASPPTPSAQA PGSSYPPHMQ VLLPALSPTM TMGTVQRWEK 
KVGEKLSEGD LLAEIETDKA TIGFEVQEEG YLAKILVPEG TRDVPLGTPL CIIVEKEADI 
SAFADYRPTE VTDLKPQVPP PTPPPVAAVP PTPQPLAPTP SAPCPATPAG PKGRVFVSPL 
AKKLAVEKGI DLTQVKGTGP DGRITKKDID SFVPSKVAPA PAAVVPPTGP GMAPVPTGVF 
TDIPISNIRR VIAQRLMQSK QTIPHYYLSI DVNMGEVLLV RKELNKILEG RSKISVNDFI 
IKASALACLK VPEANSSWMD TVIRQNHVVD VSVAVSTPAG LITPIVFNAH IKGVETIAND 
VVSLATKARE GKLQPHEFQG GTFTISNLGM FGIKNFSAII NPPQACILAI GASEDKLVPA 
DNEKGFDVAS MMSVTLSCDH RVVDGAVGAQ WLAEFRKYLE KPITMLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.