Details for: DLAT
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 113.6968
Cell Significance Index: -17.6900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 74.8098
Cell Significance Index: -18.9800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 45.2915
Cell Significance Index: -18.4000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 33.6949
Cell Significance Index: -22.6100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 19.3141
Cell Significance Index: -18.4400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.3307
Cell Significance Index: -20.1400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.5555
Cell Significance Index: -20.2400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.1900
Cell Significance Index: -20.4800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.6134
Cell Significance Index: -14.1700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.7921
Cell Significance Index: 123.9300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.7170
Cell Significance Index: 326.7500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1465
Cell Significance Index: 1035.2100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1309
Cell Significance Index: 67.9000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0462
Cell Significance Index: 113.8000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9843
Cell Significance Index: 13.4300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8707
Cell Significance Index: 141.6200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7722
Cell Significance Index: 59.2600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6732
Cell Significance Index: 66.5900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6298
Cell Significance Index: 126.3300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4727
Cell Significance Index: 13.6200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4482
Cell Significance Index: 28.2500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3845
Cell Significance Index: 76.3200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3453
Cell Significance Index: 123.8500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3443
Cell Significance Index: 238.1200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3355
Cell Significance Index: 17.4300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.3177
Cell Significance Index: 4.6900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3030
Cell Significance Index: 54.6300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2885
Cell Significance Index: 6.2500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2624
Cell Significance Index: 32.2700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2611
Cell Significance Index: 142.5900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1898
Cell Significance Index: 5.3100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1816
Cell Significance Index: 80.3100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1456
Cell Significance Index: 6.7900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1403
Cell Significance Index: 16.5400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1180
Cell Significance Index: 16.2100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1055
Cell Significance Index: 4.7800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0855
Cell Significance Index: 4.8000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0784
Cell Significance Index: 3.4700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0777
Cell Significance Index: 2.4900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0702
Cell Significance Index: 1.7600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0698
Cell Significance Index: 4.9400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0595
Cell Significance Index: 10.1600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0449
Cell Significance Index: 1.7000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0429
Cell Significance Index: 2.2500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0234
Cell Significance Index: 3.0000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0228
Cell Significance Index: 0.8000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0193
Cell Significance Index: 1.3000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0143
Cell Significance Index: 0.2400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0127
Cell Significance Index: 8.0900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0117
Cell Significance Index: 8.5600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0054
Cell Significance Index: 10.0800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0019
Cell Significance Index: 0.8700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0018
Cell Significance Index: 2.7800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0017
Cell Significance Index: 0.0400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0005
Cell Significance Index: -0.9600 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0049
Cell Significance Index: -0.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0052
Cell Significance Index: -3.8700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0075
Cell Significance Index: -4.6600 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.0092
Cell Significance Index: -0.0400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0096
Cell Significance Index: -7.2400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0107
Cell Significance Index: -14.5100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0112
Cell Significance Index: -0.3000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0216
Cell Significance Index: -12.2000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0237
Cell Significance Index: -3.0600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0252
Cell Significance Index: -0.6900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0301
Cell Significance Index: -3.4500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0390
Cell Significance Index: -2.4000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0423
Cell Significance Index: -4.3200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0424
Cell Significance Index: -1.0900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0489
Cell Significance Index: -1.7000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0533
Cell Significance Index: -11.2200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0597
Cell Significance Index: -8.6800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0657
Cell Significance Index: -7.6600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0843
Cell Significance Index: -1.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0863
Cell Significance Index: -4.0600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0894
Cell Significance Index: -5.7700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1026
Cell Significance Index: -7.6500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1194
Cell Significance Index: -13.6400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1265
Cell Significance Index: -3.6100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1318
Cell Significance Index: -3.4700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1410
Cell Significance Index: -8.6500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1423
Cell Significance Index: -3.0300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1545
Cell Significance Index: -4.5500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1669
Cell Significance Index: -2.8600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1695
Cell Significance Index: -8.8300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1760
Cell Significance Index: -13.9400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1855
Cell Significance Index: -19.3200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1985
Cell Significance Index: -2.0600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2110
Cell Significance Index: -3.1800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2630
Cell Significance Index: -6.7200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2675
Cell Significance Index: -5.6000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2954
Cell Significance Index: -6.2700 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.3027
Cell Significance Index: -4.0900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3354
Cell Significance Index: -7.7500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3596
Cell Significance Index: -10.5600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3609
Cell Significance Index: -6.0800 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.3636
Cell Significance Index: -3.0900 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3651
Cell Significance Index: -6.1400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3724
Cell Significance Index: -8.9300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3804
Cell Significance Index: -8.3300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2143941255
Symbol: ODP2_HUMAN
Name: Pyruvate dehydrogenase complex component E2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 3174635
Title: Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.
PubMed ID: 3174635
PubMed ID: 3191998
Title: Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydrogenase complex.
PubMed ID: 3191998
PubMed ID: 14638692
Title: Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
PubMed ID: 14638692
PubMed ID: 20160912
Title: Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.
PubMed ID: 20160912
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25525879
Title: Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
PubMed ID: 25525879
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 16049940
Title: Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency.
PubMed ID: 16049940
DOI: 10.1002/ana.20550
PubMed ID: 9649469
Title: Three-dimensional structure of the major autoantigen in primary biliary cirrhosis.
PubMed ID: 9649469
PubMed ID: 15861126
Title: Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.
PubMed ID: 15861126
PubMed ID: 17532006
Title: Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications.
PubMed ID: 17532006
PubMed ID: 17683942
Title: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.
PubMed ID: 17683942
PubMed ID: 18387944
Title: Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2.
PubMed ID: 18387944
PubMed ID: 20361979
Title: Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.
PubMed ID: 20361979
Sequence Information:
- Length: 647
- Mass: 68997
- Checksum: DD93A8E666E377C2
- Sequence:
MWRVCARRAQ NVAPWAGLEA RWTALQEVPG TPRVTSRSGP APARRNSVTT GYGGVRALCG WTPSSGATPR NRLLLQLLGS PGRRYYSLPP HQKVPLPSLS PTMQAGTIAR WEKKEGDKIN EGDLIAEVET DKATVGFESL EECYMAKILV AEGTRDVPIG AIICITVGKP EDIEAFKNYT LDSSAAPTPQ AAPAPTPAAT ASPPTPSAQA PGSSYPPHMQ VLLPALSPTM TMGTVQRWEK KVGEKLSEGD LLAEIETDKA TIGFEVQEEG YLAKILVPEG TRDVPLGTPL CIIVEKEADI SAFADYRPTE VTDLKPQVPP PTPPPVAAVP PTPQPLAPTP SAPCPATPAG PKGRVFVSPL AKKLAVEKGI DLTQVKGTGP DGRITKKDID SFVPSKVAPA PAAVVPPTGP GMAPVPTGVF TDIPISNIRR VIAQRLMQSK QTIPHYYLSI DVNMGEVLLV RKELNKILEG RSKISVNDFI IKASALACLK VPEANSSWMD TVIRQNHVVD VSVAVSTPAG LITPIVFNAH IKGVETIAND VVSLATKARE GKLQPHEFQG GTFTISNLGM FGIKNFSAII NPPQACILAI GASEDKLVPA DNEKGFDVAS MMSVTLSCDH RVVDGAVGAQ WLAEFRKYLE KPITMLL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.