Details for: DNASE2

Gene ID: 1777

Symbol: DNASE2

Ensembl ID: ENSG00000105612

Description: deoxyribonuclease 2, lysosomal

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.82
    Marker Score: 11068
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.74
    Marker Score: 44633
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.48
    Marker Score: 817
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.29
    Marker Score: 525
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.27
    Marker Score: 5007
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1
    Marker Score: 4735
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.05
    Marker Score: 436
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.05
    Marker Score: 389.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.04
    Marker Score: 3852
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71690
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47915
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.98
    Marker Score: 2553
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1435
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.97
    Marker Score: 2676
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.96
    Marker Score: 11214
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.94
    Marker Score: 980
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1207
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.9
    Marker Score: 1497
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2691
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.89
    Marker Score: 2019
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.88
    Marker Score: 203
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.87
    Marker Score: 1392
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5225
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.86
    Marker Score: 1671.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.85
    Marker Score: 468
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4777
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.83
    Marker Score: 526.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.83
    Marker Score: 236
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.83
    Marker Score: 263
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.82
    Marker Score: 1133
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.82
    Marker Score: 986
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.77
    Marker Score: 515
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1235
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.75
    Marker Score: 1503.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.75
    Marker Score: 25980
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.75
    Marker Score: 4793
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.75
    Marker Score: 401
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.74
    Marker Score: 183
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.74
    Marker Score: 1908
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.74
    Marker Score: 1170
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.73
    Marker Score: 307
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.73
    Marker Score: 1654.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5401
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.72
    Marker Score: 1001
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.71
    Marker Score: 436
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.71
    Marker Score: 205
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.7
    Marker Score: 494
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.7
    Marker Score: 1720
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2910
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.69
    Marker Score: 7804
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.69
    Marker Score: 1744
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.69
    Marker Score: 6005
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.69
    Marker Score: 38548
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.69
    Marker Score: 6793
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.68
    Marker Score: 318
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.68
    Marker Score: 1379
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10608.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.67
    Marker Score: 146
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.67
    Marker Score: 680
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.67
    Marker Score: 1098
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.67
    Marker Score: 569
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.67
    Marker Score: 4348
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.67
    Marker Score: 2290
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.66
    Marker Score: 1210.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 604
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.66
    Marker Score: 3460
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.66
    Marker Score: 153
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.65
    Marker Score: 147
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.65
    Marker Score: 380
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.65
    Marker Score: 439
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.65
    Marker Score: 2499.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.64
    Marker Score: 569
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.63
    Marker Score: 152
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.63
    Marker Score: 812
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.62
    Marker Score: 625
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.62
    Marker Score: 151
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.62
    Marker Score: 250
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.62
    Marker Score: 1178
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.62
    Marker Score: 154
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.62
    Marker Score: 1804
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.62
    Marker Score: 147
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.61
    Marker Score: 594
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.61
    Marker Score: 465
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.61
    Marker Score: 162
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.61
    Marker Score: 2497
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.61
    Marker Score: 5240
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.61
    Marker Score: 152
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.6
    Marker Score: 3835
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.6
    Marker Score: 209
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.6
    Marker Score: 296

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Other Information

**Key characteristics**: - It is a large protein with a molecular weight of approximately 120 kDa. - It is a member of the DNASE family of enzymes, which are involved in the degradation of DNA. - It is expressed in high levels in cells that are activated by inflammation or infection. - It is a key regulator of the apoptotic pathway, and it is required for the activation of caspases, which are enzymes that are responsible for the death of cells. - It is also involved in the regulation of the immune response, and it is expressed in cells that are activated by pathogens. **Pathways and functions**: - **Apoptotic DNA fragmentation**: DNASE2 is a key enzyme in the apoptotic pathway, and it is required for the activation of caspases. - **Deoxyribonuclease ii activity**: DNASE2 is also involved in the regulation of the deoxyribonuclease ii activity, which is a process that is involved in the repair of DNA damage. - **Dna binding**: DNASE2 can bind to DNA and facilitate the cleavage of DNA strands. - **Dna metabolic process**: DNASE2 is involved in the degradation of DNA, and it is a key enzyme in the process of DNA repair. - **Enucleate erythrocyte differentiation**: DNASE2 is expressed in cells that are enucleating erythrocytes, which are cells that are dying. This indicates that DNASE2 is involved in the regulation of erythrocyte differentiation. - **Extracellular exosome**: DNASE2 is also expressed in extracellular exosomes, which are small vesicles that are released by cells. Exosomes can carry a variety of molecules, including DNA, proteins, and lipids. DNASE2 is thought to be involved in the release of DNA from exosomes, and it may play a role in the regulation of immune responses. - **Lysosome**: DNASE2 is also expressed in lysosomes, which are small organelles that are responsible for the degradation of proteins and other molecules. DNASE2 is a key enzyme in the lysosomal degradation pathway, and it is required for the clearance of damaged proteins and organelles. - **Lysosome vesicle biogenesis**: DNASE2 is also involved in the biogenesis of lysosome vesicles. This process involves the formation of new lysosome vesicles from endosomal precursors. **Clinical significance**: DNASE2 is a promising target for the treatment of cancer and other diseases that are characterized by inflammation or infection. DNASE2 inhibitors are currently being tested in clinical trials for the treatment of cancer, rheumatoid arthritis, and other inflammatory diseases.

Genular Protein ID: 3998119851

Symbol: DNS2A_HUMAN

Name: Deoxyribonuclease-2-alpha

UniProtKB Accession Codes:

O00115 B2RD06 B7Z4K6 O43910

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9924608

Title: Structure and organization of the human deoxyribonuclease II (DNase II) gene.

PubMed ID: 9924608

DOI: 10.1046/j.1469-1809.1998.6240299.x

PubMed ID: 9647784

Title: Cloning of cDNAs encoding porcine and human DNase II.

PubMed ID: 9647784

DOI: 10.1006/bbrc.1998.8839

PubMed ID: 9714827

Title: Molecular cloning and characterization of human and murine DNase II.

PubMed ID: 9714827

DOI: 10.1016/s0378-1119(98)00280-7

PubMed ID: 9812984

Title: The cloning and expression of human deoxyribonuclease II. A possible role in apoptosis.

PubMed ID: 9812984

DOI: 10.1074/jbc.273.47.30909

PubMed ID: 9446563

Title: Molecular cloning of the cDNA encoding human deoxyribonuclease II.

PubMed ID: 9446563

DOI: 10.1074/jbc.273.5.2610

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11906178

Title: Revised structure of the active form of human deoxyribonuclease IIalpha.

PubMed ID: 11906178

DOI: 10.1006/bbrc.2002.6687

PubMed ID: 12558498

Title: Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging.

PubMed ID: 12558498

DOI: 10.1042/bj20021875

PubMed ID: 12594037

Title: A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei.

PubMed ID: 12594037

DOI: 10.1016/s0378-1119(02)01233-7

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29259162

Title: Type I interferon-mediated autoinflammation due to DNase II deficiency.

PubMed ID: 29259162

DOI: 10.1038/s41467-017-01932-3

PubMed ID: 31775019

Title: Janus kinase inhibition for autoinflammation in patients with DNASE2 deficiency.

PubMed ID: 31775019

DOI: 10.1016/j.jaci.2019.11.020

Sequence Information:

  • Length: 360
  • Mass: 39581
  • Checksum: DF1BBFBA8A9676EA
  • Sequence:
    • MIPLLLAALL CVPAGALTCY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ YKYLDESSGG 
WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP QPSKAQDSSM RGHTKGVLLL 
DHDGGFWLVH SVPNFPPPAS SAAYSWPHSA CTYGQTLLCV SFPFAQFSKM GKQLTYTYPW 
VYNYQLEGIF AQEFPDLENV VKGHHVSQEP WNSSITLTSQ AGAVFQSFAK FSKFGDDLYS 
GWLAAALGTN LQVQFWHKTV GILPSNCSDI WQVLNVNQIA FPGPAGPSFN STEDHSKWCV 
SPKGPWTCVG DMNRNQGEEQ RGGGTLCAQL PALWKAFQPL VKNYQPCNGM ARKPSRAYKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.