Details for: DRD2

Gene ID: 1813

Symbol: DRD2

Ensembl ID: ENSG00000149295

Description: dopamine receptor D2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.4
    Marker Score: 760
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1516
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.18
    Marker Score: 2193
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.86
    Marker Score: 19222
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7255
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.07
    Marker Score: 1196
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.97
    Marker Score: 538
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 445
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1389
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.7
    Marker Score: 990
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.7
    Marker Score: 656.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.69
    Marker Score: 300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 443
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10120
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.65
    Marker Score: 780
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.62
    Marker Score: 1286
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 486
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.55
    Marker Score: 291
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1069
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.48
    Marker Score: 464
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.48
    Marker Score: 762
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 420.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.39
    Marker Score: 157
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 221
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.37
    Marker Score: 578
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 218
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.35
    Marker Score: 13356
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.35
    Marker Score: 157
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.33
    Marker Score: 1343
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.29
    Marker Score: 2231
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.27
    Marker Score: 643
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.26
    Marker Score: 2428
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.23
    Marker Score: 1933
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.22
    Marker Score: 80
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.22
    Marker Score: 127
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.21
    Marker Score: 96
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.21
    Marker Score: 600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2
    Marker Score: 12437
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2
    Marker Score: 249
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 94
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 234
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.18
    Marker Score: 292
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 376
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.16
    Marker Score: 661
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.15
    Marker Score: 1433
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 65
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.13
    Marker Score: 147
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 148
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.12
    Marker Score: 210
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.11
    Marker Score: 375
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 49

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Other Information

**Key characteristics:** * DRD2 is a type of G protein-coupled receptor (GPCR). * It is a ligand-gated channel that is activated by the binding of dopamine, a neurotransmitter that is involved in a variety of physiological and behavioral processes. * DRD2 is a highly important receptor for dopamine, and its activation by dopamine is essential for the survival and function of dopamine-producing neurons. * DRD2 is also involved in the regulation of inflammation and pain. **Pathways and functions:** * DRD2 is a key regulator of the growth and differentiation of neurons. * It is also involved in the regulation of apoptosis, or programmed cell death. * DRD2 is also involved in the regulation of inflammation and pain. * In addition to its roles in development and homeostasis, DRD2 is also involved in a variety of other cellular processes, including metabolism, reproduction, and learning and memory. **Clinical significance:** DRD2 is a promising target for the treatment of a variety of diseases, including Parkinson's disease, schizophrenia, and depression. Parkinson's disease is a neurodegenerative disorder that is characterized by the loss of dopamine-producing neurons in the brain. DRD2 is a key target for the treatment of Parkinson's disease, and the development of drugs that target DRD2 is an active area of research.

Genular Protein ID: 127472768

Symbol: DRD2_HUMAN

Name: D(2) dopamine receptor

UniProtKB Accession Codes:

P14416 Q9NZR3 Q9UPA9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 16 EMDB 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 7 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2533064

Title: The major dopamine D2 receptor: molecular analysis of the human D2A subtype.

PubMed ID: 2533064

DOI: 10.1089/dna.1.1989.8.683

PubMed ID: 2531656

Title: The dopamine D2 receptor: two molecular forms generated by alternative splicing.

PubMed ID: 2531656

DOI: 10.1002/j.1460-2075.1989.tb08585.x

PubMed ID: 2138729

Title: Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region.

PubMed ID: 2138729

DOI: 10.1093/nar/18.5.1299

PubMed ID: 2532362

Title: Cloning of the cDNA and gene for a human D2 dopamine receptor.

PubMed ID: 2532362

DOI: 10.1073/pnas.86.24.9762

PubMed ID: 2137193

Title: Molecular cloning and expression of a dopamine D2 receptor from human retina.

PubMed ID: 2137193

PubMed ID: 2144985

Title: DNA homology screening: isolation and characterization of the human D2A dopamine receptor subtype.

PubMed ID: 2144985

PubMed ID: 1363862

Title: Structure and expression of human and rat D2 dopamine receptor genes.

PubMed ID: 1363862

DOI: 10.1016/0197-0186(92)90071-x

PubMed ID: 1835903

Title: D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA.

PubMed ID: 1835903

DOI: 10.1007/bf00734808

PubMed ID: 8471125

Title: Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2.

PubMed ID: 8471125

DOI: 10.1038/npp.1993.15

PubMed ID: 10719223

Title: New dopamine receptor, D2(Longer), with unique TG splice site, in human brain.

PubMed ID: 10719223

DOI: 10.1016/s0169-328x(99)00343-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15857609

Title: Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).

PubMed ID: 15857609

DOI: 10.1016/j.bcp.2005.02.015

PubMed ID: 17550964

Title: Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.

PubMed ID: 17550964

DOI: 10.1242/jcs.005611

PubMed ID: 21184734

Title: Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions.

PubMed ID: 21184734

DOI: 10.1016/j.bbrc.2010.12.083

PubMed ID: 21645528

Title: Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.

PubMed ID: 21645528

DOI: 10.1016/j.neuropharm.2011.05.023

PubMed ID: 17264214

Title: Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity.

PubMed ID: 17264214

DOI: 10.1073/pnas.0608599104

PubMed ID: 22408789

Title:

PubMed ID: 22408789

DOI: 10.1073/pnas.1200173109

PubMed ID: 26535572

Title: Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.

PubMed ID: 26535572

DOI: 10.1371/journal.pone.0140661

PubMed ID: 25979333

Title: Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.

PubMed ID: 25979333

DOI: 10.1074/jbc.m114.627059

PubMed ID: 29466326

Title: Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.

PubMed ID: 29466326

DOI: 10.1038/nature25758

PubMed ID: 7902708

Title: A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys).

PubMed ID: 7902708

DOI: 10.1006/bbrc.1993.2404

PubMed ID: 10220438

Title: Association of a missense change in the D2 dopamine receptor with myoclonus dystonia.

PubMed ID: 10220438

DOI: 10.1073/pnas.96.9.5173

PubMed ID: 15389757

Title: Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics.

PubMed ID: 15389757

DOI: 10.1002/ajmg.b.30085

PubMed ID: 10716258

Title: Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia.

PubMed ID: 10716258

DOI: 10.1002/1531-8249(200003)47:3<369::aid-ana14>3.3.co;2-0

PubMed ID: 21179162

Title: A population-specific HTR2B stop codon predisposes to severe impulsivity.

PubMed ID: 21179162

DOI: 10.1038/nature09629

Sequence Information:

  • Length: 443
  • Mass: 50619
  • Checksum: 9BF8EA36C988A2E2
  • Sequence:
    • MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS 
REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA 
SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNADQN 
ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL 
KGNCTHPEDM KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP 
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK TRTSLKTMSR 
RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD CNIPPVLYSA FTWLGYVNSA 
VNPIIYTTFN IEFRKAFLKI LHC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.