Details for: DUSP3

Gene ID: 1845

Symbol: DUSP3

Ensembl ID: ENSG00000108861

Description: dual specificity phosphatase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.63
    Marker Score: 1496
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.51
    Marker Score: 832
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.48
    Marker Score: 9020
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.25
    Marker Score: 2186
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.15
    Marker Score: 29361
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.14
    Marker Score: 1184
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.07
    Marker Score: 1644
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.06
    Marker Score: 3776
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.06
    Marker Score: 2597
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.06
    Marker Score: 9072
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.03
    Marker Score: 416
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16039
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1
    Marker Score: 680
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71722
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47946
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.99
    Marker Score: 55361
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.99
    Marker Score: 1129
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.98
    Marker Score: 60279
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.95
    Marker Score: 2167
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.95
    Marker Score: 394
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.93
    Marker Score: 1955
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.9
    Marker Score: 960
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.9
    Marker Score: 1080
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.87
    Marker Score: 2186
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.86
    Marker Score: 426
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.86
    Marker Score: 2138
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.86
    Marker Score: 426
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.85
    Marker Score: 905
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.85
    Marker Score: 8052
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4830
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.84
    Marker Score: 3231
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.84
    Marker Score: 2238
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 267
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.82
    Marker Score: 2013.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 319
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.79
    Marker Score: 8189
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.79
    Marker Score: 323
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.79
    Marker Score: 1302
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.78
    Marker Score: 7354
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.78
    Marker Score: 290
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.78
    Marker Score: 4962
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.78
    Marker Score: 302
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.77
    Marker Score: 26063
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.76
    Marker Score: 3662
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.76
    Marker Score: 773
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.76
    Marker Score: 193
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1417.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.75
    Marker Score: 541
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.75
    Marker Score: 1931
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.74
    Marker Score: 4851
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.74
    Marker Score: 1095
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.74
    Marker Score: 1686
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.74
    Marker Score: 464
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.73
    Marker Score: 488
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.73
    Marker Score: 231
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.73
    Marker Score: 1031
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.72
    Marker Score: 1048
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.72
    Marker Score: 1432
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.72
    Marker Score: 172
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.72
    Marker Score: 1394
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1454
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.71
    Marker Score: 160
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.71
    Marker Score: 2219
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2929
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.7
    Marker Score: 706
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.7
    Marker Score: 696
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.68
    Marker Score: 452
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.68
    Marker Score: 1203
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.67
    Marker Score: 711
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.67
    Marker Score: 292
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.67
    Marker Score: 166
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.66
    Marker Score: 1056
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.66
    Marker Score: 13172
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.66
    Marker Score: 441
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.66
    Marker Score: 622
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1545
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.65
    Marker Score: 444
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.65
    Marker Score: 1045
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.65
    Marker Score: 184
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.65
    Marker Score: 411
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.65
    Marker Score: 377
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.64
    Marker Score: 507
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.64
    Marker Score: 628
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.64
    Marker Score: 711
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.64
    Marker Score: 266
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.64
    Marker Score: 5473

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Other Information

**Key characteristics:** - DUSP3 is a serine/threonine phosphatase that is involved in various cellular processes, including cell cycle regulation, apoptosis, and inflammation. - It has two specific substrates: MAPKAPK and STAT3. - It is a key regulator of the innate immune response, as it is expressed in high levels in immune cells and is involved in the regulation of inflammation and cell death. **Pathways and functions:** - DUSP3 is involved in the regulation of inflammation by dephosphorylating and activating MAPKAPK and STAT3, which are key regulators of the inflammatory response. - It also regulates the expression of pro-inflammatory cytokines and chemokines. - It contributes to the regulation of the innate immune response by controlling the activation of macrophages and dendritic cells. **Clinical significance:** - Mutations in DUSP3 have been linked to several autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma. - Dysregulation of DUSP3 has been implicated in the pathogenesis of these diseases. - Therefore, targeting DUSP3 is a promising therapeutic strategy for these diseases. **Additional points:** - DUSP3 is a highly conserved protein with a wide expression in mammals. - It is a member of the dual specificity phosphatase family of enzymes. - It is regulated by a variety of factors, including cytokines, growth factors, and cell signaling pathways.

Genular Protein ID: 2143342612

Symbol: DUS3_HUMAN

Name: Dual specificity protein phosphatase 3

UniProtKB Accession Codes:

P51452 D3DX45 Q5U0J1 Q8IYJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1281549

Title: Expression cloning of a human dual-specificity phosphatase.

PubMed ID: 1281549

DOI: 10.1073/pnas.89.24.12170

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10224087

Title: Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.

PubMed ID: 10224087

DOI: 10.1074/jbc.274.19.13271

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 8650541

Title: Crystal structure of the dual specificity protein phosphatase VHR.

PubMed ID: 8650541

DOI: 10.1126/science.272.5266.1328

PubMed ID: 11863439

Title: Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.

PubMed ID: 11863439

DOI: 10.1021/bi015799l

PubMed ID: 19888758

Title: Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.

PubMed ID: 19888758

DOI: 10.1021/jm901016k

Sequence Information:

  • Length: 185
  • Mass: 20478
  • Checksum: C1045DD9B226FD94
  • Sequence:
    • MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL 
NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV 
LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE 
GKLKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.