Details for: DUSP3

Gene ID: 1845

Symbol: DUSP3

Ensembl ID: ENSG00000108861

Description: dual specificity phosphatase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.5181
    Cell Significance Index: -25.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.1947
    Cell Significance Index: -22.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 64.3043
    Cell Significance Index: -26.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.1173
    Cell Significance Index: -25.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.8217
    Cell Significance Index: -23.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.8280
    Cell Significance Index: -25.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0822
    Cell Significance Index: -24.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5306
    Cell Significance Index: -25.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4595
    Cell Significance Index: -19.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7017
    Cell Significance Index: -10.2900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.8811
    Cell Significance Index: 30.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5346
    Cell Significance Index: 41.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1264
    Cell Significance Index: 67.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0926
    Cell Significance Index: 314.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9463
    Cell Significance Index: 153.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9426
    Cell Significance Index: 851.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8088
    Cell Significance Index: 87.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7666
    Cell Significance Index: 153.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7437
    Cell Significance Index: 16.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6658
    Cell Significance Index: 17.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4934
    Cell Significance Index: 9.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4502
    Cell Significance Index: 12.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4198
    Cell Significance Index: 31.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3599
    Cell Significance Index: 46.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3582
    Cell Significance Index: 71.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3549
    Cell Significance Index: 16.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3429
    Cell Significance Index: 65.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3053
    Cell Significance Index: 23.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2973
    Cell Significance Index: 162.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2755
    Cell Significance Index: 47.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2624
    Cell Significance Index: 13.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2530
    Cell Significance Index: 90.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1997
    Cell Significance Index: 9.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1897
    Cell Significance Index: 83.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1853
    Cell Significance Index: 33.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1730
    Cell Significance Index: 21.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1502
    Cell Significance Index: 4.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1271
    Cell Significance Index: 17.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1231
    Cell Significance Index: 3.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0939
    Cell Significance Index: 9.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0285
    Cell Significance Index: 1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0102
    Cell Significance Index: 0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0101
    Cell Significance Index: 7.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0091
    Cell Significance Index: 1.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0089
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0061
    Cell Significance Index: 11.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0098
    Cell Significance Index: -15.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0194
    Cell Significance Index: -1.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0195
    Cell Significance Index: -8.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0251
    Cell Significance Index: -14.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0262
    Cell Significance Index: -1.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0297
    Cell Significance Index: -4.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0357
    Cell Significance Index: -4.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0461
    Cell Significance Index: -1.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0483
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0552
    Cell Significance Index: -11.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0596
    Cell Significance Index: -0.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0660
    Cell Significance Index: -4.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0761
    Cell Significance Index: -8.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0993
    Cell Significance Index: -3.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1014
    Cell Significance Index: -6.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1015
    Cell Significance Index: -11.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1191
    Cell Significance Index: -3.4000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1450
    Cell Significance Index: -2.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1696
    Cell Significance Index: -4.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1760
    Cell Significance Index: -20.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1832
    Cell Significance Index: -4.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1955
    Cell Significance Index: -15.4800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2065
    Cell Significance Index: -3.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2158
    Cell Significance Index: -7.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2292
    Cell Significance Index: -23.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2496
    Cell Significance Index: -6.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2571
    Cell Significance Index: -15.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2573
    Cell Significance Index: -15.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2892
    Cell Significance Index: -16.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2918
    Cell Significance Index: -12.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3210
    Cell Significance Index: -4.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3260
    Cell Significance Index: -8.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3578
    Cell Significance Index: -13.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3621
    Cell Significance Index: -6.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3990
    Cell Significance Index: -7.0500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3998
    Cell Significance Index: -6.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4154
    Cell Significance Index: -8.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4284
    Cell Significance Index: -7.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4565
    Cell Significance Index: -13.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4612
    Cell Significance Index: -5.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4652
    Cell Significance Index: -6.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4839
    Cell Significance Index: -12.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4963
    Cell Significance Index: -25.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5121
    Cell Significance Index: -17.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5324
    Cell Significance Index: -17.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5328
    Cell Significance Index: -16.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5587
    Cell Significance Index: -20.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5605
    Cell Significance Index: -5.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Dual specificity phosphatase activity**: DUSP3 exhibits dual specificity phosphatase activity, enabling it to dephosphorylate and inactivate both MAPKs and their downstream targets. 2. **Negative regulation of MAPK signaling**: DUSP3 negatively regulates the MAPK signaling pathway by dephosphorylating and inactivating MAPKs and their downstream targets. 3. **High expression in immune cells and epithelial cells**: DUSP3 is highly expressed in various immune cells, including macrophages, dendritic cells, and T cells, as well as epithelial cells, such as those found in the choroid plexus and pancreatic ductal cells. 4. **Regulation of cell migration, proliferation, and differentiation**: DUSP3's ability to regulate the MAPK signaling pathway has significant implications for cell migration, proliferation, and differentiation, making it a crucial regulator of various cellular processes. **Pathways and Functions** 1. **MAPK signaling pathway**: DUSP3 negatively regulates the MAPK signaling pathway, which is involved in various cellular processes, including cell migration, proliferation, differentiation, and apoptosis. 2. **Immune response regulation**: DUSP3 plays a crucial role in regulating immune responses, including the activation and deactivation of immune cells, such as macrophages and T cells. 3. **Cellular homeostasis**: DUSP3's ability to regulate the MAPK signaling pathway helps maintain cellular homeostasis by preventing excessive cell growth and promoting apoptosis. 4. **Neurotransmission and synaptic plasticity**: DUSP3's expression in neurons suggests its involvement in neurotransmission and synaptic plasticity, particularly in the context of the MAPK signaling pathway. **Clinical Significance** 1. **Cancer**: DUSP3's overexpression has been implicated in various cancers, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 2. **Inflammatory disorders**: DUSP3's dysregulation has been linked to inflammatory disorders, such as rheumatoid arthritis and atherosclerosis, where it may contribute to the excessive activation of immune cells. 3. **Neurological disorders**: DUSP3's expression in neurons suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the pathogenesis of these conditions. 4. **Therapeutic potential**: Targeting DUSP3 may provide a novel therapeutic strategy for the treatment of various diseases, including cancer, inflammatory disorders, and neurological disorders. In conclusion, DUSP3 is a crucial regulator of the MAPK signaling pathway, playing a pivotal role in maintaining cellular homeostasis and regulating immune responses. Its dysregulation has been implicated in various diseases, highlighting the potential for therapeutic intervention. Further research is needed to fully elucidate the mechanisms by which DUSP3 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 2143342612

Symbol: DUS3_HUMAN

Name: Dual specificity protein phosphatase 3

UniProtKB Accession Codes:

P51452 D3DX45 Q5U0J1 Q8IYJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1281549

Title: Expression cloning of a human dual-specificity phosphatase.

PubMed ID: 1281549

DOI: 10.1073/pnas.89.24.12170

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10224087

Title: Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.

PubMed ID: 10224087

DOI: 10.1074/jbc.274.19.13271

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27346674

Title: Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation.

PubMed ID: 27346674

DOI: 10.1038/srep28634

PubMed ID: 27941812

Title: VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Abeta accumulation via enhancement of ERK phosphatase VHR activity.

PubMed ID: 27941812

DOI: 10.1038/srep38452

PubMed ID: 8650541

Title: Crystal structure of the dual specificity protein phosphatase VHR.

PubMed ID: 8650541

DOI: 10.1126/science.272.5266.1328

PubMed ID: 11863439

Title: Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.

PubMed ID: 11863439

DOI: 10.1021/bi015799l

PubMed ID: 19888758

Title: Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.

PubMed ID: 19888758

DOI: 10.1021/jm901016k

Sequence Information:

  • Length: 185
  • Mass: 20478
  • Checksum: C1045DD9B226FD94
  • Sequence:
    • MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL 
NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV 
LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE 
GKLKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.